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BRCA1 and BRCA2 Gene Sequencing Panel

BRCA1 and BRCA2 Gene Sequencing Panel

Also referred as
Hereditary Breast & Ovarian Cancer Test
For men & women
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The BRCA1 and BRCA2 Gene Sequencing Panel is a blood test that checks for inherited mutations in the BRCA1 and BRCA2 genes. These genes normally help repair DNA and prevent uncontrolled cell growth. Detecting mutations helps doctors understand your risk for breast, ovarian, prostate, and pancreatic cancers; guide preventive measures; and support personalized treatment planning.

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Understanding BRCA1 and BRCA2 Gene Sequencing Panel

The BRCA1 and BRCA2 Gene Sequencing Panel is a comprehensive genetic test designed to evaluate the BRCA1 and BRCA2 genes, which are tumor suppressor genes critical for DNA repair and preventing cells from becoming cancerous. Mutations in these genes can disrupt normal cell growth and increase the risk of several cancers, most commonly breast and ovarian cancer, but also prostate and pancreatic cancers.

By sequencing these genes, the panel identifies small mutations as well as large deletions or duplications that may predispose individuals to cancer. For individuals over 18 years old who carry these mutations, early detection allows for preventive strategies such as increased monitoring, risk-reducing surgeries, lifestyle modifications, or other medical interventions.

Doctors may recommend the BRCA1 and BRCA2 Gene Sequencing Panel for individuals who have a strong family history of breast or ovarian cancer, a personal history of these cancers at a young age, or if family members are known carriers of BRCA mutations. Genetic counseling is recommended for all individuals undergoing testing to help understand the results and discuss preventive or therapeutic strategies.

For this test, it is important to provide the histopathological report of the patient (in primary cases), relevant family history (for first-degree relative screening), clinical history, other test reports, and a doctor’s prescription at the time of sample collection. The Tata 1mg consolidated Test Requisition Form (TRF) must be filled and submitted along with the sample. Consent forms are required for minors to ensure proper authorization for testing.

Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation. Therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for a proper understanding of the test results.

Note: Genetic counseling can be provided. If interested, please send the request to this email id: [email protected]  

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What does BRCA1 and BRCA2 Gene Sequencing Panel measure?

The BRCA1 and BRCA2 Gene Sequencing Panel detects mutations in the BRCA1 and BRCA2 genes, which are tumor suppressor genes responsible for repairing DNA and preventing uncontrolled cell growth. The test identifies both small genetic changes (like point mutations) and larger deletions or duplications in these genes. Detecting such mutations helps assess an individual’s inherited risk for breast, ovarian, prostate, and pancreatic cancers. By understanding whether these genetic alterations are present, doctors can guide preventive strategies, inform treatment decisions in affected individuals, and provide genetic counseling for family members at risk.

FAQs related to BRCA1 and BRCA2 Gene Sequencing Panel

The BRCA1 and BRCA2 Gene Sequencing Panel is a genetic test that identifies mutations in the BRCA1 and BRCA2 genes, which play a key role in repairing DNA and preventing cancer. This test helps assess the inherited risk of breast, ovarian, prostate, and pancreatic cancers and supports preventive strategies and treatment decisions.
This panel is recommended for individuals with a strong personal or family history of breast or ovarian cancer, those diagnosed with cancer at a young age, or family members of individuals known to carry BRCA1 or BRCA2 mutations. It can also be advised for individuals seeking predictive and preventive genetic information.
No special preparations are required for the test. Patients should provide their clinical history, histopathology reports (for primary cancer cases), relevant family history, previous test reports, and a doctor’s prescription at the time of sample collection. A Tata 1mg consolidated Test Requisition Form (TRF) must also be duly filled. In case of minors, a consent form is required.
A phlebotomist will clean your skin using an antiseptic alcohol cotton swab or wipe and take blood samples from your vein using a needle. The blood sample will be stored safely and transported to the laboratory for analysis.
No fasting is required for this panel. You can schedule it at your convenience without avoiding food or water beforehand.
No, the BRCA1 and BRCA2 Gene Sequencing Panel is generally safe with minimal risks. However, you may feel slight discomfort during blood sample collection, but the chances of serious complications are extremely rare.
A positive result indicates the presence of mutations in the BRCA1 or BRCA2 genes, suggesting a higher risk of developing certain cancers. A negative result indicates no pathogenic mutations were detected.
If a mutation is detected, your doctor or genetic counselor will discuss preventive strategies, early screening, and potential treatments. Family members may also be advised to undergo testing.
HBOC is a condition where multiple family members have breast or ovarian cancer, often due to inherited BRCA1 or BRCA2 gene mutations. Early testing helps with prevention, early detection, and personalized management.
Content created by
Written by:
Shweta Prakash
MSc, BSc
Reviewed by:
Dr. Swati Gupta (Anand)
MD Lab Medicine, MBBS
Want to know moreRead our editorial policy
Last Updated13th Dec 2025

BRCA1 and BRCA2 Gene Sequencing Panel test price for other cities

Price inHyderabadRs. 9880
Price inBangaloreRs. 9880
Price inGurgaonRs. 9880
Price inPuneRs. 9880
Price inMumbaiRs. 9880

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BRCA1 and BRCA2 Gene Sequencing Panel