Difine-OD 500 Tablet ER
Prescription Required
Product introduction
Difine-OD 500 Tablet ER is a medication used to treat epilepsy, seizures, bipolar disorder, mania, trigeminal neuralgia, and migraines. It works by stabilizing brain activity. Always use it under medical supervision for safe and effective treatment.
Difine-OD 500 Tablet ER may be used alone or in combination with other medicines. Your doctor will determine the appropriate dose and frequency to effectively control your symptoms. You can take this medicine with or without food, but for the best results, take it at the same time each day. It usually takes a couple of weeks to work. It is important to take this medicine regularly and for as long as you are advised, even if you feel well. Missing doses may trigger seizures, and if you stop, your condition may get worse. It should never be stopped suddenly.
The most common side effects of Difine-OD 500 Tablet ER include headache, constipation, nausea, vomiting, dizziness, weight gain, rash, back pain, and abdominal pain. Most of these are not serious. Continue taking the medicine, but consult your doctor if these side effects persist or become bothersome. However, if you notice a skin rash or redness, tell your doctor straight away. Long-term treatment with this medicine can cause osteoporosis (reduced bone mass) and increase your risk of breaking a bone. Also, Difine-OD 500 Tablet ER may rarely lead to suicidal thoughts and behaviors. If your mood becomes depressed, tell your doctor.
Difine-OD 500 Tablet ER may not be suitable for everybody. Before using it, tell your doctor if you have ever had heart problems, kidney or liver disease, difficulty urinating, depression, or suicidal thoughts. Some medicines can interfere with it and should not be taken together, so tell your doctor about all the medicines you are taking to make sure it is safe for you. If you are pregnant, do not take this medicine without asking your doctor. Avoid drinking alcohol, as it may enhance certain side effects and increase the risk of seizures. You may need frequent blood tests to help your doctor make sure you are taking the right dose both before you start and while you are using it.
Uses of Difine Tablet ER
Benefits of Difine Tablet ER
In Treatment of Mania
Difine-OD 500 Tablet ER helps stabilize mood swings in people with bipolar disorder, reducing episodes of extreme highs (mania). It improves emotional balance, controls impulsive behavior, and promotes a calmer, more stable state of mind.
In Treatment of Migraine
Difine-OD 500 Tablet ER can help prevent migraines by reducing the frequency and severity of attacks. It works by stabilizing brain activity, making it an effective option for those who suffer from frequent, disabling migraines.
In Treatment of Bipolar disorder
Difine-OD 500 Tablet ER works by restoring your brain's normal balance of nerve activity. It helps prevent extreme mood changes and helps you feel less agitated. You may experience fewer episodes of low mood. It may take several weeks for this medicine to take effect, and you may continue to feel low during this period. You will likely take this medicine for at least six months but possibly much longer. It must be taken regularly to be effective. Do not stop taking it unless directed by your doctor. You should continue to eat well and keep fit to reduce symptoms of bipolar disorder.
In Treatment of Trigeminal neuralgia
For trigeminal neuralgia, a condition causing severe facial pain, Difine-OD 500 Tablet ER helps reduce nerve overactivity. This can lead to fewer and less intense pain episodes, improving daily comfort and quality of life.
In Treatment of Epilepsy/Seizures
Difine-OD 500 Tablet ER is an anticonvulsant (or anti-epileptic) medicine that works by decreasing the nerve impulses that cause seizures. Controlling the frequency of seizures helps you go about your daily activities with more confidence. It also helps reduce symptoms such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety. This medicine is not associated with any physical or psychological dependence (addiction), but it should not be stopped suddenly. It must be taken regularly as prescribed to be effective. Missing doses may trigger a seizure.
Side effects of Difine Tablet ER
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Difine
- Abdominal pain
- Accidental injury
- Hair loss
- Blurred vision
- Memory loss
- Decreased appetite
- Weakness
- Abnormality of voluntary movements
- Back pain
- Bronchitis (inflammation of the airways)
- Constipation
- Depression
- Diarrhea
- Double vision
- Dizziness
- Indigestion
- Breathlessness
- Ecchymosis (discoloration of the skin resulting from bleeding underneath)
- Emotional lability
- Fever
- Influenza like syndrome
- Headache
- Increased appetite
- Insomnia (difficulty in sleeping)
- Nausea
- Nervousness
- Nystagmus (involuntary eye movement)
- Peripheral edema
- Sore throat
- Rash
- Inflammation of the nose
- Sleepiness
- Altered thinking
- Low blood platelets
- Ringing in ear
- Tremors
- Vomiting
- Weight gain
- Weight loss
How to use Difine Tablet ER
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Difine-OD 500 Tablet ER may be taken with or without food, but it is better to take it at a fixed time.
How Difine Tablet ER works
Difine-OD 500 Tablet ER works by calming overactive nerve signals in the brain. It increases certain chemicals that help control brain activity, prevent seizures, stabilize mood in bipolar disorder, and reduce migraine frequency. Balancing brain signals helps manage symptoms effectively and improves overall well-being.
Safety advice
Alcohol
UNSAFE
Difine-OD 500 Tablet ER may cause excessive drowsiness with alcohol.
Pregnancy
CONSULT YOUR DOCTOR
Difine-OD 500 Tablet ER is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
CAUTION
Difine-OD 500 Tablet ER should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
Driving
UNSAFE
Difine-OD 500 Tablet ER may cause side effects which could affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Difine-OD 500 Tablet ER is safe to use in patients with kidney disease. No dose adjustment of Difine-OD 500 Tablet ER is recommended.
Liver
UNSAFE
Difine-OD 500 Tablet ER is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
What if you forget to take Difine Tablet ER?
If you miss a dose of Difine-OD 500 Tablet ER, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
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Quick tips
- Take your medication regularly as directed by your doctor, as missing doses can trigger seizures.
- Take it at the same time every day to maintain consistent levels in your body.
- It can be taken with or without food; however, consider taking it with food to avoid an upset stomach.
- Do not change the brand of your medicine, and make sure that you have a sufficient amount of medicine present with you.
- It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
- Monitor your weight during treatment with this medicine, as it can cause weight gain.
- Your doctor may get regular blood tests done to monitor how the medication is affecting your body. Inform your doctor if you notice yellowing of the eyes or skin, dark urine, or stomach pain.
- Avoid consuming alcohol when taking Difine-OD 500 Tablet ER, as it may cause excessive sleepiness or drowsiness.
- Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
- Do not take Difine-OD 500 Tablet ER if you are pregnant or planning to conceive or breastfeed.
Fact Box
Chemical Class
Aliphatic Carboxylic acid Derivatives
Habit Forming
No
Therapeutic Class
NEURO CNS
Action Class
Sodium Channel Modulators- Antiepileptic drugs (AEDs)
Patient concerns
FAQs
What happens if I stop taking Difine-OD 500 Tablet ER?
You should not stop taking Difine-OD 500 Tablet ER without consulting your doctor. The dose of Difine-OD 500 Tablet ER should be reduced gradually and eventually can be stopped under the supervision of a doctor or specialist. Suddenly stopping the medication may trigger seizures or lead to the recurrence of symptoms.
Is Difine-OD 500 Tablet ER a mood stabilizer?
Yes, Difine-OD 500 Tablet ER can sometimes be used as a mood stabilizer. It is given in patients who experience rapid changes in their mood. It works by calming the hyperactivity of the brain during mood changes.
Can Difine-OD 500 Tablet ER cause weight gain?
Yes, Difine-OD 500 Tablet ER may cause weight gain. The gain in weight could be due to an increase in hunger. Keep a check on your diet and exercise regularly to prevent any weight gain. If you are have concerns related to weight gain, consult your doctor.
Does Difine-OD 500 Tablet ER make you sleepy?
Yes, Difine-OD 500 Tablet ER may make you feel sleepy. Avoid driving or other work that requires mental focus until you know how it affects you.
Does Difine-OD 500 Tablet ER cause hair loss?
Yes, Difine-OD 500 Tablet ER may cause hair loss. However, it is only for a short time and is usually dose-related. Consult your doctor if the hair loss bothers you or persists for a longer duration.
Can Difine-OD 500 Tablet ER damage my liver?
Yes, Difine-OD 500 Tablet ER can cause damage to the liver. The risk is more likely to occur during the first 6 months of starting the treatment with Difine-OD 500 Tablet ER. Symptoms of liver damage may include nausea or vomiting, loss of appetite, stomach pain, dark-colored urine, facial swelling, yellowing of the skin, or white eyes. Therefore, it is important to have liver function tests done before starting the medicine. Tests should be done periodically during the first 6 months of therapy, especially in those who are likely to be at risk and those with a prior history of liver disease.
Can I take alcohol while I am taking Difine-OD 500 Tablet ER?
Avoid alcohol consumption while you are on treatment with Difine-OD 500 Tablet ER. Taking alcohol with this medicine may make you feel more drowsy, light headed or dizzy.
What are the laboratory tests recommended before taking Difine-OD 500 Tablet ER?
The doctor may suggest blood tests before starting the treatment with Difine-OD 500 Tablet ER. The tests may include blood cell count, including platelet count, bleeding time, and coagulation tests. These tests are also advised to avoid any spontaneous bruising or bleeding. In addition to this, liver function tests are advised before therapy. It is recommended to periodically monitor liver function during the first 6 months of therapy, primarily in those who seem most at risk and those with a prior history of liver disease.
What should be done if I start experiencing abdominal pain, nausea and anorexia?
If you experience acute, severe abdominal pain along with nausea and vomiting, it may be due to pancreatitis. Immediately consult your doctor in case you experience these symptoms. Your doctor may get your levels of serum amylase checked. In case the test shows positive results for pancreatitis, the medication should be stopped immediately.
How to check for overdose of Difine-OD 500 Tablet ER?
An overdose of Difine-OD 500 Tablet ER may cause headaches, blurred eyesight due to the pupils of the eyes becoming smaller, lack of reflexes, confusion, and tiredness. You may also experience weak or “floppy” muscles, fits (seizures), loss of consciousness, behavioral changes, and breathing difficulties such as fast breathing, shortness of breath, or chest pain. Immediate medical assistance is required in case of overdose.
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
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- Divalproex Sodium [Drug Label]. North Chicago, IL: Abbott Laboratories; 2006. [Accessed 19 Feb. 2025] (online) Available from:
- Divalproex Sodium [Medication Guide]. Halol, Gujarat: Sun Pharmaceutical Industries Ltd.; 2022. [Accessed 20 June 2023]. (online) Available from:
- Divalproex Sodium [Prescribing Information]. Ghaziabad, UP: Unichem Laboratories Ltd.; 2023. [Accessed 20 June 2023]. (online) Available from:
- Divalproex Sodium [Prescribing Information].Toronto, Ontario: Apotex Inc.; 2025. [Accessed 24 Feb 2025]. (online) Available from:
Marketer details
Name: Vanprom Lifesciences Pvt Ltd
Address: GC Complex, 1st Floor, Jwala Heri Market, Paschim Vihar, New Delhi, Delhi - 110063, India
Country of origin: India
Expires on or after: July, 2026
A licensed vendor partner from your nearest location will deliver Difine-OD 500 Tablet ER. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
Expires on or after: July, 2026
A licensed vendor partner from your nearest location will deliver Difine-OD 500 Tablet ER. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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