Duzela 40 Capsule DR is used in the treatment of depression, anxiety disorder, diabetic nerve pain, fibromyalgia (a condition in which there are generalized pain and tenderness in the body), neuropathic pain, and stress urinary incontinence.
Duzela 40 Capsule DR works by increasing the level of chemical messengers (serotonin and noradrenaline) in the brain that have a calming effect on the brain and relax the nerves, thus treating your illness. It may be taken with or without food. It is advised to take this medicine at a fixed time each day to maintain a consistent level in the blood. If you miss any doses, take it as soon as you remember. Do not skip any doses and finish the full course of treatment even if you feel better. This medication mustn't be stopped suddenly as it may worsen your symptoms.
Some common side effects of this medicine include nausea, headache, decreased libido, abnormal dreams, blurred vision, and dry mouth. It even causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. However, these side effects are temporary and usually resolve on their own in some time. Please consult your doctor if these do not subside or bother you.
Before taking Duzela 40 Capsule DR, inform your doctor if you have any problems with your kidneys, heart, liver, or have a history of seizures (epilepsy or fits). Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or if you have any suicidal thoughts.
High levels of blood sugar (glucose) levels in diabetic patients can cause damage to nerves and this can cause pain sensation. Duzela 40 Capsule DR helps reduce this damage by affecting chemicals in the brain called neurotransmitters. By relieving pain, it helps improve your quality of life.
In Treatment of Depression
Duzela 40 Capsule DR increases the levels of certain chemicals in the brain that improve our mood and behavior. This creates a feeling of wellbeing, relieves anxiety, reduces tension, helps you sleep better, and increases your energy levels. It is an effective antidepressant but may cause drowsiness. You need to take it regularly as it is prescribed for it to be most effective and should not stop taking it suddenly, even if you feel better, as it may worsen your condition.
In Treatment of Anxiety disorder
Duzela 40 Capsule DR stops your brain from releasing the chemicals that make you feel anxious so it can reduce the symptoms of excessive anxiety and worry. It can also reduce feelings of restlessness, tiredness, difficulty concentrating, feeling irritable, and sleep problems that often come with Anxiety Disorder. It will therefore help you go about your daily activities more easily and be more productive. Keep taking this medicine even if you feel well. Stopping suddenly can cause serious problems.
In Treatment of Neuropathic pain
Duzela 40 Capsule DR is used to treat long-lasting (chronic) pain caused by nerve damage due to diabetes, shingles, or spinal cord injury. It interferes with pain signals that travel through the damaged nerves and the brain. Taking this medicine regularly will improve your physical and social functioning and overall quality of life. It takes a few weeks to work so you need to take it regularly even if you feel it is not doing any good.
In Treatment of Fibromyalgia
Duzela 40 Capsule DR may also be used to treat pain in people with fibromyalgia. It reduces pain and also the mood changes, sleep problems, and tiredness that can be caused by the pain. It interferes with pain messages traveling through the brain. Taking this medicine regularly will have an impact on your overall quality of life. Keep taking the medicine until your doctor advises you to stop.
In Treatment of Stress urinary incontinence
Stress urinary incontinence refers to the loss of urine without conscious intention. It may occur due to a disturbed state of mind and thoughts. Duzela 40 Capsule DR helps in increasing the activity of those nerves in the brain that control muscles in our bladder that are responsible for passing urine. This helps in improving bladder control.
Side effects of Duzela Capsule DR
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Duzela
Nausea
Headache
Dryness in mouth
Sleepiness
Dizziness
Blurred vision
Decreased libido
Abnormal dreams
How to use Duzela Capsule DR
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Duzela 40 Capsule DR may be taken with or without food, but it is better to take it at a fixed time.
How Duzela Capsule DR works
Duzela 40 Capsule DR works by increasing the levels of chemical messengers (serotonin and noradrenaline), natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain.
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Duzela 40 Capsule DR.
Pregnancy
CONSULT YOUR DOCTOR
Duzela 40 Capsule DR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Duzela 40 Capsule DR is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Duzela 40 Capsule DR may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CAUTION
Duzela 40 Capsule DR should be used with caution in patients with severe kidney disease. Dose adjustment of Duzela 40 Capsule DR may be needed. Please consult your doctor.
Liver
UNSAFE
Duzela 40 Capsule DR is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
What if you forget to take Duzela Capsule DR?
If you miss a dose of Duzela 40 Capsule DR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
Duzela 40 Capsule DR helps in treating depression and anxiety.
It may also be used to treat nerve pain from diabetes and some other forms of chronic pain.
It may take 2 to 4 weeks for Duzela 40 Capsule DR to start working. Keep taking it as prescribed.
It may cause dizziness and sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
Avoid consuming alcohol when taking Duzela 40 Capsule DR as it may cause excessive drowsiness and increase the risk of liver damage.
It may cause a sensation of restlessness, especially when you first start taking it. Inform your doctor if this happens to you.
Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
Do not stop taking the medication suddenly without talking to your doctor.
Fact Box
Chemical Class
Naphthalene Derivative
Habit Forming
No
Therapeutic Class
NEURO CNS
Interaction with drugs
Taking Duzela with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Hi.I am suffering with lot's of nerves pain only in the right side of the body and also with lot's of dizziness please say me what type of problem do I have. I can't bare it any more.now,I stopped washing cloths.since from 4to5 days
Feel occasional sharp bouts of pain in legs and feet mostly in nights. Am diabetic for last 15 years. Please advise some medicine as cure and avoid recurrances
I have pain from neck to hand via shoulder This problem began from 2 year ago I consulted to dr.puneet dixit who is a neuro physician he advised me for MRI I have done MRI check up This is my MRI report
Dr. Vikas Sharma
Neurology
show to neurosurgeon ; take cap duzela 40 mg od for pain
I am suffering from nerve pain in legs and arms.i am asthma patient since 8 years I am using salbutamol but last one year nerve pain is very high and not tolerate plz suggest the medication
Dr. Vikas Sharma
Neurology
get nerve conduction done; show 2 neuro dr; try cap duzela 30 mg daily
Severe nerve pain ,ischemia along with bone pain in hip and lumbar region.nerve pain become intense after having meal and drinking cold or normal water.i am postmenopausal with osteoporosis for past 2 years.
Dr. Vikas Sharma
Neurology
do MRI LS spine; start cap duzela 40 mg hs; show to neurologist
Q. How long does Duzela 40 Capsule DR take to work?
In people with depression and anxiety, Duzela 40 Capsule DR mostly starts working within two weeks of treatment. However, you may take 2-4 weeks to feel better. Consult your doctor if you do not see any improvement after this time. In people with diabetic neuropathic pain, you may take a few weeks to feel better. Consult your doctor if you do not feel better after 2 months.
Q. If I start feeling better, can I stop taking Duzela 40 Capsule DR?
No, you should not stop Duzela 40 Capsule DR suddenly and without consulting your doctor. In cases of depression and anxiety, if you have been feeling better for 6 months or more, your doctor may reduce your doses gradually. In case of pain and incontinence, if you are feeling better, continue taking it for the long term. Your doctor will keep monitoring your response to the medicine every few months.
Q. Is Duzela 40 Capsule DR highly addictive?
No, Duzela 40 Capsule DR is not habit-forming (addictive). This means that it does not make you physically or psychologically dependent on it.
Q. What will be the consequences if I stop taking Duzela 40 Capsule DR suddenly?
If you stop Duzela 40 Capsule DR suddenly, you may feel dizzy, tired, agitated or restless, anxious and irritated. You may also experience sleep disturbances (vivid dreams, nightmares, inability to sleep), nausea, vomiting, shaking, muscle pain, diarrhea, a piercing sensation (pins and needles) especially in the head, and excessive sweating or vertigo. Always consult your doctor before you stop taking Duzela 40 Capsule DR. Your doctor will reduce the dose gradually.
Q. I am taking warfarin, does Duzela 40 Capsule DR interfere with warfarin? Is it safe to take both together?
You should be cautious if you are taking both Duzela 40 Capsule DR and warfarin since there is a risk of bleeding or you may experience petechiae or purpura.
Q. Is Duzela 40 Capsule DR safe to use for long term?
Duzela 40 Capsule DR is safe to use for a long duration, provided you follow your doctor’s advice regarding the treatment.
Q. I am a hypertensive patient. I have noticed that my blood pressure has increased after I started taking Duzela 40 Capsule DR. Is it because of Duzela 40 Capsule DR, what should be done?
Duzela 40 Capsule DR may cause an increase in blood pressure. Therefore, regular monitoring of blood pressure is required, especially during the first month of use. If your blood pressure increase is constant, consult your doctor. It may indicate that your Duzela 40 Capsule DR dose either needs to be reduced or discontinued gradually.
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
Stahl SM, editor. Duloxetine. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 219-24.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 442-43.
Duloxetine hydrochloride. Basingstoke, Hampshire: Eli Lilly and Company Limited; 2004 [revised 09 Nov. 2018]. [Accessed 23 Jan. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Duloxetine. [Updated 2020 Jan 20]. [Accessed 20 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 22 Mar. 2019] (online) Available from:
Duloxetine Gastro-Resistant Tablets [Patient Information Sheet]. Gangtok, Sikkim: Torrent Pharmaceuticals Ltd.; 2022. [Accessed 20 Feb. 2024] (online) Available from:
Marketer details
Name: Sun Pharmaceutical Industries Ltd
Address: Plot no 107/108,Namli block , Ranipool, East Sikkim 737135
Country of origin: India Expires on or after: September, 2025
A licensed vendor partner from your nearest location will deliver Duzela 40 Capsule DR. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
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