Norvelzo 3.5mg Injection
Prescription Required
Product introduction
Norvelzo 3.5mg Injection is used in the treatment of multiple myeloma and mantle-cell lymphoma. It shows its working by stopping or slowing down the growth of cancer cells.
Norvelzo 3.5mg Injection is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Fatigue, nausea, vomiting, and loss of appetite are some common side effects of this medicine. You may be advised to drink plenty of fluids every day during the treatment. You should not drive or operate machinery as medicine may cause tiredness and dizziness. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.
Before taking Norvelzo 3.5mg Injection, consult with your doctor if you have any liver, kidney, heart disease or bleeding problem. It is important to consult a doctor if you develop symptoms like memory loss or trouble in thinking. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of Norvelzo Powder for Injection
Side effects of Norvelzo Powder for Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Norvelzo
- Fungal infection
- Anemia (low number of red blood cells)
- Breathlessness
- Decreased white blood cell count (neutrophils)
- Dehydration
- High blood pressure
- Itching
- Erythema (skin redness)
- Gastrointestinal bleeding
- Herpes zoster
- Pneumonia
- Motor neuropathy
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
- Dry skin
- Edema (swelling)
- Low blood platelets
- Decreased white blood cell count (lymphocytes)
- Lymphopenia
- Decreased potassium level in blood
- Decreased sodium level in blood
- Decreased calcium level in blood
How to use Norvelzo Powder for Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Norvelzo Powder for Injection works
Norvelzo 3.5mg Injection is an anti-cancer medication. It works by blocking or slowing the breakdown of proteins in cells. As a result, there is an increase in a number of proteins in the cancer cells leading to their death.
Safety advice
Alcohol
UNSAFE
Norvelzo 3.5mg Injection may cause excessive drowsiness with alcohol.
Pregnancy
CONSULT YOUR DOCTOR
Norvelzo 3.5mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
UNSAFE
Norvelzo 3.5mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
UNSAFE
Norvelzo 3.5mg Injection may cause side effects which could affect your ability to drive.
Norvelzo 3.5mg Injection might cause tiredness, dizziness, fainting, or blurred vision which may affect your ability to drive.
Norvelzo 3.5mg Injection might cause tiredness, dizziness, fainting, or blurred vision which may affect your ability to drive.
Kidney
CAUTION
Norvelzo 3.5mg Injection should be used with caution in patients with severe kidney disease. Dose adjustment of Norvelzo 3.5mg Injection may be needed. Please consult your doctor.
Liver
CAUTION
Norvelzo 3.5mg Injection should be used with caution in patients with liver disease. Dose adjustment of Norvelzo 3.5mg Injection may be needed. Please consult your doctor.
What if you forget to take Norvelzo Powder for Injection?
If you miss a dose of Norvelzo 3.5mg Injection, please consult your doctor.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
- Norvelzo 3.5mg Injection is given as an injection into veins or skin under the supervision of a healthcare professional.
- Do not skip any dose and complete the course as suggested by your doctor.
- Use an effective method of birth control to avoid pregnancy while taking this medication.
- You may need to have blood tests to monitor your blood cells, platelets count, liver function and kidney function during treatment.
- Inform your doctor immediately if you experience coughing, shortness of breath and swelling of feet.
- Norvelzo 3.5mg Injection is given as an injection into veins or skin under the supervision of a healthcare professional.
- Do not skip any dose and complete the course as suggested by your doctor.
- Use an effective method of birth control to avoid pregnancy while taking this medication.
- You may need to have blood tests to monitor your blood cells, platelets count, liver function and kidney function during treatment.
- Inform your doctor immediately if you experience coughing, shortness of breath and swelling of feet.
Fact Box
Chemical Class
Phenylalanine Derivatives
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Proteasome inhibitor
Patient concerns
FAQs
Q. When should I call my doctor right away?
Get medical help right away if you have muscle cramping, muscle weakness, confusion, visual loss or disturbances, blindness, seizures, headaches, shortness of breath, swelling of your feet or changes in your heartbeat, high blood pressure, tiredness, fainting, coughing and breathing difficulties or tightness in the chest.
Q. How will you know that Norvelzo 3.5mg Injection is working?
Keep taking this medicine exactly as directed until your doctor tells you to stop. Regular scans will reveal whether your tumor is responding to the treatment. Your doctor will determine when those scans should be scheduled.
Q. What precautions should I take to reduce the chances of getting infected during treatment with Norvelzo 3.5mg Injection?
Since Norvelzo 3.5mg Injection lowers the number of white blood cells and platelets in your blood, it puts you at risk of getting an infection or bleeding. In order to prevent, avoid people who have infections. Check with your doctor immediately if you think you may be getting an infection, or if you get a fever, chills, cough; be careful not to cut yourself when you are using sharp objects such as a razor or nail cutters, and use a toothbrush with soft bristles to prevent bleeding from gums.
Q. Can Norvelzo 3.5mg Injection be used during pregnancy?
No, this medicine should not be used during pregnancy as it can harm your unborn baby. Avoid getting pregnant and use an effective method of birth control during your treatment and for at least 3 months after the last dose of Norvelzo 3.5mg Injection.
Q. Can Norvelzo 3.5mg Injection affect my lungs? What should I do?
Yes, this medicine might cause potentially fatal problems in your lung. If you feel severe shortness of breath, confusion, dry cough, dizziness, or extreme tiredness, talk to your doctor right away.
Q. Does Norvelzo 3.5mg Injection cause hair loss?
Yes, while taking this medicine, your hair may become brittle and break. You may also experience patchy hair loss or thinning. These conditions tend to resolve once treatment is stopped. Be gentle when brushing and washing hair to manage hair loss.
Q. Are there any precautions for tingling sensation and numbness in my arms and legs?
This medicine causes tingling, numbness, pain, or burning sensation in your arms or legs. Be careful when moving around, as the numbness may make it harder to walk, feel your hands or feet, or increase your risk of falls. Talk to your doctor if you feel these symptoms. You may need to change your dose or schedule.
Q. I have noticed some changes in my skin after taking Norvelzo 3.5mg Injection? What should I do?
Use a moisturizer to get relief from rashes, dry and itchy skin. Avoid direct sunlight, wear protective clothing, and use sunscreen with (SPF more than 15) whenever you step outdoors. Do not go swimming if you have a rash because the chlorine in the water can make it worse. Avoid hot water bath and wear loose and cotton fabric clothes. Your skin will tend to become better once treatment is stopped.
Q. How to relieve constipation during the treatment?
To relieve constipation, include fiber in your diet (fruits and vegetables), drink 8-10 glasses of fluids a day, and keep active. A stool softener (with a doctor's prescription) once or twice a day may prevent constipation. If you do not have a bowel movement for 2-3 days, consult your doctor.
Q. I am experiencing nausea and extreme tiredness. Is this due to Norvelzo 3.5mg Injection?
Nausea and fatigue or tiredness are some of the common side-effects of this medicine. Eat smaller, more frequent meals to reduce the feeling of nausea. Avoid food that is salty, spicy, fried, or fatty. Take plenty of rest and do light exercise daily to keep yourself active and reduce fatigue.
Q. I am noticing a change in my taste. How shall I improve my taste?
You may experience a metallic taste or find that food has no taste at all. You may dislike foods or beverages that you liked before receiving cancer treatment. Rinse your mouth with a solution of salt and bicarbonate of soda before mealtimes to neutralize the bad taste in your mouth. You can also add extra flavor or seasonings to your food.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1742-43.
- Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 958.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 153-54.
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:
- Bortezomib. Beerse Belgium: Janssen Pharmaceutica NV; [Accessed 26 Mar. 2019] (online) Available from:
- Bortezomib [Prescribing Information]. Cambridge, MA: Millennium Pharmaceuticals, Inc.; 2008. [Accessed 25 Jul. 2024] (online) Available from:
Marketer details
Name: Taj Pharma India Ltd
Address: first floor, 15-6-108 afzal gunj, hyderabad, telangana 500012
Country of origin: India
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1.0 Powder for Injection in 1 vial
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