Probis Plus 2.5mg/6.25mg Tablet
Prescription Required
View available alternative with same salt composition
Product introduction
Probis Plus 2.5mg/6.25mg Tablet is a combination of two medicines used to treat hypertension (high blood pressure). It helps to control blood pressure when a single medication is not effective. It also helps to reduce the chances of any future heart attack and stroke.
Probis Plus 2.5mg/6.25mg Tablet is taken with or without food, preferably in the morning to avoid frequent urination at night. Keep taking it for as long as advised by your doctor. Even if you feel well, do not stop this medicine on your own because high blood pressure often has no symptoms. If you stop taking it, your condition may get worse. Maintaining an active lifestyle through regular exercise, managing your weight, and consuming a healthy diet will also help regulate your blood pressure. Follow your doctor’s advice while taking this medicine.
Common side effects of this medicine include nausea, vomiting, constipation, diarrhea, decreased blood pressure, and fatigue. Consult your doctor if any of these bother you, or get worse, or do not go away. Drink plenty of fluids while taking medication to help alleviate muscle weakness, dry mouth, and extreme thirst. Dizziness or headache may occur due to low blood pressure, but this gets better with time.
Before taking it, let your doctor know if you have any liver or kidney problems. Pregnant or breastfeeding women should also consult their doctor for advice before taking this medicine. You also need to inform your doctor about any other medications you are taking, especially those used to treat high blood pressure or heart conditions. You should have your blood pressure, kidney function, blood sugar level, and the levels of salts such as potassium or magnesium checked regularly to make sure that this medicine is working properly.
Uses of Probis Plus Tablet
Benefits of Probis Plus Tablet
In Treatment of Hypertension (high blood pressure)
Probis Plus 2.5mg/6.25mg Tablet works by blocking the effects of some chemicals on your heart and blood vessels. It slows down your heart rate and helps the heart beat with less force. Additionally, it eliminates excess water from the body and increases urine output. This lowers your blood pressure and helps in reducing your risk of having a stroke, a heart attack, other heart problems, or kidney problems in the future. This medicine needs to be taken regularly to be effective, so keep taking it even if you feel well. Do not stop without talking to your doctor.
Side effects of Probis Plus Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Probis Plus
- Constipation
- Fatigue
- Headache
- Altered blood lipid level
- Decreased magnesium level in blood
- Vomiting
- Decreased blood pressure
- Nausea
- Diarrhea
- Dizziness
- Cold extremities
- Slow heart rate
- Increased blood uric acid
How to use Probis Plus Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Probis Plus 2.5mg/6.25mg Tablet may be taken with or without food.
How Probis Plus Tablet works
Probis Plus 2.5mg/6.25mg Tablet is a combination of two blood-pressure-lowering medicines: Bisoprolol and Hydrochlorothiazide. Bisoprolol is a beta blocker. It works specifically on the heart to improve its efficiency in pumping blood throughout the body. Hydrochlorothiazide is a diuretic that lowers blood pressure by removing extra water from the body. Over time, it also relaxes blood vessels and improves blood flow.
Safety advice
Alcohol
UNSAFE
Do not drink alcohol while you are taking this medicine. Probis Plus 2.5mg/6.25mg Tablet may cause excessive drowsiness when taken with alcohol.
Pregnancy
CONSULT YOUR DOCTOR
The safety of Probis Plus 2.5mg/6.25mg Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding
UNSAFE
Probis Plus 2.5mg/6.25mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
UNSAFE
Probis Plus 2.5mg/6.25mg Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
UNSAFE
Probis Plus 2.5mg/6.25mg Tablet is unsafe to use in patients with kidney disease and should be avoided.
Liver
UNSAFE
Probis Plus 2.5mg/6.25mg Tablet is unsafe to use in patients with liver disease and should be avoided.
What if you forget to take Probis Plus Tablet?
If you miss a dose of Probis Plus 2.5mg/6.25mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Probis Plus 2.5mg/6.25mg Tablet
₹4.97/Tablet
Lodoz 2.5 Tablet
Merck Ltd
₹9.97/tablet
101% costlier
Bisobis H 2.5mg/6.25mg Tablet
Corona Remedies Pvt Ltd
₹5.74/tablet
15% costlier
Quick tips
- Probis Plus 2.5mg/6.25mg Tablet is a combination of two blood pressure-lowering medications used for the treatment of high blood pressure.
- Do not stop taking Probis Plus 2.5mg/6.25mg Tablet suddenly, as it can cause your blood pressure to rise suddenly, thereby increasing the risk of heart attack and stroke.
- It may cause dizziness. If this happens to you, get up slowly when rising from a sitting or lying position.
- It can hide symptoms of low blood sugar if you're diabetic. Monitor your blood sugar levels regularly.
- Probis Plus 2.5mg/6.25mg Tablet may cause dehydration. Drink plenty of fluids and inform your doctor if you develop extreme thirst, muscle weakness, or very dry mouth.
Fact Box
Habit Forming
No
Therapeutic Class
CARDIAC
Patient concerns
FAQs
What is Probis Plus 2.5mg/6.25mg Tablet used for?
Probis Plus 2.5mg/6.25mg Tablet is used to treat high blood pressure. It combines a beta-blocker (bisoprolol) that slows your heart rate with a water pill (hydrochlorothiazide) that helps remove extra salt and fluid from your body, thereby lowering blood pressure.
What are the serious side effects of Probis Plus 2.5mg/6.25mg Tablet?
Serious side effects of Probis Plus 2.5mg/6.25mg Tablet may include allergic reactions, slow or irregular heartbeat, severe dizziness, difficulty breathing, swelling, or signs of skin cancer. If you notice any of these, contact a doctor immediately.
What should I avoid while taking Probis Plus 2.5mg/6.25mg Tablet?
While taking Probis Plus 2.5mg/6.25mg Tablet, you should avoid alcohol, certain decongestants, and medicines that affect your heart or sugar levels without consulting your doctor. They may increase side effects or reduce the medicine’s effectiveness.
Can Probis Plus 2.5mg/6.25mg Tablet affect my eyes or vision?
Although rare, Probis Plus 2.5mg/6.25mg Tablet may affect your eyes or vision. Some people may experience dry eyes, reduced tear flow, eye pain, or even vision loss due to fluid pressure in the eye. Contact your doctor if you notice any eye issues.
Can I stop taking Probis Plus 2.5mg/6.25mg Tablet if I feel better?
No, you should not stop taking Probis Plus 2.5mg/6.25mg Tablet suddenly, as it can cause your blood pressure to rise again quickly. Always follow your doctor’s instructions before stopping.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Bisoprolol fumarate and hydrochlorothiazide. Pomona, New York: Duramed Pharmaceuticals, Inc.; 2011. [Accessed 11 Apr. 2019] (online) Available from:
- Hydrochlorothiazide: Important Patient Information. Rochester, New York: University of Rochester Medical Center. [Accessed 06 Feb. 2019] (online) Available from:
- Bisoprolol Fumarate and Hydrochlorothiazide [Prescribing Information]. Burbank, CA: Bryant Ranch Prepack, Inc.; 2025. [Accessed 20 Jan. 2026] (online) Available from:
Marketer details
Name: Aci Pharma Pvt Ltd
Address: S402a, School Block, Shakarpur, Delhi - 110092
Country of origin: India
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₹49.7
Inclusive of all taxes
MRP₹56.44 12% OFF
10.0 tablets in 1 strip
SOLD OUT
Available alternative with same salt composition
Lodoz 2.5 Tablet
strip of 10 tablets
by Merck Ltd
Get by 11pm
₹99.7
10% off
Bisoprolol (2.5mg) + Hydrochlorothiazide (6.25mg)