Isotane 5mg Capsule belongs to a group of medicines called retinoids (vitamin A derivative). It is used to treat severe acne that has not responded to other treatments.

Isotane 5mg Capsule should be used in the dose and duration as advised by your doctor. Take it with food, preferably at the same time each day to avoid a missed dose. It may take several weeks for your symptoms to improve but keep taking the medicine regularly to get the most benefit. If you notice no improvement after a few weeks, see your doctor again.

The most common side effects include dry skin, rash, and increased liver enzymes. They are not usually serious and often disappear after getting used to the medicine but if they bother you or do not go away, tell your doctor.

Isotane 5mg Capsule may make you more sensitive to sunlight so you should limit your exposure to the sun. It may also make your skin more fragile. Avoid any waxing (hair removal), or laser treatments during treatment. Additionally, it may cause dryness of the mouth, lips, and eyes so drink plenty of water and use a moisturizer. This medicine may lead to birth defects, do consult your doctor if you are pregnant or planning pregnancy.

Uses of Isotane Capsule

Treatment of Acne

Benefits of Isotane Capsule

In Treatment of Acne

Isotane 5mg Capsule helps treat acne by reducing the production of sebum (a natural substance) that causes acne. This kills acne-causing bacteria and prevents spots or pimples from appearing. It usually takes a few weeks to have a noticeable effect so keep taking it even if it appears not to be working. Sometimes acne may get worse before it gets better, however, with proper use, your skin will get clearer. This medicine will help improve your mood and uplift your confidence as your skin becomes acne-free.

Side effects of Isotane Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Isotane

Dry skin
Increased liver enzymes
Rash

How to use Isotane Capsule

Take this medicine in the dose and duration as advised by your doctor. Isotane 5mg Capsule is to be taken with food.

How Isotane Capsule works

Isotane 5mg Capsule is a derivative of vitamin A. It acts on glands (sebaceous) to reduce the production of a natural substance (sebum) that causes acne. Also, the controlled sebum production kills acne-causing bacteria. It also works as an anti-inflammatory to decrease inflammation (redness and swelling).

Safety advice

Alcohol

CAUTION

Caution is advised when consuming alcohol with Isotane 5mg Capsule. Please consult your doctor.

Pregnancy

UNSAFE

Isotane 5mg Capsule is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Breast feeding

CONSULT YOUR DOCTOR

Isotane 5mg Capsule is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Isotane 5mg Capsule may cause side effects which could affect your ability to drive.
Your night vision may get worse during your treatment. This can happen suddenly. Drowsiness and dizziness have been reported very rarely. This may affect your driving ability.

Kidney

CAUTION

Isotane 5mg Capsule should be used with caution in patients with kidney disease. Dose adjustment of Isotane 5mg Capsule may be needed. Please consult your doctor.

Liver

UNSAFE

Isotane 5mg Capsule is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.

What if you forget to take Isotane Capsule?

If you miss a dose of Isotane 5mg Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Isotane 5mg Capsule

₹7.43/Capsule

Isotroin 5 Capsule

Cipla Ltd

₹13.94/capsule

88% costlier

Tretiva 5 Capsule

Intas Pharmaceuticals Ltd

₹10.2/capsule

37% costlier

Acutret 5 Capsule

Ipca Laboratories Ltd

₹11.8/capsule

59% costlier

Metteclear 5mg Capsule

Medimind Drugs and Chemicals

₹9.16/capsule

23% costlier

Saferet 5mg Capsule

Canixa Life Sciences Pvt Ltd

₹8.34/capsule

12% costlier

View all substitutes

Quick tips

You have been prescribed Isotane 5mg Capsule for the treatment of severe acne.
Take it with food.
Avoid exposure to sunlight while using Isotane 5mg Capsule. Use protective measures such as sunscreen or protective clothing.
Avoid face waxing and laser treatment while using this medicine as it makes your skin more fragile.
It may cause dryness of mouth, lips, and eyes. Drink plenty of water, use moisturiser and avoid wearing contact lenses. Inform your doctor if it bothers you.
Do not take Isotane 5mg Capsule if you are pregnant, planning pregnancy or breastfeeding.

Fact Box

Chemical Class

Retinoid

Habit Forming

Therapeutic Class

DERMA

Action Class

Retinoids- First generation

Interaction with drugs

Taking Isotane with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Doxycycline (Oral Route) Life-threatening

Concurrent use may cause a risk of increased pressure around the brain. Do not consume Isotretinoin with Doxycycline.

Demeclocycline (Oral Route) Life-threatening

Concurrent use may cause a risk of increased pressure around the brain. Do not consume Isotretinoin with Demeclocycline.

Doxycycline (Oral Route) Life-threatening

Concurrent use may cause a risk of increased pressure around the brain. Do not consume Isotretinoin with Doxycycline.

Doxycycline (Injection Route) Life-threatening

Concurrent use may cause a risk of increased pressure around the brain. Do not consume Isotretinoin with Doxycycline.

Lymecycline (Oral Route) Life-threatening

Concurrent use may cause a risk of increased pressure around the brain. Do not consume Isotretinoin with Lymecycline.

View all drug interactions

Patient concerns

Dear doctor i have acne problem.now i am taking isotane capsules.but scars and black spot are as usual.plz consult me

Dr. Souvik Sardar

Dermatology

Plz continue the treatment for acne nw let it stop Then the treatment of scars and black spots can b done jst kip patience during this phase

I had a lot of pimples on my face itook isotane for a month on a doctors advise pimples got cured but marks are asit is what do you suggest to do.

Dr. Banashree Majumdar

Dermatology

I can understand your problem, but you need to understand that getting acne at this age is not uncommon, you should not use any product from outside particularly the oily one. Apply Clindac A gel twice daily and Cetaphil cleansing lotion for oily skin.

I had lot of pimples on my face on advise of a doctor i took isotane for 1 month , pimples are cured now but marks are as it is what do you suggest to do.

Dr. Banashree Majumdar

Dermatology

FAQs

Is Isotane 5mg Capsule safe to use?

Isotane 5mg Capsule should be used with care since it is associated with significant adverse reactions. It should be used only for patients with severe nodular acne who are unresponsive to conventional therapy, including systemic antibiotics. In addition, Isotane 5mg Capsule should not be used by pregnant women because it can cause severe birth defects.

Is Isotane 5mg Capsule a steroid?

No, Isotane 5mg Capsule is a retinoid (vitamin A) which is used to treat severe types of acne.

What are the recommended tests during Isotane 5mg Capsule therapy?

Your liver enzymes and serum lipids will be checked before the treatment is started. These levels will also be monitored 1 month after the start of treatment and subsequently at 3 monthly intervals unless more frequent monitoring is clinically indicated.

Is the effect of Isotane 5mg Capsule permanent?

It has been observed in many patients that a single 15-20-week course effectively cures the condition and prevents it from coming back. If at all a second course is required, one should wait for at least 8 weeks after completion of the first course. This is because experience with Isotane 5mg Capsule has shown that the symptoms in the patients with acne may continue to improve following treatment with Isotane 5mg Capsule.

Why is Isotane 5mg Capsule so dangerous during pregnancy?

If pregnancy occurs during treatment with Isotane 5mg Capsule then, there is an extremely high risk that the baby may be born with severe birth defects.

Can Isotane 5mg Capsule cause cancer?

No, there are no reports of Isotane 5mg Capsule causing cancer. In fact, it may be useful in some forms of head, skin, and neck cancers.

What are the long-term side effects of Isotane 5mg Capsule?

A normal course of treatment of Isotane 5mg Capsule is 15–20 weeks. Therefore, the long-term effects of low doses have not been studied. However, it may have some effect on bone mineral density. It may decrease bone mineral density in some patients, resulting in osteoporosis or fractures.

Does Isotane 5mg Capsule affect male fertility?

No, Isotane 5mg Capsule does not affect the fertility of male patients. No significant effects were seen on ejaculate volume, sperm count, total sperm motility, morphology, or seminal plasma fructose.

Does Isotane 5mg Capsule damage your liver?

There may be a transient increase in liver enzymes with Isotane 5mg Capsule use. Therefore, regular laboratory tests are required. These values generally return to normal after some time. If the levels remain elevated for a long time, your doctor may discontinue the use of Isotane 5mg Capsule.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Robertson DB, Maibach HI. Dermatologic Pharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 1056.
Burkhart C, Morrell D, Goldsmith L. Dermatological Pharmacology. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1812.
Sardana K, Madan A. How to Treat Acne. Sardana K, editor. In: Clinical Approach to Acne Vulgaris. 1st ed. New Delhi: CBS Publishers & Distributors Pvt. Ltd.; 2015. pp. 64-67.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 745-47.
Isotretinoin. Nutley, New Jersey: Roche Laboratories Inc.; 2002. [Accessed on 2 Apr. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 03 Apr. 2019] (online) Available from:
Central Drugs Standard Control Organization. Safety guidelines for isotretinoin. 2018. [Accessed 05 Jul. 2023]. (online) Available from:
CiplaMed. Isotretinoin [Prescribing Information]. [Last Revised: 29 Nov. 2019]. [Accessed 05 Jul. 2023]. (online) Available from:

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