Labetol Injection is a medicine used in the urgent treatment of hypertensive emergency (severely increased blood pressure). It also helps to treat severe hypertension in pregnancy, when rapid control of blood pressure is essential.
Labetol Injection brings about an immediate reduction in blood pressure and the workload of the heart. It is administered by a doctor and requires continuous blood pressure monitoring.
Common side effects of this medicine include dizziness, fatigue, nausea, vomiting, paresthesia, impotence, edema, and cold fingers or toes. Let your doctor know if they persist or get worse. They may be able to suggest ways to prevent or reduce the side effects.
Before taking it, let your doctor know if you are suffering from any kidney or liver disease. If you are pregnant or breastfeeding then you should always inform the doctor. Labetol Injection brings about an immediate reduction in blood pressure and the workload of the heart. It is administered by a doctor and requires continuous blood pressure monitoring.
Labetol Injection blocks the effect of some chemicals on your heart and blood vessels. This slows down the heart rate and helps the heart beat with less force thereby lowering your blood pressure. This medicine is injected into a vein under the supervision of a doctor. It is used for immediate reduction of very high blood pressure (hypertensive emergency). A controlled blood pressure reduces the risk of having a heart attack, stroke, or kidney problems.
Side effects of Labetol Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Labetol
Dizziness
Vomiting
Fatigue
Impotence
Paresthesia (tingling or pricking sensation)
Nausea
Edema (swelling)
Cold extremities
How to use Labetol Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Labetol Injection works
Labetol Injection is an alpha and beta blocker. It works by slowing down the heart rate and relaxing blood vessels which makes the heart more efficient at pumping blood around the body.
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Labetol Injection.
Pregnancy
CONSULT YOUR DOCTOR
Labetol Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
SAFE IF PRESCRIBED
Labetol Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
UNSAFE
Labetol Injection may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
SAFE IF PRESCRIBED
Labetol Injection is safe to use in patients with kidney disease. No dose adjustment of Labetol Injection is recommended. However, talk to your doctor if you have any underlying kidney disease. Regular monitoring of blood pressure is recommended for better dose adjustment.
Liver
CAUTION
Labetol Injection should be used with caution in patients with liver disease. Dose adjustment of Labetol Injection may be needed. Please consult your doctor.
What if you forget to take Labetol Injection?
If you miss a dose of Labetol Injection, consult your doctor.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
It is given as an injection into veins or as drip under the supervision of a medical professional.
Check your blood pressure 1 week after starting Labetol Injection, and inform your doctor if it has not improved.
Labetol Injection may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
It may cause you to feel lightheaded or weak especially when you stand up (orthostatic hypotension). Rise slowly if you have been sitting or lying down.
It is best to avoid drinking alcohol while taking Labetol Injection as it may make the side effects worse.
Do not stop taking Labetol Injection suddenly as it can cause your blood pressure to rise suddenly, thereby increasing the risk of heart attack and stroke.
Fact Box
Chemical Class
Salicylamide derivative
Habit Forming
No
Therapeutic Class
CARDIAC
Action Class
Alpha & beta blocker
Interaction with drugs
Taking Labetol with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Concomitant use may cause acute narrowing and obstruction of the respiratory airway.
Do not use Labetalol with Theophylline in any form if you have asthma or breathing issues, as ... More
Concomitant use may cause acute narrowing and obstruction of the respiratory airway.
Do not use Labetalol with Theophylline in any form if you have asthma or breathing issues, as ... More
Concurrent use may decrease heart activity.
watch out for symptoms such as breathlessness, fatigue, drowsiness, sedation or faintness or vomiting and consult your doctor if you ex... More
Labetalol may reduce efficacy of Adrenaline.
watch out for symptoms such as breathlessness, fatigue, drowsiness, sedation or faintness or vomiting and consult your doctor if you e... More
For last 3-4 days, fever around 100? C, severe pain in knees, wrists & hips, some pain in shoulder, back. Swelling in both hand fingers. Feeling too thirsty so taking lots of water & other liquid diet. No test done. Taking following medicine for last two days - Dolo-650 - 1 bd, traumasure plus - 1bd, Evion -LC - 1td
Labetol Injection is generally considered a safe medicine if it is taken as directed by the doctor. The side effects that result with use of Labetol Injection occur during the first few weeks of treatment and disappear with time.
Why is Labetol Injection used in pregnancy?
It is important to appropriately treat high blood pressure in pregnancy. Studies have shown that poorly controlled high blood pressure in pregnancy can lead to an increased risk of certain birth defects, stillbirth, reduced growth of the baby within the womb, and premature birth. For some women with high blood pressure, treatment with Labetol Injection in pregnancy might be considered to be the best option. Your doctor is the best person to help you decide what is right for you and your baby.
Does Labetol Injection cause itching?
Yes, itchy skin, a rash or tingly scalp are common side effects of Labetol Injection. Speak to your doctor if the itchiness or rash gets worse or lasts for more than a week.
Is it safe to use Labetol Injection in patients with diabetes?
Diabetic patients while using Labetol Injection should regularly check the blood sugar levels. Labetol Injection may make it difficult to recognize the warning signs of low blood sugar such as shaking and a racing heartbeat. Consult your doctor if the blood sugar levels are reduced while taking Labetol Injection.
Does Labetol Injection affect heart rate?
Labetol Injection slows down your heart rate and makes it easier for your heart to pump blood around your body. Your doctor may regularly check your blood pressure and pulse (heart rate) during therapy to determine your response to the medicine.
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References
Westfall TC, WestfallIn DP. Adrenergic Agonists and Antagonists. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 328-29.
Benowitz NL. Antihypertensive Agents. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 176-77.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 764-65.
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 19 Mar. 2019] (online) Available from:
Labetalol hydrochloride [Prescribing Information]. Lake Forest, IL: Hospira, Inc.; 2018. [Accessed 20 Feb. 2024] (online) Available from:
National Health Service (NHS). Side effects of labetalol. [Accessed 20 Feb. 2024]. [Last reviewed: 7 Mar 2022]. (online) Available from:
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