Metclam 2.5mg/400mg Tablet
Prescription Required
Product introduction
Metclam 2.5mg/400mg Tablet belongs to a category of medicines known as anti-diabetic drugs. It is a combination of two medicines used to treat type 2 diabetes mellitus in adults. It helps control blood sugar levels in people with diabetes.
Metclam 2.5mg/400mg Tablet should be taken with food. Take it regularly at the same time each day to get the most benefit. Your doctor will decide what dose is best for you and this may change from time to time according to how it is working according to your blood sugar levels.
Keep taking this medicine, even if you feel well or your blood sugar levels are controlled. If you stop it without consulting your doctor, your blood sugar levels could rise and put you at risk of kidney damage, blindness, nerve problems and loss of limbs. Remember that it is only part of a treatment program that should also include a healthy diet, regular exercise, and weight reduction as advised by your doctor. Your lifestyle plays a big part in controlling diabetes.
The most common side effect of Metclam 2.5mg/400mg Tablet is low blood glucose levels (hypoglycemia). Make sure you recognize the signs of having low blood glucose levels, such as sweating, dizziness, headache, and shaking and know how to deal with it. To prevent this, it's important to have regular meals and always carry a fast-acting source of glucose such as sugary food or fruit juice with you. Drinking alcohol can also increase your risk of low blood sugar levels and should be avoided. Other side effects that may be seen on taking this medicine include nausea, diarrhea, stomach pain, headache, and upper respiratory tract infection. Some people may find that they put on weight with this medicine.
You should not take it if you have type 1 diabetes mellitus, if you have diabetic ketoacidosis (high levels of acid in your blood), or if you have severe kidney or liver disease. Before taking this medicine, tell your doctor if you have ever had heart disease. It may not be suitable. Pregnant or breastfeeding women should also consult their doctor before taking it. Your blood sugar levels should be checked regularly and your doctor may also advise blood tests to monitor your blood cell counts and liver function.
Uses of Metclam Tablet
Side effects of Metclam Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Metclam
- Dizziness
- Diarrhea
- Nausea
- Flatulence
- Headache
- Upper respiratory tract infection
How to use Metclam Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Metclam 2.5mg/400mg Tablet is to be taken with food.
How Metclam Tablet works
Glibenclamide is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide which works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin.
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Metclam 2.5mg/400mg Tablet.
Pregnancy
SAFE IF PRESCRIBED
Metclam 2.5mg/400mg Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Breast feeding
CAUTION
Metclam 2.5mg/400mg Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
Driving
CONSULT YOUR DOCTOR
It is not known whether Metclam 2.5mg/400mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney
UNSAFE
Metclam 2.5mg/400mg Tablet is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor.
Liver
CAUTION
Metclam 2.5mg/400mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Metclam 2.5mg/400mg Tablet may be needed. Please consult your doctor.
What if you forget to take Metclam Tablet?
If you miss a dose of Metclam 2.5mg/400mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Metclam 2.5mg/400mg Tablet
₹1.94/Tablet
Glucored Tablet
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₹2.27/tablet
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Iscept 2.5 mg/400 mg Tablet
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Recilet 2.5 mg/400 mg Tablet
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₹1.98/tablet
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Quick tips
- You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Metclam 2.5mg/400mg Tablet.
- Take it with food to lower your chance of having an upset stomach.
- It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
- Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic.
- Tell your doctor immediately if you experience any deep or rapid breathing or if you have persistent nausea, vomiting, and stomach pain as Metclam 2.5mg/400mg Tablet may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
- Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).
- Take it with food to lower your chance of having an upset stomach.
- You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Metclam 2.5mg/400mg Tablet.
- It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
- Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic.
- Tell your doctor immediately if you experience any deep or rapid breathing or if you have persistent nausea, vomiting, and stomach pain as Metclam 2.5mg/400mg Tablet may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
- Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).
Fact Box
Habit Forming
No
Therapeutic Class
ANTI DIABETIC
Patient concerns
FAQs
What is Metclam 2.5mg/400mg Tablet?
Metclam 2.5mg/400mg Tablet is a combination of two medicines: Glibenclamide and Metformin. This medicine is used in the treatment of type 2 diabetes mellitus (DM). It improves the blood glucose levels in adults when taken along with proper diet and regular exercise. Glibenclamide lowers the blood glucose levels by increasing the release of insulin from the pancreas. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. This combination is not indicated for the treatment of Type 1 DM.
What is type 2 diabetes?
Type 2 diabetes is the most common form of diabetes. It is a condition in which the body is unable to make enough insulin, and the insulin produced by the body does not work well. When this happens, the glucose level in the blood rises and leads to serious medical problems. Symptoms of high blood sugar include frequent urination, increased thirst and increased hunger. Diabetes, if not treated properly, can cause long-term complications like neuropathy (nerve damage), nephropathy (kidney damage), eye damage (retinopathy), foot problems and also a higher risk of developing heart diseases.
What are the possible side effects of Metclam 2.5mg/400mg Tablet?
The use of Metclam 2.5mg/400mg Tablet is associated with common side effects like hypoglycemia (low blood sugar level), nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. Its use can also lead to serious but rare side effects like lactic acidosis. On long-term use, it can also lead to vitamin B12 deficiency.
Can the use of Metclam 2.5mg/400mg Tablet cause hypoglycemia?
Yes, the use of Metclam 2.5mg/400mg Tablet can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with this medicine. So, regular monitoring of blood sugar level is important. Always keep a quick source of sugar like glucose tablets, honey or fruit juice with you.
Can the use of Metclam 2.5mg/400mg Tablet lead to Vitamin B12 deficiency?
Yes, the use of Metclam 2.5mg/400mg Tablet can cause vitamin B12 deficiency on long-term use as it interferes with the absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient may feel a tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of Vitamin B12 from outside sources at least once every year.
Are there any specific conditions in which Metclam 2.5mg/400mg Tablet should not to be taken?
The use of Metclam 2.5mg/400mg Tablet should be avoided in patients with known allergy to any of the components or excipients of this medicine. It should also be avoided in patients with moderate to severe kidney disease and in patients with underlying metabolic acidosis including diabetic ketoacidosis.
Is it safe to take alcohol while I am also taking Metclam 2.5mg/400mg Tablet?
No, it is not safe to take Metclam 2.5mg/400mg Tablet along with alcohol, as it may lower your low blood sugar levels (hypoglycemia) and can increase the chances of lactic acidosis.
What are the instructions for storage and disposal of Metclam 2.5mg/400mg Tablet?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
What is Metclam 2.5mg/400mg Tablet?
Metclam 2.5mg/400mg Tablet is a combination of two medicines: Glibenclamide and Metformin. This medicine is used in the treatment of type 2 diabetes mellitus (DM). It improves the blood glucose levels in adults when taken along with proper diet and regular exercise. Glibenclamide lowers the blood glucose levels by increasing the release of insulin from the pancreas. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. This combination is not indicated for the treatment of Type 1 DM.
What is type 2 diabetes?
Type 2 diabetes is the most common form of diabetes. It is a condition in which the body is unable to make enough insulin, and the insulin produced by the body does not work well. When this happens, the glucose level in the blood rises and leads to serious medical problems. Symptoms of high blood sugar include frequent urination, increased thirst and increased hunger. Diabetes, if not treated properly, can cause long-term complications like neuropathy (nerve damage), nephropathy (kidney damage), eye damage (retinopathy), foot problems and also a higher risk of developing heart diseases.
What are the possible side effects of Metclam 2.5mg/400mg Tablet?
The use of Metclam 2.5mg/400mg Tablet is associated with common side effects like hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. Its use can also lead to serious but rare side effects like lactic acidosis. On long-term use, it can also lead to vitamin B12 deficiency.
Can the use of Metclam 2.5mg/400mg Tablet cause hypoglycemia?
Yes, the use of Metclam 2.5mg/400mg Tablet can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with this medicine. So, regular monitoring of blood sugar level is important. Always keep a quick source of sugar like glucose tablets, honey or fruit juice with you.
Can the use of Metclam 2.5mg/400mg Tablet lead to Vitamin B12 deficiency?
Yes, the use of Metclam 2.5mg/400mg Tablet can cause vitamin B12 deficiency on long-term use as it interferes with the absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient may feel a tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of Vitamin B12 from outside sources at least once every year.
Are there any specific conditions in which Metclam 2.5mg/400mg Tablet should not to be taken?
The use of Metclam 2.5mg/400mg Tablet should be avoided in patients with known allergy to any of the components or excipients of this medicine. It should also be avoided in patients with moderate to severe kidney disease and in patients with underlying metabolic acidosis including diabetic ketoacidosis.
Is it safe to take alcohol while I am also taking Metclam 2.5mg/400mg Tablet?
No, it is not safe to take Metclam 2.5mg/400mg Tablet along with alcohol, as it may lower your low blood sugar levels (hypoglycemia) and can increase the chances of lactic acidosis.
What are the instructions for storage and disposal of Metclam 2.5mg/400mg Tablet?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Glyburide and Metformin HCl Tablets [FDA Prescribing information]. Princeton, NJ: Bristol-Myers Squibb Company; 2013. [Accessed 28 Oct. 2021] (online) Available from:
- Glyburide and Metformin HCl. Princeton, New Jersey: Bristol-Myers Squibb Company; 2009. [Accessed 08 Apr. 2019] (online) Available from:
- Glyburide and Metformin HCl [Drug Label]. Princeton, NJ: Bristol-Myers Squibb Company; 2013. [Accessed 14 Aug. 2024] (online) Available from:
Marketer details
Name: Anthus Pharmaceuticals Pvt Ltd
Address: Anthus Pharamaceuticals Pvt. Ltd., 190 A, Pettukola Towers, P. H. Road, Kilpauk, Chennai - 600 010
Country of origin: India
The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.
The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.
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