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Histaglobulin Injection

Written By Dr. Sakshi Jain, MS, BDS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 19 Mar 2026 | 01:52 PM (IST)
Histaglobulin Injection is a medicine used to prevent various allergic conditions such as allergic rhinitis, eczema, urticaria, and generalized skin allergies. It works by producing protective antibodies (proteins) that neutralize the chemical messengers, which cause allergic reactions.
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Histaglobulin Injection image
Histaglobulin Injection image

Product introduction

Histaglobulin Injection is given by your doctor or nurse. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early, your symptoms may come back, and your condition may worsen.


Histaglobulin Injection is well tolerated and does not usually cause any common side effects. However, it may cause injection site reactions such as pain, redness, and swelling in some people. Get medical advice if you experience any additional symptoms.


Let your doctor know about all other medications you are taking, as some may affect, or be affected by, this medicine. Before taking this medicine, you should tell your doctor if you have any kidney or liver diseases so that your doctor can prescribe a suitable dose for you. You should also tell your doctor if you are pregnant, planning pregnancy, or breastfeeding. Histaglobulin Injection should not be used in acute allergic attacks.

Uses of Histaglobulin Injection

Benefits of Histaglobulin Injection

Treatment of Allergic conditions
Histaglobulin Injection is used to manage various allergic conditions. It helps improve the quality of life for allergy sufferers by reducing the frequency and severity of allergic reactions. It helps patients experience fewer flare-ups and prolonged symptom relief. This allows individuals to engage in daily activities with greater comfort and improves overall quality of life.

Side effects of Histaglobulin Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Histaglobulin
  • Limited data available

How to use Histaglobulin Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Histaglobulin Injection works

Histaglobulin Injection is a combination of human normal immunoglobulin, histamine dihydrochloride, and sodium thiosulphate that work together to help manage allergic reactions. Human normal immunoglobulin strengthens the immune system by providing antibodies that regulate immune activity and reduce excessive allergic responses. Histamine dihydrochloride helps control immune cell function and manage allergic reactions. Sodium thiosulphate acts as a detoxifying agent, neutralizing harmful substances and reducing oxidative stress that can worsen allergy symptoms. Together, this combination helps modulate immune reactions, improve circulation, and detoxify allergens, leading to reduced inflammation, relief from symptoms like swelling and irritation, and overall better immune balance.

All substitutes for Histaglobulin Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

  • Histaglobulin Injection is generally given intramuscularly by a doctor or a nurse; do not self-administer.
  • Watch for redness, swelling, or mild pain at the injection site; seek help for severe reactions.
  • Stay for observation after the injection if recommended to monitor for adverse reactions.
  • Keep hydrated and maintain a healthy diet to support immune function.
  • Report any unusual symptoms like dizziness, breathing difficulty, or severe itching immediately.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Histaglobulin Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Histaglobulin Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CAUTION
Histaglobulin Injection should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Histaglobulin Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney

Kidney

CAUTION
Histaglobulin Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Histaglobulin Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Frequently asked questions

Histaglobulin Injection is a specialized medicine used for treating long-term allergies like allergic rhinitis (runny nose), asthma, eczema or skin allergies, migraines caused by allergies, and premenstrual allergy symptoms. It helps reduce allergic reactions over time by training the immune system to be less sensitive to allergens.
Histaglobulin Injection is given under the skin (subcutaneously) by a doctor. The dosage depends on the condition. Usually, 3 injections spaced 4 to 8 days apart, and may need booster doses later or more injections for seasonal allergies, eczema, or migraines. Your doctor may advise a tailored treatment plan based on your condition and its severity.
You should avoid Histaglobulin Injection if you are pregnant or having your period (menstruation), are experiencing an active allergic attack (like an asthma attack), and have an infection that’s not treated yet. Always tell your doctor about your full medical history before starting.
You should not start Histaglobulin Injection treatment during an allergy attack, complete any infection treatments before starting Histaglobulin Injection, and let your doctor know if you’re using steroids, as the doses might be adjusted. Be patient, as results may take 3 to 4 weeks after finishing treatment.
No, Histaglobulin Injection is not a quick fix or emergency treatment, but a long-term immune therapy. It can reduce the frequency and severity of allergic reactions and help you manage allergies better over time.
Histaglobulin Injection is reactive to high temperature, which can make it ineffective. You should store Histaglobulin Injection in a cool, dry place below 8 degrees Celsius. Do not freeze the vial.
The exact time Histaglobulin Injection takes to show results is not known. However, you can expect improvement in your symptoms in 3 to 4 weeks after completion of your treatment course.
Your doctor may prescribe the required dose of Histaglobulin Injection based on your symptoms and the severity of your condition. Your doctor may prescribe 3-4 injections with a specific time interval based on what needs to be treated.
If you miss a Histaglobulin Injection scheduled dose, contact your doctor immediately. Do not attempt to compensate with extra doses to make up for the missed one.
Yes, Histaglobulin Injection can be used in children, but only after a consultation with a doctor. Your doctor may advise Histaglobulin Injection to children if they are about to undergo adenoidectomy (removal of adenoids from the back of the throat) or tonsillectomy (removal of tonsils) and have a family history of allergy. Your doctor may assess the severity and symptoms and prescribe a suitable dose.

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User feedback

Once A Week
54%
Once A Day
19%
Twice A Month
10%
Once A Month
10%
Twice A Week
6%
Twice A Day
2%
Allergic conditions
83%
Infections
9%
Others
7%
Excellent
50%
Average
30%
Poor
20%
No Side Effect
87%
Flushing (sense of warmth in the face, ears, neck and trunk)
7%
Headache
7%
With or without food
43%
With food
36%
Empty stomach
21%
Expensive
64%
Average
28%
Not Expensive
8%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Serum Institute Of India Ltd
Address: 212/2, Hadapsar, Off Soli Poonawalla Road, Pune 411028 India

Vendor Details

Country of origin: India
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