Nefrograf 0.5mg Capsule is used along with other medicines to prevent your body from rejecting a new organ (e.g., liver, kidney, or heart) after transplant. It does so by weakening your body’s immune system, so it does not attack the new organ. This medication belongs to a class of drugs known as immunosuppressants.

The amount of Nefrograf 0.5mg Capsule you take and how often you take it depends on the type of transplant you have, your body weight, and what other medicines you are taking. Follow your doctor’s instructions carefully. You should take it on an empty stomach, at least 1 hour before or 2 hours after a meal. Take this medicine regularly to get the maximum benefit and keep taking it, even if you feel well. If you stop taking it, you may increase the chances of rejecting your transplanted organ.

Nefrograf 0.5mg Capsule has many potential side effects. It can cause or worsen diabetes and kidney problems. These need urgent medical attention. Other common side effects include tremor, infections, high blood pressure, headache, and insomnia. If the side effects do not go away or get worse, tell your doctor. Nefrograf 0.5mg Capsule lowers your immune system making you susceptible to catching more infections than usual.

Before taking this medicine, tell your doctor if you have kidney, liver, or heart problems, diabetes, or high blood pressure. Also let your doctor know what other medications you are taking, especially for infections, pain, and arthritis. These and others may affect, or be affected by, this medicine. You should limit your exposure to the sun and UV (ultraviolet) light while taking it because immunosuppressants could increase your risk of skin cancer.

Both men and women using this medicine should use effective birth control to prevent pregnancy. This medicine is not normally recommended during pregnancy or while breastfeeding unless it is clearly needed. Before and during treatment you will need frequent medical tests to monitor your progress, and your blood pressure will need to be checked often.

Uses of Nefrograf Capsule

Prevention of organ rejection in transplant patients

Benefits of Nefrograf Capsule

In Prevention of organ rejection in transplant patients

Nefrograf 0.5mg Capsule belongs to a group of medicines known as immunosuppressants. Organ rejection happens when your immune system treats the new organ as an invader and attacks it. This medicine weakens your immune response (which usually fights infection) and reduces the chance of your body attacking the transplanted organ. It is used in combination with other medicines to make it much more likely that your transplant operation will be successful. You should continue taking the medicine and should not stop it until your doctor says so.

Side effects of Nefrograf Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Nefrograf

High blood pressure
Increased glucose level in blood
Kidney damage
Insomnia (difficulty in sleeping)
Tremors
Headache
Abnormal liver function tests
Infection

How to use Nefrograf Capsule

Take this medicine in the dose and duration as advised by your doctor. Nefrograf 0.5mg Capsule is to be taken empty stomach.

How Nefrograf Capsule works

Nefrograf 0.5mg Capsule is an immunosuppressant. It works by suppressing your body’s immune response following the transplant of an organ (e.g., liver, kidney, heart). This helps your body to accept the new organ as if it were your own.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Nefrograf 0.5mg Capsule.

Pregnancy

CONSULT YOUR DOCTOR

Nefrograf 0.5mg Capsule may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Nefrograf 0.5mg Capsule is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Nefrograf 0.5mg Capsule may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Nefrograf 0.5mg Capsule should be used with caution in patients with kidney disease. Dose adjustment of Nefrograf 0.5mg Capsule may be needed. Please consult your doctor.

Liver

CAUTION

Nefrograf 0.5mg Capsule should be used with caution in patients with liver disease. Dose adjustment of Nefrograf 0.5mg Capsule may be needed. Please consult your doctor.

What if you forget to take Nefrograf Capsule?

If you miss a dose of Nefrograf 0.5mg Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Nefrograf 0.5mg Capsule

₹16.2/Capsule

Taclog 0.5mg Capsule

Calren Care Lifesciences Pvt Ltd

₹18.4/capsule

14% costlier

Pangraf 0.5 Capsule

Panacea Biotec Pharma Ltd

₹23/capsule

42% costlier

Vingraf 0.5 Capsule

Emcure Pharmaceuticals Ltd

₹20.3/capsule

25% costlier

Takfa 0.5 Capsule

Intas Pharmaceuticals Ltd

₹22.1/capsule

36% costlier

Tacrograf 0.5 Capsule

Eris Lifesciences Ltd

₹23.1/capsule

43% costlier

View all substitutes

Quick tips

Nefrograf 0.5mg Capsule is used to prevent organ rejection in transplant patients.
It may take 3 to 4 months for the medication to work. Keep taking it as prescribed.
Your doctor may get regular blood tests done to check the levels of blood cells in your blood. Inform your doctor if you experience unexplained bruising or bleeding, sore throat, mouth ulcers, fever, or general illness.
Your doctor may monitor your kidney function regularly. Drink 8 to 10 glasses of water per day to help with your kidney function.
Do not stop taking Nefrograf 0.5mg Capsule without talking to your doctor first.

Fact Box

Chemical Class

Macrolide Lactams

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Immunosuppressant- Calcineurin inhibitors

Interaction with drugs

Taking Nefrograf with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Natalizumab (Oral Route) Life-threatening

Long-term concurrent use may increase the risk of certain brain infections. Do not consume Natalizumab with Tacrolimus.

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route) Life-threatening

Concurrent use may cause fatal infections. Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) should not be used while undergoing treatment with Tacrolimus or for up to 6 ... More

Domperidone (Oral Route) Life-threatening

Concomitant use may affect heart rhythm and can be fatal. Do not consume Tacrolimus with Domperidone.

Acyclovir (Oral Route) Severe

Concurrent use may increase the risk of kidney damage. If concurrent use is essential, your doctor may monitor your tacrolimus levels, potassium levels and kidney function closely... More

Aceclofenac (Injection Route) Severe

Concurrent use may increase the risk of serious damage to the kidneys. If concurrent use is essential, your doctor may monitor your tacrolimus levels, potassium levels and kidney ... More

View all drug interactions

Patient concerns

Difficulty in excretory, and rejection of stool.

Dr. Aanchal Maheshwari

Ayurveda

take triphala churan 1 spoon at night wioth abhyarishtam 20 ml mixed with water

Dear respected sir/madam, my uncle is suffering from alcoholic liver cirrhosis and ascites due to prolonng drinking. Water is accumulated around the belly. Less ddesire to eat anything. Doctor is saying for liver transplant. Could please suggest the best treatment available in allopathy to treat this problem. Thank you very very much.

Dr. Pushkar Mani

Physician

liver transplant only, consult in ILBS delhi

Prevention of acene and pimples

Dr. Manju Singh

Homeopathy

Wash acne-prone areas only twice a day. Washing removes excess oil and dead skin cells. But too much washing can irritate the skin. Wash affected areas with a gentle cleanser and use oil-free, water-based skin care products. Use non- oily makeup. Choose oil-free cosmetics that won't clog pores. Remove makeup before going to bed. Going to sleep with cosmetics on your skin can clog your pores. Avoid touching or picking at the problem areas. Doing so can trigger more acne. Always use a clean towel or cloth to wipe your face. Always keep your hands clean and wash them regularly so that you may not touch your skin with dirty hands.

FAQs

Is Nefrograf 0.5mg Capsule an antibiotic?

Yes, Nefrograf 0.5mg Capsule is a type of antibiotic which belongs to a group of medicines called macrolides. It is mostly used after organ transplantation. This medicine’s immune-suppressing property helps prevent organ rejection after kidney, heart, or liver transplant.

Which vaccines should not be taken while taking Nefrograf 0.5mg Capsule?

You should avoid taking any live vaccines (vaccines that use pathogens that are still alive, but are attenuated, that is, weakened) while taking Nefrograf 0.5mg Capsule. These may include vaccinations for measles, mumps, rubella, BCG (TB vaccine), yellow fever, chicken pox and typhoid. You should also avoid taking polio drops (by mouth) or flu vaccine (through nose).

Who should not take Nefrograf 0.5mg Capsule?

Patients who are allergic to it or have a weak immune system, high blood pressure, and kidney failure should avoid Nefrograf 0.5mg Capsule. This medicine should also be avoided in pregnant or breastfeeding women, and in people who plan to receive any live vaccines (e.g. MMR vaccine).

What should I tell my doctor before taking Nefrograf 0.5mg Capsule?

Inform your doctor if you are pregnant, have allergies, long-term infection, high blood sugar, or high blood pressure. You should also inform your doctor if you have high blood potassium levels or a weakened immune system. Tell your doctor if you have a history of any medication, have recently received, or are scheduled to receive a live vaccine.

What should I be aware of before I start taking Nefrograf 0.5mg Capsule?

This medicine suppresses the immune system and hence there is always an increased risk of infection. Moreover, in some cases, Nefrograf 0.5mg Capsule can increase the risk of some kind of cancer like skin and lymph gland cancer (lymphoma). It can lower the ability of your immune system to fight infections. Consult your doctor before you start taking this medication and in case you notice any symptoms of infections like fever, sweats or chills, cough or flu-like symptoms, muscle aches, warm, red, or painful areas on your skin.

Does Nefrograf 0.5mg Capsule have an abuse potential?

No, Nefrograf 0.5mg Capsule does not have abuse potential and thus, is not a controlled substance. Controlled substances have potential for abuse so they need permission from authorities and doctors for use.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Burkhart C, Morrell D, Goldsmith L. Dermatological Pharmacology. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1822.
Lake DF, Briggs AD, Akporiaye ET. Immunopharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 972.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1305-309.
Tacrolimus monohydrate. Camberley, Surrey: Sandoz Limited; 2010 [revised 27 Mar. 2017]. [Accessed 23 Jan. 2019] (online) Available from:
Tacrolimus. Princeton, New Jersey: Sandoz Inc; 2009. [Accessed 06 Apr. 2019] (online) Available from:
Central Drugs Standard Control Organisation. Tacrolimus. [Accessed 06 Aug. 2023]. (online) Available from:
Tacrolimus [package Insert]. Karapakkam, Chennai: The Madras Pharmaceuticals; 2020. [Accessed 06 Aug. 2023]. (online) Available from:

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Country of origin: India

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