Loyzide M 60mg/500mg Tablet XR
Prescription Required
Product introduction
Loyzide M 60mg/500mg Tablet XR belongs to a category of medicines known as anti-diabetic drugs. It is a combination of two medicines used to treat type 2 diabetes mellitus in adults. It helps control blood sugar levels in people with diabetes.
Loyzide M 60mg/500mg Tablet XR should be taken with food. Take it regularly at the same time each day to get the most benefit. Your doctor will decide what dose is best for you and this may change from time to time according to how it is working according to your blood sugar levels.
Keep taking this medicine, even if you feel well or your blood sugar levels are controlled. If you stop it without consulting your doctor, your blood sugar levels could rise and put you at risk of kidney damage, blindness, nerve problems and loss of limbs. Remember that it is only part of a treatment program that should also include a healthy diet, regular exercise, and weight reduction as advised by your doctor. Your lifestyle plays a big part in controlling diabetes.
The most common side effect of Loyzide M 60mg/500mg Tablet XR are low blood glucose levels (hypoglycemia), constipation, and vomiting. Make sure you recognize the signs of having low blood glucose levels, such as sweating, dizziness, headache, and shaking and know how to deal with it. To prevent this, it's important to have regular meals and always carry a fast-acting source of glucose such as sugary food or fruit juice with you. Drinking alcohol can also increase your risk of low blood sugar levels and should be avoided. Other side effects that may be seen on taking this medicine include taste changes, nausea, diarrhea, stomach pain, headache, and upper respiratory tract infection. Some people may find that they put on weight with this medicine.
You should not take it if you have type 1 diabetes mellitus, if you have diabetic ketoacidosis (high levels of acid in your blood), or if you have severe kidney or liver disease. Before taking this medicine, tell your doctor if you have ever had heart disease. It may not be suitable. Pregnant or breastfeeding women should also consult their doctor before taking it. Your blood sugar levels should be checked regularly and your doctor may also advise blood tests to monitor your blood cell counts and liver function.
Uses of Loyzide M Tablet XR
Side effects of Loyzide M Tablet XR
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Loyzide M
- Hypoglycemia (low blood glucose level)
- Headache
- Dizziness
- Diarrhea
- Upper respiratory tract infection
- Nausea
- Flatulence
- Constipation
How to use Loyzide M Tablet XR
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Loyzide M 60mg/500mg Tablet XR is to be taken with food.
How Loyzide M Tablet XR works
Loyzide M 60mg/500mg Tablet XR is a combination of two antidiabetic medicines: Gliclazide and Metformin.
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Loyzide M 60mg/500mg Tablet XR.
Pregnancy
CONSULT YOUR DOCTOR
Loyzide M 60mg/500mg Tablet XR is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Loyzide M 60mg/500mg Tablet XR is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
Kidney
CAUTION
Loyzide M 60mg/500mg Tablet XR should be used with caution in patients with kidney disease. Dose adjustment of Loyzide M 60mg/500mg Tablet XR may be needed. Please consult your doctor.
Use of Loyzide M 60mg/500mg Tablet XR is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.
Use of Loyzide M 60mg/500mg Tablet XR is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.
Liver
CAUTION
Loyzide M 60mg/500mg Tablet XR should be used with caution in patients with liver disease. Dose adjustment of Loyzide M 60mg/500mg Tablet XR may be needed. Please consult your doctor.
Loyzide M 60mg/500mg Tablet XR is generally started with low dose in patients with mild to moderate liver disease and its use is not recommended in patients with severe liver disease.
Loyzide M 60mg/500mg Tablet XR is generally started with low dose in patients with mild to moderate liver disease and its use is not recommended in patients with severe liver disease.
What if you forget to take Loyzide M Tablet XR?
If you miss a dose of Loyzide M 60mg/500mg Tablet XR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
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Quick tips
- Monitor your blood sugar level regularly while you are taking this medicine.
- It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
- Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic.
- Tell your doctor immediately if you experience any deep or rapid breathing or if you have persistent nausea, vomiting, and stomach pain as Loyzide M 60mg/500mg Tablet XR may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
- Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).
- Monitor your blood sugar level regularly while you are taking this medicine.
- It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
- Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic.
- Tell your doctor immediately if you experience any deep or rapid breathing or if you have persistent nausea, vomiting, and stomach pain as Loyzide M 60mg/500mg Tablet XR may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
- Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).
Fact Box
Habit Forming
No
Therapeutic Class
ANTI DIABETIC
Patient concerns
FAQs
What is Loyzide M 60mg/500mg Tablet XR?
Loyzide M 60mg/500mg Tablet XR is a combination of two medicines: Gliclazide and Metformin. This medicine is used in the treatment of type 2 diabetes mellitus (DM). It improves blood glucose levels in adults when taken along with proper diet and regular exercise. Gliclazide lowers the blood glucose levels by increasing the release of insulin from the pancreas. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. This combination is not indicated for the treatment of Type 1 DM.
What are the possible side effects of Loyzide M 60mg/500mg Tablet XR?
The use of Loyzide M 60mg/500mg Tablet XR is associated with common side effects. These side effects may include hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. Its use can also lead to serious but rare side effects like lactic acidosis. On long-term use, it can also lead to vitamin B12 deficiency.
Can the use of Loyzide M 60mg/500mg Tablet XR cause hypoglycemia?
Yes, the use of Loyzide M 60mg/500mg Tablet XR can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, regular monitoring of blood sugar level is important. Always keep glucose tablets, honey or fruit juice with you.
Can the use of Loyzide M 60mg/500mg Tablet XR cause lactic acidosis?
Yes, the use of Loyzide M 60mg/500mg Tablet XR can lead to lactic acidosis. It is a medical emergency which is caused by increased levels of lactic acid in the blood. It is also known as MALA (Metformin associated lactic acidosis). It is a rare side effect associated with the use of metformin. It is avoided in patients with underlying kidney disease, old age patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain or slow heart rate. If you have these symptoms, stop taking Loyzide M 60mg/500mg Tablet XR and immediately consult your doctor.
Can the use of Loyzide M 60mg/500mg Tablet XR lead to Vitamin B12 deficiency?
Yes, the use of Loyzide M 60mg/500mg Tablet XR can cause vitamin B12 deficiency on long-term use. The deficiency occurs as the medicine interferes with absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can have tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of vitamin B12 from outside sources at least once every year.
Are there any specific conditions in which Loyzide M 60mg/500mg Tablet XR should not to be taken?
The use of Loyzide M 60mg/500mg Tablet XR should be avoided in patients with known allergy to any of the component or excipients of this medicine. It is also avoided in patients with moderate to severe kidney disease or with underlying metabolic acidosis including diabetic ketoacidosis.
Is it safe to take alcohol while I am also taking Loyzide M 60mg/500mg Tablet XR?
No, it is not safe to take alcohol along with Loyzide M 60mg/500mg Tablet XR. It may lower your low blood sugar levels (hypoglycemia) and can increase the chances of lactic acidosis.
What is Loyzide M 60mg/500mg Tablet XR?
Loyzide M 60mg/500mg Tablet XR is a combination of two medicines: Gliclazide and Metformin. This medicine is used in the treatment of type 2 diabetes mellitus (DM). It improves blood glucose levels in adults when taken along with proper diet and regular exercise. Gliclazide lowers the blood glucose levels by increasing the release of insulin from the pancreas. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. This combination is not indicated for the treatment of Type 1 DM.
What are the possible side effects of Loyzide M 60mg/500mg Tablet XR?
The use of Loyzide M 60mg/500mg Tablet XR is associated with common side effects. These side effects may include hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. Its use can also lead to serious but rare side effects like lactic acidosis. On long-term use, it can also lead to vitamin B12 deficiency.
Can the use of Loyzide M 60mg/500mg Tablet XR cause hypoglycemia?
Yes, the use of Loyzide M 60mg/500mg Tablet XR can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, regular monitoring of blood sugar level is important. Always keep glucose tablets, honey or fruit juice with you.
Can the use of Loyzide M 60mg/500mg Tablet XR cause lactic acidosis?
Yes, the use of Loyzide M 60mg/500mg Tablet XR can lead to lactic acidosis. It is a medical emergency which is caused by increased levels of lactic acid in the blood. It is also known as MALA (Metformin associated lactic acidosis). It is a rare side effect associated with the use of metformin. It is avoided in patients with underlying kidney disease, old age patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain or slow heart rate. If you have these symptoms, stop taking Loyzide M 60mg/500mg Tablet XR and immediately consult your doctor.
Can the use of Loyzide M 60mg/500mg Tablet XR lead to Vitamin B12 deficiency?
Yes, the use of Loyzide M 60mg/500mg Tablet XR can cause vitamin B12 deficiency on long-term use. The deficiency occurs as the medicine interferes with absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can have tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of vitamin B12 from outside sources at least once every year.
Are there any specific conditions in which Loyzide M 60mg/500mg Tablet XR should not to be taken?
The use of Loyzide M 60mg/500mg Tablet XR should be avoided in patients with known allergy to any of the component or excipients of this medicine. It is also avoided in patients with moderate to severe kidney disease or with underlying metabolic acidosis including diabetic ketoacidosis.
Is it safe to take alcohol while I am also taking Loyzide M 60mg/500mg Tablet XR?
No, it is not safe to take alcohol along with Loyzide M 60mg/500mg Tablet XR. It may lower your low blood sugar levels (hypoglycemia) and can increase the chances of lactic acidosis.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Gottwald-Hostalek U, Schlachter J, Geloneze B. Combination Therapy with Metformin plus Gliclazide in Patients with Type 2 Diabetes. J Dia Res Ther. 2016;2(3). [Accessed 08 Apr. 2019] (online) Available from:
- Metformin hydrochloride. Princeton, New Jersey: Bristol-Myers Squibb Company. [Accessed 08 Apr. 2019] (online) Available from:
- Gliclazide+Metformin [Product Monograph]. Solan, Himachal Pradesh: Panacea Biotec Limited; 2019. [Accessed 23 Sept. 2021] (online) Available from:
- American Diabetes Association. 9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes-2020. Diabetes Care. 2020;43(Suppl 1): S98-S110. [Accessed 23 Sept. 2021] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 13 Mar. 2019] (online) Available from:
- Gliclazide and Metformin [Product Monograph]. Solan, Himachal Pradesh: Panacea Biotec Limited; 2019. [Accessed 28th Sept. 2023] (online) Available from:
- Gliclazide and Metformin Hydrochloride (SR) [Prescribing Information]. Bangalore, India: Biocon Limited. [Accessed 28th Sept. 2023] (online) Available from:
Marketer details
Name: Lloyd Healthcare Pvt Ltd
Address: 702, Balaji Business Park, Andheri Kurla Road, Marol Naka, Andheri East, Gamdevi, Marol, Andheri East, Mumbai, Maharashtra 400059
Country of origin: India
The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.
The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.
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