Priunta 440 Injection
Prescription Required
Product introduction
Priunta 440 Injection is used in the treatment of breast and stomach cancer. It works by killing the cancer cells by inhibiting HER2 (human epidermal growth factor receptor protein).
Priunta 440 Injection is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include nausea, headache, rash, insomnia, and infection. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels. You must have to inform your doctor if you experience breathlessness, cough, shivering, swelling of legs and arm.
Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Priunta 440 Injection is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include nausea, headache, rash, insomnia, and infection. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels. You must have to inform your doctor if you experience breathlessness, cough, shivering, swelling of legs and arm.
Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of Priunta Injection
Benefits of Priunta Injection
In Breast cancer
Priunta 440 Injection is used to treat breast cancer when other medicines have failed to show significant improvement. It helps to stop cancer growth and further spread and relieves the symptoms of breast cancer such as breast lumps, bloody discharge from nipple or changes in the shape or texture of the breast. This medicine is given as an injection by a doctor or nurse. Follow your doctor’s instructions carefully to get the most benefit.
In Stomach cancer
Stomach cancer also known as gastric cancer, may occur in the inner lining (called mucosa) of the stomach or in the walls of the stomach. These are of various kinds depending on the origin, affected area and severity of the cancer. Priunta 440 Injection helps to kill the cancer cells and also stops their further growth and spread. Follow your doctor’s instructions carefully to get the most benefit.
Side effects of Priunta Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Priunta
- Anemia (low number of red blood cells)
- Chills
- Common cold
- Cough
- Decreased blood cells (red cells, white cells, and platelets)
- Diarrhea
- Fatigue
- Fever
- Headache
- Heart failure
- Infection
- Insomnia (difficulty in sleeping)
- Mucosal inflammation
- Nausea
- Rash
- Stomatitis (Inflammation of the mouth)
- Taste change
- Upper respiratory tract infection
- Weight loss
How to use Priunta Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Priunta Injection works
Priunta 440 Injection is a recombinant IgG1 monoclonal antibody. It works against the HER2 (human epidermal growth factor receptor protein) receptors which are responsible for the over-proliferation of cancer cells in breast cancer and stomach cancer cells. It destroys the cancer cells by inhibiting HER2. It also inhibits various cancer-causing downstream signaling pathways.
Safety advice
Alcohol
UNSAFE
Priunta 440 Injection may cause excessive drowsiness with alcohol.
Pregnancy
CONSULT YOUR DOCTOR
Priunta 440 Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Priunta 440 Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
CONSULT YOUR DOCTOR
It is not known whether Priunta 440 Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney
SAFE IF PRESCRIBED
Priunta 440 Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Priunta 440 Injection may not be needed in these patients. Please consult your doctor.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Priunta 440 Injection in patients with liver disease. Please consult your doctor.
What if you forget to take Priunta Injection?
If you miss a dose of Priunta 440 Injection, please consult your doctor.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Priunta 440 Injection
₹48525/Injection
Canmab 440mg Injection
Biocon
₹54662.74/injection
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Hertraz 440mg Injection
Mylan Pharmaceuticals Pvt Ltd - A Viatris Company
₹58820/injection
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Herclon Injection
Roche Products India Pvt Ltd
₹61270/injection
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Haltrust 440 Injection
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₹54663/injection
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Kintsugi 440mg Injection
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₹24515/injection
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Quick tips
- It is given as an injection into your vein or under the skin, usually over 1 hour.
- Use effective contraception method to prevent pregnancy while taking this medicine and for 7 months after you stop the treatment.
- Your doctor will monitor your heart regularly while taking this medicine. Inform your doctor if you notice symptoms such as breathlessness, cough, shivering, swelling of legs and arm.
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Fact Box
Chemical Class
Monoclonal antibody (mAb)
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
HER2/neu (ErbB2) Inhibitor- Monoclonal antibody
Interaction with drugs
Taking Priunta with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Concurrent use may increase the risk of infections.
Do not use Trastuzumab with Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted).
Voriconazole may raise blood levels of Trastuzumab.
Do not consume Trastuzumab with Voriconazole. If concurrent use is essential, watch out for symptoms such as taste change, naus
Atazanavir may raise blood levels of Trastuzumab.
Do not consume Trastuzumab with Atazanavir. If concurrent use is essential, watch out for symptoms such as taste change, nausea,
Voriconazole may raise blood levels of Trastuzumab.
Do not consume Trastuzumab with Voriconazole. If concurrent use is essential, watch out for symptoms such as taste change, naus
Concurrent use may increase the risk of infections.
Do not use Trastuzumab with Cholera Vaccine (Inactivated).
Patient concerns
FAQs
What are the serious side effects of Priunta 440 Injection?
There are various side effects related to Priunta 440 Injection such as sore throat, fever, chills, excessive tiredness, pale skin, nosebleeds, and other unusual bruising or bleeding. One can also experience stomach pain, seizures, hallucinations, muscle cramps, and spasms. Along with that, nausea or vomiting, loss of appetite, fatigue, rapid heart beat, discoloration of urine; decreased amount of urine, difficulty in urinating, pain when urinating, and other signs of infection can also be observed with the use of Priunta 440 Injection. You should call your doctor immediately if you notice any such symptoms.
How long after Priunta 440 Injection therapy can I get pregnant?
Women of child-bearing age should use effective contraception during Priunta 440 Injection therapy and for 7 months after completing the treatment. You can plan your pregnancy after 7 months of treatment with Priunta 440 Injection.
How long should Priunta 440 Injection be taken?
Patients with early breast cancer should take Priunta 440 Injection for 1 year or until disease recurs, whichever occurs first. It is not advised to extend the treatment beyond 1 year in patients of early breast cancer.
Is fasting required before administering Priunta 440 Injection?
No, fasting is not required before administering Priunta 440 Injection. It should be given under the guidance of a doctor who is experienced in giving cancer chemotherapy and should be given only by a healthcare professional.
How is Priunta 440 Injection given, intravenously or intramuscularly?
There are 2 different formulations available for administration of Priunta 440 Injection, one is given as an infusion into a vein (intravenous infusion) and the other is given as an injection under the skin (subcutaneous injection). It is important to check the product labels to ensure that the correct formulation is being given as prescribed. Priunta 440 Injection intravenous formulation is not for subcutaneous use and should be given as an intravenous infusion only. Your doctor may consider switching your Priunta 440 Injection intravenous treatment to Priunta 440 Injection subcutaneous treatment (and vice versa) if considered appropriate for you.
Can Priunta 440 Injection be given to HER2 negative cancer patients?
No, Priunta 440 Injection cannot be given in patients with HER2 negative cancer cells. Priunta 440 Injection belongs to class of monoclonal antibody. It binds selectively to a protein called human epidermal growth factor receptor 2 (HER2). HER2 is found, in large amounts, on the surface of some cancer cells. When Priunta 440 Injection binds to HER2, it stops the growth and spread of the cancer cells. Therefore, it is only effective in HER2 positive patients (in which HER2 is present) and will not be beneficial for HER2 negative patients (in which HER2 is not present).
Why has my doctor advised for investigations of heart?
Priunta 440 Injection when used with anthracycline class of anti-cancer medicines (eg doxorubicin) may adversely affect your heart. Hence, your doctor needs to check the health of your heart initially before starting treatment and during treatment.
How frequently heart investigations are required?
Heart investigations should be performed at the starting of the treatment. It should be repeated every 3 months during treatment and every 6 months after the discontinuation of treatment until 24 months from the last administration of Priunta 440 Injection. Those patients who already have heart-related problems will require investigations every 12 weeks.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1737.
- Lake DF, Briggs AD, Akporiaye ET. Immunopharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 978.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1390-91.
- Trastuzumab. South San Francisco, California: Genentech, Inc.; 1998 [revised Oct. 2010]. [Accessed 27 Mar. 2019] (online) Available from:
- Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Trastuzumab. [Updated 2019 Jun 30]. [Accessed 19 Feb. 2020] (online) Available from:
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