Pregatex AT 10mg/50mg Tablet
Prescription Required
Product introduction
Pregatex AT 10mg/50mg Tablet is a prescription medicine used in the treatment of neuropathic pain. It works by increasing the level of chemical messengers in the brain. This helps in regulating the mood and stopping the movement of pain signals from nerves to brain.
Pregatex AT 10mg/50mg Tablet is taken by mouth with or without food. However, it is advised to take it at a fixed time each day to maintain a consistent level of medicine in the blood. In case you miss a dose of this medicine, take it as soon as you remember. Try never to skip any doses and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to the doctor as it may worsen your symptoms.
Some common side effects of this medicine include constipation, weight gain, sleepiness, dryness of mouth, and increased heart rate. Initially, this medicine may cause a sudden drop in the blood pressure when you change positions, so it is better to rise slowly if you have been sitting or lying down. It even causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. This medicine may cause weight gain and to control it, you should exercise regularly and take a balanced diet. Remember to inform the doctor if you develop any unusual changes in the mood as this medicine may lead to suicidal thoughts.
Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Uses of Pregatex AT Tablet
Side effects of Pregatex AT Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Pregatex AT
- Constipation
- Weight gain
- Sleepiness
- Dizziness
- Tiredness
- Blurred vision
- Dryness in mouth
- Increased heart rate
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
- Difficulty in urination
How to use Pregatex AT Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pregatex AT 10mg/50mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Pregatex AT Tablet works
Pregatex AT 10mg/50mg Tablet is a combination of two medicines: Amitriptyline and Pregabalin. Amitriptyline is a tricyclic antidepressant which increases the levels of chemical messengers (serotonin and noradrenaline) that stop the movement of pain signals in the brain. Together, they relieve neuropathic pain (pain from damaged nerves). Pregabalin is an alpha 2 delta ligand which decreases pain by modulating calcium channel activity of the nerve cells.
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Pregatex AT 10mg/50mg Tablet.
Pregnancy
CONSULT YOUR DOCTOR
Pregatex AT 10mg/50mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Pregatex AT 10mg/50mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Pregatex AT 10mg/50mg Tablet may cause side effects which could affect your ability to drive.
Pregatex AT 10mg/50mg Tablet may impair your alertness which may affect your ability to drive.
Pregatex AT 10mg/50mg Tablet may impair your alertness which may affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Pregatex AT 10mg/50mg Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Pregatex AT 10mg/50mg Tablet may not be needed in these patients. Please consult your doctor.
Liver
SAFE IF PRESCRIBED
Pregatex AT 10mg/50mg Tablet is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Pregatex AT 10mg/50mg Tablet may not be needed in these patients. Please consult your doctor.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Pregatex AT 10mg/50mg Tablet
₹20.6/Tablet
Gabritab 50-AT Tablet
Sparsh Remedies Pvt Ltd
₹13.8/tablet
33% cheaper
Quick tips
- Pregatex AT 10mg/50mg Tablet is used to treat certain types of long-lasting pain caused by damage to nerves.
- It may ease the pain within a few days but it may take 2-3 weeks before you see maximum benefit.
- Inform your doctor if you are taking any other pain-relieving medicines.
- Along with taking this medicine, your doctor might advise you to undergo physiotherapy to get relief from pain.
- Pregatex AT 10mg/50mg Tablet might cause dry mouth. Frequent sips of water may help ease the discomfort.
Fact Box
Habit Forming
No
Therapeutic Class
NEURO CNS
Patient concerns
FAQs
What is Pregatex AT 10mg/50mg Tablet?
Pregatex AT 10mg/50mg Tablet is a combination of two medicines: Pregabalin and Amitriptyline. This medicine is useful in the treatment of nerve pain (neuropathic pain). This medicine calms the damaged or overactive nerves by acting on the patient's brain, thereby decreasing the pain sensation.
Can I stop taking Pregatex AT 10mg/50mg Tablet when my pain is relieved?
No, you should not stop taking Pregatex AT 10mg/50mg Tablet even if your pain is relieved. Continue to take it as advised by your doctor. If you suddenly stop taking Pregatex AT 10mg/50mg Tablet, you may experience withdrawal symptoms such as anxiety, sleeping difficulties, nausea, pain and sweating. You may need to gradually taper the dose before you stop the medication completely.
How to manage weight gain associated with the use of Pregatex AT 10mg/50mg Tablet?
Pregatex AT 10mg/50mg Tablet can make you feel hungry which might make you eat more, thereby increasing your chances of putting on weight. However, preventing weight gain is easier than losing increased weight. Try to eat a healthy balanced diet without increasing your portion sizes (per-meal intake). Do not eat foods that contain a lot of calories, such as soft drinks, oily food, chips, cakes, biscuits, and sweets. If you feel hungry between meals, avoid eating junk food and eat fruits, vegetables and low-calorie foods. Regular exercise will also help prevent weight gain. If you keep good eating habits and exercise regularly, you might not gain any weight.
Can the use of Pregatex AT 10mg/50mg Tablet cause sleepiness or drowsiness?
Yes, Pregatex AT 10mg/50mg Tablet may make you feel drowsy or you may suddenly fall asleep during your daily activities. Sometimes, you might not even feel drowsy or have any other warning signs before you suddenly fall asleep. Avoid driving a car, operating machinery, working at heights or participating in potentially dangerous activities at the beginning of your treatment until you know how the medicine affects you. Inform your doctor if you experience such episodes while taking this medicine.
Can the use of Pregatex AT 10mg/50mg Tablet affect my sex life?
The use of Pregatex AT 10mg/50mg Tablet can affect the sexual life of both men and women. Different sexual problems can occur due to Pregatex AT 10mg/50mg Tablet like decreased sexual desire, erectile dysfunction (inability to develop or maintain erection during the sexual activity) and inability to reach orgasm. It can also cause a decrease in satisfaction and cause discomfort during intercourse. If you experience these problems, discuss with your doctor but do not stop taking Pregatex AT 10mg/50mg Tablet.
Can the use of Pregatex AT 10mg/50mg Tablet change the color of urine?
Yes, Pregatex AT 10mg/50mg Tablet can change the color of the urine to blue or green. This change of color is expected while using Pregatex AT 10mg/50mg Tablet, and it is not harmful. Your urine color becomes normal once you stop taking Pregatex AT 10mg/50mg Tablet.
Are there any serious side effects associated with the use of Pregatex AT 10mg/50mg Tablet?
Serious side effects with Pregatex AT 10mg/50mg Tablet are uncommon and rare. Tell your doctor as soon as possible if you notice changes in body temperature, difficulty in breathing, increased heartbeat (palpitations), weakness, unsteadiness when walking, reduced coordination or slowed reactions, unusual changes in mood or behavior such as restlessness, nervousness, or excitement, signs of depression, seeing or hearing things that are not there, irrational thinking, blurred or double vision, uncontrollable jerky eye movements, difficulty seeing, signs of frequent infections such as fever, severe chills, sore throat or mouth ulcers. These side effects are uncommon but may be serious and may need urgent medical attention.
How long will Pregatex AT 10mg/50mg Tablet take to act?
An initial benefit with Pregatex AT 10mg/50mg Tablet may be seen after 2 weeks of treatment. However, it may take around 2-3 months to see full benefit. It may even take longer in some patients.
What if I forget to take Pregatex AT 10mg/50mg Tablet?
If you forget to take the scheduled dose of Pregatex AT 10mg/50mg Tablet and it is almost time for your next dose, skip the dose you missed and take your next dose at the scheduled time. Otherwise, take it as soon as you remember, and then go back to taking your medicine as you would normally. Do not take a double dose to make up for the dose you missed because this may increase the risk of unwanted side effect due to overdosage. If you are not sure what to do, ask your doctor about taking Pregatex AT 10mg/50mg Tablet.
What if I take too much of this drug by mistake?
In a situation like this, contact your doctor immediately or seek emergency help at the nearest hospital. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. Symptoms of an overdose may include drowsiness, weakness, unsteady when walking, having double visions, slurred speech or diarrhea, confusion, blurred vision, dizziness, body temperature changes (low and high), difficulty in breathing and increased heart beat.
Will a higher than the recommended dose of Pregatex AT 10mg/50mg Tablet be more effective?
No, taking a higher than the recommended dose may not be more effective, rather it may increase the chances of having some serious side effects and toxicity. If you experience increased severity of your symptoms, that are not relieved by the recommended doses, please consult your doctor for re-evaluation.
Is there anything I need to avoid while taking Pregatex AT 10mg/50mg Tablet?
Pregatex AT 10mg/50mg Tablet may impair your thinking or reactions. Be careful while driving or doing an activity that requires you to be alert. Do not drink alcohol while taking Pregatex AT 10mg/50mg Tablet. It can increase the effects of alcohol, which could be dangerous. Grapefruit and grapefruit juice may also interact with this medicine and cause unwanted side effects. Avoid exposure to sunlight or tanning beds. Use of Pregatex AT 10mg/50mg Tablet can make you more prone to sunburns. Wear protective clothing and use sunscreen when you are outdoors during daytime.
How often should I see the doctor?
You may need to see your doctor regularly if you have started taking Pregatex AT 10mg/50mg Tablet. However, you must consult your doctor if the recommended doses do not relieve your symptoms or you experience some unwanted side effects that affect your routine activities.
What are the instructions for the storage and disposal of Pregatex AT 10mg/50mg Tablet?
Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Centaur Pharma. Amitriptyline+Pregabalin. [Accessed 22 Apr. 2019] (online) Available from:
- Thour A, Marwaha R. Amitriptyline. [Updated 2023 Jul 18]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024. [Accessed 16 Sep. 2024] (online) Available from:
- Pregabalin [Prescribing Information]. New York, NY: Parke-Davis; 2018. [Accessed 16 Sep. 2024] (online) Available from:
Marketer details
Name: Zancortex Pharma
Address: H NO 9-8-161/2 BESIDE ANDHRA BANK SAROOR NAGAR HYDERABAD Ranga Reddy Telangana 500035
Country of origin: India
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