Depzil Plus 5mg/5mg Tablet is a prescription medicine used to treat Alzheimer's disease. It helps to slow down the progression of moderate to severe Alzheimer's by improving memory and thinking. It also increases the levels of a chemical messenger involved in the transmission of nerve signals.

Depzil Plus 5mg/5mg Tablet can be taken with or without food, but you may take it with food to avoid a stomach upset. However, it is advised to take it at the same time each day to maintain a consistent level of medicine in the blood. Do not skip any doses, but if you miss a dose of this medicine, take it as soon as you remember. Finish the full course of treatment even if you feel better and do not stop taking it suddenly.

Some common side effects of this medicine include nausea, vomiting, loss of appetite, fatigue, and headache. It may also cause dizziness and sleepiness. So, do not drive or do anything that requires mental focus until you know how this medicine affects you. Drink plenty of fluids to keep yourself hydrated while taking this medicine as this medicine may cause diarrhea.

Before using this medicine, you should tell your doctor if you have ever had heart problems, stomach ulcers, epilepsy or asthma. It may also affect, or be affected by, some other drugs you are using so let your doctor know what these are to be safe. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Uses of Depzil Plus Tablet

Alzheimer's disease

Benefits of Depzil Plus Tablet

In Alzheimer's disease

Depzil Plus 5mg/5mg Tablet improves learning, memory and information processing (cognitive function) in people with mild to moderate Alzheimer's disease. These problems in memory and thinking may start interfering with daily activities and worsen your condition. This medicine will help in managing Alzheimer’s disease effectively. It will make it easier for you to carry out your daily activities and improve your quality of life. Do not stop taking it unless advised by the doctor. It can take several weeks for your symptoms to improve; so keep using the medicine even if you do not think it is working.

Side effects of Depzil Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Depzil Plus

Nausea
Vomiting
Loss of appetite
Diarrhea
Headache
Dizziness
Insomnia (difficulty in sleeping)
Fatigue
Muscle cramp

How to use Depzil Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Depzil Plus 5mg/5mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Depzil Plus Tablet works

Depzil Plus 5mg/5mg Tablet is a combination of two medicines: Donepezil and Memantine which treat Alzheimer’s disease. Donepezil is a cholinesterase inhibitor while Memantine is an NMDA inhibitor. Together, they balance the levels of chemical messengers in the brain and help in the transmission of nerve signals.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Depzil Plus 5mg/5mg Tablet.

Pregnancy

CONSULT YOUR DOCTOR

Depzil Plus 5mg/5mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Depzil Plus 5mg/5mg Tablet during breastfeeding is not available. Please consult your doctor.

Driving

UNSAFE

Depzil Plus 5mg/5mg Tablet may cause side effects which could affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Depzil Plus 5mg/5mg Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Depzil Plus 5mg/5mg Tablet may not be needed in these patients. Please consult your doctor.

Liver

CAUTION

Depzil Plus 5mg/5mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Depzil Plus 5mg/5mg Tablet may be needed. Please consult your doctor.

What if you forget to take Depzil Plus Tablet?

If you miss a dose of Depzil Plus 5mg/5mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Depzil Plus 5mg/5mg Tablet

₹9.89/Tablet

Donamem 5 Tablet

Sun Pharmaceutical Industries Ltd

₹17.7/tablet

79% costlier

Alzil-M 5 Tablet

Intas Pharmaceuticals Ltd

₹22.5/tablet

128% costlier

Donep-M Tablet

Alkem Laboratories Ltd

₹21.67/tablet

119% costlier

Larentine D 5mg/5mg Tablet

La Renon Healthcare Pvt Ltd

₹14.3/tablet

45% costlier

Donecept M Tablet

Cipla Ltd

₹20.5/tablet

107% costlier

View all substitutes

Quick tips

Depzil Plus 5mg/5mg Tablet is used for the symptomatic treatment of alzheimer's disease. It does not cure alzheimer's, but may help with brain function and doing daily activities.
Monitor your body weight regularly as both Depzil Plus 5mg/5mg Tablet and alzheimer's disease can cause weight loss.
Don't drive or do anything that requires mental focus until you know how it affects you.
Inform your doctor if you have a history of seizures as it may raise the chances of seizure if you had them in the past.
It may cause stomach ulcers, specially if you are also taking medications for inflammation or pain. Talk to your doctor if you vomit blood or have black colored stools.

Fact Box

Habit Forming

Therapeutic Class

NEURO CNS

Patient concerns

Why the failure of Alzheimer's therapy now a days???

Dr. Vikas Sharma

Neurology

as the disese mechanisms are still not defined in absolute terms; still PATIENT is needed and is ongoing

Sir, My father ( an advocate) has developed symptoms of Alzheimer recently and sometimes he takes medicines on his own. He gets weak and unable to walk after taking tablets. Is there any test which can tell which medicines that he took? He takes Ayurved, Allopath, Homeopathy all and does not listen to me. Kindly help

Dr. Ila Jain Khandelwal

Pathology

Dear Sir Thank you for consulting with me. Alzheimer's disease is a difficult disease to handle since patient develops dementia or forgetfulness. There are no blood tests which can tell you which medicines he took. Please consult a neurologist/ Psychiatrist

I am suffering from alzehimer. I forget things like where I put key in morning. Some small things which makes me to suffer from condolence. What is the reason and how can I cure it ?

Dr. Ambrish Dharmadhikari

Psychiatry

Alzheimer's have many reasons which may be genetic, vitamins deficiency, hormonal problems, alcohol, other drugs, age related and others. We need to investigate you for finding cause. I strongly advice consultation with psychiatrist. If you are from Mumbai, see me.There is no cure to Alzheimer's, but we can suppress symptoms. Looking at your age, I am very much sure you are not suffering from Alzheimer's!!!!

Myself and wife started infertility treatment. My doctor has prescribed ubefit, carnimed plus and linearity for sperm count increase. Will these drugs improve my sperm count? When I checked the indication of these drugs in Google, it shows different indications like heart disease, cancer, Alzheimer's disease like that, hence I am afraid of taking these drugs. Kindly provide your valuable comments.

Dr. Sonu Balhara Ahlawat

Obstetrics and Gynaecology

It is not predictableBut benefit is less

FAQs

What are the instructions for the storage and disposal of Depzil Plus 5mg/5mg Tablet?

Keep this medicine in the packet or container it came in, tightly closed. Store it as mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children, and other people.

What are the contraindications to the use of Depzil Plus 5mg/5mg Tablet?

Depzil Plus 5mg/5mg Tablet is contraindicated in patients who are allergic to Memantine, Donepezil or any of its constituents. Also, inform your doctor about all of patients medical history before using this medicine.

What should I inform my doctor before using Depzil Plus 5mg/5mg Tablet?

Before taking Depzil Plus 5mg/5mg Tablet, tell the doctor about all of patient's past and present medical conditions, including: problem in heart, lung, liver, kidney or bladder, seizures, stomach ulcers or any scheduled medical procedures. Also, inform your doctor about all the medicines patient takes.

What if the patient takes more of Depzil Plus 5mg/5mg Tablet than recommended?

If the patient overdose on Depzil Plus 5mg/5mg Tablet, go to nearest medical emergency department or call your doctor immediately.

Can the use of Depzil Plus 5mg/5mg Tablet cause diarrhea?

Yes, the use of Depzil Plus 5mg/5mg Tablet can cause diarrhea. In case, the patient experience diarrhea, talk to the doctor. Do not take any other medicines without speaking to a doctor.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Medscape. Donepezil+Memantine. [Accessed 23 Apr. 2019] (online) Available from:
Drugs.com. Donepezil+Memantine. [Accessed 23 Apr. 2019] (online) Available from:

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