Evolon Cream is identical to a female hormone, estriol (a type of estrogen). It is used to treat symptoms associated with menopause. This topical preparation helps to treat vaginal burning, dryness, and itching caused by a lack of estriol or estrogen.

You should use Evolon Cream in the way your doctor advises. It may depend on whether you have had any kind of hormonal replacement treatment (HRT) before. Even if your symptoms improve, you should continue the treatment as it has been prescribed. Follow hygiene instructions and complete the full course. Consult your doctor for any concerns or side effects.

Common side effects of Evolon Cream include fluid retention, nausea, breast discomfort, and pain (mastalgia), postmenopausal spotting (vaginal bleeding), cervical discharge (vaginal discharge), and vaginal irritation. Not everyone should experience the same side effects; they can differ. Consult your doctor if you experience any severe side effects or if they worsen. Tell your doctor if you experience bleeding in your vagina. Your doctor may give you an alternative medicine.

Before using this medicine, you should tell your doctor if you have unexplained vaginal bleeding or if you have ever had a blood clot in your legs or your lungs. Once you have started using this medicine, you should have regular checkups to discuss the benefits of your treatment. It should not interact with any other medicines. It is not usually recommended during pregnancy or breastfeeding.

Uses of Evolon Vaginal Cream

Treatment of Menopausal symptoms

Benefits of Evolon Vaginal Cream

In Treatment of Menopausal symptoms

Evolon Cream is a female hormone, identical to a hormone that your body makes naturally called estriol. When you have too little of this hormone (after menopause), the vaginal wall can become thin and dry. This can make sexual intercourse painful, and you may get vaginal infections. Evolon Cream will help relieve vaginal dryness, inflammation, and itching that may occur after menopause. It may take a few weeks before you notice an improvement, so keep using the medicine even if you think it is not working to get the full benefits. It has very few side effects and will also make you less likely to have vaginal or urinary infections.

Side effects of Evolon Vaginal Cream

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Evolon

Vaginal irritation
Vaginal itching
Edema (swelling)
Nausea
Breast pain
Abnormal vaginal bleeding
Vaginal discharge
Flu-like symptoms

How to use Evolon Vaginal Cream

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream by using applicator. Wash your hands after applying.

How Evolon Vaginal Cream works

Evolon Cream contains estriol (a type of estrogen—female sex hormone). It works by delivering estriol (estrogens) directly into the vagina to relieve vaginal symptoms of menopause such as dryness, burning, irritation, and painful sexual intercourse. Additionally, it helps restore the normal vaginal pH and microflora, improving the health of the urogenital epithelium and reducing the risk of infections.

Safety advice

Alcohol

No interaction found/established

Pregnancy

UNSAFE

Evolon Cream is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Breast feeding

UNSAFE

Evolon Cream is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

No interaction found/established

Kidney

No interaction found/established

Liver

No interaction found/established

What if you forget to take Evolon Vaginal Cream?

If you miss a dose of Evolon Cream, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Evolon Cream

₹289.0/Vaginal Cream

Evalon Cream

Torrent Pharmaceuticals Ltd

₹559/vaginal cream

93% costlier

Evalon Cream

Torrent Pharmaceuticals Ltd

₹530/vaginal cream

83% costlier

Quick tips

Evolon Cream can be applied to the external vaginal area or inserted into the vagina using the applicator provided.
It does not expose the rest of your body to the medicine, thereby avoiding side effects that happen more often with pills.
Do not have sex right after using Evolon Cream, as some of the medicine can be absorbed into your partner's skin.
Inform your doctor if you experience any vaginal bleeding or spotting, abnormal vaginal discharge, or vaginal discomfort while using this medicine.
Do not use Evolon Cream if you are pregnant or breastfeeding or have a history of blood clots or heart diseases.

Fact Box

Chemical Class

Estrogens Derivatives

Habit Forming

Therapeutic Class

GYNAECOLOGICAL

Action Class

Estrogens

Interaction with drugs

Taking Evolon with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Fulvestrant (Injection Route) Severe

Do not consume Fulvestrant with Estriol if you have or had breast cancer. If essential, consult your doctor. Estriol may reduce the efficacy of Fulvestrant.

Raloxifene (Oral Route) Severe

If concurrent use is essential, please consult with your doctor. Estriol may reduce efficacy of Raloxifene.

Tamoxifen (Oral Route) Severe

If concurrent use is essential, please consult with your doctor. Estriol may reduce efficacy of Tamoxifen.

Letrozole (Oral Route) Severe

If concurrent use is essential, please consult with your doctor. Estriol may reduce efficacy of Letrozole.

Pomalidomide (Oral Route) Severe

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Concurrent use may increase the risk of formation of blood clo... More

View all drug interactions

Patient concerns

Body heats up abnormally why?? Please give some consultation I had a surgery in which my ovary and uterus was removed and after that I am suffering from this problems

Dr. Sonu Balhara Ahlawat

Obstetrics and Gynaecology

It is ok These are menopausal symptoms

Ovaries taken out chest pain and intense sweat high heart beats

Dr. Suman Rao

Obstetrics and Gynaecology

These are the symptoms of menopause. Consult a gynaec nearby and discuss about post menopausal therapy

Having urine burning problem past month. with the homeop medicine 70% relief i got. now i stopped medicine to have. five year back hystectomy done overies still remain. due to computer work eyes get dried and tired. shoulders also pain. past 1.7 year back pain started. some time hot flashes also come suddenly. all blood investigation and u/s are normal. as per dr. advise take sweet less. hair fall are more. no dandruff.

Dr. Megha Tuli

Obstetrics and Gynaecology

It is normal to have hot flashes and these post menopausal symptoms after hysterectomyYou can take hormone therapy if you want however symptoms will recurrent when you stop treatment

sir/mam How we cure menopause symptomes? is there any solid treatment for this?

Dr. Megha Tuli

Obstetrics and Gynaecology

Yes PATIENT replacement can be done for a period of upto 6 months if you are experiencing sever menopausal symptoms. However it is not advisable to take hormones beyond 6 months due to the side effects. I suggest you visit a gynaecologist in your area for detailed discussion.

User feedback

Patients taking Evolon Cream

Once A Day

71%

Twice A Week

14%

Twice A Day

14%

What are you using Evolon Vaginal Cream for?

Hormone repla*

100%

*Hormone replacement therapy

FAQs

What is Evolon Cream and what it is used for?

Evolon Cream contains a medicine called estriol. Estriol is a form of the female sex hormone, estrogen. It is used to treat vaginal problems (itching, dryness, and irritation) caused by a lack of estrogen. It may also be used as a hormone replacement therapy in postmenopausal women.

How to use Evolon Cream?

Evolon Cream usually comes with an applicator and directions for use. You must clean and dry the affected area before applying the Evolon Cream. Use this medicine only as advised by your doctor.

What if I forget to use the Evolon Cream?

You may apply the missed dose as soon as you remember, unless you are not 12 hours late. If you are more than 12 hours late, skip the missed dose and follow the usual dosing schedule.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Masters SB. Hypothalmic & Pituitary Hormones. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 701-702.
Estriol [EMC Label]. Dublin, Ireland: Aspen; 2016. [Accessed 23 Jan. 2019]. (online) Available from:
Estriol Cream [Package Insert]. Mehsana, Gujarat: Torrent Pharmaceuticals Ltd.; 2021. [Accessed 06 Apr. 2024] (online) Available from:

Marketer details

Name: Glaxo SmithKline Pharmaceuticals Ltd

Address: Dr. Annie Besant Road, Mumbai - 400 030

Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.