Epletone 25mg Tablet is a medicine known as a diuretic (water pill). It is mainly used in the treatment of heart failure and high blood pressure. It is also used to reduce swelling (edema) caused by some other conditions.

Epletone 25mg Tablet can be taken with or without food, but you should take it, in the same way, each time to get the most benefit. Taking it with food can reduce some side effects and taking it early in the day can prevent you from having to get up at night to go to the toilet. You should keep using this medicine as it has been prescribed, even if you feel well. If you stop taking it, your condition may get worse. If you are being treated for high blood pressure, lifestyle changes such as taking regular exercise and changes to your diet may increase the effectiveness of this medicine.

The common side effects include nausea, dizziness, diarrhea, headache, and cough. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Drinking alcohol can increase certain side effects.

You should be careful about using Epletone 25mg Tablet if you have kidney problems or are unable to urinate. Before taking it, tell your doctor if you have ever had kidney, liver, or heart disease or you are pregnant. Also let your healthcare team know about all other medications you are using as they may affect, or be affected by this medicine. This medicine should only be used if it is clearly needed during pregnancy and while breastfeeding. While using this medicine, you may be advised to limit your intake of salt or salt substitutes, and you should have your blood pressure checked frequently. Some other tests will be done to monitor your progress.

Uses of Epletone Tablet

Benefits of Epletone Tablet

In Treatment of Heart failure

Heart failure means your heart is weak and cannot pump enough blood to your lungs and the rest of your body. The most common symptoms are breathlessness, tiredness, and swelling in your legs, ankles, abdomen and other parts of your body. Epletone 25mg Tablet makes it easier for your heart to pump blood around your body and is therefore an effective treatment for heart failure.

This medicine will help relieve your symptoms, making you feel better and more energetic. You should make appropriate lifestyle changes (such as eating healthily and keeping active) to help this medicine be effective. Take it regularly and keep taking it even if you feel better.

Side effects of Epletone Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Epletone

Dizziness
Diarrhea
Nausea
Cough
Flu-like symptoms
Fatigue
Increased potassium level in blood
Increased creatinine level in blood
Headache

How to use Epletone Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Epletone 25mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Epletone Tablet works

Epletone 25mg Tablet is a potassium-sparing diuretic. It works by stopping aldosterone (a natural substance) from increasing your blood pressure. It also reduces the fluid around your heart. This helps improve your heart function after a heart attack and can help prevent heart attacks, strokes or heart failure getting worse.

Safety advice

Alcohol

UNSAFE

Epletone 25mg Tablet may cause excessive drowsiness with alcohol.

Pregnancy

SAFE IF PRESCRIBED

Epletone 25mg Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Epletone 25mg Tablet during breastfeeding is not available. Please consult your doctor.

Driving

UNSAFE

Epletone 25mg Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Epletone 25mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Epletone 25mg Tablet may be needed. Please consult your doctor.
Use of Epletone 25mg Tablet is not recommended in patients with severe kidney disease.

Liver

CAUTION

Epletone 25mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Epletone 25mg Tablet may be needed. Please consult your doctor.
Use of Epletone 25mg Tablet is not recommended in patients with severe liver disease as the data available is limited.

What if you forget to take Epletone Tablet?

If you miss a dose of Epletone 25mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.\n

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Epletone 25mg Tablet

₹34.4/Tablet

Eplehef 25 Tablet

Sun Pharmaceutical Industries Ltd

₹23.1/tablet

33% cheaper

Exenta 25 Tablet

Alembic Pharmaceuticals Ltd

₹26.5/tablet

23% cheaper

Epnone 25mg Tablet

MSN Laboratories Ltd

₹26.1/tablet

24% cheaper

Planep Tablet

Lupin Ltd

₹28.27/tablet

18% cheaper

Ezuric 25mg Tablet

Alkem Laboratories Ltd

₹29.5/tablet

14% cheaper

View all substitutes

Quick tips

Epletone 25mg Tablet helps remove fluid from your body when used with other drugs.
It can make you feel dizzy for the first few days. Do not drive or do anything requiring concentration until you know how Epletone 25mg Tablet affects you.
It may increase the level of potassium in your blood. Avoid taking potassium supplements and potassium-rich foods such as banana and broccoli.
Your doctor will regularly check your kidney function and the amount of potassium in your blood while you are on this medicine.
Notify your doctor if you experience dizziness, diarrhea, vomiting, fast or irregular heartbeat, swelling in feet, or difficulty breathing.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Epletone 25mg Tablet helps remove fluid from your body when used with other drugs.
It can make you feel dizzy for the first few days. Do not drive or do anything requiring concentration until you know how Epletone 25mg Tablet affects you.
It may increase the level of potassium in your blood. Avoid taking potassium supplements and potassium-rich foods such as banana and broccoli.
Your doctor will regularly check your kidney function and the amount of potassium in your blood while you are on this medicine.
Notify your doctor if you experience dizziness, diarrhea, vomiting, fast or irregular heartbeat, swelling in feet, or difficulty breathing.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Fact Box

Chemical Class

Potassium sparing diuretics

Habit Forming

Therapeutic Class

CARDIAC

Action Class

Potassium-Sparing Diuretics

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FAQs

What does Epletone 25mg Tablet do? Is it a beta blocker or a diuretic?

Epletone 25mg Tablet is a potassium-sparing diuretic. It is prescribed with other medicines to control increased blood pressure and to treat heart failure in patients who have had a heart attack. It is not a beta blocker but mineralocorticoid receptor blocker.

How long does Epletone 25mg Tablet take to work?

Epletone 25mg Tablet controls high blood pressure but does not cure it. You may not see any improvement because high blood pressure does not have any symptoms. But, if you get your blood pressure checked, you may notice a change within 2 weeks of starting Epletone 25mg Tablet. However, the medicine may take 4 weeks or longer to show its maximum benefits.

Does Epletone 25mg Tablet cause erectile dysfunction?

No, Epletone 25mg Tablet does not cause erectile dysfunction. Epletone 25mg Tablet does not have any effect on fertility, in both males and females.

My blood pressure is now controlled, still the doctor has asked me to continue the treatment. Can I stop Epletone 25mg Tablet?

No, you should not stop Epletone 25mg Tablet. If your doctor has advised you to continue treatment, keep taking it. Epletone 25mg Tablet does not cure blood pressure, but keeps the blood pressure in control. Therefore, keep taking the medicine even if your blood pressure is controlled. Stopping it may make your condition worse and you may have unwanted side effects.

Epletone 25mg Tablet is a potassium-sparing diuretic. Does this mean that I will have more potassium in my body? Will it be beneficial for me?

Potassium-sparing diuretic are those medicines which increase the urination without causing any loss in potassium levels. Epletone 25mg Tablet allows sodium loss by body in exchange for potassium which is retained. It may result in an increase in the levels of potassium. Therefore, your doctor may monitor your potassium levels continuously. You may need to get it measured before starting Epletone 25mg Tablet, within the first week and one month after the start of treatment or after a change in dose. Potassium levels above normal range are not good for you or anyone.

Does Epletone 25mg Tablet have any effect on the blood sugar levels?

Although it is not very common, but Epletone 25mg Tablet may increase your blood sugar levels. Therefore, it is important that you keep a regular check on your blood sugar levels if you are a diabetic. The use of Epletone 25mg Tablet should be avoided in patients who have type 2 diabetes along with some kidney problem in which the patient loses protein (albumin) in very small quantities in urine.

I had been using Losartan for quite some time and was tolerating it well. Now my doctor has prescribed me Epletone 25mg Tablet along with Hydrochlorothiazide. I want to know why he just could not add Epletone 25mg Tablet with Losartan?

It could be possible that Losartan was not able to control your blood pressure adequately. Therefore, your doctor may have suggested an alternative medicine for blood pressure control (Epletone 25mg Tablet), but Eplerenone when taken with Losartan can enhance the chances of raised potassium levels which could be harmful for you. To prevent this rise in potassium levels, the combination of Epletone 25mg Tablet with hydrochlorothiazide may have been prescribed.

Is there anything I need to be careful about if I am taking aspirin and have now started Epletone 25mg Tablet?

Aspirin may interfere with the working of Epletone 25mg Tablet due to which your blood pressure may not get adequately controlled. Aspirin and Epletone 25mg Tablet may increase the chances of rise in potassium levels in patients with kidney problems. Therefore, if both are to be used together, keep monitoring your blood pressure and potassium levels.

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References

Reilly RF, Jackson EK. Regulation of Renal Function and Vascular Volume. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 692-95.
Pfeffer MA, Opie LH. Inhibitors of the Renin-Angiotensin-Aldosterone System. In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. pp. 159-61.
Eplerenone. New York, New York: Pfizer, Inc.; 2002 [revised May 2016]. [Accessed 18 Mar. 2019] (online) Available from:
Eplerenone. West Ryde, New South Wales: Pfizer Australia Pty Ltd.; 2014. [Accessed 17 Jun. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). Eplerenone. [Accessed 18 Mar. 2019] (online) Available from:
Eplerenone [Prescribing Information]. New York, NY: G.D. Searle LLC; 2021. [Accessed 22 Jun. 2023] (online) Available from:
Hughes JC, Cassagnol M. Eplerenone. [Updated 2023 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. [Accessed 22 Jun. 2023] (online) Available from:

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