Aprilife Plus Tablet
Prescription Required
Product introduction
Aprilife Plus Tablet is used in the treatment of heart failure. It is a combination of two medicines that effectively control symptoms of heart failure.
Aprilife Plus Tablet should be taken with food regularly at a fixed time each day. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you remember to take it. The dose and duration of treatment will depend on what you are being treated for. Do not stop taking it until you have finished the complete course, even when you feel better. Lifestyle changes like a low-fat diet, exercise, and not smoking may help this medicine to work better.
It is generally safe and suitable for most people but has some potential side effects. The most common side effects of this medicine include nausea, vomiting, diarrhea, low blood pressure, and loss of appetite. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. It makes you feel dizzy as of orthostatic hypotension (sudden lowering of blood pressure on standing). Hence, rise slowly while from a sitting position or avoid driving. You may be asked for regular monitoring of blood pressure while on the treatment.
Before taking this medicine, tell your doctor if you have liver or kidney disease. You must tell your doctor if you are pregnant, planning pregnancy, or breastfeeding. You should also let your healthcare team know all other medicines you are taking as they may affect, or be affected by this medicine.
Uses of Aprilife Plus Tablet
Benefits of Aprilife Plus Tablet
In Treatment of Heart failure
Heart failure means your heart is weak and cannot pump enough blood to your lungs and the rest of your body. The most common symptoms are breathlessness, tiredness, and swelling in your legs, ankles, abdomen and other parts of your body. Aprilife Plus Tablet makes it easier for your heart to pump blood around your body and is therefore an effective treatment for heart failure.
This medicine will help relieve your symptoms, making you feel better and more energetic. You should make appropriate lifestyle changes, such as eating healthy and keeping active, to help this medicine be effective. Take it regularly and keep taking it even if you feel better.
This medicine will help relieve your symptoms, making you feel better and more energetic. You should make appropriate lifestyle changes, such as eating healthy and keeping active, to help this medicine be effective. Take it regularly and keep taking it even if you feel better.
Side effects of Aprilife Plus Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Aprilife Plus
- Nausea
- Headache
- Dizziness
- Weakness
- Ventricular tachycardia
- Paralysis of ileus
- Hypotension (low blood pressure)
- Visual impairment
How to use Aprilife Plus Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Aprilife Plus Tablet is to be taken with food.
How Aprilife Plus Tablet works
Aprilife Plus Tablet is a combination of two medicines:
Safety advice
Alcohol
UNSAFE
Consuming alcohol while taking Aprilife Plus Tablet may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
Pregnancy
CONSULT YOUR DOCTOR
Aprilife Plus Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
SAFE IF PRESCRIBED
Aprilife Plus Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
UNSAFE
Aprilife Plus Tablet may cause side effects which could affect your ability to drive.
As Aprilife Plus Tablet may cause headaches or lead to difficulty in concentration and this may affect your ability to drive.
As Aprilife Plus Tablet may cause headaches or lead to difficulty in concentration and this may affect your ability to drive.
Kidney
CAUTION
Aprilife Plus Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Aprilife Plus Tablet may be needed. Please consult your doctor.
Regular monitoring of blood pressure is recommended for better dose adjustment.
Regular monitoring of blood pressure is recommended for better dose adjustment.
Liver
SAFE IF PRESCRIBED
Aprilife Plus Tablet is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Aprilife Plus Tablet may not be needed in these patients. Please consult your doctor.
What if you forget to take Aprilife Plus Tablet?
If you miss a dose of Aprilife Plus Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
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Quick tips
- Aprilife Plus Tablet is a combination of two medicines that helps improve symptoms of heart failure and keeps your heart healthier.
- This medicine may temporarily cause headaches, especially when starting treatment. Inform your doctor if it does not go away.
- Aprilife Plus Tablet may cause dizziness. Do not drive or do anything requiring concentration until you know how it affects you.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
- It is best to avoid drinking alcohol while taking Aprilife Plus Tablet as it may make the side effects worse.
- Do not take it in combination with medicines that treat erectile dysfunction (eg. sildenafil, tadalafil, vardenafil) or high blood pressure, as that can cause a major drop in blood pressure.
- Do not stop taking Aprilife Plus Tablet suddenly without talking to your doctor as it can increase the risk of heart attack and stroke.
Fact Box
Habit Forming
No
Therapeutic Class
CARDIAC
Patient concerns
FAQs
Can I stop taking Aprilife Plus Tablet if I feel well?
No, keep using Aprilife Plus Tablet as advised by your doctor, even if you feel well. Stopping Aprilife Plus Tablet suddenly may lead to serious complications of heart failure.
Are there any special instructions regarding storage and disposal of this medicine?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Can the use of Aprilife Plus Tablet cause headache?
Aprilife Plus Tablet can frequently cause headaches, especially at the start of the treatment. As the treatment continues, your headache may become less intense and frequent. However, inform your doctor if headache continues.
Can the use of Aprilife Plus Tablet cause dizziness?
Yes, the use of Isosorbide Aprilife Plus Tablet can make you feel dizzy. This may often occur when you suddenly rise up from lying or sitting position. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Ferdinand KC, Elkayam U, Mancini D, et al. Use of isosorbide dinitrate and hydralazine in African-Americans with heart failure 9 years after the African-American Heart Failure Trial. Am J Cardiol. 2014;114(1):151-9. [Accessed 21 Jan. 2019] (online) Available from:
- Mastanamma SK, Saidulu P, Sravanthi A, et al. Stability Indicating Validated RP-HPLC Method for Simultaneous Determination of Hydralazine Hydrochloride and Isosorbide Dinitrate in Bulk and Pharmaceutical Dosage Form. Int J Pharm Sci Rev Res. 2016;40(1):1411-48. [Accessed 21 Jan. 2019] (online) Available from:
- Cheng JW. A review of isosorbide dinitrate and hydralazine in the management of heart failure in black patients, with a focus on a new fixed-dose combination. Clin Ther. 2006;28(5):666-78. [Accessed 21 Jan. 2019] (online) Available from:
- Isosorbide dinitrate and hydralazine hydrochloride. Seymour, Indiana: Kremers Urban Pharmaceuticals Inc.; 2005 [revised Apr. 2015]. [Accessed 23 Jan. 2019] (online) Available from:
- Isosorbide dinitrate and hydralazine hydrochloride [Prescribing Inforamtion]. Seymour, IN: Kremers Urban Pharmaceuticals Inc.; 2015. [Accessed 28th Sept. 2023] (online) Available from:
- Central Drugs Standard Control Organization. Isosorbide Dinitrate+Hydralazine. [Accessed 28th Sept. 2023] (online) Available from:
- ScienceDirect. Isosorbide Dinitrate. [Accessed 28th Sept. 2023] (online) Available from:
Marketer details
Name: Biocent Scientific India Pvt. Ltd
Address: 22/252 D, 2nd Floor, Kochin Business Bay, NH 85, Near Hill Palace, Cochin - 682305
Country of origin: India
The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.
The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.
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