Darbenef 40mcg Injection
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Product introduction
Darbenef 40mcg Injection is used in the treatment of anemia that may have occurred due to chronic kidney disease or chemotherapy. It works by stimulating the bone marrow to produce more red blood cells.
Darbenef 40mcg Injection is a medicine that needs to be used with utmost care because it can lead to serious side effects. It is important that you seek treatment from a doctor who is experienced in providing this medical therapy. You should follow all the directions of the doctor strictly. It is given under the supervision of a healthcare professional.
Common side effects include abdominal pain, high blood pressure, rash, injection site pain, breathlessness, cough, and peripheral edema. Inform your doctor if there are symptoms of very high blood pressure such as severe headache, problems with your eyesight, nausea, vomiting, or fits (seizures).
Your doctor may get your blood tests done regularly to monitor the levels of salts (electrolytes such as potassium), hemoglobin, and blood cells in your blood. You should stop taking it and consult with a doctor if you develop shortness of breath or skin rash.
Before taking Darbenef 40mcg Injection, tell your doctor if you have heart disease, high blood pressure, or have had a seizure or stroke. If you are pregnant or breastfeeding, or plan to become pregnant or breastfeed, consult your doctor to make sure it is safe for you.
Darbenef 40mcg Injection is a medicine that needs to be used with utmost care because it can lead to serious side effects. It is important that you seek treatment from a doctor who is experienced in providing this medical therapy. You should follow all the directions of the doctor strictly. It is given under the supervision of a healthcare professional.
Common side effects include abdominal pain, high blood pressure, rash, injection site pain, breathlessness, cough, and peripheral edema. Inform your doctor if there are symptoms of very high blood pressure such as severe headache, problems with your eyesight, nausea, vomiting, or fits (seizures).
Your doctor may get your blood tests done regularly to monitor the levels of salts (electrolytes such as potassium), hemoglobin, and blood cells in your blood. You should stop taking it and consult with a doctor if you develop shortness of breath or skin rash.
Before taking Darbenef 40mcg Injection, tell your doctor if you have heart disease, high blood pressure, or have had a seizure or stroke. If you are pregnant or breastfeeding, or plan to become pregnant or breastfeed, consult your doctor to make sure it is safe for you.
Uses of Darbenef Injection
Benefits of Darbenef Injection
In Treatment of Anemia due to chronic kidney disease
Anemia is a condition where your body does not have enough red blood cells to carry oxygen around your body. Chronic kidney disease (CKD) refers to the loss of normal kidney function over a long span of time. CKD progresses gradually over a few years but may become permanent if left untreated. CKD can lead to anemia. Darbenef 40mcg Injection can boost your levels of red blood cells and reduce the symptoms of anemia such as tiredness and weakness. Taking this injection improves the quality of life.
In Treatment of Anemia due to cancer chemotherapy
Low red blood cell count is termed as anemia. Cancer treatment with chemotherapy often causes many side effects, one of the major ones being anemia. Darbenef 40mcg Injection stimulates the production of red blood cells in bone marrow and regulates the haemoglobin in the blood. This treats anemia in cancer patients receiving chemotherapy.
Side effects of Darbenef Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Darbenef
- Abdominal pain
- High blood pressure
- Rash
- Injection site pain
- Breathlessness
- Cough
- Peripheral edema
- Procedural hypotension (low blood pressure)
- Convulsion
- Thromboembolism
How to use Darbenef Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Darbenef Injection works
Darbenef 40mcg Injection is an erythropoiesis-stimulating agent (ESA). It works by stimulating the bone marrow (soft tissue inside the bones which produces red blood cells) to produce more red blood cells.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Darbenef 40mcg Injection. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Darbenef 40mcg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Darbenef 40mcg Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
SAFE
Darbenef 40mcg Injection does not usually affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Darbenef 40mcg Injection is safe to use in patients with kidney disease. No dose adjustment of Darbenef 40mcg Injection is recommended.
Liver
CAUTION
Darbenef 40mcg Injection should be used with caution in patients with liver disease. Dose adjustment of Darbenef 40mcg Injection may be needed. Please consult your doctor.
What if you forget to take Darbenef Injection?
If you miss a dose of Darbenef 40mcg Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
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Quick tips
- Darbenef 40mcg Injection helps in the treatment of anemia that may have occurred due to chronic kidney disease or cancer chemotherapy.
- It is given as a single injection under your skin, additionally, it can be given intravenously.
- Your doctor may get your blood tests done regularly to monitor the levels of hemoglobin, blood cells, in your blood.
- Stop taking Darbenef 40mcg Injection and inform your doctor if you develop shortness of breath or skin rash.
Fact Box
Chemical Class
Amino Acids, Peptides Analogues
Habit Forming
No
Therapeutic Class
BLOOD RELATED
Action Class
Erythropoiesis-stimulating agent (ESA)
Interaction with drugs
Taking Darbenef with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Concurrent use may increase the risk of high blood potassium levels.
If concurrent use is essential, your doctor may monitor your potassium levels along with your overall treatmen
Concurrent use may increase the risk of formation of blood clots.
If concurrent use is essential, watch out for symptoms such as unusual bleeding, swelling in one leg or arm, new
Concurrent use may increase the risk of blood clots.
If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.
Darbepoetin alfa may raise blood levels of Thalidomide.
If concurrent use is essential, watch out for symptoms such as fatigue, shortness of breath, unusual paleness, easy bruisin
Darbepoetin alfa may reduce efficacy of Olmesartan Medoxomil. Concurrent use may increase the risk of high blood potassium levels. Olmesartan Medoxomil may reduce efficacy of Darbe
Patient concerns
FAQs
How long does it take for Darbenef 40mcg Injection to start working?
You will be able to notice an increase in the count of red blood cells (hemoglobin levels) in 2-6 weeks of starting Darbenef 40mcg Injection. If you have any other concerns, consult your doctor.
Is Darbenef 40mcg Injection safe to use?
Darbenef 40mcg Injection is a medicine that needs to be used with utmost care because it can lead to serious side effects and even death of the patient. It is important that you seek treatment from a doctor who is experienced in providing Darbenef 40mcg Injection therapy. Follow all the directions strictly.
Other than PRCA, can there be other reasons for not responding to Darbenef 40mcg Injection?
You may not respond to Darbenef 40mcg Injection if you have deficiencies of iron, folic acid or vitamin B12. It is important that you take measures to correct these deficiencies. Other reasons behind not responding to the treatment could be bleeding, infections, inflammation and bone marrow fibrosis. Therefore, consult our doctor regarding the same.
Can Darbenef 40mcg Injection be used in children?
Yes, Darbenef 40mcg Injection is used to treat anemia due to chronic kidney disease in children who are above 1 year of age. The effectiveness of Darbenef 40mcg Injection and side effects seen in children are similar to adults. However, consult your doctor if you are not sure.
Can Darbenef 40mcg Injection affect blood pressure?
Yes, Darbenef 40mcg Injection can affect blood pressure. During initial therapy with Darbenef 40mcg Injection, blood pressure should be monitored and those who have high blood pressure should take appropriate measures to control blood pressure. Your doctor may stop Darbenef 40mcg Injection if the blood pressure remains uncontrolled.
Who should not take Darbenef 40mcg Injection?
Individuals who have cancer but have not been prescribed Darbenef 40mcg Injection by the doctor should not take it. Additionally, patients with uncontrolled hypertension (high blood pressure), patients with a history of anemia called pure red cell aplasia (PRCA) that starts after treatment with Darbenef 40mcg Injection or other erythropoietin medicines, and patients with a history of serious allergic reaction to this medicine should not take this medicine.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Kaushansky K, Kipps TJ. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1071-72.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 358-59.
- Darbepoetin alfa. Milton Road, Cambridge: Amgen Ltd.; 2001 [revised Sep. 2017]. [Accessed 23 Jan. 2019] (online) Available from:
- Darbepoetin alfa. Thousand Oaks, CA: Amgen Inc.; 2001. [Accessed 07 Apr. 2019] (online) Available from:
- CiplaMed. Darbepoetin Alfa [Product Information]. [Last Reviewed: June 2019]. [Accessed 17 Jun. 2023] (online) Available from:
- Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006. Darbepoetin. [Accessed 17 Jun. 2023] (online) Available from:
- Darbepoetin alfa [Prescribing Information]. Thousand Oaks, California: Amgen Inc.; 2019. [Accessed 17 Jun. 2023] (online) Available from:
- Aranesp Injection (Darbepoetin alfa) [Product Information]. [Accessed 17 Jun. 2023] (online) Available from:
Marketer details
Name: Merynova Lifesciences India Private Limited
Address: NO 22, ADARSH NAGAR SWAROOP NAGAR, UPPAL HYDERABAD Hyderabad TG 500039 IN
Country of origin: India
Expires on or after: March, 2025
A licensed vendor partner from your nearest location will deliver Darbenef 40mcg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
Expires on or after: March, 2025
A licensed vendor partner from your nearest location will deliver Darbenef 40mcg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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0.4 ml in 1 prefilled syringe
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