Orib 2000mg Tablet
Prescription Required
Product introduction
Orib 2000mg Tablet belongs to the class of medicines known as tyrosine kinase inhibitors used in the treatment of liver cancer, kidney cancer, and thyroid cancer.
Orib 2000mg Tablet should be taken on an empty stomach, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Fatigue, nausea, loss of appetite, hair loss and diarrhea are some common side effects of this medicine. It might cause high blood pressure, so the doctor may ask you for a regular check-up of blood pressure. You must inform your doctor if you notice severe skin reaction such as skin rash, or any pain, swelling, and redness of your hands and feet.
Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or high blood pressure. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Orib 2000mg Tablet should be taken on an empty stomach, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Fatigue, nausea, loss of appetite, hair loss and diarrhea are some common side effects of this medicine. It might cause high blood pressure, so the doctor may ask you for a regular check-up of blood pressure. You must inform your doctor if you notice severe skin reaction such as skin rash, or any pain, swelling, and redness of your hands and feet.
Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or high blood pressure. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of Orib Tablet
Benefits of Orib Tablet
In Liver cancer
Liver cancer is the cancer that develops in the cells of the liver called hepatocytes. There may be no symptoms present in the early stages of the cancer but as the disease advances to later stages symptoms such as weight loss, stomach pain, vomiting and yellowed skin. Orib 2000mg Tablet kills the cancer cells and prevents further growth and spread of cancer to other unaffected areas. Follow your doctor’s instructions carefully and do not drink alcohol or smoke. Alcohol intake or smoking can worsen your condition and hinder your recovery.
In Kidney cancer
Orib 2000mg Tablet is used to treat kidney cancer and its associated symptoms such as blood in the urine, unexplained low back pain or weight loss, fatigue, loss of appetite, etc. It stops cancer growth and prevents multiplication of cancer cells. This restricts the advancement of cancer to other unaffected regions. You need to follow your doctor’s instructions very carefully to recover.
In Thyroid cancer
Thyroid is a butterfly-shaped gland located at the base of your neck. Your thyroid produces hormones that regulate your heart rate, blood pressure, body temperature and weight. Thyroid cancer occurs in the cells of the thyroid and it might not cause any symptoms at first. Orib 2000mg Tablet restricts the oxygen supply of the cancer cells and stops its growth as well as further spread. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol or smoking while having this treatment and drink plenty of water to stay hydrated.
Side effects of Orib Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Orib
- Fatigue
- Nausea
- Loss of appetite
- Diarrhea
- Abdominal pain
- Hair loss
- Weight loss
- Rash
- Painful blisters on hands and feet
How to use Orib Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Orib 2000mg Tablet is to be taken empty stomach.
How Orib Tablet works
Orib 2000mg Tablet is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Orib 2000mg Tablet. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Orib 2000mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
UNSAFE
Orib 2000mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
SAFE
Orib 2000mg Tablet does not usually affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Orib 2000mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Orib 2000mg Tablet is recommended.
Regular monitoring of blood tests may be advised while you are taking this medicine.
Regular monitoring of blood tests may be advised while you are taking this medicine.
Liver
CAUTION
Orib 2000mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Orib 2000mg Tablet may be needed. Please consult your doctor.
What if you forget to take Orib Tablet?
If you miss a dose of Orib 2000mg Tablet, skip it and continue with your normal schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
- Orib 2000mg Tablet is used in the treatment of liver, kidney, and thyroid cancer.
- Take it without food, or with a low fat meal and a full glass of water.
- Take it at the same time everyday to maintain consistent levels in your body.
- Women who could get pregnant should use a reliable method of contraception to prevent pregnancy while taking this medicine.
- Your doctor may regularly monitor your blood pressure while you are taking this medicine.
- Inform your doctor if you get a skin rash, or any pain, swelling, and redness of your hands and feet while you are taking this medicine.
- Do not change the dose or discontinue use without consulting your doctor.
Fact Box
Chemical Class
Diarylethers Derivative
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Tyrosine kinase inhibitors
Interaction with drugs
Taking Orib with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Concomitant use may affect heart rhythm and may be fatal.
Do not consume Escitalopram Oxalate with Sorafenib.
Concomitant use may affect heart rhythm and may be fatal.
Do not consume Sildenafil with Sorafenib.
Concomitant use may affect heart rhythm and may be fatal.
Do not consume Ranolazine with Sorafenib.
Concomitant use may affect heart rhythm and may be fatal.
Do not consume Amiodarone with Sorafenib.
Concomitant use may affect heart rhythm and may be fatal.
Do not consume Pimozide with Sorafenib.
Patient concerns
FAQs
How is Orib 2000mg Tablet administered?
Orib 2000mg Tablet is an oral medicine and you should take it exactly as per your doctor’s advice. It can be taken without food or with low to moderate fat meal. It should not be taken with high-fat meal which will make Orib 2000mg Tablet less effective. If you are taking high-fat meal, take Sorafenib 1 hour before or two hours after high-fat meal.
For how long do I need to take Orib 2000mg Tablet?
If Orib 2000mg Tablet suits you well, then you should continue taking it for the duration suggested by the doctor. However, if you experience any side effect that bothers you, talk to your doctor immediately.
Do I need to take a treatment along with Orib 2000mg Tablet for it to work?
Orib 2000mg Tablet is used as a monotherapy, that is, it is a medicine which is used alone rather than in combination with other treatments like radiotherapy or chemotherapy.
How do I know if I am responding to Orib 2000mg Tablet?
While receiving treatment with Orib 2000mg Tablet, your doctor will most likely recommend regular scans to monitor the size of the tumor. You may also need to get regular blood tests to see if the deranged liver or kidney functions have improved or not.
What are the serious side effects that can occur while taking Orib 2000mg Tablet?
The possible serious side effects that may occur (not in everyone) include heart attack and heart failure, increased risk of bleeding, high blood pressure, skin problems and wound healing problems. Some other side effects which get highlighted when you go through various tests are decreased blood flow to the heart, swelling of the liver, an opening in the wall of stomach or intestines (perforation), changes in electrical activity of the heart (QT prolongation) and changes in thyroid hormone levels.
Does Orib 2000mg Tablet affect blood sugar levels?
Yes, Orib 2000mg Tablet can cause a decrease in the blood sugar levels. In fact, the levels can decrease to the extent that the patient may faint. So, it is important that the patients having diabetes check their blood sugar levels regularly. Additionally, you should also consult the doctor if the dose of anti-diabetic medicines needs to be adjusted.
I have developed redness and pain in my palms and soles ever since I started using Orib 2000mg Tablet. My skin is also coming off. Is this dangerous? What should I do?
It seems you have developed hand and foot skin reaction due to Orib 2000mg Tablet. Consult your doctor who will either interrupt your therapy for sometime or change your dose. He might also suggest some cream or lotion to treat the problem. If the problem is severe, consult a skin doctor.
Want to share the information?
Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1740.
- Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 955.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1274-75.
- Sorafenib. Emeryville, California: Onyx Pharmaceuticals, Inc.; 2005 [revised Oct. 2010]. [Accessed 24 Jan. 2019] (online) Available from:
- Sorafenib tosilate. Reading, Berkshire: Bayer Plc.; 2006 [revised Jun. 2018]. [Accessed 27 Mar. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:
Marketer details
Name: Hetero Healthcare Limited
Address: S.no: 80-84, Melange towers, PatrikaNagar,Madhapur,Hyderabad. Telangana-500081.
Country of origin: India
Lab tests offered by us
Related/Popular tests
₹5817
Inclusive of all taxes
MRP₹6000 3% OFF
30.0 tablets in 1 bottle
SOLD OUT