Overview
Uses and benefits
Side effects
How to use
How drug works
Safety advice
Missed dose
All substitutes
Quick tips
Fact box
Patient concerns
FAQs

Author Details

Written By

Dr. Swati Mishra

BDS

Last updated

28 Apr 2025 | 04:25 PM (IST)

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Gibtulio-S 25/100 Tablet

Prescription Required

Marketer

Lupin Ltd

SALT COMPOSITION

Empagliflozin (25mg) + Sitagliptin (100mg)

Storage

Store below 30°C

Click here to view all substitutes

Product introduction

Gibtulio-S 25/100 Tablet is a medicine used to treat type 2 diabetes. It lowers blood sugar by helping the kidneys remove excess sugar and by improving the body’s insulin response for better glucose control. It supports long-term diabetes management when combined with a healthy lifestyle.

Take Gibtulio-S 25/100 Tablet regularly as prescribed to keep your blood sugar levels under control. Consistent use helps the medicine work effectively and reduces the risk of serious diabetes-related complications such as nerve damage, kidney problems, and heart issues. Even if you start feeling better, do not stop taking it without your doctor’s advice, as diabetes is a long-term condition that requires ongoing care. Follow your treatment plan, along with healthy eating and regular exercise, for better long-term outcomes.

Gibtulio-S 25/100 Tablet may cause some common side effects such as urinary tract infections, upper respiratory tract infections, fungal infections, and headaches. If any of these side effects persist or worsen, discuss them with your doctor. They may be able to provide supportive treatments or adjust your dosage.

Before using Gibtulio-S 25/100 Tablet, let your doctor know if you have any history of kidney or liver problems, urinary tract infections, or heart conditions. This medicine is not recommended for people with type 1 diabetes or those with a history of diabetic ketoacidosis. It should also be used with caution in older adults and in those who are dehydrated or on diuretics, as it may increase the risk of low blood pressure. Pregnant and breastfeeding women should consult their doctor before taking this medicine to make sure it is safe for them.

Uses of Gibtulio-S Tablet

Treatment of Type 2 diabetes mellitus

Benefits of Gibtulio-S Tablet

In Treatment of Type 2 diabetes mellitus

In individuals with type 2 diabetes, Gibtulio-S 25/100 Tablet helps lower and maintain blood sugar levels in adults when diet and exercise alone are not enough. It supports better long-term control of diabetes and helps reduce the risk of complications related to high blood sugar.

Side effects of Gibtulio-S Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Gibtulio-S

Urinary tract infection
Fungal infection
Upper respiratory tract infection
Headache

How to use Gibtulio-S Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Gibtulio-S 25/100 Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Gibtulio-S Tablet works

Gibtulio-S 25/100 Tablet is a combination of two medicines, empagliflozin and sitagliptin, which help control blood sugar levels in people with type 2 diabetes. Empagliflozin works by helping the kidneys remove extra sugar from the body through urine. Sitagliptin helps the body release more insulin when blood sugar is high and reduces the amount of sugar made by the liver. By working in different ways, these two medicines complement each other and provide better blood sugar control than either medicine alone.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Gibtulio-S 25/100 Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Gibtulio-S 25/100 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Gibtulio-S 25/100 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

CAUTION

Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.

Kidney

CAUTION

Gibtulio-S 25/100 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Gibtulio-S 25/100 Tablet may be needed. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited information available on the use of Gibtulio-S 25/100 Tablet in patients with liver disease. Please consult your doctor.

What if you forget to take Gibtulio-S Tablet?

If you miss a dose of Gibtulio-S 25/100 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Gibtulio-S 25/100 Tablet

₹18.4/Tablet

Empazio S 25+100 Tablet

Torrent Pharmaceuticals Ltd

₹21.3/tablet

16% costlier

Sitaglo E 25/100 Tablet

Aristo Pharmaceuticals Pvt Ltd

₹17.9/tablet

3% cheaper

Empamed S 25/100 Tablet

Shilpex Pharmysis

₹39.7/tablet

116% costlier

Empaone-S 25/100 Tablet

MSN Laboratories

₹22.2/tablet

21% costlier

Empagreat-S 25 Tablet

Mankind Pharma Ltd

₹13.1/tablet

29% cheaper

View all substitutes

Quick tips

Let your doctor know if you are taking any other diabetes medicines with Gibtulio-S 25/100 Tablet, especially insulin or sulfonylureas, to avoid the risk of hypoglycemia (low blood sugar).
Do not stop taking Gibtulio-S 25/100 Tablet suddenly without consulting your doctor, even if you feel well or your blood sugar improves.
If you plan to undergo surgery or any major procedure, inform your doctor in advance, as temporary discontinuation may be advised.
Gibtulio-S 25/100 Tablet is not suitable for people with type 1 diabetes or the treatment of diabetic ketoacidosis.

Fact Box

Habit Forming

Therapeutic Class

ANTI DIABETIC

Patient concerns

Diabetes mellitus type 2 ,thirst

Dr. Sanjay Bhatt

Physician

A person can control his or her sugar levels by doing regular exercise and walk or regular aerobic exercises at least 30 to 45 minutes per day.MEDICAL NUTRITIONAL THERAPY THAT IS TO MAINTAIN CALORIES INTAKE AS PER BMI .TAKE HELP OF DIABETIC EDUCATOR. VISIT YOUR DOCTOR AND FOLLOW ALL WHAT DOCTOR SUGGESTED.IN TIME ALL ROUTINE INVESTIGATIONS SHOULD BE DONE.you should not treat it as disease but a start of a healthy life.Uncontrolled sugar levels for long time leads to lower limb weakness which is neuropathy and which is followed by foot ulcers and other complications like kidney or heart problems .online prescription is not allowed without seeing pt.so contact doctor nearby for any change or dose adjustment or visit my clinic at gurgaon sector 52 RdCity snergy multi speciality clinic near SRS MARKET

Diabetes mellitus type 2 required only ayurvedic medicine

Dr. Sanjay Bhatt

Physician

Go for allopathic medicine

Any latest discoveris for type 1 mellitus Diabetes?

Dr. Sanjay Bhatt

Physician

Diabetes Ireland is delighted to hear of the Harvard success and congratulate Professor Melton and colleagues on figuring out the complex series of steps necessary to turn stem cells into beta cells. Hopefully, they can negotiate the regulations for mass production so that an abundant supply of beta cells is available an new and innovative methods will be developed to cure/treat Type 1 diabetes. Type I diabetes is an autoimmune condition whereby the body kills off its own beta (insulin producing) cells resulting in the need for daily insulin administration through the skin. Replacing beta cells in the first step towards a cure, but the replaced beta cells need to be protected from the body?s autoimmune response. This means protecting them in a coating or taking drugs to prevent the response (possible worse side effects than diabetes).

I am suffering from type 2 diabetes from last 15 years and from last year my doctor recommended to take insulin . My BP remains 110/80, My fasting -128 , pp- 204 and with insulin I am consuming voglinorm GM forte 2, gibtulio 25mg , teneligliptin 20mg . I wanted to ask that am i consuming right dosage or not ???

Dr. Sanjay Bhatt

Physician

A person can control his or her sugar levels by regular exercise and walk or regular aerobic exercises at least 30 to 45 minutes per day.MEDICAL NUTRITIONAL THERAPY THAT IS TO MAINTAIN CALORIES INTAKE AS PER BMI .TAKE HELP OF DIABETIC EDUCATOR. VISIT YOU DOCTOR AND LOW ALL WHAT DOCTOR SUGGESTED.IN TIME ALL ROUTINE INVESTIGATIONS SHOULD BE DONE.you souls not treat it as disease but start of a healthy life.Uncontrolled sugar levels for long time leads to lower limb weakness which is neuropathy and which is followed by foot ulcers and other complications.online prescription is not allowed without seeing pt.so contact doctor nearby for any change or dose adjustment or visit my clinic at gurgaon sector 52 RdCity snergy multi speciality clinic near SRS MARKET

Can I stop taking Gibtulio-S 25/100 Tablet if my blood sugar becomes normal?

No, you should not stop taking Gibtulio-S 25/100 Tablet without your doctor’s advice. Type 2 diabetes is a long-term condition that requires ongoing treatment, even if your sugar levels improve.

Do I need to follow a special diet while taking Gibtulio-S 25/100 Tablet?

A healthy, balanced diet is important for managing diabetes. Your doctor or dietitian may suggest specific dietary changes to get the best results from Gibtulio-S 25/100 Tablet.

Is it safe to take Gibtulio-S 25/100 Tablet with other diabetes medications?

Yes, it may be prescribed along with other diabetes medicines, but your doctor will decide the best combination based on your condition and response to treatment.

Can Gibtulio-S 25/100 Tablet cause dehydration?

Yes, especially empagliflozin, which increases urination. Drink enough fluids throughout the day to stay hydrated and avoid dizziness or low blood pressure.

Related lab tests

Glucose - Fasting Blood

Glucose - Postprandial Blood

Glycosylated Hemoglobin

Top Diabetologists

4.5 ★

4.4 ★

3.9 ★

MBBS, Diploma, Fellowship

4.3 ★

Dr. Narender K. Gupta

MBBS, MD, Fellowship

4.3 ★

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Empagliflozin [Product Information]. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc.; 2022 [Accessed 07/04/2025] (online) Available from:
Sitagliptin [Product Information]. Woburn, MA: Azurity Pharmaceuticals, Inc.; 2025 [Accessed 07/04/2025] (online) Available from:
Empagliflozin and Sitagliptin [Product Information]. Haridwar, Uttarakhand: Torrent Pharmaceuticals Ltd; 2025 [Accessed 07/04/2025] (online) Available from:

Marketer details

Name: Lupin Ltd

Address: 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India

Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.