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Vitamin E deficiency

Vitamin E deficiency

Also known as Alpha-tocopherol deficiency

Overview

 

Vitamin E, a fat-soluble antioxidant, protects cells from damage by fighting free radicals and supporting vision, fertility, immunity, and brain and nerve health. Vitamin E deficiency is rare and characterized by muscular pain, weakness, loss of control over body movement, difficulty walking, numbness, and vision problems.

 

Vitamin E deficiency is often caused by issues that impair fat absorption, such as cystic fibrosis, liver disease, and Crohn's disease since vitamin E is fat-soluble. Premature infants and those with genetic disorders affecting vitamin E metabolism are also at higher risk.

 

Vitamin E deficiency is typically treated with oral vitamin E supplements, adjusted to meet individual needs. Higher doses or specialized formulations may be prescribed in severe cases, especially for those with absorption issues.

Key Facts

Usually seen in
  • Children between 5 to 20 years 
  • Adults over the age of 55 years.
Gender affected
  • Both men and women but more common in men.
Body part(s) involved
  • Blood
  • Brain
  • Heart
  • Skin
  • Eyes
  • Digestive system
  • Nervous System
  • Gastrointestinal tract
Mimicking Conditions
  • Friedreich ataxia
  • Ataxia with vitamin E deficiency (AVED)
  • Stroke
  • Cerebral palsy
  • Paraneoplastic syndrome
  • Biliary disease
  • Short-Bowl syndrome
  • Mutations in the tocopherol transfer protein causing impaired fat metabolism 
  • Cystic fibrosis 
  • Chronic cholestatic hepatobiliary disease 
  • Crohn disease
  • Exocrine pancreatic insufficiency
  • Liver disease 
  • Abetalipoproteinemia
  • Isolated vitamin E deficiency
Necessary health tests/imaging
Treatment
  • Dietary changes 
  • Oral Vitamin E tablets 
  • Intramuscular Injection
Specialists to consult
  • General Physician
  • Nutritionist
  • Gastroenterologist
  • General medicine specialist

Symptoms Of Vitamin E Deficiency 

 

The deficiency of Vitamin E is rare and can be marked by the following signs and symptoms:

 

  • Muscular pain

  • Weakness 

  • Difficulty in walking 

  • Numbness and tingling 

  • Loss of control of body movements

  • Vision problems 

  • Weakened immune system 

  • Loss of feeling in the arms and legs 

 

Children may experience the following additional symptoms: 

 

  • Hyporeflexia (decreased muscle response to the stimuli)

  • Loss of position sense (reduced awareness of posture, weight, movement, and limb position)

  • Retinopathy (damage to the blood vessels of the eye)

Did you know?

Vitamin E deficiency in premature infants can cause hemolytic anemia. It is a serious form of anemia in which red blood cells rupture. 

With new medical advancements, you can now know if you are at risk of hemolytic anemia with just a simple blood test.

Did you know?

Causes Of Vitamin E Deficiency 

 

  • Vitamin E is a crucial antioxidant that protects cell membranes from oxidative damage, supports immune function, and maintains skin and eye health. 

  • When vitamin E is deficient, the body lacks this antioxidant protection, leading to increased oxidative stress, especially in nerve and muscle cells.

  • This can result in neurological symptoms (such as muscle weakness and coordination issues) and immune dysfunction, as cell membranes become more susceptible to damage.

 

Factors that can increase the risk of Vitamin E deficiency are discussed below.

Risk Factors Of Vitamin E Deficiency

1. Fat malabsorption

Vitamin E requires fat for absorption, so individuals with fat absorption issues are at higher risk of deficiency due to conditions like:

  • Chronic pancreatitis

  • Celiac disease

  • Cholestatic liver disease

  • Cystic fibrosis

  • Short bowel syndrome 

  • Gall bladder disorders 

  • Liver disorders

 

Liver Disorders Are Increasing In India! A recent report suggests that 1 in every 3 people in India suffer from fatty liver. Want to know more about this condition?

2. Family History

One of the primary reasons for Vitamin E deficiency is in our genes. Many times, this deficiency is passed on from the generations. 

 

Note: If there is a history of vitamin E deficiency in the family, then it is of utmost importance to keep a regular eye on vitamin E levels. 

 

3. Low birth weight

  • The likelihood of this deficiency is also high among newborns and premature babies with lower birth weights. 

  • Premature babies often have underdeveloped digestive systems that can also interfere with the absorption of fat and Vitamin E. 

 

Premature baby at home? Here is how to care

4. Age and Gender

  • Vitamin E deficiency is most common among the elderly and children due to limited dietary diversity and low fruit and vegetable intake.

  • Among adults, many studies have demonstrated a higher prevalence of Vitamin E deficiency in men than in women. 

 

5. Environmental Factors

  • Obesity 

  • Surgery Foods

  • Low dietary intake of Vitamin E

  • Smoking 

 

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Diagnosis Of Vitamin E Deficiency 

 

The diagnosis of Vitamin E deficiency includes:

1. Medical history and physical examination 

  • The medical practitioner analyzes the potential risk factors and the personal health history during screening for Vitamin E deficiency. 

  • The presence of various signs and symptoms are evaluated.

 

2. Vitamin E (tocopherol) test

  • This test measures blood levels of Vitamin E, helping to detect deficiencies that may impact immune function, vision, and skin health.

 

3. Imaging tests 

These tests may be required to identify the underlying cause or the outcomes of Vitamin E deficiency. 

 

  • X-rays: A prolonged Vitamin E deficiency can cause bone damage due to impaired calcium absorption. X-rays are used to assess bone density.

  • Magnetic resonance imaging (MRI): The severe deficiency of Vitamin E can damage nerves. MRI is used to examine the condition of the brain and spinal cord, particularly in the presence of symptoms such as numbness, tingling, or balance problems. 

 

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Prevention Of Vitamin E Deficiency 

 

Here are a few tips suggested to avoid vitamin E deficiency:

 

1. Add Vitamin E to your diet 

 

To meet these requirements, include plant-based oil, nuts, seeds, fruits, and vegetables sources of Vitamin E in your diet. 

 

2. Include good sources of fat 

Vitamin E can not be absorbed without fat. It is important to include good sources of polyunsaturated fatty acids (PUFAs) in the diet. Some examples include:

  • Walnuts

  • Sunflower seeds

  • Flax seeds or flax oil

  • Fish, such as salmon, mackerel, herring, albacore tuna, and trout

  • Corn oil

  • Soybean oil

  • Safflower oil

 

3. Increase the intake of Vitamin C

Vitamin C helps in supporting the antioxidant effects of Vitamin E. To keep your vitamin E level high, make sure to eat vitamin C-rich foods.

 

Unable to meet the dietary intake of Vitamin C? Try our Vitamin C supplements after consulting with your doctor.

4. Limit starch-containing foods 

  • People who eat a lot of starchy foods such as sweets, bread, and potatoes tend to have lower Vitamin E levels. 

  • Limit the amount of starch-containing foods and add green vegetables and nuts to the diet. 

Did you know?

Vitamin E, often known as the "beauty vitamin," helps prevent cell damage, especially in skin cells, by shielding the epidermis from UV rays and harmful free radicals. It also maintains skin hydration, keeping it smooth and supple.

Did you know?

Specialist to Visit 

 

Medical professionals to consult in case of Vitamin E deficiency include:

 

  • General physician

  • General medicine specialist

  • Gastroenterologist

  • Nutritionist


A general physician can help in the diagnosis and treatment of Vitamin E deficiency. 

 

A gastroenterologist helps in managing cases where deficiency develops due to malabsorption.

 

A general medicine specialist can diagnose vitamin E deficiency, assess overall health, and provide guidance on supplementation and dietary changes to address the deficiency.

 

A nutritionist can help with Vitamin E deficiency by assessing your dietary habits and developing a personalized meal plan to ensure adequate intake of this essential nutrient. 

 

Consult India’s best doctors online with a single click.

Treatment Of Vitamin E Deficiency 

 

The treatment of Vitamin E deficiency focuses on correcting the underlying cause such as fat malabsorption along with supplementation. Here are some common methods used to treat Vitamin E deficiency:

 

1. Dietary modifications

  • A modification in diet helps to a greater extent in the course of treatment. 

  • Individuals are advised to increase their intake of leafy vegetables, whole grains, nuts, seeds, vegetable oils, and fortified cereals. 

 

2. Vitamin E supplementation

  • Oral supplements are typically prescribed in the form of tablets or soft gel capsules for mild to moderate deficiency. 

  • Severe Vitamin E deficiency due to genetic defects or chronic diseases requires lifelong supplementation with high doses of vitamin E to prevent nerve damage and other complications.

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  • Intramuscular injections are recommended for individuals having issues with the small intestine or oral ingestion. 

 

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Home-care For Vitamin E deficiency

 

To obtain the recommended intake of Vitamin E, it is advisable to consume a diverse selection of foods, including the following options:

 

Sunflower Seeds (Soorajmukhi ke Beej): These are rich in vitamin E, making them an excellent snack to help prevent or address vitamin E deficiency.

 

How To Use It?

Sprinkling sunflower seeds in yogurt, oatmeal, or salad can provide a variety of nutrients.

 

Buy the best sunflower seeds with just a few clicks. 

Almonds (badam): Almonds are rich in vitamin E, providing a nutritious way to prevent or alleviate vitamin E deficiency.

 

Here are 8 amazing benefits of almonds.

 

Spinach (palak): Spinach is loaded with vitamin E, making it a beneficial leafy green for boosting vitamin E levels.

 

Want to know some more health benefits of spinach?

 

Eggs (ande): These are an excellent source of Vitamin E, especially the egg yolks which contain higher levels of the nutrient compared to the whites.

 

Here are 8 reasons to have eggs daily.

 

Fortified cereals: These include food items such as whole wheat and oats. They are also an excellent choice for Vitamin E and regular consumption can help raise Vitamin E levels.

 

Milk and other dairy products: Milk, along with cheese and paneer, is rich in vitamin E, protein, calcium, and minerals, and is absorbed quickly and easily in the stomach.

Complications Of Vitamin E deficiency

 

Vitamin E deficiency can lead to various complications and health problems. Here are some of the potential complications associated with Vitamin E deficiency:

 

  • Low immunity: Vitamin E deficiency impairs the immune response, making the body more prone to infectious and chronic diseases.

    Boost your immune system from our wide range of supplements. 


  • Cancer: People with low Vitamin E lack its powerful endogenous anticancer properties. Low Vitamin E is associated with certain types of cancers such as melanoma (skin cancer), oral cancer, etc.

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  • Anemia: People with Vitamin E deficiency are prone to hemolytic anemia which causes excessive red blood cell destruction.

    Check some of the common symptoms of anemia that you might be ignoring


  • Heart disease and stroke: Antioxidants like Vitamin E are crucial for a healthy heart and blood vessels. Vitamin E deficiency can lead to stroke or heart failure

 

  • Reduced fertility: Vitamin E plays a vital role in reproductive health in both men and women. Low levels may reduce the chance of conception and successful pregnancy.

 

  • Vision problems: Lack of Vitamin E can cause vision loss by reducing the number of light receptors in the retina. This leads to impaired vision over time.

Living With Vitamin E Deficiency

 

Living with Vitamin E deficiency requires careful management and attention to your diet and overall health. Here are some suggestions to help you live with a Vitamin E deficiency:

1. Take supplements regularly

To restore the levels, the doctor may prescribe oral or injectable supplements. Follow their dosage recommendations.

2. Monitor your diet

Maintain a food diary to track your Vitamin E intake and discover any inadequacies. This might help in identifying patterns and making appropriate adjustments.

3. Be aware of symptoms

Stay alert for any symptoms of Vitamin E deficiency and report any new symptoms to the doctor as soon as possible.

4. Go for regular check-ups

Schedule regular check-ups to monitor Vitamin E levels and get guidance on treatment adjustments as needed.

5. Be cautious of certain medications 

People on blood thinners should avoid taking Vitamin E supplements as high levels may increase the risk of bleeding. 

Frequently Asked Questions

References

  1. Kemnic TR, Coleman M. Vitamin E Deficiency. [Updated 2023 Jul 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan:External Link
  2. PIB Press Release. Available online at External Link
  3. Vitamin E. Harvard T.H CHAN. March 2023.External Link
  4. Traber MG. Vitamin E inadequacy in humans: causes and consequences. Adv Nutr. 2014 Sep;5External Link
  5. Lobo LMC, Hadler MCCM. Vitamin E deficiency in childhood: a narrative review. Nutr Res Rev. 2022 Aug 5External Link
  6. Medina J, Gupta V. Vitamin E. 2023 May 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 JanExternal Link
  7. Niki E, Traber MG. A history of vitamin E. Ann Nutr Metab. 2012;61(3):207-12. doi: 10.1159/000343106. Epub 2012 Nov 26. PMID: 23183290.External Link
  8. Office of Dietary Supplements. Vitamin E - Health Professional Fact Sheet [Internet]. National Institutes of Health; 2022 [cited 2024 Oct 29]. Available from:External Link
  9. Traber MG. Vitamin E. In: Shils ME, Shike M, Ross AC, Caballero B, Cousins R, eds. Modern Nutrition in Health and Disease. 10th ed. Baltimore, MD: Lippincott Williams & Wilkins, 2006External Link
  10. Tanyel MC, Mancano LD. Neurologic findings in vitamin E deficiency. Am Fam Physician. 1997 JanExternal Link
  11. Sokol RJ. Vitamin E deficiency and neurologic disease. Annu Rev Nutr. 1988External Link
  12. Md Amin NA, Sheikh Abdul Kadir SH, Arshad AH, Abdul Aziz N, Abdul Nasir NA, Ab Latip N. Are Vitamin E Supplementation Beneficial for Female Gynaecology Health and Diseases? Molecules. 2022 Mar 15;27(6):1896.External Link
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