Napri-D 500 Tablet is a medicine used in the prevention of migraines. It inhibits the release of certain chemical messengers that cause pain, inflammation, and fever. It also blocks the signals in the brain that cause nausea and vomiting associated with migraines.

Napri-D 500 Tablet may be prescribed alone or in combination with another medicine. It can be taken with or without food. The dose and duration will depend on the severity of your condition and how well it helps your symptoms. Use it regularly and do not discontinue it until the doctor tells you it is right to stop.

Using Napri-D 500 Tablet may cause common side effects such as headaches, ringing in the ears, dizziness, tiredness, rashes, and vision changes. If you experience such side effects that do not go away or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms.

In general, you should try to use the smallest amount necessary to control your symptoms. Before using the medicine, you should tell your doctor if you have any other illnesses or disorders. It may also affect, or be affected by, some other medicines you are using, so let your doctor know all the other medicines you are taking. Pregnant and breastfeeding women should consult their doctors first before using the medicine.

Uses of Napri-D Tablet

Prevention of Migraine

Benefits of Napri-D Tablet

In Prevention of Migraine

Napri-D 500 Tablet blocks chemicals responsible for pain sensation and signals that cause nausea/vomiting associated with migraines. Preventing and reducing the frequency of migraines and headaches can help you carry out your daily activities and have a better quality of life.

Side effects of Napri-D Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Napri-D

Headache
Ringing in ear
Altered vision
Tiredness
Dizziness
Drowsiness
Rash

How to use Napri-D Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Napri-D 500 Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Napri-D Tablet works

Napri-D 500 Tablet is a combination of two medicines: naproxen and domperidone. Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that works by blocking the release of certain chemical messengers that cause pain due to migraine. Domperidone works on the region in the brain that controls vomiting associated with migraine. Together, they provide relief from migraine symptoms.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Napri-D 500 Tablet.

Pregnancy

CONSULT YOUR DOCTOR

Napri-D 500 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

SAFE IF PRESCRIBED

Napri-D 500 Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

Driving

UNSAFE

Napri-D 500 Tablet may cause side effects which could affect your ability to drive.
Napri-D 500 Tablet may make you feel dizzy, depressed, sleepy, tired, or make it difficult to sleep. It may also affect your vision. This may affect your driving ability.

Kidney

CAUTION

Napri-D 500 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Napri-D 500 Tablet may be needed. Please consult your doctor.

Liver

CAUTION

Napri-D 500 Tablet should be used with caution in patients with liver disease. Dose adjustment of Napri-D 500 Tablet may be needed. Please consult your doctor.
Use of Napri-D 500 Tablet is not recommended in patients with moderate and severe liver disease.

What if you forget to take Napri-D Tablet?

If you miss a dose of Napri-D 500 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Napri-D 500 Tablet

₹9.21/Tablet

Napra D 500 Tablet

Intas Pharmaceuticals Ltd

₹12.9/tablet

40% costlier

Napaxin 500 Tablet

Matias Healthcare Pvt Ltd

₹11.5/tablet

25% costlier

Minado 500 Tablet

Tas Med India Pvt Ltd

₹8.4/tablet

9% cheaper

Macprox DP 500 Tablet

Macleods Pharmaceuticals Pvt Ltd

₹10.5/tablet

14% costlier

Xenadom 500 Tablet

Icon Life Sciences

₹11/tablet

19% costlier

View all substitutes

Quick tips

Do not take it to treat an acute attack of migraine.
Some tips that may help avoid a migraine attack include eating your meals at the same time every day, avoiding bright lights and extreme temperatures, avoiding loud music and noisy places, and abstaining from chocolates, cheese, processed food, alcohol, and smoking.
Napri-D 500 Tablet may cause dizziness. Do not drive or do anything that requires mental focus until you know how Napri-D 500 Tablet affects you.
Take Napri-D 500 Tablet as prescribed by your doctor, even if your symptoms go away.

Fact Box

Habit Forming

Therapeutic Class

NEURO CNS

Patient concerns

Problem of migraine and sinas and also gastract problem I have continue taking tablet D veniz50 and SARTIMA LAST 2 YEAR BUT NOT SATISFIED RESULT AND CURRENTLY I HAVE TAKING D-VENIZ-50MG-TABLET AND NEXITO 0.5 PLS SUGGEST

Dr. Vikas Sharma

Neurology

startv tab topaz 25 mg hs;do mri brain

Ravi site d tablet for back pain ??

Dr. Mehtab Baig

Orthopaedic Physiotherapy

How many days suffered back ache

What is Napri-D 500 Tablet?

Napri-D 500 Tablet is a combination of two medicines used to relieve migraine symptoms such as headache, nausea, and vomiting. Naproxen works by blocking chemical messengers responsible for pain and inflammation. Domperidone helps prevent nausea and vomiting by improving gut movement and acting on the brain’s vomiting center. Together, they provide effective relief from both headache and associated stomach discomfort during migraines.

Can the use of Napri-D 500 Tablet cause diarrhea?

Yes, the use of Napri-D 500 Tablet can cause diarrhea. In case you experience diarrhea, drink plenty of water or other fluids. Talk to your doctor if diarrhea persists and you notice any signs of dehydration, like less urination with dark-colored and strong-smelling urine. Do not take any other medicine without consulting a doctor.

Are there any specific contraindications associated with the use of Napri-D 500 Tablet?

The use of Napri-D 500 Tablet is considered to be harmful for patients with known allergies to any of the components or excipients of this medicine or in patients with known allergies to other painkillers belonging to NSAIDs. The use of this medicine should preferably be avoided in patients with a history of stomach ulcers or patients with active, recurrent stomach ulcers/bleeding. It should also be avoided in patients with a history of heart failure, high blood pressure, and liver or kidney disease.

Can the use of Napri-D 500 Tablet cause damage to the kidneys?

Yes, the long-term use of Napri-D 500 Tablet can cause damage to the kidneys. Normal kidneys produce a chemical called prostaglandins that protects them from damage. The use of painkillers lowers the levels of prostaglandins in the body, which leads to kidney damage on long-term use. The use of painkillers is not recommended for patients with underlying kidney disease.

Can I take a higher dose than the recommended dose of Napri-D 500 Tablet?

No, taking a higher dose than the recommended dose of Napri-D 500 Tablet can increase the risks of side effects. If you are experiencing increased severity of migraine attacks that are not relieved by the recommended doses, please consult your doctor for reevaluation.

What are the recommended storage conditions for Napri-D 500 Tablet?

Keep this medicine in the container or the pack it came in, tightly closed. Store it as mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children, and other people.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Naproxen [Prescribing Information]. Nutley, New Jersey: Roche Laboratories Inc. [Accessed 22 Apr. 2019] (online) Available from:
Leeford Healthcare: Naproxen and domperidone [Product Information]. [Accessed 20 Feb. 2025] (online) Available from:
Domperidon and Naproxen [Product Information]. Ahmedabad, Gujarat: Torrent Pharmaceuticals Ltd.; 2024 [Accessed 20 Feb. 2025] (online) Available from:

Marketer details

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Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.