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PhD (Pharmacology), PGDPRA
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MD Pharmacology, MBBS
Last updated
17 Dec 2024 | 01:02 AM (IST)

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Kombina 400mg/80mg Tablet

Prescription Required

Product introduction

Kombina 400mg/80mg Tablet is a combination medicine that is used to treat various types of bacterial infections such as pneumonia, bronchitis, infections of the urinary tract, ear, and abdomen. It prevents the growth of microorganisms to cure the infection.

Kombina 400mg/80mg Tablet is a prescription medicine that is advised to be taken as suggested by the doctor. It should be taken with food and it must be taken at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as an overdose of it may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The treatment must be completed even if you feel better to ensure a complete recovery.

Kombina 400mg/80mg Tablet may lead to some side effects such as nausea, vomiting, stomach pain, loss of appetite, headache, etc. To overcome any such side effects, it is advised to eat a healthy balanced diet and drink plenty of fluid. If any of the side effects get aggravated, contact your doctor immediately. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must consult your doctor immediately.

Before taking this medicine, you should tell your doctor if you have any problems with your liver or kidneys. Also, tell your doctor if you are on any medication for any health condition. Pregnant or breastfeeding women should also consult with the doctor before taking it. Avoid drinking alcohol as it can cause excessive dizziness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. If you are a known allergic to the medicine, you must refrain from using this medicine and consult your doctor. It is advised to take proper rest during the course of treatment for the medicine to work effectively.

Uses of Kombina Tablet

Benefits of Kombina Tablet

In Treatment of Bacterial infections

Infections caused by bacteria are known as bacterial infections. Kombina 400mg/80mg Tablet is an antibiotic which is used to treat different types of bacterial infections. Kombina 400mg/80mg Tablet works by stopping the growth of the bacteria. It is effective for bacterial infections of the lungs, throat, urinary tract, ear and stomach. It is advisable to continue taking it as long as it is prescribed even when you feel better, to make sure that all bacteria are killed. Stopping it early may make the infection come back and difficult to treat.

Side effects of Kombina Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Kombina

  • Nausea
  • Vomiting
  • Increased potassium level in blood
  • Candida overgrowth
  • Headache
  • Rash
  • Diarrhea
  • Decreased appetite
  • Red spots or bumps

How to use Kombina Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Kombina 400mg/80mg Tablet is to be taken with food.

How Kombina Tablet works

Kombina 400mg/80mg Tablet is a combination of two antibiotics: Sulfamethoxazole and Trimethoprim. These antibiotics work by preventing the bacteria from producing folic acid, a nutrient required for bacterial multiplication. Together, they treat your infection effectively.

Safety advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Kombina 400mg/80mg Tablet. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Kombina 400mg/80mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
SAFE IF PRESCRIBED
Kombina 400mg/80mg Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
There may be a possibility of skin rash in the baby.
Driving
CONSULT YOUR DOCTOR
It is not known whether Kombina 400mg/80mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney
CAUTION
Kombina 400mg/80mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Kombina 400mg/80mg Tablet may be needed. Please consult your doctor.
Use of Kombina 400mg/80mg Tablet is not recommended in patients with severe kidney disease.
Liver
CAUTION
Kombina 400mg/80mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Kombina 400mg/80mg Tablet may be needed. Please consult your doctor.
Use of Kombina 400mg/80mg Tablet is not recommended in patients with the severe liver disease.

What if you forget to take Kombina Tablet?

If you miss a dose of Kombina 400mg/80mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Kombina 400mg/80mg Tablet
₹0.59/Tablet
Septran Tablet
Koye Pharmaceuticals Pvt ltd
₹0.99/tablet
68% costlier
₹0.82/tablet
39% costlier
Comax 400 mg/80 mg Tablet
Agron Remedies Pvt Ltd
₹0.66/tablet
12% costlier
Otrim 400mg/80mg Tablet
Biochem Pharmaceutical Industries
₹0.62/tablet
5% costlier
Danatrim 400mg/80mg Tablet
Dana Pharmaceuticals Pvt Ltd
₹0.86/tablet
46% costlier

Quick tips

  • You have been prescribed Kombina 400mg/80mg Tablet for the treatment of many types of bacterial infections.
  • Finish the prescribed course of Kombina 400mg/80mg Tablet, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
  • Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
  • Stop taking Kombina 400mg/80mg Tablet and inform your doctor if you develop skin rash/blisters or other unexplained skin reaction while taking Kombina 400mg/80mg Tablet.
  • In case of long-term use, have regular monthly blood tests to monitor your blood cells as suggested by your doctor.

Fact Box

Habit Forming
No
Therapeutic Class
ANTI INFECTIVES

Patient concerns

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Scar on face due to bacterial infections
Dr. Atul Jain
Dermatology
Pic is not clear, plz visit for proper opinion
I have a history of recurring yeast and bacterial vaginosis infections.
Dr. Sonu Balhara Ahlawat
Obstetrics and Gynaecology
Tab metrogyl 500 mg twice a day x 5 days and tab fluconazole 150 mg three doses alternate days
arrow

FAQs

What is Kombina 400mg/80mg Tablet?

Kombina 400mg/80mg Tablet is a combination of two medicines: Sulfamethoxazole+Trimethoprim. It is an antibiotic used to treat certain bacterial infections and works by stopping the growth of the bacteria causing the infection. It treats urinary tract infections, ear infections, enteritis (inflammation of the small intestine), pneumonia, traveler's diarrhea, and episodes of difficulty breathing in people with chronic (long-term) bronchitis.

Is it safe to use Kombina 400mg/80mg Tablet?

Yes, Kombina 400mg/80mg Tablet is safe to use in most patients. However, in some patients, it may cause some unwanted common side effects like Nausea, Vomiting, Skin rash, Allergic reaction. Inform your doctor as soon as possible if you experience any persistent problem while taking this medication.

Can the use of Kombina 400mg/80mg Tablet cause nausea and vomiting?

Yes, the use of Kombina 400mg/80mg Tablet can cause nausea and vomiting. In case, you experience nausea while taking this medicine, take it with milk, food or with antacids. Avoid taking fatty or fried foods. If you start to experience vomiting, drink plenty of water or other fluids. Try small frequent sips of the liquid. Talk to your doctor if you have persistent vomiting and signs of dehydration like dark colored and strong-smelling urine and a low frequency of urination. Do not take any other medicines without speaking to a doctor.

Are there any specific contraindications associated with the use of Kombina 400mg/80mg Tablet?

Kombina 400mg/80mg Tablet is contraindicated in patients with known allergy to any of the component or excipients of this medicine and in patients with a history of drug-induced immune thrombocytopenia (low platelet count), megaloblastic anemia due to folate deficiency. The medicine is also contraindicated in pediatric patients less than 2 months of age and in patients with marked hepatic damage or with severe renal insufficiency when renal function status cannot be monitored.

What should be avoided while taking the Kombina 400mg/80mg Tablet?

It is advised to not skip the dose. Skipping doses or not completing the full course of the medicine can decrease its effectiveness and can lead to the growth of bacteria that are resistant to the effects of it.

Does Kombina 400mg/80mg Tablet expire?

Yes, Kombina 400mg/80mg Tablet does expire. The expiry date is written on the pack of the medicine and it refers to the last day of the month mentioned. Do not use Kombina 400mg/80mg Tablet after the expiry date.

What is Kombina 400mg/80mg Tablet?

Kombina 400mg/80mg Tablet is a combination of two medicines: Sulfamethoxazole and Trimethoprim. It is an antibiotic which treats certain bacterial infections and works by stopping the growth of the bacteria causing the infection.

Can the use of Kombina 400mg/80mg Tablet cause nausea and vomiting?

Yes, the use of Kombina 400mg/80mg Tablet can cause nausea and vomiting. Taking it with milk, food or with antacids can prevent nausea. Avoid taking fatty or fried foods along with this medication. In case of vomiting, drink plenty of water or other fluids by taking small frequent sips. Talk to your doctor if vomiting persists and you notice signs of dehydration, like dark colored and strong-smelling urine and a low frequency of urination. Do not take any other medicine without speaking to a doctor.

Are there any specific contraindications associated with the use of Kombina 400mg/80mg Tablet?

Kombina 400mg/80mg Tablet is considered to be harmful for patients with known allergy to any of the components or excipients of this medicine. It is also avoided in patients with a history of drug-induced immune thrombocytopenia (low platelet count), megaloblastic anemia caused due to folate deficiency. The medicine is also harmful for pediatric patients less than 2 months of age and for patients with marked hepatic damage or with severe renal insufficiency when renal function status cannot be monitored.

Can I stop taking Kombina 400mg/80mg Tablet when my symptoms are relieved?

No, do not stop taking Kombina 400mg/80mg Tablet and complete the full course of treatment, even if you feel better. Your symptoms may improve before the infection is completely cured.

What is the recommended storage condition for Kombina 400mg/80mg Tablet?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Can I stop taking Kombina 400mg/80mg Tablet when I feel better?

No, do not stop taking Kombina 400mg/80mg Tablet and complete the full course of treatment even if you feel better. Your symptoms may improve before the infection is completely cured.

What if I miss my dose?

Take Kombina 400mg/80mg Tablet as soon as you remember it. However, do not take it if it's almost time for your next dose. Also, do not take an extra dose to make up for your missed dose.

What if I don't get better after using Kombina 400mg/80mg Tablet?

Inform your doctor if you don't feel better after finishing the full course of treatment. Also, inform him if your symptoms are getting worse while using this medicine.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Sulfamethoxazole and trimethoprim. [Accessed 10 Apr. 2019] (online) Available from:External Link
  2. Sulfamethoxazole and trimethoprim. Philadelphia, PA: AR Scientific, INC; 2013. [Accessed 10 Apr. 2019] (online) Available from:External Link
  3. Drugs.com. Sulfamethoxazole and Trimethoprim. [Accessed 18 Apr. 2019] (online) Available from:External Link

Marketer details

Name: Deys Medical
Address: 6/D, Nelly Sengupta Sarani (Formerly Lindsay Street) , Kolkata - 700 087
Country of origin: India

5.9
Inclusive of all taxes
MRP5.91  
10.0 tablets in 1 strip
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