Plus 500mg Injection is used to prevent premature labor in pregnant women in order to reduce the risk of giving birth too early (preterm birth). It prevents miscarriage and lowers the risk of premature birth in women who have had one premature delivery in the past.

Plus 500mg Injection is administered only by or under the supervision of a doctor. It should be taken as your doctor advice. Your doctor will decide how much you need to take and for how much time. You should take this injection for as long as it is prescribed for you.

The most common side effects of this medicine include local site reactions at the injection site, nausea, itching, diarrhea, and rash. If any of these bothers you, let your doctor know. There may be ways of reducing or preventing them. It may affect blood sugar levels, so monitor your blood sugar regularly. It is better to inform the doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain while using this medicine.

Before taking this medicine inform doctor, if you have ever had any problems with your blood circulation or have diabetes, or any liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works.

Uses of Plus Injection

Prevention of Premature Labor

Benefits of Plus Injection

In Prevention of Premature Labor

Plus 500mg Injection is a man-made form of the female hormone called progesterone, that helps lower the risk of delivering the baby too early (premature labor), particularly in women who have had this complication in an earlier pregnancy. Progesterone is a hormone that thickens the lining of the uterus and prepares it for the growth and development of the baby. So, it helps your uterus grow during pregnancy and also prevents any contractions that can otherwise lead to miscarriage.

Side effects of Plus Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Plus

Injection site pain
Injection site swelling
Red spots or bumps
Rash

How to use Plus Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Plus Injection works

Plus 500mg Injection is a progestin (female hormone).

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Plus 500mg Injection. Please consult your doctor.

Pregnancy

SAFE IF PRESCRIBED

Plus 500mg Injection is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Breast feeding

SAFE IF PRESCRIBED

Plus 500mg Injection is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

Driving

SAFE

Plus 500mg Injection does not usually affect your ability to drive.

Kidney

CONSULT YOUR DOCTOR

There is limited information available on the use of Plus 500mg Injection in patients with kidney disease. Please consult your doctor.
This medicine contains progesterone which can cause fluid retention in patients with underlying kidney disease.

Liver

UNSAFE

Plus 500mg Injection is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.

What if you forget to take Plus Injection?

If you miss a dose of Plus 500mg Injection, please consult your doctor.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Plus 500mg Injection

₹278/Injection

Anin 500mg Injection

Ind Swift Laboratories Ltd

₹361/injection

24% costlier

Maintane 500 Injection

Jagsonpal Pharmaceuticals Ltd

₹350.42/injection

21% costlier

Pro 9 500mg Injection

Abbott

₹354.12/injection

22% costlier

NT-Natal 500 Injection

Kee Pharma

₹210/injection

28% cheaper

Uniprogestin 500mg Injection

Torrent Pharmaceuticals Ltd

₹436.52/injection

51% costlier

View all substitutes

Quick tips

Plus 500mg Injection is used in pregnant women to help lower the risk of giving birth too early (preterm birth).
It is only given to a woman who has had a preterm delivery in the past.
It is not for use in women who are pregnant with more than one baby (twins, triplets, etc.).
It is administered only by or under the immediate supervision of your doctor. Your doctor can start giving you the injection every week between 16 and 20 weeks and continue through week 37, or until you deliver.
It may affect blood sugar levels. Monitor your blood sugar regularly.
Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain. These could be symptoms of a serious liver problem.
Inform your doctor immediately if you have pain in the chest, groin or legs, difficulty with breathing, sudden severe headache, slurred speech, sudden unexplained shortness of breath, a sudden loss of coordination, or vision changes while using this medicine.

Fact Box

Chemical Class

Gluco/Mineralocorticoids, Progestogins Derivatives

Habit Forming

Therapeutic Class

GYNAECOLOGICAL

Action Class

Progestins (First generation)

Interaction with drugs

Taking Plus with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Fulvestrant (Injection Route) Severe

Hydroxyprogesterone may reduce the efficacy of Fulvestrant. Do not consume Fulvestrant with Hydroxyprogesterone if you have or had breast cancer. If essential, consult your doctor... More

Anastrozole (Injection Route) Severe

Hydroxyprogesterone may reduce the efficacy of Anastrozole. Do not consume Anastrozole with Hydroxyprogesterone if you have or had breast cancer. If essential, consult your doctor... More

Tamoxifen (Injection Route) Severe

Hydroxyprogesterone may reduce the efficacy of Tamoxifen. Do not consume Tamoxifen with Hydroxyprogesterone if you have or had breast cancer. If essential, consult your doctor.

Letrozole (Injection Route) Severe

Hydroxyprogesterone may reduce the efficacy of Letrozole. Do not consume Letrozole with Hydroxyprogesterone if you have or had breast cancer. If essential, consult your doctor.

Raloxifene (Injection Route) Severe

Hydroxyprogesterone may reduce the efficacy of Raloxifene. Do not consume Raloxifene with Hydroxyprogesterone. If concurrent use is essential, please consult your doctor.

View all drug interactions

Patient concerns

Right hand pain up to batam pain right hand. 15days. Nurokind Plus injection take or not.

Dr. Vikas Sharma

Neurology

get mri cervical spine; tab gabapin NT 400 once at nite ; show to neurolohist

Swelling plus redness plus pain plus mucopurulent discharge left eye since 15 days. Suspected subacute viral conjunctivitis.

Dr. Richa Jain

Ophthalmology

Take treatment under supervision of immediately

Suffering from schizophrenia since last 40yrs controlled on risdone plus and resizing plus alternate days And traizzine s not resizing plus

Dr. Jyoti Kapoor Madan

Psychiatry

Schzophrenia is a chronic problem caused by Neuro chemical disturbance in brain. It is characterised by fear, odd experiences and distorted thought pattern. Treatment is with antipsychotic medicines which may need to continue throughout life. Regular follow up with psychiatrist is essential for monitoring side effects and response.

I am having chronic daily headache from last 4 years and now a days sometimes anxiety ,tingling in legs and hands and dizziness has also been started. I also have constipation. Now when I get my blood check up , found that my vitamin b12 is 146 , iron is 63 and vitamin d is 15. Is these deficiency are responsible for all these ?

Dr. Pushkar Mani

Physician

take CALCIMAX OP capsules once daily for 60 daystake cholecalciferol injection IM once weekly for 6 weekstake becosule plus once daily for 60 days

FAQs

What is Plus 500mg Injection? What is it used for?

Plus 500mg Injection is a type of female sex hormone called progesterone. It helps to lower the risk of preterm delivery (early birth) in a pregnant woman, who had delivered a preterm baby in the past.

How and in what dose should I use Plus 500mg Injection?

Plus 500mg Injection is given as an injection, by a doctor or trained nurse. The dose will be decided by your doctor, depending on your exact medical condition.

What if I miss a dose of Plus 500mg Injection?

Ideally, you should try not to miss any dose. However, if you miss a dose consult with your doctor as soon as you remember.

Who should not receive Plus 500mg Injection?

Plus 500mg Injection should not be used if you have: -blood clots or other blood clotting problems now or in the past -high blood pressure that is not controlled -liver problems, including liver tumors -breast cancer or other hormone-sensitive cancers now or in the past -unusual vaginal bleeding not related to your current pregnancy -yellowing of your skin due to liver problems during your pregnancy.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 671-72.
Mayo Clinic. Hydroxyprogesterone. [Accessed 03 Apr. 2019] (online) Available from:
Drugs.com. Hydroxyprogesterone. [Accessed 03 Apr. 2019] (online) Available from:
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 03 Apr. 2019] (online) Available from:
Hydroxyprogesterone Caproate Injection [Package Insert]. Ranipur, Uttarakhand: Akums Drugs & Pharmaceuticals Ltd. [Accessed 05 Jul. 2023]. (online) Available from:
Hydroxyprogesterone Caproate Injection [Prescribing Information]. Waltham, MA: AMAG Pharmaceuticals, Inc.; 2022. [Accessed 05 Jul. 2023]. (online) Available from:

Marketer details

Name: Plusplus Lifesciences LLP

Address: 309A, Sector 15A Gautam Buddha Nagar Noida Gautam Buddha Nagar UP 201301 IN

Country of origin: India

₹278

Inclusive of all taxes

MRP₹290 4% OFF

2.0 ml in 1 vial

SOLD OUT

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