Advagraf 1mg Capsule PR is used along with other medicines to prevent your body from rejecting a new organ (e.g., liver, kidney, or heart) after transplant. It does so by weakening your body’s immune system, so it does not attack the new organ. This medication belongs to a class of drugs known as immunosuppressants.
The amount of Advagraf 1mg Capsule PR you take and how often you take it depends on the type of transplant you have, your body weight, and what other medicines you are taking. Follow your doctor’s instructions carefully. You should take it on an empty stomach, at least 1 hour before or 2 hours after a meal. Take this medicine regularly to get the maximum benefit and keep taking it, even if you feel well. If you stop taking it, you may increase the chances of rejecting your transplanted organ.
Advagraf 1mg Capsule PR has many potential side effects. It can cause or worsen diabetes and kidney problems. These need urgent medical attention. Other common side effects include tremor, infections, high blood pressure, headache, and insomnia. If the side effects do not go away or get worse, tell your doctor. Advagraf 1mg Capsule PR lowers your immune system making you susceptible to catching more infections than usual.
Before taking this medicine, tell your doctor if you have kidney, liver, or heart problems, diabetes, or high blood pressure. Also let your doctor know what other medications you are taking, especially for infections, pain, and arthritis. These and others may affect, or be affected by, this medicine. You should limit your exposure to the sun and UV (ultraviolet) light while taking it because immunosuppressants could increase your risk of skin cancer.
Both men and women using this medicine should use effective birth control to prevent pregnancy. This medicine is not normally recommended during pregnancy or while breastfeeding unless it is clearly needed. Before and during treatment you will need frequent medical tests to monitor your progress, and your blood pressure will need to be checked often.
In Prevention of organ rejection in transplant patients
Advagraf 1mg Capsule PR belongs to a group of medicines known as immunosuppressants. Organ rejection happens when your immune system treats the new organ as an invader and attacks it. This medicine weakens your immune response (which usually fights infection) and reduces the chance of your body attacking the transplanted organ. It is used in combination with other medicines to make it much more likely that your transplant operation will be successful. You should continue taking the medicine and should not stop it until your doctor says so.
Side effects of Advagraf Capsule PR
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Advagraf
High blood pressure
Increased glucose level in blood
Kidney damage
Insomnia (difficulty in sleeping)
Tremors
Headache
Abnormal liver function tests
Infection
How to use Advagraf Capsule PR
Use it as advised by your doctor or check the label for directions before use. Advagraf 1mg Capsule PR is to be taken empty stomach.
How Advagraf Capsule PR works
Advagraf 1mg Capsule PR is an immunosuppressant. It works by suppressing your body’s immune response following the transplant of an organ (e.g., liver, kidney, heart). This helps your body to accept the new organ as if it were your own.
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Advagraf 1mg Capsule PR.
Pregnancy
CONSULT YOUR DOCTOR
Advagraf 1mg Capsule PR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Advagraf 1mg Capsule PR is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Advagraf 1mg Capsule PR may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CAUTION
Advagraf 1mg Capsule PR should be used with caution in patients with kidney disease. Dose adjustment of Advagraf 1mg Capsule PR may be needed. Please consult your doctor.
Liver
CAUTION
Advagraf 1mg Capsule PR should be used with caution in patients with liver disease. Dose adjustment of Advagraf 1mg Capsule PR may be needed. Please consult your doctor.
What if you forget to take Advagraf Capsule PR?
If you miss a dose of Advagraf 1mg Capsule PR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
Advagraf 1mg Capsule PR is used to prevent organ rejection in transplant patients.
It may take 3 to 4 months for the medication to work. Keep taking it as prescribed.
Your doctor may get regular blood tests done to check the levels of blood cells in your blood. Inform your doctor if you experience unexplained bruising or bleeding, sore throat, mouth ulcers, fever, or general illness.
Your doctor may monitor your kidney function regularly. Drink 8 to 10 glasses of water per day to help with your kidney function.
Do not stop taking Advagraf 1mg Capsule PR without talking to your doctor first.
Fact Box
Chemical Class
Macrolide Lactams
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Immunosuppressant- Calcineurin inhibitors
Patient concerns
Difficulty in excretory, and rejection of stool.
Dr. Aanchal Maheshwari
Ayurveda
take triphala churan 1 spoon at night wioth abhyarishtam 20 ml mixed with water
Dear respected sir/madam, my uncle is suffering from alcoholic liver cirrhosis and ascites due to prolonng drinking. Water is accumulated around the belly. Less ddesire to eat anything. Doctor is saying for liver transplant. Could please suggest the best treatment available in allopathy to treat this problem. Thank you very very much.
Wash acne-prone areas only twice a day. Washing removes excess oil and dead skin cells. But too much washing can irritate the skin. Wash affected areas with a gentle cleanser and use oil-free, water-based skin care products. Use non- oily makeup. Choose oil-free cosmetics that won't clog pores. Remove makeup before going to bed. Going to sleep with cosmetics on your skin can clog your pores. Avoid touching or picking at the problem areas. Doing so can trigger more acne. Always use a clean towel or cloth to wipe your face. Always keep your hands clean and wash them regularly so that you may not touch your skin with dirty hands.
If eye ratina is fully damaged then eye can be transplant
Dr. Vishal Maniar
Ophthalmology
Complete eye transplant yet not done not possible yet Only corneal transplant can be doneIf retina is fully damaged corneal transplant is not advisable as the visual prognosis is guarded
*Prevention of organ rejection in transplant patients
How much was the improvement?
Excellent
78%
Average
22%
What were the side-effects while using Advagraf 1mg Capsule PR?
No Side Effec*
100%
*No Side Effect
How do you take Advagraf Capsule PR?
With food
60%
Empty stomach
40%
Please rate Advagraf 1mg Capsule PR on price
Expensive
60%
Not Expensive
27%
Average
13%
FAQs
Q. Is Advagraf 1mg Capsule PR an antibiotic?
Yes, Advagraf 1mg Capsule PR is a type of antibiotic which belongs to a group of medicines called macrolides. It is mostly used after organ transplantation. This medicine’s immune-suppressing property helps prevent organ rejection after kidney, heart, or liver transplant.
Q. Which vaccines should not be taken while taking Advagraf 1mg Capsule PR?
You should avoid taking any live vaccines (vaccines that use pathogens that are still alive, but are attenuated, that is, weakened) while taking Advagraf 1mg Capsule PR. These may include vaccinations for measles, mumps, rubella, BCG (TB vaccine), yellow fever, chicken pox and typhoid. You should also avoid taking polio drops (by mouth) or flu vaccine (through nose).
Q. Who should not take Advagraf 1mg Capsule PR?
Patients who are allergic to it or have a weak immune system, high blood pressure, and kidney failure should avoid Advagraf 1mg Capsule PR. This medicine should also be avoided in pregnant or breastfeeding women, and in people who plan to receive any live vaccines (e.g. MMR vaccine).
Q. What should I tell my doctor before taking Advagraf 1mg Capsule PR?
Inform your doctor if you are pregnant, have allergies, long-term infection, high blood sugar, or high blood pressure. You should also inform your doctor if you have high blood potassium levels or a weakened immune system. Tell your doctor if you have a history of any medication, have recently received, or are scheduled to receive a live vaccine.
Q. What should I be aware of before I start taking Advagraf 1mg Capsule PR?
This medicine suppresses the immune system and hence there is always an increased risk of infection. Moreover, in some cases, Advagraf 1mg Capsule PR can increase the risk of some kind of cancer like skin and lymph gland cancer (lymphoma). It can lower the ability of your immune system to fight infections. Consult your doctor before you start taking this medication and in case you notice any symptoms of infections like fever, sweats or chills, cough or flu-like symptoms, muscle aches, warm, red, or painful areas on your skin.
Q. Does Advagraf 1mg Capsule PR have an abuse potential?
No, Advagraf 1mg Capsule PR does not have abuse potential and thus, is not a controlled substance. Controlled substances have potential for abuse so they need permission from authorities and doctors for use.
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References
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Lake DF, Briggs AD, Akporiaye ET. Immunopharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 972.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1305-309.
Tacrolimus monohydrate. Camberley, Surrey: Sandoz Limited; 2010 [revised 27 Mar. 2017]. [Accessed 23 Jan. 2019] (online) Available from:
Tacrolimus. Princeton, New Jersey: Sandoz Inc; 2009. [Accessed 06 Apr. 2019] (online) Available from:
Central Drugs Standard Control Organisation. Tacrolimus. [Accessed 06 Aug. 2023]. (online) Available from:
Tacrolimus [package Insert]. Karapakkam, Chennai: The Madras Pharmaceuticals; 2020. [Accessed 06 Aug. 2023]. (online) Available from:
Marketer details
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