Overview
Uses and benefits
How to use
How drug works
Safety advice
Missed dose
All substitutes
Quick tips
Fact box
Patient concerns
FAQs

Author Details

Written By

Dr. Subita Alagh

BDS

Reviewed By

Dr. Lalit Kanodia

MBA, MD Pharmacology

Last updated

31 Aug 2025 | 12:49 PM (IST)

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Mesna 100mg Injection

Prescription Required

NPPA Regulated

Marketer

Getwell Pharma (I) Pvt Ltd

SALT COMPOSITION

Mesna (100mg/ml)

Storage

Store below 30°C

Product introduction

Mesna 100mg Injection is used to prevent ifosfamide-induced hemorrhagic cystitis (bleeding in the bladder that may be caused as a side effect due to treatment with a cancer chemotherapy drug called ifosfamide). However, it is not used to reduce the risk of bladder bleeding due to other medical conditions.

Mesna 100mg Injection is given under the supervision of a doctor. The dose and duration of the treatment vary based on your need and response to treatment. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Some common side effects of this medicine include nausea, headache, lightheadedness, lethargy, and abdominal pain. It is advised to drink at least 1 liter of fluid daily when you are on treatment with this medicine. You should seek immediate medical attention if you experience signs of severe allergic reactions like rash, itching, breathing difficulty, chest tightness, and swelling of the mouth, face, lips, or tongue while taking this medicine. Regular blood tests are required to check your blood cells along with the kidney, liver, and blood uric acid levels.

Before taking it, tell your doctor if you have an autoimmune disorder, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Mesna Injection

Treatment of Ifosfamide-induced hemorrhagic cystitis

Benefits of Mesna Injection

In Treatment of Ifosfamide-induced hemorrhagic cystitis

Ifosfamide-induced hemorrhagic cystitis is an inflammatory condition due to the use of a medicine called Ifosfamide that causes bleeding in the bladder. Mesna 100mg Injection helps to suppress the body’s immune system, thereby reducing the progression of the disease. It reduces the inflammation of the damaged area, prevents further damage, and stabilises your condition

How to use Mesna Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Mesna Injection works

Mesna 100mg Injection helps to reduce the risk of inflammation and bleeding in the bladder, who receive ifosfamide (a medicine used to treat cancer).

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Mesna 100mg Injection. Please consult your doctor.

Pregnancy

SAFE IF PRESCRIBED

Mesna 100mg Injection is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Breast feeding

UNSAFE

Mesna 100mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Mesna 100mg Injection may cause side effects which could affect your ability to drive.
As patients undergoing treatment with Mesna 100mg Injection may experience undesirable effects such as lightheadedness, lethargy, dizziness, and blurred vision which could affect the ability to drive.

Kidney

CAUTION

Mesna 100mg Injection should be used with caution in patients with kidney disease. Dose adjustment of Mesna 100mg Injection may be needed. Please consult your doctor.

Liver

CAUTION

Mesna 100mg Injection should be used with caution in patients with liver disease. Dose adjustment of Mesna 100mg Injection may be needed. Please consult your doctor.

What if you forget to take Mesna Injection?

If you miss a dose of Mesna 100mg Injection, please consult your doctor.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

No substitutes found for this medicine

Quick tips

Mesna 100mg Injection is given as in injection or infusion under the supervision of a doctor only.
Do not skip any dose and complete the course as suggested by your doctor.
It is advisable to drink plenty of water to stay hydrated while taking this medicine.
Your doctor may get a regular urine and blood tests done to monitor your blood cell count (CBC).

Fact Box

Chemical Class

Sulfhydryl compound, {organosulfonic acid}

Habit Forming

Therapeutic Class

BLOOD RELATED

Action Class

Cytoprotective agents- Bladder

Patient concerns

Cystitis, left renal calculi. .

Dr. Aanchal Maheshwari

Ayurveda

Take tablet neeri , tablet cystone, tablet chandraprabha vati all 3, 2 tablet twice daily water. Drink more of water

What is the best medicine for bladder infection

Dr. Sunil Sekhri

Diabetology

Cystitis has to be diagnosed after some investigations and clinical examination and treatment given after that

Why it is given with ifosamide or cyclophosphamise (Cytoxan)?

It is given along with the chemotherapy drug ifosfamide or cyclophosphamide to reduce the side effects of these drugs

Is mesna compatible with potassium chloride and doxorubicin?

Yes, Mesna is compatible with potassium chloride and doxorubicin

Is Mesna 100mg Injection a chemotherapy drug?

Mesna 100mg Injection is not a chemotherapy drug

Is Mesna 100mg Injection cytotoxic?

No. Mesna 100mg Injection is not cytotoxic drug. It is cytoprotective drug

Is Mesna 100mg Injection a vesicant?

No, Mesna 100mg Injection is not a vesicant.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 870-71.
Mesna. Thetford, Norfolk: Baxter Healthcare Ltd.; 2003 [revised Oct. 2014]. [Accessed 28 Jan. 2019] (Online) Available from:
Mesna. Los Angeles, California: American pharmaceutical partners; 2001. [Accessed 26 Mar. 2019] (online) Available from: