Prothiaden Tablet is a tricyclic antidepressant. It is mostly used to treat depression that is unresponsive to alternative treatment. It is also used in the management of anxiety disorder.
Prothiaden Tablet works by increasing the levels of chemical messengers in the brain that stabilizes and enhances the mood. It is better to take it before bedtime because it can make you feel drowsy. It can be taken with or without food, but you should take it at a fixed time each day for better efficacy. The dose and duration will be decided by your doctor so that you get the right amount to control your symptoms. Do not skip any dose and finish the full course of treatment even if you feel better. This medication must not be stopped suddenly without talking to the doctor. Your dose may be modified or gradually decreased before stopping the medication.
The most common side effects of Prothiaden Tablet include increased heart rate, blurred vision, dryness in the mouth, and constipation. Initially, this medicine may also cause a sudden drop in blood pressure, especially when you change positions. It may even cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. It may also lead to weight gain in some people. Most of the common side effects tend to be mild and temporary. Your doctor may be able to suggest ways of preventing or reducing them. Serious side effects associated with this medicine are rare.
Before taking this medicine, it is important to tell your doctor if you are taking or have recently taken any other medicines for the same or any other diseases. Pregnant and breastfeeding women should take this medicine with proper consultation and caution. This medicine is not known to be addictive, but you can experience additional side effects (withdrawal symptoms) if you stop taking it suddenly. If you notice any sudden mood change or get suicidal or self-harm thoughts, you must consult the doctor without delay. Also, remember to take this medicine strictly as advised by the doctor as an overdose of this medication may lead to a serious health emergency. Consumption of alcohol should strictly be avoided as alcohol interacts with this medicine to cause serious health issues.
Prothiaden Tablet is thought to work by stopping your brain from releasing the chemicals that make you feel anxious so it can reduce the symptoms of excessive anxiety and worry. It can also reduce feelings of restlessness, tiredness, difficulty concentrating, irritability, and sleep problems that often come with Generalised Anxiety Disorder. It will, therefore, help you go about your daily activities more easily and be more productive. Keep taking this medicine even if you feel well. Stopping suddenly can cause serious problems.
Side effects of Prothiaden Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Prothiaden
Dryness in mouth
Increased heart rate
Orthostatic hypotension (sudden lowering of blood pressure on standing)
Difficulty in urination
Constipation
Blurred vision
How to use Prothiaden Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Prothiaden Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Prothiaden Tablet works
Prothiaden Tablet is a tricyclic antidepressant. It increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression.
Safety advice
Alcohol
UNSAFE
Prothiaden Tablet may cause excessive drowsiness with alcohol.
Pregnancy
CONSULT YOUR DOCTOR
Prothiaden Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Prothiaden Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Prothiaden Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CONSULT YOUR DOCTOR
There is limited information available on the use of Prothiaden Tablet in patients with kidney disease. Please consult your doctor. However, some studies suggest a cautious use of this medicine in patients with kidney disease.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Prothiaden Tablet in patients with liver disease. Please consult your doctor.
What if you forget to take Prothiaden Tablet?
If you miss a dose of Prothiaden Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Diabetes from past 22 years. Now I am suffering from severe leg pain during night. It's is a neoropathic pain and is unbearable. I have been taking pregabalin-more m and neurocap od. Please suggest me how to deal with this pain.
Dr. Vikas Sharma
Neurology
do nerve conduction; start tab prothiaden 50 mg at nite
Lower back pain.After MRI doctor say sciatica problem. Take medicine. But not completely overcome from this problem.when walking some problem feel in waste and knee region Some mild press in ls4 and LS5
Sir, I have been prescribed prothiaden for depression before 1 year and i'm recovered Now I'm taking inosert-sterline for anxiety both these medicines are prescribed by a psychiatrist kindly help me to know difference between the medicines
Dr. Jyoti Kapoor Madan
Psychiatry
Prothiaden belongs to TCA class od antidepressants and Sertraline belongs to SSRI group of antidepressants. The side effect profile of SSRIs is better and therefore these drugs are more ofte prescribed and can be continued for prolonged periods.
Depression is a persistent state of sadness that is the result of interaction between one's inner biological and psychological state and gets triggered of with environmental stressors. Reactive depression is in response to a situation like loss, sickness, trauma etc. Endogenous depression occurs without any noticeable environmental stressors. Psychological symptoms include lack of interest, negative thinking, irritability, frustration, feeling demotivated etc. Somatic symptoms like fatigue/ weakness/ lack of sleep/ lack of appetite and other physical symptoms are common. Anxiety is common. In severe cases one may feel helpless and hopeless enough to wish for death or attempt suicide. Treatment includes physical and psychiatric work up following which medicines can be prescribed. In milder cases, psychotherapy or counselling is recommended.
Right side headache. Diabetes patient. On novomix 30 44 IU , metformin 1gm, januvia 100mg, rosuvas 10mg. Taking prothiaden 75, nexito forte , mirtaz 7.5 but not getting some relief from headache. Please advice something
Dr. Jyoti Kapoor Madan
Psychiatry
Based on your clinical history, your doctor plans the type of medicine and it's dose and duration. For first episode of anxiety/ depression/ panic, the usual maintenance phase is 6 months of asymptomatic period, after which medicines can be gradually tapered. But treatment may need to continue longer depending on severity and frequency of episodes. Treatment for Recurrent Depressive Disorder , psychotic disorders, Bipolar Affective Disorder and OCD usually lasts for much longer.To monitor any potential side effects and to take any decision to change medication or stop them, several factors have to be taken in account for which regular follow up with your psychiatrist is important. For second opinion, seek a proper consultation with another psychiatrist and take along your previous prescriptions.
Doctor I had done my tonsilitis operation 2years ago as I had an allergic tonsils to cold. But now from past 3montgs that is from January I have throat pain, I had taken cefixime, then cefpodixim proxetil for throat pain as instructed by My physician. Then but my pain did not subside, then knew that I have molar pain as my wisdom tooth was growing horizontally leading to throat pain. Now I have removed the tooth it's been 28 days But still have throat pain Then my physician prescribed for Evion LC tab. I have taken for one week but still my pain is not reducing. Please guide me These are the medicine recently prescribed EVION LC AND ETOVA P 400
Dr. Shubhra Chandan Pradhan
ENT
It needs clinical examination to diagnose. Can try prothiaden 10 mg twice daily
What were the side-effects while using Prothiaden Tablet?
No Side Effec*
38%
Dryness in mo*
22%
Weight gain
10%
Orthostatic h*
8%
Increased hea*
8%
*No Side Effect, Dryness in mouth, Orthostatic hypotension (sudden lowering of blood pressure on standing), Increased heart rate
How do you take Prothiaden Tablet?
With food
70%
With or witho*
30%
*With or without food
Please rate Prothiaden Tablet on price
Average
50%
Expensive
26%
Not Expensive
25%
FAQs
What is Prothiaden Tablet used for?
Prothiaden Tablet is a medicine used to treat anxiety disorder and depression that is unresponsive to other alternative medicines. It is also used to relieve nerve pain and fibromyalgia. Prothiaden Tablet should be taken only if prescribed by a doctor, exactly as directed.
Is Prothiaden Tablet a muscle relaxant?
No. Prothiaden Tablet is not a muscle relaxant. It is a tricyclic antidepressant (TCA) used in the treatment of depression, nerve pain, and anxiety disorder.
What is the difference between Prothiaden Tablet and amitriptyline?
Prothiaden Tablet is chemically related to Amitriptyline and both are tricyclic antidepressant (TCA) medicine. There is overlap in pharmacological property of this medicine.
Is Prothiaden Tablet the same as doxepin?
Prothiaden Tablet and doxepin are different medicines but belong to the similar chemical class. Doxepin, at low doses, can improve sleep in patients with insomnia. It is also available in the topical form for use in various neuro-dermatitis syndrome, especially itching.
How to stop Prothiaden Tablet?
If your doctor asks you to stop Prothiaden Tablet, you should reduce the dose slowly over 4 weeks. You should not discontinue it abruptly. Sudden discontinuation may cause aggression, anxiety, blurred vision, concentration impairment, constipation and crying spell.
Is Prothiaden Tablet fatal?
Yes. Prothiaden Tablet can be fatal (can cause death) in overdose. This is due to a life-threatening or dangerous side effect in overdose like hyperthermia, seizure, arrhythmia, tachycardia, orthostatic hypotension or sudden death. That's why it is generally not considered a first-line option for depression because of side effect profile.
Can I take Prothiaden Tablet with diazepam?
It is better to avoid this combination. Diazepam is a sedative drug and Prothiaden Tablet may cause sedation as a side effect too. Taking both of them together can increase the drowsiness or sleepiness. Inform your doctor if you are taking diazepam.
Can Prothiaden Tablet be used in the treatment of trigeminal neuralgia?
No. Prothiaden Tablet is not approved for the treatment of trigeminal neuralgia. Trigeminal neuralgia is a chronic pain condition that affects the trigeminal or 5th cranial nerve, one of the most widely distributed nerves in the head.
Can Prothiaden Tablet be used in the treatment of burning mouth syndrome?
No. Prothiaden Tablet is not approved for the treatment of burning mouth syndrome. Burning mouth syndrome is a painful condition of mouth that is burning, scalding, tingling or feeling of numbness that may occur every day for months or longer.
Can I take Prothiaden Tablet for depression?
Yes. Prothiaden Tablet is indicated for the treatment of depression. It has a potential advantage in the patient with depression if associated with insomnia and anxiety. It is generally not considered a first-line option for depression because of side effect profile but very useful for severe or treatment-resistant depression.
Can Prothiaden Tablet used to treat IBS (Irritable Bowel Syndrome)?
No. Prothiaden Tablet is not approved for the treatment of Irritable Bowel Syndrome (IBS). Irritable Bowel Syndrome is a functional gastrointestinal disorder characterised by chronic or recurrent abdominal pain or discomfort associated with altered bowel habits.
Can Prothiaden Tablet be used to treat insomnia with depression?
Yes. Prothiaden Tablet may be used for the treatment of insomnia (too much arousal both at night and during the day) associated with depression. Because it can cause drowsiness or sedation as side effects, it is effective in treating insomnia associated with depression.
Can I use Prothiaden Tablet for fibromyalgia?
Yes. Prothiaden Tablet is not approved for the treatment of fibromyalgia. Fibromyalgia is a pain syndrome with tenderness but no structural pathology in muscles, ligamanets or joints.
Can I use Prothiaden Tablet for nerve pain?
Yes. Prothiaden Tablet is indicated for the treatment of nerve pain/neuropathic pain. Chronic pain/Neuropathic pain is described as pain that arises from damage to, or dysfunction of, any part of peripheral or central nervous system. It is associated with the disease which can affect nerves like diabetes mellitus or herpes infections.
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References
Stahl SM, editor. Dothiepin. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 205-10.
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 20 Mar. 2019] (online) Available from:
PubChem. Dothiepin. [Accessed 22 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 22 Mar. 2019] (online) Available from:
Dosulepin [Package Insert]. Debrecen, Hungary: TEVA Pharmaceutical Work Private Limited; 2021. [Accessed 25 Jul. 2024] (online) Available from: