Kombiglyze XR 5mg/1000mg Tablet
Prescription Required
Product introduction
Kombiglyze XR 5mg/1000mg Tablet is a combination of two medicines that help control high blood sugar levels in people with type 2 diabetes mellitus. Controlling your blood sugar levels supports overall health and reduces the risk of diabetes-related complications, promoting long-term well-being.
Kombiglyze XR 5mg/1000mg Tablet may be prescribed alone or together with other diabetes medications. The dose you are given will depend on your condition, blood sugar levels, and what other medicines you are taking. Taking it with meals helps reduce the chances of developing an upset stomach. It is important to stay on the diet and exercise program recommended by your doctor while taking this medicine. Your lifestyle plays a big part in controlling diabetes.
The most common side effects of taking this medicine include diarrhea, nausea, vomiting, headache, tiredness, dizziness, and muscle pain. Low blood sugar level (hypoglycemia) is a possible side effect if you are also taking other diabetes medicines like insulin or sulfonylurea, so you need to know how to recognize and deal with it.
Before taking it, you should let your doctor know if you have ever had kidney, liver, or heart disease; problems with your pancreas; or if you drink a lot of alcohol. Pregnant or breastfeeding women should also consult their doctor before taking this medicine.
Some other medicines can affect this one, so tell your doctor about all the medicines you are taking to make sure Kombiglyze XR 5mg/1000mg Tablet is safe for you. You should try to avoid drinking alcohol as it lowers blood glucose. Your doctor will check your kidney function and blood sugar levels before and during treatment.
Uses of Kombiglyze Tablet ER
Benefits of Kombiglyze Tablet ER
In Treatment of Type 2 diabetes mellitus
Kombiglyze XR 5mg/1000mg Tablet helps control your blood glucose levels, which is an essential part of managing type 2 diabetes. Controlling blood glucose levels lowers the risk of serious complications of diabetes, such as kidney damage, eye damage, nerve problems, and loss of limbs. Additionally, proper control of diabetes can also reduce the risk of heart disease and stroke. Take this medicine regularly along with a proper diet and exercise for maximum benefits.
Side effects of Kombiglyze Tablet ER
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Kombiglyze
- Vomiting
- Diarrhea
- Abdominal pain
- Loss of appetite
- Nausea
- Headache
- Muscle pain
- Indigestion
- Urinary tract infection
- Upper respiratory tract infection
- Nasopharyngitis (inflammation of the throat and nasal passages)
- Stomach inflammation
- Sinus infection
- Flatulence
- Gastroenteritis
- Dizziness
- Fatigue
How to use Kombiglyze Tablet ER
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Kombiglyze XR 5mg/1000mg Tablet is to be taken with food.
How Kombiglyze Tablet ER works
Kombiglyze XR 5mg/1000mg Tablet is the combination of two medicines: saxagliptin and metformin. Saxagliptin is a dipeptidyl peptidase-4 inhibitor that works by increasing the release of insulin from the pancreas and decreasing the hormones that raise blood sugar levels. This reduces both fasting and post-meal sugar levels. Metformin is an anti-diabetic medication (biguanide). It works by lowering glucose production in the liver, delaying glucose absorption from the intestines, and increasing the body's sensitivity to insulin.
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Kombiglyze XR 5mg/1000mg Tablet.
Pregnancy
CONSULT YOUR DOCTOR
Kombiglyze XR 5mg/1000mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Kombiglyze XR 5mg/1000mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
Kidney
UNSAFE
Kombiglyze XR 5mg/1000mg Tablet is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor.
Liver
UNSAFE
Kombiglyze XR 5mg/1000mg Tablet is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
What if you forget to take Kombiglyze Tablet ER?
If you miss a dose of Kombiglyze XR 5mg/1000mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Kombiglyze XR 5mg/1000mg Tablet
₹60.86/Tablet ER
Riax-M XR 5mg/1000mg Tablet
Dr Reddy's Laboratories Ltd
₹49.43/tablet er
19% cheaper
Quick tips
- Take Kombiglyze XR 5mg/1000mg Tablet with food to lower your chance of having an upset stomach and improve absorption.
- The chances of low blood sugar are lower compared to other diabetes medicines.
- Inform your doctor about Kombiglyze XR 5mg/1000mg Tablet if you are scheduled for surgery with general anesthesia.
- Tell your doctor immediately if you experience any deep or rapid breathing, persistent nausea, vomiting, or stomach pain, as Kombiglyze XR 5mg/1000mg Tablet may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
Fact Box
Habit Forming
No
Therapeutic Class
ANTI DIABETIC
Patient concerns
User feedback
Patients taking Kombiglyze XR 5mg/1000mg Tablet
Once A Day
100%
What are you using Kombiglyze Tablet ER for?
Type 2 diabet*
100%
*Type 2 diabetes mellitus
How much was the improvement?
Excellent
57%
Average
38%
Poor
5%
What were the side-effects while using Kombiglyze XR 5mg/1000mg Tablet?
No Side Effec*
67%
Taste change
33%
*No Side Effect
How do you take Kombiglyze Tablet ER?
With food
78%
Empty stomach
22%
Please rate Kombiglyze XR 5mg/1000mg Tablet on price
Expensive
56%
Not Expensive
31%
Average
14%
FAQs
What should I tell my doctor before taking Kombiglyze XR 5mg/1000mg Tablet?
Before taking Kombiglyze XR 5mg/1000mg Tablet, inform your doctor if you have any problems with your kidneys, liver, bladder, heart, or pancreas. Tell your doctor if you have ever had or have any risk factors for ketoacidosis (such as type 1 diabetes, changes in diet, reduced appetite, or if you are going to have surgery). Let your doctor know about all the other medicines or supplements you are taking because they may affect, or be affected by, this medicine. Consult your doctor before taking Kombiglyze XR 5mg/1000mg Tablet if you are planning to conceive or if you are pregnant or breastfeeding to avoid any harmful effects on the baby.
Who should not take Kombiglyze XR 5mg/1000mg Tablet?
Kombiglyze XR 5mg/1000mg Tablet is not recommended for people who are allergic to it, have severe kidney problems, or are on dialysis. Additionally, avoid taking Kombiglyze XR 5mg/1000mg Tablet if you are trying to get pregnant, are already pregnant, or are breastfeeding to avoid any harmful effects on the baby.
Does Kombiglyze XR 5mg/1000mg Tablet cause weight gain?
No, Kombiglyze XR 5mg/1000mg Tablet is not known to cause weight gain by itself. However, keeping a healthy weight is an important part of managing diabetes. Consult your doctor if you experience weight gain while taking Kombiglyze XR 5mg/1000mg Tablet.
Do I still have to manage my diet and exercise while on Kombiglyze XR 5mg/1000mg Tablet?
Yes, it is important to manage your diet and exercise while taking Kombiglyze XR 5mg/1000mg Tablet. In addition to medicine, making healthy food choices and being physically active are also important to effectively manage blood sugar levels. You may consult a dietitian and follow a diet chart that suits you best. A well-balanced diet is one part of a healthy lifestyle for people with type 2 diabetes. Additionally, thirty minutes of exercise, such as a brisk walk, is recommended.
Can my blood sugar levels go too low on Kombiglyze XR 5mg/1000mg Tablet?
Yes, your blood sugar levels may become very low (hypoglycemia). The chances are higher if you are on any other antidiabetic medicine or insulin along with Kombiglyze XR 5mg/1000mg Tablet. Additionally, blood sugar levels can take a huge dip if you skip meals, exercise more than usual, or take an overdose of Kombiglyze XR 5mg/1000mg Tablet. If you experience a sudden fall in your sugar levels, inform your doctor. The doctor may suggest dose modification to prevent your blood sugar levels from decreasing significantly (hypoglycemia). Follow your doctor’s advice and monitor your blood sugar levels regularly.
What is the most important information I should know about Kombiglyze XR 5mg/1000mg Tablet?
Kombiglyze XR 5mg/1000mg Tablet is safe to use if taken in the dose and duration prescribed by the doctor. However, in rare cases, some serious side effects can also be observed. In some people, Kombiglyze XR 5mg/1000mg Tablet may cause inflammation of the pancreas (pancreatitis), which could be severe and can even lead to death. If you experience severe and persistent pain in your stomach area (abdomen), stop the medication and immediately contact your doctor.<br><br>Kombiglyze XR 5mg/1000mg Tablet can also cause heart failure. This means the heart is not able to pump blood well enough; therefore, inform your doctor if you have or ever had heart problems before you start taking Kombiglyze XR 5mg/1000mg Tablet. In addition to that, problems related to the kidneys should also be discussed with the doctor.
What will happen if I accidentally take more than the prescribed dose of Kombiglyze XR 5mg/1000mg Tablet?
If you have accidentally taken more than the prescribed dose of Kombiglyze XR 5mg/1000mg Tablet, your blood sugar levels may become too low (hypoglycemia). This hypoglycemia may be mild or severe. Monitor your blood sugar levels more frequently for the next 24 hours. Mild episodes of hypoglycemia (with symptoms like anxiety, sweating, weakness, tremors, and fast heartbeat) can usually be corrected with the help of sugary foods such as sugar or glucose candy, fruit juice, and glucose/glucon-D.<br><br>However, it is important to consult your doctor to decide on the further course of treatment. More severe episodes of hypoglycemia may even lead to a seizure (fit) or unconsciousness. This can be life-threatening, and immediate medical help may be required.
How long do I need to take Kombiglyze XR 5mg/1000mg Tablet?
Kombiglyze XR 5mg/1000mg Tablet only helps to manage your blood sugar levels, but does not cure your diabetes. Keep taking Kombiglyze XR 5mg/1000mg Tablet as long as your doctor recommends it. You may have to take it lifelong. It is important to keep your blood sugar levels under control, as any fluctuations in your blood sugar levels may cause serious problems. Therefore, do not stop taking it without talking to your doctor.
Is Kombiglyze XR 5mg/1000mg Tablet safe to be taken for the long term?
Yes, it is safe to take Kombiglyze XR 5mg/1000mg Tablet for a long time. Its long-term use, which can continue for months, years, or even lifelong, has not shown any harmful effects. Keep taking Kombiglyze XR 5mg/1000mg Tablet as long as your doctor recommends it. Remember, Kombiglyze XR 5mg/1000mg Tablet only helps to keep your blood sugar levels under control, but it does not cure your diabetes.
Want to share the information?
Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Saxagliptin and metformin hydrochloride extended release [Prescribing Information]. Wilmington, Delaware: AstraZeneca Pharmaceuticals LP; 2017. [Accessed 22 Jan. 2019] (online) Available from:
- Saxagliptin/metformin [EMC Label]. Macclesfield, Cheshire: AstraZeneca UK Limited; 2017. [Accessed 28 Jan. 2019] (online) Available from:
- Metformin hydrochloride + saxagliptin hydrochloride [EMC Label]. Sweden: AstraZeneca AB; 2011 [revised 13 Aug. 2018]. [Accessed 08 Apr. 2019] (online) Available from:
- Saxagliptin and metformin hydrochloride [Summary of Product Characteristics]. Södertälje, Sweden: AstraZeneca AB. [Accessed 28th Sept. 2023] (online) Available from:
- Saxagliptin and metformin [Product Information]. Morgantown, WV: Mylan Pharmaceuticals Inc.; 2023. [Accessed 28th Sept. 2023] (online) Available from:
Marketer details
Name: AstraZeneca
Address: Corporate & Registered Office, Block N1, 12th Floor, Manyata Embassy Business Park, Rachenahalli, Outer Ring Road, 560045, Bangalore
Country of origin: India
Lab tests offered by us
Related/Popular tests
2,662 people viewed this recently₹426
Inclusive of all taxes
MRP₹431 1% OFF
7.0 tablet er in 1 strip
SOLD OUT