Advagraf 5mg Capsule PR
Prescription Required
Product introduction
Advagraf 5mg Capsule PR is used along with other medicines to prevent your body from rejecting a new organ (e.g., liver, kidney, or heart) after transplant. It does so by weakening your body’s immune system, so it does not attack the new organ. This medication belongs to a class of drugs known as immunosuppressants.
The amount of Advagraf 5mg Capsule PR you take and how often you take it depends on the type of transplant you have, your body weight, and what other medicines you are taking. Follow your doctor’s instructions carefully. You should take it on an empty stomach, at least 1 hour before or 2 hours after a meal. Take this medicine regularly to get the maximum benefit and keep taking it, even if you feel well. If you stop taking it, you may increase the chances of rejecting your transplanted organ.
Advagraf 5mg Capsule PR has many potential side effects. It can cause or worsen diabetes and kidney problems. These need urgent medical attention. Other common side effects include tremor, infections, high blood pressure, headache, and insomnia. If the side effects do not go away or get worse, tell your doctor. Advagraf 5mg Capsule PR lowers your immune system making you susceptible to catching more infections than usual.
Before taking this medicine, tell your doctor if you have kidney, liver, or heart problems, diabetes, or high blood pressure. Also let your doctor know what other medications you are taking, especially for infections, pain, and arthritis. These and others may affect, or be affected by, this medicine. You should limit your exposure to the sun and UV (ultraviolet) light while taking it because immunosuppressants could increase your risk of skin cancer.
Both men and women using this medicine should use effective birth control to prevent pregnancy. This medicine is not normally recommended during pregnancy or while breastfeeding unless it is clearly needed. Before and during treatment you will need frequent medical tests to monitor your progress, and your blood pressure will need to be checked often.
Uses of Advagraf Capsule PR
Benefits of Advagraf Capsule PR
In Prevention of organ rejection in transplant patients
Advagraf 5mg Capsule PR belongs to a group of medicines known as immunosuppressants. Organ rejection happens when your immune system treats the new organ as an invader and attacks it. This medicine weakens your immune response (which usually fights infection) and reduces the chance of your body attacking the transplanted organ. It is used in combination with other medicines to make it much more likely that your transplant operation will be successful. You should continue taking the medicine and should not stop it until your doctor says so.
Side effects of Advagraf Capsule PR
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Advagraf
- High blood pressure
- Increased glucose level in blood
- Insomnia (difficulty in sleeping)
- Kidney damage
- Tremors
- Headache
- Abnormal liver function tests
- Infection
How to use Advagraf Capsule PR
Use it as advised by your doctor or check the label for directions before use. Advagraf 5mg Capsule PR is to be taken empty stomach.
How Advagraf Capsule PR works
Advagraf 5mg Capsule PR is an immunosuppressant. It works by suppressing your body’s immune response following the transplant of an organ (e.g., liver, kidney, heart). This helps your body to accept the new organ as if it were your own.
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Advagraf 5mg Capsule PR.
Pregnancy
CONSULT YOUR DOCTOR
Advagraf 5mg Capsule PR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Advagraf 5mg Capsule PR is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Advagraf 5mg Capsule PR may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CAUTION
Advagraf 5mg Capsule PR should be used with caution in patients with kidney disease. Dose adjustment of Advagraf 5mg Capsule PR may be needed. Please consult your doctor.
Liver
CAUTION
Advagraf 5mg Capsule PR should be used with caution in patients with liver disease. Dose adjustment of Advagraf 5mg Capsule PR may be needed. Please consult your doctor.
What if you forget to take Advagraf Capsule PR?
If you miss a dose of Advagraf 5mg Capsule PR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
- Advagraf 5mg Capsule PR is used to prevent organ rejection in transplant patients.
- It may take 3 to 4 months for the medication to work. Keep taking it as prescribed.
- Your doctor may get regular blood tests done to check the levels of blood cells in your blood. Inform your doctor if you experience unexplained bruising or bleeding, sore throat, mouth ulcers, fever, or general illness.
- Your doctor may monitor your kidney function regularly. Drink 8 to 10 glasses of water per day to help with your kidney function.
- Do not stop taking Advagraf 5mg Capsule PR without talking to your doctor first.
Fact Box
Chemical Class
Macrolide Lactams
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Immunosuppressant- Calcineurin inhibitors
Interaction with drugs
Taking Advagraf with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Long-term concurrent use may increase the risk of certain brain infections.
Do not consume Natalizumab with Tacrolimus.
Concurrent use may cause fatal infections.
Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) should not be used while undergoing treatment with Tacrolimus or for up to 6
Concomitant use may affect heart rhythm and can be fatal.
Do not consume Tacrolimus with Domperidone.
Concurrent use may increase the risk of serious damage to the kidneys.
If concurrent use is essential, your doctor may monitor your tacrolimus levels, potassium levels and kidney
Concurrent use may cause serious disturbance in heart rhythm.
Factors such as old age, chronic heart issues, or low potassium levels may more frequently cause disturbance in heart
Patient concerns
FAQs
Is Advagraf 5mg Capsule PR an antibiotic?
Yes, Advagraf 5mg Capsule PR is a type of antibiotic which belongs to a group of medicines called macrolides. It is mostly used after organ transplantation. This medicine’s immune-suppressing property helps prevent organ rejection after kidney, heart, or liver transplant.
Which vaccines should not be taken while taking Advagraf 5mg Capsule PR?
You should avoid taking any live vaccines (vaccines that use pathogens that are still alive, but are attenuated, that is, weakened) while taking Advagraf 5mg Capsule PR. These may include vaccinations for measles, mumps, rubella, BCG (TB vaccine), yellow fever, chicken pox and typhoid. You should also avoid taking polio drops (by mouth) or flu vaccine (through nose).
Who should not take Advagraf 5mg Capsule PR?
Patients who are allergic to it or have a weak immune system, high blood pressure, and kidney failure should avoid Advagraf 5mg Capsule PR. This medicine should also be avoided in pregnant or breastfeeding women, and in people who plan to receive any live vaccines (e.g. MMR vaccine).
What should I tell my doctor before taking Advagraf 5mg Capsule PR?
Inform your doctor if you are pregnant, have allergies, long-term infection, high blood sugar, or high blood pressure. You should also inform your doctor if you have high blood potassium levels or a weakened immune system. Tell your doctor if you have a history of any medication, have recently received, or are scheduled to receive a live vaccine.
What should I be aware of before I start taking Advagraf 5mg Capsule PR?
This medicine suppresses the immune system and hence there is always an increased risk of infection. Moreover, in some cases, Advagraf 5mg Capsule PR can increase the risk of some kind of cancer like skin and lymph gland cancer (lymphoma). It can lower the ability of your immune system to fight infections. Consult your doctor before you start taking this medication and in case you notice any symptoms of infections like fever, sweats or chills, cough or flu-like symptoms, muscle aches, warm, red, or painful areas on your skin.
Does Advagraf 5mg Capsule PR have an abuse potential?
No, Advagraf 5mg Capsule PR does not have abuse potential and thus, is not a controlled substance. Controlled substances have potential for abuse so they need permission from authorities and doctors for use.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Burkhart C, Morrell D, Goldsmith L. Dermatological Pharmacology. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1822.
- Lake DF, Briggs AD, Akporiaye ET. Immunopharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 972.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1305-309.
- Tacrolimus monohydrate. Camberley, Surrey: Sandoz Limited; 2010 [revised 27 Mar. 2017]. [Accessed 23 Jan. 2019] (online) Available from:
- Tacrolimus. Princeton, New Jersey: Sandoz Inc; 2009. [Accessed 06 Apr. 2019] (online) Available from:
- Central Drugs Standard Control Organisation. Tacrolimus. [Accessed 06 Aug. 2023]. (online) Available from:
- Tacrolimus [package Insert]. Karapakkam, Chennai: The Madras Pharmaceuticals; 2020. [Accessed 06 Aug. 2023]. (online) Available from:
Marketer details
Name: Astellas Pharma Inc
Address: Astellas Pharma India Pvt Ltd, 301, 3rd Floor, C and B Square, 127 Andheri Kurla Road, Chakala, Andheri East, Mumbai 400 069.
Country of origin: India
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