Donibiz 5 Tablet is used to treat mild to moderate dementia in Alzheimer’s disease, a progressive illness that gradually affects memory and thinking. It does not cure this illness but may help improve memory, awareness, and other symptoms.

Your doctor will explain how to take Donibiz 5 Tablet. You may take it with food, preferably at night before going to bed. Follow the instructions carefully to get the most benefit. The dose may change from time to time to suit your individual needs. It can take up to a few weeks for symptoms to improve so keep taking your medicine regularly. You should not stop taking this medicine without consulting your doctor.

Some common side effects of this medicine include nausea, diarrhea, insomnia, vomiting, muscle cramps, fatigue, weight loss (anorexia), headache, loss of appetite, common cold, urinary incontinence, and rash. Drink plenty of fluids to keep yourself hydrated. You may have side effects more often when you start your treatment or when your dose is increased. Usually, the side effects will slowly go away as your body gets used to the Donibiz 5 Tablet. If they are severe or will not go away, you should contact your doctor.

Before using Donibiz 5 Tablet, you should tell your doctor if you have ever had heart problems, stomach ulcers, epilepsy, or asthma. It may also affect, or be affected by, some other drugs you are using so let your doctor know what these are to be safe. During pregnancy, this medicine should only be taken if it is advised.

Uses of Donibiz Tablet

Alzheimer's disease

Benefits of Donibiz Tablet

In Alzheimer's disease

In people with Alzheimer’s disease, certain nerve cells die in the brain. This results in lower levels of a chemical called acetylcholine which helps nerve cells to communicate with each other. This leads to symptoms of dementia such as memory loss, confusion, disorientation, problems with speech and language, and personality changes. Donibiz 5 Tablet increases the amount of acetylcholine and helps brain cells to communicate. It can, therefore, improve some of the symptoms such as memory, awareness, and the ability to carry out daily functions for a time. However, it is not a cure. You should use the medicine exactly as prescribed. It can take several weeks for your symptoms to improve; so keep using the medicine even if you do not think it is working.

Side effects of Donibiz Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Donibiz

Common cold
Urinary incontinence
Rash
Nausea
Diarrhea
Insomnia (difficulty in sleeping)
Weight loss
Accidental injury

How to use Donibiz Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Donibiz 5 Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Donibiz Tablet works

Memory loss in Alzheimer’s disease occurs due to disturbances of signal transmission in the brain. Donibiz 5 Tablet is a cholinesterase inhibitor. It works by increasing the levels of a chemical messenger (acetylcholine) involved in transmmission of nerve signals. This improves memory and thinking.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Donibiz 5 Tablet.

Pregnancy

CONSULT YOUR DOCTOR

Donibiz 5 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Donibiz 5 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Donibiz 5 Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

SAFE IF PRESCRIBED

Donibiz 5 Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Donibiz 5 Tablet may not be needed in these patients. Please consult your doctor.

Liver

CAUTION

Donibiz 5 Tablet should be used with caution in patients with liver disease. Dose adjustment of Donibiz 5 Tablet may be needed. Please consult your doctor.

What if you forget to take Donibiz Tablet?

If you miss a dose of Donibiz 5 Tablet, skip it and continue with your normal schedule. Do not double the dose.\n

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Donibiz 5 Tablet

₹10.9/Tablet

Donep 5 Tablet

Alkem Laboratories Ltd

₹13.55/tablet

24% costlier

Donecept 5 Tablet

Cipla Ltd

₹13.1/tablet

20% costlier

Donasure 5mg Tablet

Gentech Healthcare Pvt Ltd

₹9.39/tablet

14% cheaper

Aricep 5 Tablet

Eisai Pharmaceuticals India Pvt Ltd

₹10.3/tablet

6% cheaper

Alzil 5 Tablet

Intas Pharmaceuticals Ltd

₹13.4/tablet

23% costlier

View all substitutes

Quick tips

You have been prescribed Donibiz 5 Tablet to slow down the progression of Alzheimer's disease.
It does not cure Alzheimer's disease but may help improve brain function and ability to do daily activities.
Take it with or without food, preferably at night before going to bed.
It may cause diarrhea, nausea, and vomiting. Drink plenty of fluids to keep yourself hydrated while taking Donibiz 5 Tablet.
Monitor your body weight regularly as both Donibiz 5 Tablet and Alzheimer's disease can cause weight loss.
Do not drive or do anything that requires mental focus until you know how Donibiz 5 Tablet affects you.
Be cautious while taking this medicine if you suffer from peptic ulcer as it may cause vomiting, stomach bleeding, stomach pain, or discomfort.
Inform your doctor if you develop muscle tremors, especially if you have Parkinson’s disease.
Inform your doctor if you experience seizures or convulsions while taking this medicine.

Fact Box

Chemical Class

Carbamate Derivative

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Cholinesterase inhibitors - Alzheimer's disease

Patient concerns

Why the failure of Alzheimer's therapy now a days???

Dr. Vikas Sharma

Neurology

as the disese mechanisms are still not defined in absolute terms; still PATIENT is needed and is ongoing

Sir, My father ( an advocate) has developed symptoms of Alzheimer recently and sometimes he takes medicines on his own. He gets weak and unable to walk after taking tablets. Is there any test which can tell which medicines that he took? He takes Ayurved, Allopath, Homeopathy all and does not listen to me. Kindly help

Dr. Ila Jain Khandelwal

Pathology

Dear Sir Thank you for consulting with me. Alzheimer's disease is a difficult disease to handle since patient develops dementia or forgetfulness. There are no blood tests which can tell you which medicines he took. Please consult a neurologist/ Psychiatrist

I am suffering from alzehimer. I forget things like where I put key in morning. Some small things which makes me to suffer from condolence. What is the reason and how can I cure it ?

Dr. Ambrish Dharmadhikari

Psychiatry

Alzheimer's have many reasons which may be genetic, vitamins deficiency, hormonal problems, alcohol, other drugs, age related and others. We need to investigate you for finding cause. I strongly advice consultation with psychiatrist. If you are from Mumbai, see me.There is no cure to Alzheimer's, but we can suppress symptoms. Looking at your age, I am very much sure you are not suffering from Alzheimer's!!!!

Myself and wife started infertility treatment. My doctor has prescribed ubefit, carnimed plus and linearity for sperm count increase. Will these drugs improve my sperm count? When I checked the indication of these drugs in Google, it shows different indications like heart disease, cancer, Alzheimer's disease like that, hence I am afraid of taking these drugs. Kindly provide your valuable comments.

Dr. Sonu Balhara Ahlawat

Obstetrics and Gynaecology

It is not predictableBut benefit is less

FAQs

Why is Donibiz 5 Tablet taken at night?

Donibiz 5 Tablet is recommended to be taken before going to bed to reduce gastrointestinal side effects or nausea, which is commonly seen in some patients in the first few weeks of treatment.

Do the gastrointestinal side effects due to Donibiz 5 Tablet persist for a long time?

Gastrointestinal side effects may appear during the first few weeks of treatment with Donibiz 5 Tablet. This can be minimized by taking Donibiz 5 Tablet at bedtime and with food. Generally, these side effects are mild and disappear within a few weeks with continued treatment.

How long does it take for Donibiz 5 Tablet to start working?

Within the first month of treatment with Donibiz 5 Tablet, you may experience improvement in thinking and remembering (cognitive effect). However, it may take about 12 weeks to see the full benefits.

When should Donibiz 5 Tablet be stopped?

Do not stop Donibiz 5 Tablet without consulting your doctor. This medicine only helps to control your condition but does not cure it. Therefore, it may take several weeks to show benefits, so do not be discouraged if you do not see an improvement straight away. But, in case your condition starts worsening and you feel that it is no longer helping you, then you should consult a doctor before stopping it.

For how long does Donibiz 5 Tablet stay in your system?

Donibiz 5 Tablet gets removed from the body very slowly. It takes about two weeks or more for Donibiz 5 Tablet to be completely removed from the system.

Does Donibiz 5 Tablet cause depression?

No, Donibiz 5 Tablet does not cause depression. If you are experiencing symptoms, then it could be due to existing Alzheimer’s disease.

What if I take more than the prescribed dose of Donibiz 5 Tablet?

Taking more than the recommended dose of Donibiz 5 Tablet may cause vomiting, increased sweating or saliva production, slow heartbeat, dizziness, difficulty in breathing, seizures or fits, weakness, low blood pressure, convulsions, and inability to control your bowel motions or passing of urine (incontinence). You should seek immediate help from a doctor or emergency service of a nearby hospital.

I have been taking indomethacin for arthritis. Can I take Donibiz 5 Tablet?

Donibiz 5 Tablet does not interfere with the working of indomethacin, but indomethacin individually increases the risk of stomach bleeding when taken for a long time. Therefore, if you experience any symptoms of stomach bleeding, consult your doctor immediately.

Does Donibiz 5 Tablet cause hallucinations?

Hallucinations are a common side effect of Donibiz 5 Tablet, though not everyone is affected. Other common psychiatric side effects include agitation, aggressive behavior, nightmares, and abnormal dreams.

Who should not take Donibiz 5 Tablet?

Donibiz 5 Tablet should not be taken by patients who have hypersensitivity to Donibiz 5 Tablet hydrochloride, piperidine derivatives, or to any active ingredients used in the medicine. Also, it should not be used during pregnancy unless clearly necessary.

Can it cause insomnia?

Yes, insomnia (sleeplessness) is a common side effect of Donibiz 5 Tablet. Dizziness and fainting can also be seen as common side effects. Though these side effects are common, they do not occur in everyone.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

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Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 426-27.
Donepezil hydrochloride. Woodcliff Lake, New Jersey: Eisai Inc.; 1996 [revised Feb. 2012]. [Accessed 25 Jan. 2019] (online) Available from:
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Donepezil hydrochloride. South Ruislip, UK: Aurobindo Pharma - Milpharm Ltd.; 2013 [revised 23 Nov. 2017] [Accessed 19 Jun. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 22 Mar. 2019] (online) Available from:
Donepezil hydrochloride [Prescribing Information]. Mahabubnagar, Telangana: Hetero Labs Limited; 2023. [Accessed 20 June 2023]. (online) Available from:
Donepezil Hydrochloride [Summary of Product Characteristics]. Dublin, Ireland: Pfizer Healthcare Ireland; 2023. [Accessed 20 June 2023]. (online) Available from:

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