Megacrust-P Capsule is a prescription medicine used for the treatment of neuropathic pain. It decreases pain by modulating the calcium channel activity of the nerve cells. This medicine also protects nerve fibers and heals damaged nerve cells.

Megacrust-P Capsule may be taken with or without food, preferably at bedtime. It is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration advised by your doctor. If you miss a dose of this medicine, take it as soon as you remember. Finish the full course of treatment even if you feel better. This medication must not be stopped suddenly without talking to the doctor.

Some common side effects of this medicine include nausea, vomiting, diarrhea, constipation, blurred vision, dizziness, and sleepiness. Do not drive or do anything that requires mental focus until you know how this medicine affects you. The side effects are mild and usually improve with time. It may also cause weight gain in some people. Exercise regularly and have a balanced diet to keep your weight in check. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts.

Your doctor should also know about all other medicines you are taking, as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding to make sure it is safe for you and the developing baby.

Uses of Megacrust-P Capsule

Treatment of Neuropathic pain

Benefits of Megacrust-P Capsule

In Treatment of Neuropathic pain

Megacrust-P Capsule helps treat long-lasting (chronic) pain caused by nerve damage due to diabetes, shingles, or spinal cord injury. It reduces pain and associated symptoms, such as mood changes, sleep problems, and tiredness. It also contains nutritional supplements that improve nerve conduction.

Side effects of Megacrust-P Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Megacrust-P

Decreased appetite
Nausea
Vomiting
Diarrhea
Headache
Blurred vision
Constipation
Dizziness
Drowsiness
Fatigue
Weight gain

How to use Megacrust-P Capsule

Take this medicine in the dose and duration as advised by your doctor. Megacrust-P Capsule may be taken with or without food, but it is better to take it at a fixed time.

How Megacrust-P Capsule works

Megacrust-P Capsule is a combination of two medicines: Methylcobalamin and Pregabalin. Methylcobalamin is a form of vitamin B, which helps in the production of myelin, a substance that protects nerve fibers and rejuvenates damaged nerve cells. Pregabalin is an alpha-2 delta ligand that decreases pain by modulating the calcium channel activity of the nerve cells. Together, they relieve neuropathic pain (pain from damaged nerves).

Safety advice

Alcohol

UNSAFE

Megacrust-P Capsule may cause excessive drowsiness with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

Megacrust-P Capsule may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Megacrust-P Capsule is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Megacrust-P Capsule may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Megacrust-P Capsule should be used with caution in patients with kidney disease. Dose adjustment of Megacrust-P Capsule may be needed. Please consult your doctor.

Liver

SAFE IF PRESCRIBED

Megacrust-P Capsule is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Megacrust-P Capsule may not be needed in these patients. Please consult your doctor.

What if you forget to take Megacrust-P Capsule?

If you miss a dose of Megacrust-P Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Megacrust-P Capsule

₹14.4/Capsule

Pregeb M 75 Capsule

Torrent Pharmaceuticals Ltd

₹21.8/capsule

51% costlier

Pregalin M 75 Capsule

Torrent Pharmaceuticals Ltd

₹23.2/capsule

61% costlier

Mahagaba-M 75 Capsule

Mankind Pharma Ltd

₹15.3/capsule

6% costlier

Prelogic Capsule

Janssen Pharmaceuticals

₹17.1/capsule

19% costlier

Pregamet 75 Capsule

Abbott

₹23.9/capsule

66% costlier

View all substitutes

Quick tips

Megacrust-P Capsule may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
To lower the chances of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
Avoid consuming alcohol when taking Megacrust-P Capsule, as it may cause excessive sleepiness.
Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
Do not stop taking the medication suddenly without talking to your doctor.
Megacrust-P Capsule may cause weight gain. Exercise regularly and eat a balanced diet to manage it.

Fact Box

Habit Forming

Therapeutic Class

NEURO CNS

Patient concerns

Headetch daily, no relieve. One pain killer daily i am taking.

Dr. Pushkar Mani

Physician

Take hifenac p sos for pain

Dental problem premolar very p

Dr. Rohan Bhatt

Dental Surgery

Tab ketorol dt for painGo for x ray of tht tooth

Sugar fasting 140 p p. 180 rt

Dr. Sanjay Bhatt

Physician

A person can control his or her sugar levels by regular exercise and walk or regular aerobic exercises at least 30 to 45 minutes per day.MEDICAL NUTRITIONAL THERAPY THAT IS TO MAINTAIN CALORIES INTAKE AS PER BMI .TAKE HELP OF DIABETIC EDUCATOR. VISIT YOU DOCTOR AND FOLLOW ALL WHAT DOCTOR SUGGESTED.IN TIME ALL ROUTINE INVESTIGATIONS SHOULD BE DONE.you should not treat it as disease but start of a healthy life.Uncontrolled sugar levels for long time leads to lower limb weakness which is neuropathy and which is followed by foot ulcers and other complications.online prescription is not allowed without seeing pt.so contact doctor nearby for any change or dose adjustment or visit my clinic at gurgaon sector 52 RdCity snergy multi speciality clinic near SRS MARKET

What is Megacrust-P Capsule, and what is it used for?

Megacrust-P Capsule is a combination of two medicines: pregabalin and methylcobalamin. It is used for the treatment of nerve pain (neuropathic pain). It calms the damaged or overactive nerves by acting on the brain, thereby decreasing the pain sensation. It also helps in the regeneration of damaged nerves in the body.

Can I stop taking Megacrust-P Capsule when my pain is relieved?

No, you should not stop taking Megacrust-P Capsule even if your pain is relieved. Continue to take it as advised by your doctor. If you suddenly stop taking Megacrust-P Capsule, you may experience withdrawal symptoms such as anxiety, sleeping difficulties, nausea, pain, and sweating. You may need to gradually taper the use of Megacrust-P Capsule before you stop the medication completely.

How do you manage the weight gain associated with the use of Megacrust-P Capsule?

Megacrust-P Capsule can make you feel hungry, which might make you eat more, thereby increasing your chances of putting on weight. However, preventing weight gain is easier than losing the increased weight. Try to eat a healthy balanced diet without increasing your portion sizes (per-meal intake). Do not eat food items that contain a lot of calories, such as soft drinks, oily food, chips, cakes, biscuits, and sweets. If you feel hungry between meals, avoid eating junk food and eat fruits, vegetables, and low-calorie foods. Regular exercise will help prevent weight gain. If you maintain good eating habits and exercise regularly, you might not gain any weight.

Can the use of Megacrust-P Capsule cause sleepiness or drowsiness?

Yes, Megacrust-P Capsule may make you feel drowsy, or you may suddenly fall asleep during your daily activities. Sometimes, you might not even feel drowsy or have any other warning signs before you suddenly fall asleep. Avoid driving a car, operating machinery, working at heights, or participating in potentially dangerous activities at the beginning of your treatment until you know how the medicine affects you. Inform your doctor if you experience such episodes while you are taking this medicine.

What if I forget to take Megacrust-P Capsule?

If you forget to take the scheduled dose of Megacrust-P Capsule, and it is almost time for your next dose, skip the dose you missed and take your next dose at the scheduled time. Otherwise, take it as soon as you remember, and then go back to taking your medicine as you would normally. Do not take a double dose to make up for the dose you missed because this may increase the risk of unwanted side effects. If you are not sure what to do, consult your doctor about how to manage a situation like this.

Will a higher than the recommended dose of Megacrust-P Capsule be more effective?

No, taking a higher-than-recommended dose may not be more effective; rather, it may increase the chances of having some serious side effects and toxicity. If you experience increased severity of your symptoms that are not relieved by the recommended doses, please consult your doctor for re-evaluation.

Can I drink alcohol while taking Megacrust-P Capsule?

No, do not drink alcohol while taking Megacrust-P Capsule. Drinking alcohol can increase the severity of drowsiness or sleepiness caused by Megacrust-P Capsule.

How often should I see the doctor?

You may need to see your doctor regularly if you have started to take Megacrust-P Capsule. However, you must consult your doctor if the advised dosage of Megacrust-P Capsule does not improve your symptoms or if you continue experiencing some unwanted side effects that affect your routine activities.

Are there any special instructions regarding storage and disposal of this medicine?

Keep your tablets in the pack until it is time to take them. Store them in a cool, dry place. Store them out of sight and reach of children. Unused medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Pregabalin [Prescribing Information]. Vega Baja, Puerto Rico: Pfizer Pharmaceuticals LLC; 2009. [Accessed 22 Apr. 2019] (online) Available from:
Pregabalin [Prescribing Information]. New York, NY: Pfizer; 2004 [revised Jun 2011]. [Accessed 22 Apr. 2019] (online) Available from:
Methylcobalamin and pregabalin [Patient Information]. Pune, Maharashtra: Epion Pharmaceuticals Pvt. Ltd.; [Accessed 14 Apr. 2025] (online) Available from:
Methylcobalamin and pregabalin [Patient Information]. Ahmedabad, Gujarat: West Coast Pharmaceutical Works Ltd.; [Accessed 14 Apr. 2025] (online) Available from: