Napilex CR 333mg/145mg Tablet is a combination of two medicines used to treat epilepsy, a neurological disorder in which there are recurrent episodes of seizures or fits. It controls the abnormal activity of the brain, relaxes the nerves and hence, prevents seizures or fits.

Napilex CR 333mg/145mg Tablet should be taken with food. Your doctor will decide the correct dose for you. This may increase gradually until your condition is stable. This medicine may take several weeks to work but it is important to take it regularly to get the benefit. Do not stop taking it, even if you feel fine unless your doctor advises you to. You may have more seizures, or your bipolar disorder may get worse.

The most common side effects of this medicine are nausea and tremor. In some people, it may also cause other side effetcs like vomiting, headache, liver injury, and upper abdominal pain. Most side effects wear off, but if they bother you or do not go away, tell your doctor. There may be ways of preventing or reducing these effects.

Before taking this medicine, tell your doctor if you have kidney or liver problems, meningitis or depression or suicidal thoughts. Also let your doctor know about all other medications you are using as some may affect, or be affected by, this medicine, including contraceptive pills. If you are pregnant or breastfeeding, Napilex CR 333mg/145mg Tablet can be taken if it is clearly needed but the dose may be adjusted. You should avoid driving or riding a bicycle if this medicine makes you drowsy or dizzy. You may need frequent blood tests to check how you are responding to this medicine.

You should avoid alcohol while taking Napilex CR 333mg/145mg Tablet, as it may worsen certain side effects. This medicine can also lead to weight gain, eat a healthy balanced diet, avoid snacking with high-calorie food, and exercise regularly. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.

Uses of Napilex CR Tablet

Epilepsy

Benefits of Napilex CR Tablet

In Epilepsy

Napilex CR 333mg/145mg Tablet slows down electrical signals in the brain which cause seizures (fits). It can also help reduce symptoms such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety. The medicine can allow you to do some activities that you would otherwise be forbidden or scared to do (such as swimming and driving). It can take a few weeks for this medicine to work (because the dose has to be increased slowly) and during this time you may still have seizures. Do not stop using this medicine even if you feel well, until your doctor advises you to. Missing doses may trigger a seizure.

Side effects of Napilex CR Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Napilex CR

Nausea
Tremors

How to use Napilex CR Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Napilex CR 333mg/145mg Tablet is to be taken with food.

How Napilex CR Tablet works

Napilex CR 333mg/145mg Tablet is a combination of two antiepileptic medicines: Sodium Valproate and Valproic Acid.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Napilex CR 333mg/145mg Tablet.

Pregnancy

CONSULT YOUR DOCTOR

Napilex CR 333mg/145mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

SAFE IF PRESCRIBED

Napilex CR 333mg/145mg Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

Driving

UNSAFE

Napilex CR 333mg/145mg Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

SAFE IF PRESCRIBED

Napilex CR 333mg/145mg Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Napilex CR 333mg/145mg Tablet may not be needed in these patients. Please consult your doctor.
However, talk to your doctor if you have any underlying kidney disease.

Liver

CAUTION

Napilex CR 333mg/145mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Napilex CR 333mg/145mg Tablet may be needed. Please consult your doctor.
Use of Napilex CR 333mg/145mg Tablet is not recommended in patients with severe liver disease and active liver disease.

What if you forget to take Napilex CR Tablet?

If you miss a dose of Napilex CR 333mg/145mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Napilex CR 333mg/145mg Tablet

₹5.97/Tablet

Czo Chrono 333mg/145mg Tablet

Torrent Pharmaceuticals Ltd

₹8.04/tablet

35% costlier

Cinaval Chrono 500 Tablet

USV Ltd

₹7.98/tablet

34% costlier

Navalin Chrono 333 mg/145 mg Tablet

Molekule India Pvt Ltd

₹8.87/tablet

49% costlier

Biorate 333mg/145mg Tablet

Biosans Lifecare

₹7.11/tablet

19% costlier

Arkaval 500mg Tablet

RKG Pharma

₹7.63/tablet

28% costlier

View all substitutes

Quick tips

You have been prescribed Napilex CR 333mg/145mg Tablet for treatment and prevention of seizures.
Take it at the same time every day to maintain consistent levels in your body.
Do not drive or do anything that requires mental focus until you know how Napilex CR 333mg/145mg Tablet affects you.
Avoid consuming alcohol when taking Napilex CR 333mg/145mg Tablet, as it may cause excessive sleepiness or drowsiness.
Monitor your weight during the treatment as Napilex CR 333mg/145mg Tablet can cause weight gain.
Your doctor may monitor Napilex CR 333mg/145mg Tablet level, blood counts and liver function regularly throughout your treatment. Inform your doctor if you develop fever, stomach pain, nausea or yellowing of your eyes or skin.
Do not take Napilex CR 333mg/145mg Tablet if you are pregnant or planning to conceive or breastfeeding.
Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.

Fact Box

Habit Forming

Therapeutic Class

NEURO CNS

Patient concerns

3-4 attack of strokes in 3 yrs nothing found in CT scan & EEG.these tests are done again after 3 months. But nothing found. Doctors prescribed me Oxetol 450 mg.doctor say course of medicine is 2-3 yrs.I drink and smoke addicted to drug I don't understand if the test show nothing then why strokes happens to me?

Dr. Vikas Sharma

Neurology

is it stroke or epilepsy; as u are on medicine for epilepsy

Sir i use in tablets phenytion Last two months i use this tablets

Dr. Jyoti Kapoor Madan

Psychiatry

It's treatment for epilepsy.

FAQs

Can the use of Napilex CR 333mg/145mg Tablet cause sleepiness or drowsiness?

Yes, Napilex CR 333mg/145mg Tablet may make you feel drowsy or sleepy. Avoid driving, operating machinery, working at heights or participating in potentially dangerous activities. Inform your doctor if you experience such an episode while taking this medicine.

Can I drink alcohol while taking Napilex CR 333mg/145mg Tablet?

No, avoid drinking alcohol while taking Napilex CR 333mg/145mg Tablet. Drinking alcohol will increase the side effects caused by Napilex CR 333mg/145mg Tablet.

Can Napilex CR 333mg/145mg Tablet be stopped when epilepsy symptoms are relieved?

No, Napilex CR 333mg/145mg Tablet should be continued as advised by the doctor. Stopping Napilex CR 333mg/145mg Tablet suddenly may cause the symptoms to reappear that too with increased frequency. If any problems are experienced due to Napilex CR 333mg/145mg Tablet, consult the doctor for re-evaluation.

Will a higher than the recommended dose of Napilex CR 333mg/145mg Tablet be more effective?

No, taking a higher than the recommended dose may not be more effective, rather it may increase the chances of having serious side effects and toxicity. If the recommended doses do not relieve your symptoms or there is an increased severity of your symptoms, please consult your doctor.

What are the instructions for the storage and disposal of Napilex CR 333mg/145mg Tablet?

Keep this medicine in the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

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Top Neurologists

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MBBS, MD, DM, Fellowship

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Dr. Vikas Sharma

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Linde M, Mulleners WM, Chronicle EP, et al. Valproate (valproic acid or sodium valproate or a combination of the two) for the prophylaxis of episodic migraine in adults. Cochrane Database Syst Rev. 2013;(6):CD010611. [Accessed 23 Apr. 2019] (online) Available from:
Drugs.com. Sodium Valporate. [Accessed 23 Apr. 2019] (online) Available from:
Drugs.com. Valporic acid. [Accessed 23 Apr. 2019] (online) Available from:
Sodium Valproate and Valproic Acid [Package Information]. Gangtok, Sikkim: TORRENT PHARMACEUTICALS LTD.; 2022. [Accessed 28th Sept. 2023] (online) Available from:

Marketer details

Name: Mankind Pharma Ltd

Address: 208, Okhla Industrial Estate, Phase III, New Delhi - 110020

Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.