Grenate Plus 40mg/10mg Tablet is a combination of two medicines that helps in preventing migraine. This medicine is not used for treatment of acute migraine attack.

Grenate Plus 40mg/10mg Tablet should be taken on empty stomach, but try to have it same time regularly at a fixed time preferably at night. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. Lifestyle modifications like avoiding stress, smoking, and processed food items may help this medicine work better.

Few common side effects of this medicine include weight gain, slow heart rate, tiredness, depression, drowsiness and cold extremities. It may cause sleepiness so try not to drive or do anything that requires mental focus or rise slowly while from sitting position. The drug has the ability to hide the symptoms of the blood sugar level, hence monitor your blood sugar level regularly as well as blood pressure while taking this medicine.

Before taking this medicine, let your doctor know if you have liver or kidney, or depression disease, or if you are pregnant or breastfeeding. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works.

Uses of Grenate Plus Tablet

Prevention of Migraine

Benefits of Grenate Plus Tablet

In Prevention of Migraine

Grenate Plus 40mg/10mg Tablet helps improve the flow of blood in your brain and prevents abnormal activity of muscles that triggers migraines. It is a very effective medicine for preventing migraine attacks, however, it does not treat an attack that has already started. By preventing and reducing the frequency migraine attacks, the medicine can help you carry out your daily activities and improve your quality of life.

Side effects of Grenate Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Grenate Plus

Weight gain
Slow heart rate
Tiredness
Depression
Drowsiness
Abnormal dreams
Cold extremities

How to use Grenate Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Grenate Plus 40mg/10mg Tablet is to be taken empty stomach.

How Grenate Plus Tablet works

Grenate Plus 40mg/10mg Tablet is a combination of two medicines: Propranolol and Flunarizine, which prevents migraine. Propranolol is a beta blocker and Flunarizine is a calcium channel blocker. They work by stabilizing the reactive nerve cells and increasing the threshold to migraine activation. They also inhibit cortical spreading depression (CSD- electric waves that move across the brain and cause pain and inflammation).

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Grenate Plus 40mg/10mg Tablet.

Pregnancy

CONSULT YOUR DOCTOR

Grenate Plus 40mg/10mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Grenate Plus 40mg/10mg Tablet during breastfeeding is not available. Please consult your doctor.

Driving

UNSAFE

Grenate Plus 40mg/10mg Tablet may cause side effects which could affect your ability to drive.
Grenate Plus 40mg/10mg Tablet may cause visual disturbances, hallucinations, fatigue, mental confusion, dizziness or tiredness. This may affect your driving ability.

Kidney

SAFE IF PRESCRIBED

Grenate Plus 40mg/10mg Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Grenate Plus 40mg/10mg Tablet may not be needed in these patients. Please consult your doctor.

Liver

CAUTION

Grenate Plus 40mg/10mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Grenate Plus 40mg/10mg Tablet may be needed. Please consult your doctor.
Regular monitoring of blood pressure is advisable for dose adjustment.

What if you forget to take Grenate Plus Tablet?

If you miss a dose of Grenate Plus 40mg/10mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Grenate Plus 40mg/10mg Tablet

₹6.47/Tablet

Migrabeta Plus Tablet

Alkem Laboratories Ltd

₹16.3/tablet

152% costlier

Provanol Plus 10 Tablet

Intas Pharmaceuticals Ltd

₹18.8/tablet

191% costlier

Migon Plus Tablet

Cadila Pharmaceuticals Ltd

₹11/tablet

70% costlier

Pronate F Tablet

Linux Laboratories

₹12.9/tablet

99% costlier

Mnil Plus 40 mg/10 mg Tablet

Pharmtak Ophtalmics India Pvt Ltd

₹8.82/tablet

36% costlier

View all substitutes

Quick tips

You have been prescribed Grenate Plus 40mg/10mg Tablet for prevention of migraine headaches.
Do not take it to treat an acute attack of migraine.
Some tips that may help avoid a migraine attack:
- Have your meals at the same time everyday
- Avoid bright lights and extreme temperatures
- Avoid loud music and noisy places
- Avoid chocolates, cheese, processed food, alcohol and smoking
- Get sufficient sleep and avoid stress
It should be taken at night-time before going to bed.
It may cause sleepiness. Don't drive or do anything that requires mental focus until you know how Grenate Plus 40mg/10mg Tablet affects you.
keep taking it regularly every day, even if you don't have any symptoms.

Fact Box

Habit Forming

Therapeutic Class

CARDIAC

Patient concerns

I am facing issue of headache from last 3-4 years.i have consulted allopathy and they have given me sibelum 10 for migrane and asked to take metopar(paracetamol) when ever pain is too much.i am nit taking sibelum now but i am taking metopar when ever required.so i want a homeopathy consultatation if it can be cured by homeopathy or the level of headache can be lowered. Currently i face headache once in a week and i had to take metopar. Kindly suggest. My weight 80 kg And i am taking some neuro medicines ( stalopam 10, amitone 10) I also have cholesterol and taking (atorec 20)

Dr. Faran Siddiqui

Homeopathy

Migraine and headache are two different things migraine is primarily headache of one side in symmetrically

Some time at a sudden Strong half headache pain in left side and also left eye tearing Please consult me

Dr. Pushkar Mani

Physician

it could be migraine

FAQs

In which conditions is the use of Grenate Plus 40mg/10mg Tablet contraindicated?

Use of Grenate Plus 40mg/10mg Tablet is considered to be harmful for patients with allergy to any of the ingredients or excipients of this medicine. This medicine contains propranolol, so its use should be avoided in patients with asthma, slow heart rate, abnormal heart rhythms, or heart conditions like AV block or sick sinus syndrome. Since this medicine also contains flunarizine, the use of this medicine should be avoided in patients with the history of depression or Parkinson's disease.

What are the instructions for the storage and disposal of Grenate Plus 40mg/10mg Tablet?

Keep Grenate Plus 40mg/10mg Tablet in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Can I stop taking Grenate Plus 40mg/10mg Tablet when my symptoms are improved?

Grenate Plus 40mg/10mg Tablet is given as a prophylactic treatment for the prevention of migraine headaches. Do not stop taking this medicine until advised by your doctor as it may cause your migraine episodes to return. This medicine contains propranolol and a sudden withdrawal of propranolol may cause sweating, shaking, irregular or fast heartbeat, worsening of underlying angina or heart attack. You must take Grenate Plus 40mg/10mg Tablet exactly as advised by your doctor.

Can Grenate Plus 40mg/10mg Tablet be used for the treatment of a migraine headache?

No, Grenate Plus 40mg/10mg Tablet does not help in relieving a migraine headache that has already started. It can only be used for preventing any new episode of migraine headaches.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Drugs.com. Flunarizine. [Accessed 25 Mar. 2019] (online) Available from:
Drugs.com. Propranolol Pregnancy and Breastfeeding Warnings. [Accessed 20 Mar. 2019] (online) Available from:
Flunarizine. High Wycombe, Buckinghamshire: Janssen Cilag Ltd.; 2009 [revised Feb. 2014]. [Accessed 11 Apr. 2019] (online) Available from:

Marketer details

Name: Gentech Healthcare Pvt Ltd

Address: Crown Heights ,709,7th Floor, Near Rithala Metro Station, Opp. JIMS College., Sector-10, Rohini-110085. New Delhi

Country of origin: India

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