Macgest 400mg Tablet SR is a natural female sex hormone, progesterone. It is used to treat menstrual and pregnancy-related issues that are caused due to hormonal imbalance.

Macgest 400mg Tablet SR is also prescribed along with estrogen as a part of hormonal replacement therapy for preventing endometrial hyperplasia (thickening of the lining of the uterus). It should be taken with food. It should be taken at the same time each day to get the most benefit. You should continue taking it for as long as your doctor has told you to, even if you feel well.

The most common side effects include headache, breast pain, irregular vaginal bleeding or spotting, stomach or abdominal cramps, bloating, nausea and vomiting, hair loss, edema, and vaginal yeast infection. Side effects are more common during the first few weeks and usually lessen as your body gets used to the medicine. You may also experience bleeding or spotting between your periods, consult with your doctor if it happens frequently.

Before taking this medicine, inform your doctor if you have, or have had, breast cancer, unusual bleeding in the vagina, or liver disease. You will probably have several tests both before and during treatment to check your womb. Also, tell your doctor what other medicines you are taking as some may affect, or be affected by, this medicine. In general, it is advisable to avoid alcohol and smoking.

Uses of Macgest Tablet SR

Benefits of Macgest Tablet SR

In Hormone replacement therapy

Hormone placement therapy (HRT) is a treatment to relieve symptoms of menopause such as hot flushes, night sweats, mood swings, vaginal dryness, and reduced sex drive. Since menopause can last for several years, this treatment can make a big improvement to your daily life and mood. Progesterone is one of two important hormones (the other being is estrogen) used in this treatment. However, it may not treat all your symptoms, consult with your doctor. You should use this medicine as it is prescribed, and for as long as it is prescribed by your doctor.

In Treatment of Female infertility

Macgest 400mg Tablet SR contains progesterone, a female hormone that is important in the regulation of ovulation and menstruation. It is used to cause menstrual periods in women who have not reached menopause but are not having periods due to a lack of natural progesterone in the body. This medicine helps to prepare the uterus for pregnancy by causing the uterus lining (endometrium) to thicken. This increases the chance of a successful pregnancy. You should use the medicine as prescribed for it to be effective. You may be asked to continue with this treatment for a period after becoming pregnant.

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Side effects of Macgest Tablet SR

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Macgest

Abdominal pain
Nausea
Abnormal vaginal bleeding
Edema (swelling)
Hair loss
Abdominal bloating
Headache
Breast pain
Vomiting
Vaginal yeast infection

How to use Macgest Tablet SR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Macgest 400mg Tablet SR is to be taken with food.

How Macgest Tablet SR works

Macgest 400mg Tablet SR is a progesterone (female hormone). It helps to establish and maintain pregnancy. It also prevents the increase in thickness of the endometrium (lining of the uterus) caused by estrogen.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Macgest 400mg Tablet SR. Please consult your doctor.

Pregnancy

SAFE IF PRESCRIBED

Macgest 400mg Tablet SR is safe to use during pregnancy. Most studies have shown low or no risk to the developing baby.

Breast feeding

SAFE IF PRESCRIBED

Macgest 400mg Tablet SR is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

Driving

UNSAFE

Macgest 400mg Tablet SR may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CONSULT YOUR DOCTOR

There is limited information available on the use of Macgest 400mg Tablet SR in patients with kidney disease. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited information available on the use of Macgest 400mg Tablet SR in patients with liver disease. Please consult your doctor.

What if you forget to take Macgest Tablet SR?

If you miss a dose of Macgest 400mg Tablet SR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Macgest 400mg Tablet SR

₹43.6/Tablet SR

Gestofit 400mg SR Tablet

Alembic Pharmaceuticals Ltd

₹76.3/tablet sr

75% costlier

Naturogest SR 400 Tablet

Zydus Cadila

₹63.4/tablet sr

45% costlier

Endogest 400 SR Tablet

Cipla Ltd

₹60.3/tablet sr

38% costlier

Hald SR 400 Tablet

Intas Pharmaceuticals Ltd

₹86.9/tablet sr

99% costlier

Emprogest 400mg Tablet SR

Emcure Pharmaceuticals Ltd

₹60.7/tablet sr

39% costlier

View all substitutes

Quick tips

Macgest 400mg Tablet SR is a natural progesterone available as a micronized formulation which helps in better absorption of this medicine.
It is used as a part of hormone replacement therapy generally in combination with an estrogen.
It may also be used in the treatment of problems related to menstrual periods such as amenorrhea (absence of periods).
It also helps in the maintenance of pregnancy in women who are at higher risk of miscarriage.
It should be taken with food.
It may cause sleepiness or drowsiness. If this happens to you, do not drive or use machinery.

Fact Box

Chemical Class

Progesterone Derivative

Habit Forming

Therapeutic Class

GYNAECOLOGICAL

Action Class

Natural Progesterone

Patient concerns

What is macgest sr 300 tablet prescribed for. Iam 5 weeks pregnant. Is it a steroid? Is it safe to take it? This is my second pregnancy. I had a smooth first pregnancy

Dr. Suman Rao

Obstetrics and Gynaecology

It's a hormonal tab. It contains progesterone. Generally given to patient who are at slightly high risk of having miscarriage. In your case if you had a normal 1st pregnancy and if there is no history of bleeding or spotting then there is no need for this in my opinion.

I have been told by doctors I have cystitis also simple cyst in right ovary . What should I be doing its been two years I have this issue

Dr. Megha Tuli

Obstetrics and Gynaecology

Hi PATIENT hormone therapy helps with cysts. Ask your doctor for a hormone replacement.

Hello, Greeting for the day. Hope you fine. Macgest, anafortan and vitfol plus is medicine given by doctor And my question is can I change this with same content available from other medicine. Please guide.

Dr. Megha Tuli

Obstetrics and Gynaecology

Hi PATIENT usually there is no problem in changing the brands as long as the composition is same and the brand is reliable. Some doctors prefer certain brands because they have superior efficacy than others.

I have sexual hormone problem and infertility problem. 30 millions sperm count,motility 50 only.please send me prescription.

Dr. Pranay Gandhi

Sexology

sperm count is normal so is motility. for increasing ur testosterone levels 1.stop smoking and alcohol 2.join a gym and reduce weight. Do weight lifting exercises. 3.tablet sildenafil or viagra 1 tablet 1 hour before sexual activity. 4.Get tested so that u don?t have any of the following causes: 1.heart diseases 2. diabetes 3.neurological problems 4.hormonal problems 5.drug side effects

What are the side effects of prolonged usage of thyronorm medicine as I am having hypothyroidism since the last 20 years and I am taking the medicine since then . Thanks

Dr. Sfurti Mann

Internal Medicine

It is thyroxin hormone given as replacement of the hormone thyroxin which your body is not producing adequately. If it is being taken in the correct dose maintains your TSH in normal range then it has no side effects.

FAQs

Q. What is Macgest 400mg Tablet SR?

Macgest 400mg Tablet SR is a type of progesterone hormone which is extracted from plants, but its property matches with the human progesterone. This medicine undergoes a process called micronization where the size of the natural progesterone is reduced. The small size of the progesterone particles enhances its dissolution and absorption. This provides better availability of Macgest 400mg Tablet SR in the body and decreases its side effects.

Q. What is Macgest 400mg Tablet SR used to treat?

Macgest 400mg Tablet SR is used to treat various disorders. It is given to women with secondary amenorrhea (no menstruation for 3 months in women who have had their menses before). It is used to support pregnancy, prevent premature labor, and treat bleeding disorders that may occur before menopause. It may be used as a part of fertility treatment and may be given as hormone replacement therapy after menopause. It is also given to relieve symptoms of premenstrual syndrome and painful bleeding like in dysfunctional uterine bleeding.

Q. Can you take Macgest 400mg Tablet SR every day?

Yes, Macgest 400mg Tablet SR can be taken every day. It is usually prescribed to be taken once daily in the evening or at bedtime. The usual duration of prescription may vary from 10-12 days a month to 25 days a month. However, the number of days for which you will need to take this medicine in each cycle will be suggested by your doctor depending upon your health condition.

Q. Does Macgest 400mg Tablet SR cause weight gain?

Yes, taking Macgest 400mg Tablet SR may cause weight gain. The weight gain may be due to water retention and may not be a serious sign. However, contact your doctor in case your weight gain is worrying you. The risk of weight gain is generally less if Macgest 400mg Tablet SR is taken with estrogen as a combined pill. But, do not start any hormonal therapy without consulting your doctor.

Q. Is Macgest 400mg Tablet SR safe?

Yes, Macgest 400mg Tablet SR is safer as compared to the normal synthetic progesterone. Its smaller size helps the body absorb it easily and reduces the side effects like fluid retention, reduction of HDL cholesterol levels, headaches and mood disturbance.

Q. How is progesterone beneficial for fertility and pregnancy?

Progesterone is a very crucial hormone in fertility. It is the hormone secreted by the ovaries that helps prepare the uterus for pregnancy and maintain it. Macgest 400mg Tablet SR (natural micronized form of progesterone) is given as a medicine in cases of infertility to support the uterus in preparing itself for the pregnancy and to prevent the abortions in some cases. It is also used to prevent premature labor.

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Related lab tests

Anti Mullerian Hormone

Glycosylated Hemoglobin

Testosterone Total

Thyroid Stimulating Hormone

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Chrousos GP. The Gonadal Hormones & Inhibitors. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 706-707.
Medscape. Progesterone (Natural Micronized). [Accessed 03 Apr. 2019] (online) Available from:
Progesterone. London, UK: Besins Healthcare (UK) Ltd.; 2003 [revised 14 Jul. 2017]. [Accessed 22 Jan. 2019. (online) Available from:
Apgar S, Greenberg G. Using Progestins in Clinical Practice. Am Fam Physician. 2000;62(8):1839-46. [Accessed 03 Apr. 2019] (online) Available from:
Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006. Progesterone. [Updated 2022 May 15]. [Accessed 05 Aug. 2023] (online) Available from:

Marketer details

Name: Macleods Pharmaceuticals Pvt Ltd

Address: Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.

Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.