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MMST, MBBS
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MD Pharmacology, MBBS
Last updated
26 Nov 2024 | 02:36 PM (IST)

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Product introduction

Combi Cream is a combination medicine used in the treatment of various types of skin infections. It minimizes symptoms of inflammation such as redness, swelling, and itching by acting against the infection-causing microorganisms.

Combi Cream is only meant for external use and should be used as advised by your doctor. A thin layer of the medicine should be applied only to the affected areas of the skin with clean and dry hands. Wash your hands before and after applying the medicine. If it gets into your eyes, nose, mouth, or vagina rinse with water. It may take several days to weeks for your symptoms to improve, but you should keep using this medicine regularly. The course of the treatment should be completed to ensure better efficacy of the medicine. If your condition does not improve or gets worse, you should talk to your doctor.

This is usually a safe medicine, however, it may cause burning, irritation, itching, and redness at the application site. These side effects are usually mild and self-limiting. Serious side effects are rare. You must consult the doctor if you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.).

Before using this medicine, it is important to tell your doctor if you are taking or have recently taken any other medicines for the same disease or other diseases. Pregnant and breastfeeding women should use this medicine with proper consultation and caution. If you are a known allergic to the medicine, you must refrain from using this medicine and consult the doctor about this condition. During the course of the treatment, do not touch or scratch the infected skin areas as this may worsen or spread the infection.


Uses of Combi Cream

Benefits of Combi Cream

In Treatment of Skin infections

Combi Cream is a combination of medicines used to treat skin infections caused by microorganisms such as bacteria and fungi. It kills and stops the growth of infection causing microorganisms, thereby clearing the infection and relieving the symptoms. It also blocks the release of chemicals that cause symptoms such as itching, redness and swelling. Therefore this medicine relieves the inflammation due to these infections.
You should use Combi Cream for as long as it is prescribed, even if your symptoms disappear, otherwise they may come back. Depending on the type of infection you are treating, this may be several weeks. Even after your infection is completely cured, you may have to apply it occasionally to prevent the symptoms from returning.

Side effects of Combi Cream

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Combi

  • Thinning of skin
  • Application site reactions (burning, irritation, itching and redness)

How to use Combi Cream

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.

How Combi Cream works

Combi Cream is a combination of five medicines: Clobetasol, Gentamicin, Clioquinol (Iodochlorhydroxyquin), Ketoconazole, and Tolnaftate. Clobetasol is a steroid. It works by blocking the production of certain chemical messengers that make the skin red, swollen and itchy. Gentamicin is an antibiotic which kills bacteria by preventing the synthesis of essential proteins required by bacteria to carry out vital functions. Ketoconazole, Clioquinol, and Tolnaftate are antifungal medicines. Ketoconazole kills and stops the growth of the fungi by destroying its cell membrane, thereby treating your skin infection. Clioquinol acts by interacting with DNA synthesis thus killing the fungi that are responsible for causing the infection. Tolnaftate prevents growth of fungal cell-wall. It also prevents forming fungal colonies. This is how it causes death of fungi and relieves your infection.

Safety advice

Alcohol
No interaction found/established
Pregnancy
CONSULT YOUR DOCTOR
Information regarding the use of Combi Cream during pregnancy is not available. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Combi Cream during breastfeeding is not available. Please consult your doctor.
Driving
No interaction found/established
Kidney
No interaction found/established
Liver
No interaction found/established

What if you forget to take Combi Cream?

If you miss a dose of Combi Cream, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Combi Cream
₹5.75/gm of Cream
Ketofresh CT Cream
Smart Laboratories Pvt Ltd
₹5.82/gm of cream
1% costlier
Dermilab K5 Cream
Helplab Healthcare Pvt Ltd
₹5.04/gm of cream
12% cheaper
Kitosan-Plus Cream
Disan Pharma
₹5.82/gm of cream
1% costlier
Sinderm K6 Cream
Indoscot Healthcare LLP
₹7.07/gm of cream
23% costlier
₹5.82/gm of cream
1% costlier

Quick tips

  • Combi Cream may take several weeks to show its action. Keep using it as suggested by your doctor.
  • Wash your skin with a mild cleanser and pat it dry before applying Combi Cream.
  • Apply it as a thin layer onto clean, dry, unbroken skin affected by an infection.
  • It may cause minor burning, stinging or irritation when applied. Inform your doctor if this does not go away.
  • Avoid contact with your eyes, nose or mouth. Rinse it off with water if you accidentally get the cream in these areas.
  • It is advisable not to touch or scratch the infected area as it can worsen the situation.
     
  • Combi Cream may take several weeks to show its action. Keep using it as suggested by your doctor.
  • Wash your skin with a mild cleanser and pat it dry before applying Combi Cream.
  • Apply it as a thin layer onto clean, dry, unbroken skin affected by an infection.
  • It may cause minor burning, stinging or irritation when applied. Inform your doctor if this does not go away.
  • Avoid contact with your eyes, nose or mouth. Rinse it off with water if you accidentally get the cream in these areas.
  • It is advisable not to touch or scratch the infected area as it can worsen the situation.
     

Fact Box

Habit Forming
No
Therapeutic Class
DERMA

Patient concerns

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How many days bleeding after taking festone combi kit tablets, please suggest me please reply to my question
Dr. Megha Tuli
Obstetrics and Gynaecology
Around 5-7 days of bleeding is expected
Leg pains & nerves pain in neck iam using glimi save M2 tablets per day 2 & insuman combi 25/75 twise daily
Dr. Sanjay Bhatt
Physician
What is your HbA1cIt may due to diabetic neuropathy. Needs to examine the patient. So consult doctor near by or visit our clinic.
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FAQs

Is it safe to use Combi Cream?

Yes, Combi Cream is safe when used according to your doctor’s advice and for limited duration of time (1-2 weeks). However, in some patients it may cause some unwanted side effects like transient burning, itching and irritation at the application site. It may also cause other uncommon or rare side effects. If you experience any persistent problem due to the medication, inform your doctor as soon as possible.

How to use Combi Cream?

Follow the directions given by the healthcare provider on the medicine. Apply the medicine to the affected skin areas thinly and in sufficient quantity to cover the affected areas. Combi Cream is usually applied two or three times a day to affected areas of skin. Wash your hands after using Combi Cream, unless it is used for treating skin infection on the hands.

What are the precautions needed to be taken while using Combi Cream?

Combi Cream should not be used on the face. Do not use the medication for longer than the advised periods of time. Do not apply a bandage or dressing to the area being treated, as this will increase absorption of the preparation and increase the risk of side-effects. This medicine should only be used by the patient and never be given to other people even if their condition appears to be the same.

Can I overuse Combi Cream?

No, do not overuse Combi Cream for long periods or on large areas of skin. It can cause over-absorption of medicine into the body which may further lead to the thinning or weakening of the skin and other serious side effects. If you are experiencing increased severity of your symptoms, please consult your doctor for re-evaluation.

Can I stop taking Combi Cream when my symptoms are relieved?

No, do not stop taking Combi Cream and complete the full course of treatment, even if you feel better. Your symptoms may improve before the skin infection is completely cured.

What are the instructions for storage and disposal of Combi Cream?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Chambers HF. Aminoglycosides. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 11th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1155-1171.
  2. Chambers HF. Aminoglycosides. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 11th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1155-1171.
  3. Schimmer BP, Parker KL. Adrenocorticotropic Hormone, Adrenal Steroids, and the Adrenal Cortex. In: Brunton LL, Chabner BA, Knollmann BC (Editors). Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 13th ed. New York, New York: McGraw-Hill Medical; 2018. pp. 845-861.
  4. Bennett JE. Antimicrobial Agents: Anifungal Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 1225-1241.
  5. Chambers HF, Deck DH. Aminoglycosides & Spectinomycin. In: Katzung BG, Masters SB, Trevor AJ (Editors). Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 807-922.
  6. Chrousos GP. Adrenocorticosteroids & Adrenocortical Antagonists. In: Katzung BG, Masters SB, Trevor AJ (Editors). Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 681-697.
  7. Robertson DB, Maibach HI. Dermatologic Pharmacology. In: Katzung BG, Masters SB, Trevor AJ (Editors). Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 1047-1065.

Marketer details

Name: Matins Pharma
Address: Office Number 4 & 21 SCO. 3, Sector - 11, Panchkula -134112 Haryana
Country of origin: India

BANNED FOR SALE
As per Ministry of Health and Family Welfare

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