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Myeloproliferative Neoplasm (MPN) Reflex Panel [NGS]

Myeloproliferative Neoplasm (MPN) Reflex Panel [NGS]

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The Myeloproliferative Neoplasm (MPN) Reflex Panel [NGS] is a genetic test that examines mutations and gene fusions associated with myeloproliferative neoplasms (MPNs), a type of blood cancer. It helps doctors diagnose, classify, and monitor these conditions, allowing for personalized treatment planning.

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Understanding Myeloproliferative Neoplasm (MPN) Reflex Panel [NGS]

Chronic myeloproliferative neoplasms (MPNs) are blood disorders in which the bone marrow produces too many red blood cells, white blood cells, or platelets.

The Myeloproliferative Neoplasm (MPN) Reflex Panel [NGS] is used to evaluate genetic changes in blood cells that are characteristic of myeloproliferative neoplasms (MPNs). These include conditions such as polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF), and chronic myeloid leukemia (CML). This panel combines multiple molecular assays to detect mutations in genes associated with MPNs, including JAK2, MPL, and CALR. 

This panel works in a stepwise or “reflex” manner. It first checks for the common JAK2 V617F mutation. If this result is negative, the test automatically analyzes other regions of the JAK2 gene, followed by the MPL and CALR genes if needed. This step-by-step process helps identify mutations that cause MPNs, ensuring accurate and efficient diagnosis. 

Doctors may recommend this test if you have abnormal blood counts, symptoms such as fatigue, weakness, night sweats, or an enlarged spleen, or a family history of MPNs. The test helps differentiate between MPN subtypes, guide treatment decisions, monitor disease progression, and assess the risk of complications.

For this test, it is important to submit the clinical history, histopathology report, previous test results, and a doctor’s prescription at the time of sample collection. The Tata 1mg consolidated Test Requisition Form (TRF) must also be duly filled and submitted.

Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation. Therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for proper understanding of the test results.

Note: Genetic counseling can be provided. If interested, please send the request to this email id:[email protected]

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What does Myeloproliferative Neoplasm (MPN) Reflex Panel [NGS] measure?

The Myeloproliferative Neoplasm (MPN) Reflex Panel [NGS] detects genetic mutations in the JAK2, MPL, and CALR genes. By identifying these mutations in a sequential manner, the test provides a detailed molecular profile that helps doctors accurately diagnose and classify MPNs, including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Abnormal results indicate the presence of specific genetic changes linked to these conditions and guide safe and effective treatment planning.

FAQs related to Myeloproliferative Neoplasm (MPN) Reflex Panel [NGS]

It’s called a “reflex” panel because the testing happens step by step. The lab first checks for the common JAK2 V617F mutation. If it’s negative, it automatically tests other parts of the JAK2 gene, then the MPL gene, and finally the CALR gene if needed. This ensures no important mutation is missed.
Doctors recommend this test to identify the genetic cause of abnormal blood cell production. It helps confirm or rule out MPNs and guides treatment decisions.
This test is suggested for people who have: Persistently high red blood cell, white blood cell, or platelet counts; Symptoms such as fatigue, headaches, dizziness, or unexplained blood clots; Suspicion of conditions like PV, ET, or PMF.
A phlebotomist will clean your skin using an antiseptic alcohol cotton swab or wipe and take blood samples from your vein using a needle. The blood sample will be stored safely and transported to the laboratory for analysis.
No fasting is required for this test. You can schedule it at your convenience without avoiding food or water beforehand.
No, the Myeloproliferative Neoplasm (MPN) Reflex Panel [NGS] is generally safe with minimal risks. However, you may feel slight discomfort during blood sample collection but chances of serious complications are extremely rare.
It measures genetic mutations in the JAK2, MPL, and CALR genes. Identifying these mutations helps doctors accurately diagnose and classify specific types of MPNs and plan appropriate treatment.
Abnormal results indicate the presence of genetic mutations that are commonly found in MPNs. The specific mutation pattern helps your doctor identify the exact type of MPN and select the best treatment approach.
Yes. MPNs are a group of blood cancers that originate in the bone marrow, where blood cells are produced. They cause excessive production of one or more types of blood cells—red cells, white cells, or platelets.
Symptoms may include fatigue, weakness, headaches, dizziness, night sweats, weight loss, or enlarged spleen. Some patients may also have blood clotting or bleeding problems. However, in early stages, MPNs may not cause noticeable symptoms and are often found during routine blood tests.
There is currently no complete cure for most MPNs, but early diagnosis and treatment can effectively control symptoms, prevent complications, and improve quality of life. Some cases may be treated with targeted therapies or bone marrow transplantation, depending on disease type and stage.
Content created by
Written by:
Dr. Lipika Khurana
BDS, PGDHHM
Reviewed by:
Dr. Swati Gupta (Anand)
MBBS, MD Lab Medicine
Want to know moreRead our editorial policy
Last Updated13th Dec 2025

Myeloproliferative Neoplasm (MPN) Reflex Panel [NGS] test price for other cities

Price inBangaloreRs. 7600
Price inAgraRs. 7600
Price inPuneRs. 7600
Price inNew DelhiRs. 7600
Price inKolkataRs. 7600

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Myeloproliferative Neoplasm (MPN) Reflex Panel [NGS]