Comig 500 Tablet
Prescription Required
Product introduction
Comig 500 Tablet is a medicine used in the prevention of migraines. It inhibits the release of certain chemical messengers that cause pain, inflammation, and fever. It also blocks the signals in the brain that cause nausea and vomiting associated with migraines.
Comig 500 Tablet may be prescribed alone or in combination with another medicine. It can be taken with or without food. The dose and duration will depend on the severity of your condition and how well it helps your symptoms. Use it regularly and do not discontinue it until the doctor tells you it is right to stop.
Using Comig 500 Tablet may cause common side effects such as headaches, ringing in the ears, dizziness, tiredness, rashes, and vision changes. If you experience such side effects that do not go away or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms.
In general, you should try to use the smallest amount necessary to control your symptoms. Before using the medicine, you should tell your doctor if you have any other illnesses or disorders. It may also affect, or be affected by, some other medicines you are using, so let your doctor know all the other medicines you are taking. Pregnant and breastfeeding women should consult their doctors first before using the medicine.
Uses of Comig Tablet
Benefits of Comig Tablet
In Prevention of Migraine
Comig 500 Tablet blocks chemicals responsible for pain sensation and signals that cause nausea/vomiting associated with migraines. Preventing and reducing the frequency of migraines and headaches can help you carry out your daily activities and have a better quality of life.
Side effects of Comig Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Comig
- Headache
- Ringing in ear
- Altered vision
- Tiredness
- Dizziness
- Drowsiness
- Rash
How to use Comig Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Comig 500 Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Comig Tablet works
Comig 500 Tablet is a combination of two medicines: naproxen and domperidone. Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that works by blocking the release of certain chemical messengers that cause pain due to migraine. Domperidone works on the region in the brain that controls vomiting associated with migraine. Together, they provide relief from migraine symptoms.
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Comig 500 Tablet.
Pregnancy
CONSULT YOUR DOCTOR
Comig 500 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
SAFE IF PRESCRIBED
Comig 500 Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Driving
UNSAFE
Comig 500 Tablet may cause side effects which could affect your ability to drive.
Comig 500 Tablet may make you feel dizzy, depressed, sleepy, tired, or make it difficult to sleep. It may also affect your vision. This may affect your driving ability.
Comig 500 Tablet may make you feel dizzy, depressed, sleepy, tired, or make it difficult to sleep. It may also affect your vision. This may affect your driving ability.
Kidney
CAUTION
Comig 500 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Comig 500 Tablet may be needed. Please consult your doctor.
Liver
CAUTION
Comig 500 Tablet should be used with caution in patients with liver disease. Dose adjustment of Comig 500 Tablet may be needed. Please consult your doctor.
Use of Comig 500 Tablet is not recommended in patients with moderate and severe liver disease.
Use of Comig 500 Tablet is not recommended in patients with moderate and severe liver disease.
What if you forget to take Comig Tablet?
If you miss a dose of Comig 500 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Comig 500 Tablet
₹9.7/Tablet
Napra D 500 Tablet
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Minado 500 Tablet
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Macprox DP 500 Tablet
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₹10.5/tablet
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Xenadom 500 Tablet
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Proxidom 500 Tablet
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₹8.29/tablet
15% cheaper
Quick tips
- Do not take it to treat an acute attack of migraine.
- Some tips that may help avoid a migraine attack include eating your meals at the same time every day, avoiding bright lights and extreme temperatures, avoiding loud music and noisy places, and abstaining from chocolates, cheese, processed food, alcohol, and smoking.
- Comig 500 Tablet may cause dizziness. Do not drive or do anything that requires mental focus until you know how Comig 500 Tablet affects you.
- Take Comig 500 Tablet as prescribed by your doctor, even if your symptoms go away.
Fact Box
Habit Forming
No
Therapeutic Class
NEURO CNS
Patient concerns
User feedback
Patients taking Comig 500 Tablet
Once A Day
58%
Twice A Day
42%
What are you using Comig Tablet for?
Migraine
45%
Headache
27%
Others
27%
How much was the improvement?
Excellent
42%
Average
38%
Poor
21%
What were the side-effects while using Comig 500 Tablet?
No Side Effec*
57%
Dryness in mo*
29%
Indigestion
14%
*No Side Effect, Dryness in mouth
How do you take Comig Tablet?
With or witho*
50%
With food
33%
Empty stomach
17%
*With or without food
Please rate Comig 500 Tablet on price
Expensive
50%
Average
33%
Not Expensive
17%
FAQs
What is Comig 500 Tablet?
Comig 500 Tablet is a combination of two medicines used to relieve migraine symptoms such as headache, nausea, and vomiting. Naproxen works by blocking chemical messengers responsible for pain and inflammation. Domperidone helps prevent nausea and vomiting by improving gut movement and acting on the brain’s vomiting center. Together, they provide effective relief from both headache and associated stomach discomfort during migraines.
Can the use of Comig 500 Tablet cause diarrhea?
Yes, the use of Comig 500 Tablet can cause diarrhea. In case you experience diarrhea, drink plenty of water or other fluids. Talk to your doctor if diarrhea persists and you notice any signs of dehydration, like less urination with dark-colored and strong-smelling urine. Do not take any other medicine without consulting a doctor.
Are there any specific contraindications associated with the use of Comig 500 Tablet?
The use of Comig 500 Tablet is considered to be harmful for patients with known allergies to any of the components or excipients of this medicine or in patients with known allergies to other painkillers belonging to NSAIDs. The use of this medicine should preferably be avoided in patients with a history of stomach ulcers or patients with active, recurrent stomach ulcers/bleeding. It should also be avoided in patients with a history of heart failure, high blood pressure, and liver or kidney disease.
Can the use of Comig 500 Tablet cause damage to the kidneys?
Yes, the long-term use of Comig 500 Tablet can cause damage to the kidneys. Normal kidneys produce a chemical called prostaglandins that protects them from damage. The use of painkillers lowers the levels of prostaglandins in the body, which leads to kidney damage on long-term use. The use of painkillers is not recommended for patients with underlying kidney disease.
Can I take a higher dose than the recommended dose of Comig 500 Tablet?
No, taking a higher dose than the recommended dose of Comig 500 Tablet can increase the risks of side effects. If you are experiencing increased severity of migraine attacks that are not relieved by the recommended doses, please consult your doctor for reevaluation.
What are the recommended storage conditions for Comig 500 Tablet?
Keep this medicine in the container or the pack it came in, tightly closed. Store it as mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children, and other people.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Naproxen [Prescribing Information]. Nutley, New Jersey: Roche Laboratories Inc. [Accessed 22 Apr. 2019] (online) Available from:
- Leeford Healthcare: Naproxen and domperidone [Product Information]. [Accessed 20 Feb. 2025] (online) Available from:
- Domperidon and Naproxen [Product Information]. Ahmedabad, Gujarat: Torrent Pharmaceuticals Ltd.; 2024 [Accessed 20 Feb. 2025] (online) Available from:
Marketer details
Name: Seagull Pharmaceutical Pvt Ltd
Address: 305-307, Ansal Imperial Tower, C Block Community Centre, Naraina Vihar, New Delhi-110028, India
Country of origin: India
Expires on or after: June, 2026
A licensed vendor partner from your nearest location will deliver Comig 500 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
Expires on or after: June, 2026
A licensed vendor partner from your nearest location will deliver Comig 500 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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