Premarin Vaginal Cream
Prescription Required
Product introduction
Premarin Vaginal Cream is used to treat atrophic vaginitis, a condition caused by low estrogen levels. Atrophic vaginitis can lead to vaginal dryness, irritation, itching, and pain during intercourse. Premarin Vaginal Cream replenishes estrogen locally and helps restore moisture, thickness, and elasticity of vaginal tissues.
Premarin Vaginal Cream should be used exactly as prescribed by your doctor. It is applied inside the vagina using the applicator provided, usually at bedtime. For best results, continue using the medicine for the full duration prescribed, even if symptoms improve earlier. Staying hydrated, maintaining good vaginal hygiene, and avoiding irritants like scented soaps or douches can further help relieve symptoms and support treatment effectiveness.
Common side effects include headache, nausea, vomiting, and vaginal irritation, burning, itching, or discharge. These symptoms are usually temporary and improve as the body adjusts to the medication. If irritation persists or worsens, consult your doctor. If you experience unusual symptoms or signs of an allergic reaction, such as severe itching, swelling, or trouble breathing, seek medical attention immediately.
Before using Premarin Vaginal Cream, inform your doctor if you have a history of breast cancer, uterine cancer, blood clots, liver disease, or unexplained vaginal bleeding, as estrogen therapy may not be suitable for you. Avoid using Premarin Vaginal Cream if you are pregnant or breastfeeding. Consider regular medical check-ups, as that will help monitor your response to treatment and ensure safe use.
Uses of Premarin Vaginal Cream
Benefits of Premarin Vaginal Cream
In Treatment of Hormone replacement therapy
Atrophic vaginitis is a condition caused by low estrogen levels, leading to vaginal dryness, irritation, and thinning of the vaginal walls. Premarin Vaginal Cream helps restore moisture and elasticity, relieving symptoms like pain during intercourse (dyspareunia) and severe vaginal dryness and shrinking of the tissues (kraurosis vulvae). Regular use can improve overall vaginal health, making daily activities and intimacy more comfortable.
Side effects of Premarin Vaginal Cream
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Premarin
- Headache
- Breast pain
- Irregular vaginal bleeding
- Vaginal spotting
- Abnormal vaginal bleeding
- Abdominal cramp
- Bloating
- Nausea
- Vomiting
- Hair loss
- Edema (swelling)
- Vaginal yeast infection
- Application site reactions (burning, irritation, itching and redness)
How to use Premarin Vaginal Cream
This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream by using applicator. Wash your hands after applying.
How Premarin Vaginal Cream works
Premarin Vaginal Cream is a mixture of estrogens (a female sex hormone). As a part of the hormone replacement therapy, it works by maintaining the estrogen levels in the body in menopausal women. It also prevents the vaginal wall from becoming thin and dry thereby reducing inflammation.
Safety advice
Alcohol
No interaction found/established
Pregnancy
UNSAFE
Premarin Vaginal Cream is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breast feeding
UNSAFE
Premarin Vaginal Cream is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
No interaction found/established
Kidney
No interaction found/established
Liver
No interaction found/established
What if you forget to take Premarin Vaginal Cream?
If you miss a dose of Premarin Vaginal Cream, apply it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular schedule.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
- Premarin Vaginal Cream can be applied to the external vaginal area or inserted into the vagina using the applicator provided.
- It does not expose the rest of your body to the medicine, thereby avoiding side effects that happen more often with pills.
- Do not have sex right after using Premarin Vaginal Cream, as some of the medicine can be absorbed into your partner's skin.
- Inform your doctor if you experience any vaginal bleeding or spotting, abnormal vaginal discharge, or vaginal discomfort while using Premarin Vaginal Cream.
- Do not use Premarin Vaginal Cream if you are pregnant or breastfeeding or have active or chronic liver dysfunction or disease.
Fact Box
Chemical Class
Estradiol Congeners
Habit Forming
No
Therapeutic Class
GYNAECOLOGICAL
Action Class
Estrogens
Interaction with drugs
Taking Premarin with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.
Concurrent use may increase the risk of formation of blood clo
Avoid concurrent use.
Conjugated Estrogens is not recommended for individuals who have or had breast cancer. Conjugated Estrogens may reduce efficacy of Anastrozole.
Avoid concurrent use.
Conjugated Estrogens is not recommended for individuals who have or had breast cancer. Conjugated Estrogens may reduce efficacy of Fulvestrant.
If concurrent use is essential, watch out for bleeding and consult your doctor immediately. They may monitor your treatment and adjust the doses as per the observations. Conjugated
If concurrent use is essential, watch out for symptoms of Loxapine side effects such as blurred vision, sleepiness, headache, constipation, nausea, dizziness, faintness or fatigue
Patient concerns
User feedback
Patients taking Premarin Vaginal Cream
Once A Day
72%
Twice A Day
14%
Alternate Day
4%
Twice A Week
4%
Once A Week
2%
Thrice A Day
2%
Thrice A week
1%
What are you using Premarin Vaginal Cream for?
Others
48%
Hormone repla*
26%
Dryness in va*
22%
Contraception
4%
*Hormone replacement therapy, Dryness in vagina
How much was the improvement?
Average
42%
Excellent
30%
Poor
27%
What were the side-effects while using Premarin Vaginal Cream?
No Side Effec*
100%
*No Side Effect
How do you take Premarin Vaginal Cream?
With or witho*
100%
*With or without food
Please rate Premarin Vaginal Cream on price
Average
78%
Not Expensive
22%
FAQs
What is Premarin Vaginal Cream, and what is it used for?
Premarin Vaginal Cream is a hormonal medicine that contains a blend of conjugated estrogens, which are female sex hormones. It is used to relieve vaginal symptoms caused by low estrogen levels, commonly occurring during menopause or due to certain medical conditions. Premarin Vaginal Cream helps reduce vaginal dryness, itching, irritation, and discomfort, restoring moisture and improving the thickness and elasticity of vaginal tissues. It helps alleviate pain during intercourse (dyspareunia) and severe vaginal tissue thinning (kraurosis vulvae), improving overall vaginal health and comfort.
How to use Premarin Vaginal Cream?
Use Premarin Vaginal Cream exactly as prescribed by your doctor. Before applying, wash your hands thoroughly. Fill the applicator with the prescribed amount of Premarin Vaginal Cream, then gently insert it into the vagina and press the plunger to release the medication. After application, remove the applicator and clean it properly for future use. Always follow your doctor’s instructions regarding dosage and duration, and do not stop using it abruptly without medical advice.
What if I forget to use Premarin Vaginal Cream?
If you forget to use Premarin Vaginal Cream, apply it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for the missed one, as this may increase the risk of side effects. If you frequently forget doses, consider setting a reminder or discussing alternative treatment options with your doctor.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 501.
- Conjugated estrogens [Prescribing Information]. Philadelphia, PA: Wyeth Pharmaceuticals LLC; 1946 [revised Sep. 2018]. [Accessed 21 Jun. 2019] (online) Available from:
- Conjugated estrogens [Prescribing Information]. Philadelphia, PA: Wyeth Pharmaceuticals Inc.; 2017. [Accessed 20 Feb. 2024] (online) Available from:
- Pfizer: Premarin Vaginal Cream (conjugated estrogens) [Product Information]. 2024. [Accessed 21 Mar. 2025] (online) Available from:
- Conjugated estrogens [Prescribing Information]. Philadelphia, PA: Pfizer Inc.; 2024. [Accessed 20 Mar. 2025] (online) Available from:
- Conjugated Estrogens [Prescribing Information]. Pfizer Inc.; 2024. [Accessed 21 Mar. 2025] (online) Available from:
Marketer details
Name: Pfizer Ltd
Address: The Capital, 1802, 18th Floor , Plot No. C-70, ‘G’ Block , Bandra Kurla Complex, Bandra East , Mumbai – 400051.
Country of origin: Canada
Expires on or after: December, 2025
A licensed vendor partner from your nearest location will deliver Premarin Vaginal Cream. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
Expires on or after: December, 2025
A licensed vendor partner from your nearest location will deliver Premarin Vaginal Cream. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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