Provenef 49mg/51mg Tablet is a combination of two medicines used to treat heart failure. It reduces the risk of hospitalization and death in patients with long-lasting (chronic) heart failure. It is generally given along with other heart failure medications.

Provenef 49mg/51mg Tablet may be taken with or without food. Take it at the same time each day for maximum benefits. Your doctor will decide the dose and how often you take it, and it may change depending on how well you respond to the medicine. Keep taking the tablets regularly, as prescribed, and try not to miss doses to get the most benefit. Do not stop taking them, even if you are feeling well. The medicine prevents future complications.

Common side effects of this medicine include low blood pressure (hypotension), impaired renal function, high potassium levels in the blood (hyperkalemia), cough, and dizziness. To reduce the risk of dizziness that may be caused by low blood pressure, try getting up slowly from a sitting or lying position. Tell your doctor if these or other side effects are severe or do not go away.

Before taking this medicine, tell your doctor if you are taking any other medication for blood pressure or heart conditions or if you have kidney or liver disease. Also, let your doctor know all other medications you are using as they may affect, or be affected by, this medicine. This medicine should not be taken during pregnancy and is not recommended while breastfeeding. While on treatment with this medicine, your doctor may advise regular monitoring of blood pressure and regular kidney function.

Uses of Provenef Tablet

Treatment of Heart failure

Benefits of Provenef Tablet

In Treatment of Heart failure

Heart failure means your heart is weak and cannot pump enough blood to your lungs and the rest of your body. The most common symptoms are breathlessness, tiredness, and swelling in your legs, ankles, abdomen, and other body parts. Provenef 49mg/51mg Tablet is a combination of two medicines, namely valsartan and sacubitril. Both of these medicines work in different ways to lower blood pressure. This makes it easier for your heart to pump blood around your body and is, therefore, an effective treatment for heart failure.

This medicine will help relieve your symptoms, making you feel better and more energetic. To help this medicine be effective, you should make appropriate lifestyle changes (such as eating healthily and staying active). Take it regularly and keep taking it even if you feel better.

Side effects of Provenef Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Provenef

Hypotension (low blood pressure)
Increased potassium level in blood
Cough
Dizziness
Renal impairment

How to use Provenef Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Provenef 49mg/51mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Provenef Tablet works

Provenef 49mg/51mg Tablet is a combination of two medicines: Sacubitril and Valsartan which belong to a class of angiotensin receptor neprilysin inhibitor (ARNI). This combination treats heart failure by relaxing the blood vessels and making it easier for your heart to pump blood throughout your body. In addition, it also helps your body retain less water.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Provenef 49mg/51mg Tablet.

Pregnancy

CONSULT YOUR DOCTOR

Provenef 49mg/51mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Provenef 49mg/51mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Provenef 49mg/51mg Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Provenef 49mg/51mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Provenef 49mg/51mg Tablet may be needed. Please consult your doctor.
Regular blood pressure monitoring is recommended. No dose adjustment is needed in patients with mild to moderate kidney disease.

Liver

CAUTION

Provenef 49mg/51mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Provenef 49mg/51mg Tablet may be needed. Please consult your doctor.
No dose adjustment is recommended in patients with mild to moderate liver disease.

What if you forget to take Provenef Tablet?

If you miss a dose of Provenef 49mg/51mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Provenef 49mg/51mg Tablet

₹33.5/Tablet

CIDMUS 100mg Tablet

Dr Reddy's Laboratories Ltd

₹49.79/tablet

49% costlier

Vymada 100mg Tablet

Novartis India Ltd

₹61.57/tablet

84% costlier

Arnicor 100 Tablet

Cipla Ltd

₹31.4/tablet

6% cheaper

Sacu-V 100 Tablet

Glenmark Pharmaceuticals Ltd

₹32.36/tablet

3% cheaper

Hefcard 49mg/51mg Tablet

Torrent Pharmaceuticals Ltd

₹37.8/tablet

13% costlier

View all substitutes

Quick tips

You have been prescribed Provenef 49mg/51mg Tablet for the treatment of long-lasting (chronic) heart failure.
You should continue to be active (light walking, stretching) and eat a healthy, low-sodium diet while taking this medication.
To reduce the chances of feeling dizzy, rise slowly if sitting or lying down.
It may raise the level of potassium in your blood. Avoid taking potassium supplements and eating potassium-rich foods such as bananas and broccoli.
Inform your doctor if you have a history of liver or kidney diseases.
Do not take Provenef 49mg/51mg Tablet if you are pregnant or breastfeeding.

Fact Box

Habit Forming

Therapeutic Class

CARDIAC

Patient concerns

What is BNP test? Pls explain. What is BNP ASSAY?My result is133.0 explain

Dr. Manju Singh

Homeopathy

BNP levels below 100 pg/mL indicate no heart failure. BNP levels of 100-300 pg/mL suggest heart failure is present. BNP levels above 300 pg/mL indicate mild heart failure. BNP levels above 600 pg/mL indicate moderate heart failure.The level of BNP in the blood increases when heart failure symptoms worsen, and decreases when the heart failure condition is stable

Myself is high B.P patients .There is some swelling in the face today . what is going on?

Dr. Pushkar Mani

Physician

Kidney damage or heart failure

my mom heart ef is 35 she suffer congestive heart failure says heart rythum is not good aa result he suggest for pacemaker when she admit ef is 30 and after 10 days it shows 35 show it will increase naturally or use medicine life time any medicine in aurveda to live long and natural also suggeat intake only 2liter water a day please suggest me waiting for ur answer thanks

Dr. Deepak Kumar Soni

Ayurveda

Hi Need to consult to face to face kindly visit any ayurveda doctor at your city

What for Nefrosave tablet is recommended ???

Dr. Sanjay Bhatt

Physician

Nefrosave Tablet Uses Nefrosave Tablet is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms: High Blood Pressure Join 148 Pro Subscribers Hereditary Disorder Affecting The Exocrine Glands Hepatitis Join 48 Pro Subscribers Carbon Tetrachloride Poisoning Join 75 Pro Subscribers Acute Bronchitis Join 74 Pro Subscribers Chronic Bronchitis Paracetamol Poisoning Congestive Heart Failure High Cholesterol

Hi! My diagnosed me with Tinea Cruris which is like a red patch between my thighs near my genitals so he recommended me ITRASYS-200 MG (Twice Daily) for 30 days and gave an ointment EBERNET-M. After taking them the Tinea was almost gone when suddenly I had a breakout again and it itches a lot. I would appreciate your opinion on this matter. Thanks! :) Also kindly let me know should I take the same again? Or maybe if you could be able to suggest something better?

Dr. Souvik Sardar

Dermatology

Apply ebernet cream not ebernet m Twice daily for 6wksStart itraconazole 200 mg - 1cap daily after lunch for 3wksTake itraconazole only if u dnt HV any heart problem like heart failure

FAQs

Who should avoid taking Provenef 49mg/51mg Tablet?

Patients who are allergic to any of its components should avoid Provenef 49mg/51mg Tablet. Those who are allergic to the use of ACE inhibitors or ARBs should also avoid using this medicine. It should not be used along with other antihypertensive medicines. Do not take it for at least 36 hours before or after you take an ACE inhibitor medicine. If you are not sure, consult your doctor.

What should I tell my doctor before taking Provenef 49mg/51mg Tablet?

Tell your doctor about all of your medical conditions, including liver or kidney disease and a history of facial swelling (angioedema). Inform him if you are pregnant or are breastfeeding. Also, inform your doctor about all medicines you are taking, especially potassium supplements or medicine salt, painkillers, blood pressure, or heart failure medicines (such as ACE inhibitors, ARBs, or Aliskiren).

Can I use Provenef 49mg/51mg Tablet in pregnancy?

No, Provenef 49mg/51mg Tablet should be avoided in pregnancy. Its use can cause injury or even endanger the life of the baby. If you become pregnant while using Provenef 49mg/51mg Tablet, stop using it and contact your doctor immediately.

How would I know if I have high potassium levels?

Your doctor will check your blood potassium levels periodically to detect high potassium levels (hyperkalemia). Make sure that you do not miss any scheduled appointments with the doctor.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Medscape. Sacubitril+Valsartan. [Accessed 24 Apr. 2019] (online) Available from:
Sacubitril+Valsartan. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation; 2015 [revised Nov. 2018]. [Accessed 24 Apr. 2019] (online) Available from:
Sacubitril and Valsartan [Prescribing Information]. Telangana, India: MSN Laboratories Private Limited; 2023. [Accessed 28th Sept. 2023] (online) Available from:
Sacubitril and Valsartan [Product Monograph]. Dublin 4, Ireland: Novartis Europharm Limited.2020. [Accessed 28th Sept. 2023] (online) Available from:
Sacubitril and valsartan [Prescribing Information]. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation; 2024. [Accessed Oct. 10, 2024] (online) Available from:

Marketer details

Name: Pulse Pharmaceuticals

Address: 4F10, Ballad Estates, Tarnaka, Hyderabad - 500017, TS, India.

Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.