Denoci-OP Injection is a medicine used in the treatment of osteoporosis in postmenopausal women and in men at increased risk of fractures. It makes the bones strong and reduce the risk of fractures.
Denoci-OP Injection is given by a healthcare professional and should not be self-administered. You should use it regularly and at the same time each day to get maximum benefit from it. Continue using it as recommended by your doctor and complete the dose even if you feel better. To make it more effective, take adequate amount of calcium and vitamin D supplements while on treatment with this medicine.
Some common side effects of this medicine include headache, pain in extremity, musculoskeletal pain, nerve pain, constipation, and rash. Talk to your doctor if any of these side effects does not go away with time or get worse. Your doctor may help with ways to reduce or prevent these symptoms.
To make sure the medicine is safe for you, before taking it, let your doctor know of all the other medicines you are taking. It is important for pregnant and breastfeeding mothers to ask the advice of their doctors before using this medicine.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Denoci-OP
Rash
Musculoskeletal (bone, muscle or joint) pain
Nerve pain
Eczema
Upper respiratory tract infection
Sciatica
Pain in extremities
Headache
Back pain
Joint pain
Urinary tract infection
Constipation
Abdominal discomfort
Hair loss
Hypercholesterolemia (high cholesterol)
Cystitis
How to use Denoci-OP Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Denoci-OP Injection works
Denoci-OP Injection is a monoclonal antibody. It binds to a protein that causes bone loss, thereby strengthening the bone and minimizing the risk of fractures.
Safety advice
Alcohol
CAUTION
Caution is advised when consuming alcohol with Denoci-OP Injection. Please consult your doctor.
Pregnancy
UNSAFE
Denoci-OP Injection is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breast feeding
CONSULT YOUR DOCTOR
Denoci-OP Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
SAFE
Denoci-OP Injection does not usually affect your ability to drive.
Kidney
CAUTION
Denoci-OP Injection should be used with caution in patients with severe kidney disease. Dose adjustment of Denoci-OP Injection may be needed. Please consult your doctor.
Liver
CAUTION
Denoci-OP Injection should be used with caution in patients with severe liver disease. Dose adjustment of Denoci-OP Injection may be needed. Please consult your doctor.
What if you forget to take Denoci-OP Injection?
If you miss a dose of Denoci-OP Injection, please consult your doctor.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
I am having chronic daily headache from last 4 years and now a days sometimes anxiety ,tingling in legs and hands and dizziness has also been started. I also have constipation. Now when I get my blood check up , found that my vitamin b12 is 146 , iron is 63 and vitamin d is 15. Is these deficiency are responsible for all these ?
Dr. Pushkar Mani
Physician
take CALCIMAX OP capsules once daily for 60 daystake cholecalciferol injection IM once weekly for 6 weekstake becosule plus once daily for 60 days
There is no optimal duration of treatment of osteoporosis with Denoci-OP Injection. The patient’s response and tolerability to the medicine is continuously monitored through periodic assessments, especially after 5 years of use of Denoci-OP Injection. Depending on this, the duration of taking Denoci-OP Injection is decided.
Q. Does Denoci-OP Injection cause hair loss?
Yes, hair loss is a common side effect of Denoci-OP Injection though it does not affect everyone. Discuss with your doctor if you have concerns regarding your hair loss.
Q. Is Denoci-OP Injection a chemotherapy drug?
Denoci-OP Injection is not a chemotherapy drug. It is a protein (monoclonal antibody) that interferes with the action of another protein in order to treat bone loss and osteoporosis. Treatment with Denoci-OP Injection makes the bones stronger and less likely to break.
Q. How is Denoci-OP Injection given and how often?
Denoci-OP Injection is available as an injection and is given by a healthcare professional. It is given once in 6 months. Your doctor may also advise you to take calcium and vitamin D while taking Denoci-OP Injection.
Q. Can Denoci-OP Injection be taken during pregnancy?
No, pregnant women should not take Denoci-OP Injection. You must use an effective method of birth control during and for at least 5 months after the last dose of Denoci-OP Injection if you can become pregnant.
Q. How should Denoci-OP Injection be stored?
Denoci-OP Injection should be stored in a refrigerator at 36°F to 46°F (2°C to 8°C) in the original carton. Warm temperatures can make it ineffective, and therefore proper storage is necessary. When you remove it from the refrigerator, keep it at room temperature [up to 77°F (25°C)] in the original carton and use it within 14 days.
Q. Does Denoci-OP Injection cause osteonecrosis of the jaw?
Osteonecrosis is a rare side effect of Denoci-OP Injection. It refers to the damage caused to the bone of jaw. To avoid this, you should maintain good oral hygiene and receive routine dental check ups while taking Denoci-OP Injection. Contact your doctor and dentist immediately if you experience any problems with your mouth or teeth such as loose teeth, discharge, pain or swelling, or non-healing of sores. These could be signs of osteonecrosis of jaw.
Q. How long can you stay on Denoci-OP Injection?
There is no optimal duration of treatment of osteoporosis with Denoci-OP Injection. The patient’s response and tolerability to the medicine is continuously monitored through periodic assessments, especially after 5 years of use of Denoci-OP Injection. Depending on this, the duration of taking Denoci-OP Injection is decided.
Q. Does Denoci-OP Injection cause hair loss?
Yes, hair loss is a common side effect of Denoci-OP Injection though it does not affect everyone. Discuss with your doctor if you have concerns regarding your hair loss.
Q. Is Denoci-OP Injection a chemotherapy drug?
Denoci-OP Injection is not a chemotherapy drug. It is a protein (monoclonal antibody) that interferes with the action of another protein in order to treat bone loss and osteoporosis. Treatment with Denoci-OP Injection makes the bones stronger and less likely to break.
Q. How is Denoci-OP Injection given and how often?
Denoci-OP Injection is available as an injection and is given by a healthcare professional. It is given once in 6 months. Your doctor may also advise you to take calcium and vitamin D while taking Denoci-OP Injection.
Q. Can Denoci-OP Injection be taken during pregnancy?
No, pregnant women should not take Denoci-OP Injection. You must use an effective method of birth control during and for at least 5 months after the last dose of Denoci-OP Injection if you can become pregnant.
Q. How should Denoci-OP Injection be stored?
Denoci-OP Injection should be stored in a refrigerator at 36°F to 46°F (2°C to 8°C) in the original carton. Warm temperatures can make it ineffective, and therefore proper storage is necessary. When you remove it from the refrigerator, keep it at room temperature [up to 77°F (25°C)] in the original carton and use it within 14 days.
Q. Does Denoci-OP Injection cause osteonecrosis of the jaw?
Osteonecrosis is a rare side effect of Denoci-OP Injection. It refers to the damage caused to the bone of jaw. To avoid this, you should maintain good oral hygiene and receive routine dental check ups while taking Denoci-OP Injection. Contact your doctor and dentist immediately if you experience any problems with your mouth or teeth such as loose teeth, discharge, pain or swelling, or non-healing of sores. These could be signs of osteonecrosis of jaw.
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References
Bikle DD. Agents That Affects Bone Mineral Homoestasis. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 766.
Friedman PA. Agents Affecting Mineral Ion Homeostasis and Bone Turnover. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1299.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 370.
Drugs.com. Denosumab. [Accessed 02 Apr. 2019] (online) Available from: