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Understanding the Test
Test Measures
Interpreting Results
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Written by
Dr. Anupriya Nautiyal
MD Pathology, MBBS
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Dr. Ashish Ranjan
MBBS, MD (Pharmacology)
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Advanced Cardiac Risk Markers

Also known as Advanced Heart Check
Advanced Cardiac Risk Markers Includes 6 testsView All
2499
You need to provide
Blood, Not Applicable
This test is for
Male, Female
Test Preparation
  1. Overnight fasting is preferred but not mandatory.

Understanding Advanced Cardiac Risk Markers


What is Advanced Cardiac Risk Markers?

An Advanced Cardiac Risk Markers test is a comprehensive blood test that offers detailed information about your risk of cardiovascular disease (CVD) and the overall health of your heart. Getting tested enables you to make informed health decisions that prevent serious health complications in the future.

Specific biomarkers appear in the blood after your heart has been under severe stress or injury. These markers are valuable indicators that healthcare advisors can utilize for a more comprehensive assessment of cardiac risk factors and to tailor preventive measures and treatments.

An Advanced Cardiac Risk Markers test goes beyond the standard lipid profile. It includes a range of tests to detect biomarkers indicating heart health, such as homocysteine, apolipoprotein A, apolipoprotein B, lipoprotein A, and a high-sensitivity C-reactive protein (hs-CRP). The hs-CRP and homocysteine are markers that can indicate inflammation in the body, which is linked to a higher risk of heart disease. Apolipoproteins A is primarily associated with high-density lipoprotein (HDL), and its increased levels may indicate a reduced risk of cardiovascular disease. Meanwhile, apolipoprotein B is associated mainly with low-density lipoprotein (LDL), and its increased levels may indicate an increased risk of heart disease. Furthermore, elevated lipoprotein A levels are associated with an increased risk of atherosclerosis and cardiovascular events.

An Advanced Cardiac Risk Markers test is typically recommended for individuals with specific risk factors for heart disease, such as a family history of CVD, diabetes, or other conditions. You may need this test when you show symptoms suggestive of cardiac ailments, such as chest pain or pressure that lasts for more than several minutes; pain or discomfort in your shoulders, neck, arms, or jaw; shortness of breath; palpitations; extreme fatigue; or swelling of the feet, ankles, legs, abdomen, or neck veins. 

Usually, overnight fasting (8-12 hours) is preferred for an Advanced Cardiac Risk Markers test. Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Talk to your doctor about your specific test results. The results of this test can guide your doctor to suggest lifestyle changes, medication management, and other interventions to reduce the risk of heart disease and improve heart health.

What is Advanced Cardiac Risk Markers used for?

An Advanced Cardiac Risk Markers test is done:

  • To identify individuals at higher risk of heart-related issues, even before they develop symptoms.
  • To monitor the effectiveness of treatments and lifestyle changes in individuals already diagnosed with a heart condition.
  • To assess the functioning and overall health of the heart and as part of health checkups.
  • To determine an individual's risk of developing heart conditions, stroke, and peripheral artery disease, especially those with risk factors such as family history, obesity, diabetes, high blood pressure, and prior heart attack or stroke.

What does Advanced Cardiac Risk Markers measure?

Contains 6 tests

An Advanced Cardiac Risk Markers test assesses the level of specific proteins called cardiac markers in the blood and helps determine the risk of heart ailments. This test determines the amount of apolipoprotein A1, apolipoprotein B, lipoprotein A, homocysteine, and high-sensitivity CRP in the blood. These cardiac markers play a pivotal role in the functioning of the heart, and a deranged level of any of these might indicate a developing heart disease.

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hsCRP (High Sensitive CRP)

An hsCRP (High Sensitive CRP) test is a state-of-the-art biochemical marker to predict potential risks of future diseases. This test is more sensitive than the standard CRP test and can also detect lower CRP levels in the blood. Its accuracy in predicting cardiovascular issues, autoimmune disorders, and other health issues makes it an excellent test to detect asymptomatic conditions with limited diagnosis.

Know more about hsCRP (High Sensitive CRP)

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Apolipoprotein - A1

An Apolipoprotein - A1 test helps check the levels of Apolipoprotein A1 in your blood. Apolipoprotein A1 is the major protein for the high-density lipid (HDL), also known as “good” cholesterol and helps in its transport. Apo A1 helps the HDL to take up cholesterol from the tissues and is bound by receptors in the liver where the cholesterol is destroyed. Assessing the levels of Apolipoprotein A1 directly reflects the high-density lipoprotein levels. In this way, apolipoprotein A can help to lower your risk for cardiovascular disease.

Know more about Apolipoprotein - A1

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Apolipoprotein B/A1 Ratio

An Apolipoprotein B/A1 Ratio test helps predict the risk of cardiovascular disease (CVD) in individuals at high risk, such as those who are obese, have a family history of heart disease, have high cholesterol, or have had similar health issues in the past. Apolipoprotein A1 is the primary protein associated with HDL cholesterol (good cholesterol), and its increased concentrations are associated with a reduced risk of cardiovascular disease. Apolipoprotein B is the primary protein associated with LDL cholesterol (bad cholesterol) and other lipid molecules. An increase in LDL cholesterol is associated with increased risk of cardiovascular disease. Therefore, an Apolipoprotein B/A1 Ratio test is a key marker of developing potential cardiovascular disease (CVD) or heart-related ailments. 

Know more about Apolipoprotein B/A1 Ratio

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Serum Homocysteine

The Serum Homocysteine test measures your blood levels of homocysteine that serves in the body as an intermediate in the metabolism of methionine and cysteine. Methionine is an essential amino acid and antioxidant that synthesizes proteins. Cysteine is a nonessential amino acid synthesized from methionine. It reduces inflammation, increases communication between immune cells, and increases liver health.

The human body generally has low levels of homocysteine. This is because our body uses vitamins B12, B6, and folic acid (also called folate or vitamin B9) to break down homocysteine rapidly, convert it into other compounds, and transport it to our body. However, high levels can damage blood vessels and increase the risk of heart attacks, damage to arteries, and brain stroke.

Know more about Serum Homocysteine

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Apolipoprotein - B

The Apolipoprotein B test is used to evaluate the level of Apolipoprotein B in your blood. It is a type of protein that aids in the transportation of fat and cholesterol throughout the body. Apo B serves as the primary protein component of lipoproteins such as very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), and chylomicrons. It binds to LDL or “bad” cholesterol, causing plaque accumulation in the blood vessels. This can lead to the development and progression of cardiovascular disease that can be life-threatening if left untreated.

Know more about Apolipoprotein - B

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Lipoprotein A

The Lipoprotein A test measures the amount of lipoprotein A (Lp-A) particles in your blood. Lipoprotein A is a mixture of Low-density lipoprotein (LDL) and a protein called apolipoprotein a. Lp-A levels are largely determined by genetics. Lp-A levels are not significantly affected by diet, exercise, or lifestyle changes, unlike other types of cholesterol. That is why testing for Lp-A is essential, particularly for individuals with a strong family history of cardiovascular (heart or blood vessel) disease as it is considered an independent risk factor for heart attack and stroke. This test can help identify individuals who are at high risk, enabling early intervention to prevent future complications.

Know more about Lipoprotein A

Interpreting Advanced Cardiac Risk Markers results


Interpretations

Lipoprotein (a) helps to determine the risk of heart disease in patients with a family history of premature CHD or Stroke, Hypertension, Cigarette smoking, Obesity, Diabetes mellitus, increased levels of LDL, and decreased levels of HDL.
High levels of Lp(a) increase the risk of heart disease by 2-3 times normal.

Apolipoprotein A1 is the primary protein associated with HDL Cholesterol. It shows a protective function against heart disease. Increased levels are associated with reduced risk of cardiovascular disease. 

Apolipoprotein B is the primary protein associated with LDL Cholesterol and plaque formation. Increased levels are associated with an increased risk of heart disease. 

The ratio of these two correlates with the risk of cardiovascular disease.

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about Advanced Cardiac Risk Markers


Frequently Asked Questions about Advanced Cardiac Risk Markers

Q. What is an Advanced Cardiac Risk Markers test?

An Advanced Cardiac Risk Markers test is a blood test that measures different types of biomarkers to evaluate the functioning of your heart and help in the early detection of developing heart diseases. This test is typically recommended for individuals with specific risk factors for heart disease, such as a family history of cardiovascular disease, diabetes, hypertension, or other conditions.

Q. What are the cardiac risk markers?

Cardiac risk markers, also known as cardiovascular risk markers, are substances or indicators in the body that are associated with an individual's risk of developing cardiovascular disease (CVD), which includes conditions such as heart disease and stroke. These markers are released into the blood when the heart is damaged or stressed and provide valuable information about the health of the heart and blood vessels.

Q. What does an Advanced Cardiac Risk Markers test measure?

An Advanced Cardiac Risk Markers test measures the levels of apolipoproteins A and B, lipoprotein A, homocysteine, and high-sensitivity CRP in your blood. An abnormal value of these blood tests may indicate your heart is unhealthy. However, the test parameters may vary from lab to lab.

Q. Do I need to fast before an Advanced Cardiac Risk Markers test?

Yes, you need to fast before an Advanced Cardiac Risk Markers test; this means not eating or drinking anything other than water for 8 to 12 hours before the test. It is necessary because food can affect the levels of specific cardiac risk markers in your blood, potentially making the test results less accurate. It should be noted that fasting is preferred, but not mandatory before undergoing a Advanced Cardiac Risk Markers test. Follow all the instructions thoroughly given by your healthcare provider.

Q. What are the ways to keep my heart healthy?

You can keep your heart healthy by making a few changes in your lifestyle, such as eating heart-healthy food, managing your body weight by exercising regularly, and avoiding alcohol and smoking.
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Advanced Cardiac Risk Markers test price for other cities


Price inBangaloreRs. 2499
Price inMumbaiRs. 2399
Price inNew DelhiRs. 2499
Price inNoidaRs. 2380
Price inHyderabadRs. 2499
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