Bosenat 125 Tablet is a prescription medicine used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to the lungs). It even helps to improve your quality of life, exercising ability and delay in disease progression.

Bosenat 125 Tablet should be taken with or without food. This medicine should be used regularly to get the most benefit from it. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you.

The most common side effects of this medicine include headache, swelling of the legs and ankles, and diarrhea. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Some serious side effects which mean your doctor should know immediately include Anemia (low number of red blood cells) and abnormal liver function such as nausea, vomiting, dark urine, fever, and dark urine. Your doctor might check you for blood tests to check for anemia and liver function.

Before taking this medicine, let your doctor know if you have liver dysfunctioning. Inform your doctor if you are pregnant or breastfeeding. Women are suggested to use reliable contraceptive pills to avoid pregnancy and should continue even after one month of stopping the treatment. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works.

Uses of Bosenat Tablet

Pulmonary arterial hypertension (PAH)

Benefits of Bosenat Tablet

In Pulmonary arterial hypertension (PAH)

Pulmonary arterial hypertension can cause shortness of breath, tiredness, dizziness, chest pain and swelling in your ankles and legs. It is caused by thickening of walls of the arteries that supply your lungs making it hard for blood to get through. Bosenat 125 Tablet relaxes the blood vessels and can help lower the blood pressure in the arteries of your lungs. You will be able to carry out your daily activities more easily and feel less tired or dizzy.

Side effects of Bosenat Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Bosenat

Headache
Ankle swelling
Edema (swelling)
Diarrhea
Anemia (low number of red blood cells)
Respiratory tract infection

How to use Bosenat Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Bosenat 125 Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Bosenat Tablet works

Bosenat 125 Tablet is an endothelin receptor blocker. It blocks the action of endothelin (a natural substance) that causes blood vessels to narrow (constrict). This narrowing increases the pressure in the blood vessels of the lungs. Bosenat 125 Tablet helps relax these blood vessels and increases the supply of blood to the lungs.

Safety advice

Alcohol

UNSAFE

Bosenat 125 Tablet may cause excessive drowsiness with alcohol.

Pregnancy

UNSAFE

Bosenat 125 Tablet is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Breast feeding

CONSULT YOUR DOCTOR

Bosenat 125 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Bosenat 125 Tablet may cause side effects which could affect your ability to drive.
As Bosenat 125 Tablet can induce hypotension (decrease of your blood pressure) which can make you feel dizzy and this can affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Bosenat 125 Tablet is safe to use in patients with kidney disease. No dose adjustment of Bosenat 125 Tablet is recommended.

Liver

CAUTION

Bosenat 125 Tablet should be used with caution in patients with liver disease. Dose adjustment of Bosenat 125 Tablet may be needed. Please consult your doctor.
Use of Bosenat 125 Tablet is not recommended in patients with moderate and severe liver disease.

What if you forget to take Bosenat Tablet?

If you miss a dose of Bosenat 125 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.\n

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Bosenat 125 Tablet

₹131.8/Tablet

Bosentas 125 Tablet

Cipla Ltd

₹161.7/tablet

23% costlier

Bozetan 125mg Tablet

Lupin Ltd

₹184.2/tablet

40% costlier

LUPIBOSE 125 MG TABLET

Lupin Ltd

₹117.9/tablet

11% cheaper

Bosentan 125 Tablet

Care Formulation Labs Pvt Ltd

₹154.2/tablet

17% costlier

PULVANCE 125 MG TABLET

Sun Pharmaceutical Industries Ltd

₹110.5/tablet

16% cheaper

Quick tips

Your doctor has prescribed Bosenat 125 Tablet to treat high pressure in the blood vessels that carry blood from the heart to the lungs (the pulmonary arteries).
It helps improve your quality of life, exercising ability, and delay disease progression.
Notify your doctor if you are pregnant or planning to conceive or breastfeeding.
Your doctor may ask you to get routine blood tests done to check for anemia and to assess the functioning of your liver.
Do not drive or do anything requiring concentration until you know how Bosenat 125 Tablet affects you.
Females with reproductive potential should use a reliable form of birth control while using and 1 month after stopping Bosenat 125 Tablet as it is toxic to an unborn baby.
Inform your doctor if you notice weight gain, swelling of your arms and legs, or difficulty breathing.
Inform your doctor if you notice yellowing of skin/eye, dark urine, or stomach pain.

Fact Box

Chemical Class

Sulfonamide and Pyrimidine Derivative

Habit Forming

Therapeutic Class

CARDIAC

Action Class

Endothelin receptor blocker

Patient concerns

Having high Pulmonary Atrial Hypertension

Dr. Nabajit Talukdar

Cardiology

What medicines r u on

Hiii my wife having hurt patient ( pulmonary hypertension ) she's taking pulmonext 5mg tablet but this tablet is very costly for me of Rs. 1450/- 10tab. I want to know any another tablet available in same drugs with low price

Dr. Sfurti Mann

Internal Medicine

This can't be decided online Your doctor is the best judge about your patients pulmonary hypertension

Hello Dr. My Dad is facing High Pulmonary Hypertension of 63 and average is 32. He has liver cirrhosis as well, he is advised for liver transplant. As the PAH is high cannot proceed with the surgery. Can you please advise if there is any way out. Age : 49yrs. Medicines for heart taken at present is : Ambrisentan 5mg Assurance 20mg Trimium Inhaler.

Dr. Nabajit Talukdar

Cardiology

Currently no other treatment apart from ambrisantan n assurance will have to wait n see response to medicines if pulmonary pressure comes down only then surgery possible

User feedback

How much was the improvement?

Excellent

100%

What were the side-effects while using Bosenat 125 Tablet?

No Side Effec*

100%

*No Side Effect

How do you take Bosenat Tablet?

With or witho*

100%

*With or without food

Please rate Bosenat 125 Tablet on price

Expensive

67%

Average

33%

FAQs

How is Bosenat 125 Tablet administered?

Bosenat 125 Tablet is given as a tablet form and can be taken with or without food. The tablets are to be taken twice daily in the morning and evening. The exact dosage and frequency of dose will be decided by the doctor on the basis of age and weight of the patient.

Are there chances of anemia with Bosenat 125 Tablet?

Yes, there are chances that Bosenat 125 Tablet may cause anemia. It can cause a dose-related decrease in hemoglobin in the blood which could lead to anemia. Regular hemoglobin check is advised while taking this medicine and consult your prescribing doctor for his advice. In some cases, blood transfusion is done to treat anemia.

Can I take Bosenat 125 Tablet if I have liver problems?

It has been found that in some cases Bosenat 125 Tablet can cause liver damage in patients who are prone to have liver disease. This medicine can also lead to increased liver enzymes. Hence, it should be used with caution in prone patients or in patients with history of liver disease. Before starting the medication inform your doctor if you have had a history of liver disease.

Is Bosenat 125 Tablet safe in pregnancy?

No, Bosenat 125 Tablet is not safe during pregnancy. There is evidence to show that it can cause major birth defects in the newborn baby and can harm the baby in womb. It is not advised to take Bosenat 125 Tablet if you are planning to become pregnant. You should use reliable contraception methods while you take Bosenat 125 Tablet. Consult your doctor before starting this medication or planning pregnancy.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Barnes PJ. Pulmonary Pharmacology. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1059.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 154-56.
Bosentan. Beerse Belgium: Janssen-Cilag International NV; 2013 [revised Sep. 2018]. [Accessed 01 Apr. 2019] (online) Available from:
Bosentan. South San Francisco, California: Actelion Pharmaceuticals US, Inc.; 2001 [revised Aug. 2009]. [Accessed 23 Jan. 2019] (online) Available from:
Bosentan. South San Francisco, CA: Actelion Pharmaceuticals; 2001. [Accessed 01 Apr. 2019] (online) available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 01 Apr. 2019] (online) Available from:
Bosentan [Prescribing Information]. Titusville, NJ: Actelion Pharmaceuticals US, Inc.; 2022. [Accessed 09 Jun, 2023] (online) Available from:

Marketer details

Name: Natco Pharma Ltd

Address: Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India

Country of origin: India

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