Test Detail
Understanding the Test
Test Measures
References
Other Tests
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Written by
Dr. Shreya Gupta
BDS, MDS - Oral and Maxillofacial Pathology
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Dr. Ashish Ranjan
MBBS, MD (Pharmacology)
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Apple

You need to provide
Blood
This test is for
Male, Female
Test Preparation
  1. No special preparation is required.

Understanding Apple


What is Apple?

The Apple test is a blood test tailored to detect specific immunoglobulin E (IgE) antibodies in response to apple proteins (antigens). This test helps identify apple and apple-based food allergies.

Apples are a popular fruit loved for their crunchy texture, sweet-tart taste, and health benefits, including vitamins, fiber, and antioxidants. However, some individuals can have allergic reactions to apples, causing stomach problems, skin rashes, or more serious reactions. The Apple test helps detect an apple allergy by checking for specific antibodies (IgE) that the body makes against proteins present in apples. This test helps confirm if the immune system is mistakenly treating apples as a threat and causing an allergy.

The Apple test is recommended when individuals experience symptoms like swelling, itching, or discomfort in the mouth or throat, skin rashes, nausea, stomach pain, or diarrhea after eating apples or apple-based foods. It helps distinguish apple allergies from other conditions like food intolerances or oral allergy syndrome (OAS), a type of food allergy that causes allergic reactions in the lips, mouth, and throat upon eating certain raw fruits and vegetables. 

A positive test result for apple-specific IgE antibodies means there is an ongoing apple allergy, and avoiding apples is usually recommended to prevent reactions. If the result is negative, more tests may be needed to find other causes for the symptoms, such as food sensitivities that don’t involve IgE antibodies.

No special preparation is required for the Apple test. However, it is important to inform the doctor about any medications (such as antihistamines) or supplements being taken, as these may affect the test results. Lab test results can vary depending on the specific test method and allergens used, so they should be interpreted alongside clinical symptoms.

What is Apple used for?

The Apple test is done:

  • To confirm an allergy to apples in individuals who exhibit allergic reactions or symptoms after consuming apples.
  • To find out the cause of symptoms like nausea, stomach pain, itching, swelling, or stomach issues that happen after eating apples.
  • To help formulate treatment plans, including dietary changes and medication to manage allergies.
  • To monitor the effectiveness of ongoing apple allergy treatments.
  • To identify individuals at risk of developing food allergies, especially those with a family history of allergies.

What does Apple measure?

The Apple test measures the amount of specific antibodies (IgE) in the body that react to apple proteins. This test is important for diagnosing apple allergies and distinguishing them from other conditions like food sensitivities or oral allergy syndrome (OAS). It helps doctors understand how severe the allergy might be, guiding the next steps in diagnosis and treatment.

References

  1. Dougherty JM, Alsayouri K, Sadowski A. Allergy. [Updated 2023 Jul 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK545237/ External Link
  2. Lopez CM, Yarrarapu SNS, Mendez MD. Food Allergies. [Updated 2023 Jul 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482187/ External Link
  3. Causes and prevention of food allergy [Internet]. NIH; 23 Mar. 2023. [Accessed 22 Jan. 2025]. Available from: https://www.niaid.nih.gov/diseases-conditions/food-allergy-causes-prevention External Link
  4. Allergens [Internet]. NIH; 07 Sep. 2022. [Accessed 22 Jan. 2025]. Available from: https://www.niehs.nih.gov/health/topics/agents/allergens/index.cfm External Link
  5. Portnoy JM. Appropriate {test_name} testing and interpretation. Mo Med. 2011 Sep-Oct;108(5):339-43. PMID: 22073491; PMCID: PMC6188374. [Accessed 22 Jan. 2025]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188374/ External Link
  6. Siekierzynska A, Piasecka-Kwiatkowska D, Myszka A, Burzynska M, Sozanska B, Sozanski T. Apple allergy: Causes and factors influencing fruits allergenic properties-Review. Clin Transl Allergy. 2021 Jun 2;11(4):e12032. [Accessed 22 Jan. 2025]. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8171779/ External Link
  7. Kopac P, Rudin M, Gentinetta T, Gerber R, Pichler Ch, Hausmann O, Schnyder B, Pichler WJ. Continuous apple consumption induces oral tolerance in birch-pollen-associated apple allergy. Allergy. 2012 Feb;67(2):280-5. [Accessed 22 Jan. 2025]. Available from: https://pubmed.ncbi.nlm.nih.gov/22070352/ External Link
  8. Pollen Food Allergy Syndrome [Internet]. American College of Allergy, Asthma & Immunology. [Accessed 22 Jan. 2025]. Available from: https://acaai.org/allergies/allergic-conditions/food/pollen-food-allergy-syndrome/ External Link

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