Pylozol 40mg Tablet is used to treat conditions related to excessive stomach acid production, such as gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger-Ellison syndrome. It reduces the amount of acid produced in the stomach and provides relief from symptoms and promotes healing.

Pylozol 40mg Tablet can also be used to prevent stomach ulcers caused by certain medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs). Take the medicine as per your doctor's prescription. The dose will depend on what you are being treated for, but it is usually the lowest dose for the shortest time that is needed to treat your condition. It is usually taken on an empty stomach, preferably in the morning or at least 1 hour prior to meal. Continue taking the medicine even if your symptoms disappear until the doctor say it is okay to stop. If you are taking this medicine for a long time, your doctor may carry out regular tests to check your levels of magnesium which can fall with this medicine.

Common side effects include headache, constipation or diarrhea, stomach pain, and feeling or being sick. These tend to be mild but talk to your doctor if they bother you or do not go away. The risk of side effects may increase the longer you take this medicine. You may be more likely to have a broken bone if you take it for a long time. It is best to avoid foods that seem to make your symptoms worse, such as rich, spicy, and fatty foods. Cutting down on caffeinated drinks, such as tea, coffee, and cola, as well as alcohol may also help.

This medicine is not suitable for some people. Before taking this medicine, you need to tell your doctor if you have severe liver problems, are taking medicines for HIV, have had an allergic reaction to similar medicines in the past, or have osteoporosis. Alcohol does not interfere with the way Pylozol 40mg Tablet works. However, drinking alcohol makes your stomach produce more acid than normal. This medicine can make you feel dizzy, sleepy, or affect your vision. If this happens, do not drive, cycle, or use machinery or tools until you feel better. It is not usually recommended during pregnancy and breastfeeding.

Uses of Pylozol Tablet

Acidity
Gastroesophageal reflux disease (Acid reflux)
Peptic ulcer disease
Treatment of Zollinger-Ellison syndrome

Benefits of Pylozol Tablet

In Treatment of Zollinger-Ellison syndrome

Zollinger-Ellison syndrome is a rare disorder where excessive stomach acid production leads to multiple peptic ulcers. Symptoms include abdominal pain, diarrhea, and heartburn. Pylozol 40mg Tablet By reducing the production of stomach acid, it helps alleviate symptoms such as abdominal pain, heartburn, and diarrhea. Esomeprazole also aids in the healing of peptic ulcers, which are common in this condition. By controlling the excessive acid secretion associated with Zollinger-Ellison syndrome, esomeprazole helps improve the overall digestive health and prevents complications such as gastrointestinal bleeding.

Side effects of Pylozol Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Pylozol

Headache
Dryness in mouth
Nausea
Abdominal pain
Constipation
Flatulence
Diarrhea

How to use Pylozol Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pylozol 40mg Tablet is to be taken empty stomach.

How Pylozol Tablet works

Pylozol 40mg Tablet is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in relief of acid related indigestion and heartburn.

Safety advice

Alcohol

CAUTION

Caution is advised when consuming alcohol with Pylozol 40mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Information regarding the use of Pylozol 40mg Tablet during pregnancy is not available. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Pylozol 40mg Tablet during breastfeeding is not available. Please consult your doctor.
Caution should be exercised when Pylozol 40mg Tablet is administered to breastfeeding women.

Driving

UNSAFE

Pylozol 40mg Tablet may cause side effects which could affect your ability to drive.
In rare cases, Pylozol 40mg Tablet may cause dizziness and blurred vision, do not drive or use machines if you experience such symptoms.

Kidney

SAFE IF PRESCRIBED

Pylozol 40mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Pylozol 40mg Tablet is recommended.
However, due to lack of data, exercised should be caution in patients with severe renal insufficiency.

Liver

CAUTION

Pylozol 40mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Pylozol 40mg Tablet may be needed. Please consult your doctor.
However, no dose adjustment is required for patients with mild to moderate liver disease.

What if you forget to take Pylozol Tablet?

If you miss a dose of Pylozol 40mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Pylozol 40mg Tablet

₹9.6/Tablet

Esomefol Tablet

Leeford Healthcare Ltd

₹5.8/tablet

40% cheaper

Espra 40mg Tablet

Zydus Cadila

₹8.8/tablet

8% cheaper

Nexpro 40 Tablet

Torrent Pharmaceuticals Ltd

₹12.53/tablet

31% costlier

Sompraz 40 Tablet

Sun Pharmaceutical Industries Ltd

₹11.73/tablet

22% costlier

Esomac 40 Tablet

Cipla Ltd

₹12.8/tablet

33% costlier

View all substitutes

Quick tips

It is a well-tolerated medicine and provides relief for a long time.
Some healthy tips to prevent acidity from happening:
- Avoid excessive intake of carbonated beverages/soft drinks, citrus juices, fried food, caffeinated beverages like tea and coffee.
- Avoid alcohol and smoking.
- Avoid eating late at night or before bedtime.
Inform your doctor if you get watery diarrhea, fever or stomach pain that does not go away.
Long-term use of Pylozol 40mg Tablet can cause weak bones and a deficiency of minerals such as magnesium. Take adequate dietary intake of calcium and magnesium or their supplements as prescribed by your doctor.
Consult your doctor right away if you develop decreased urination, edema (swelling due to fluid retention), lower back pain, nausea, fatigue, and rash or fever. These could be signs of a kidney problem.
Pylozol 40mg Tablet should be taken 1 hour before a meal, preferably in the morning.
It is a well-tolerated medicine and provides relief for a long time.
Some healthy tips to prevent acidity from happening:
- Avoid excessive intake of carbonated beverages/soft drinks, citrus juices, fried food, caffeinated beverages like tea and coffee.
- Avoid alcohol and smoking.
- Avoid eating late at night or before bedtime.
Inform your doctor if you get watery diarrhea, fever or stomach pain that does not go away.
Inform your doctor if you do not feel better after taking it for 14 days as you may be suffering from some other problem that needs attention.
Long-term use of Pylozol 40mg Tablet can cause weak bones and a deficiency of minerals such as magnesium. Take adequate dietary intake of calcium and magnesium or their supplements as prescribed by your doctor.
Consult your doctor right away if you develop decreased urination, edema (swelling due to fluid retention), lower back pain, nausea, fatigue, and rash or fever. These could be signs of a kidney problem.

Fact Box

Chemical Class

Sulfinylbenzimidazole Derivative

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

Proton-Pump Inhibitors

Interaction with drugs

Taking Pylozol with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Erlotinib (Oral Route) Severe

Esomeprazole may reduce blood levels of Erlotinib. Do not consume Erlotinib with Esomeprazole.

Clomipramine (Oral Route) Moderate

Esomeprazole may decrease the metabolism of Clomipramine. If concurrent use is essential, watch out for symptoms such as drowsiness, fatigue, dizziness, dry mouth, constipation, b... More

Cilostazol (Oral Route) Moderate

Esomeprazole may raise blood levels of Cilostazol. If concurrent use is essential, watch out for symptoms of Cilostazol side effects such as headache, palpitations, dizziness, swe... More

Cefpodoxime Proxetil (Oral Route) Moderate

Citalopram (Oral Route) Moderate

Esomeprazole may increase the rate of release of Citalopram in the blood. If concurrent use is essential, please consult your doctor. Factors such as old age, chronic heart issues... More

View all drug interactions

Patient concerns

Heartburn Mental disorder Depression Frequent persistent heartburn Gastroesophageal reflux disease Irritable bowel syndrome Indigestion Back flow of acid from stomach Difficulty in swallowing Inflammation of esophagus Excess acid secretion by stomach Intestinal or stomach ulcers

Dr. Sunil Sekhri

Diabetology

You need to be examined in clinic to reach a diagnosis and then appropriate medicine can be prescribed

Moderate Throat Pain in left side Moderate Ear pain. Acid reflux too often

Dr. Vijay Verma

ENT

it may be due to acidity also you may have got some ulcer or infection in that region visit ent specialist near you for proper examination

Suffering from acid reflux disease due to which pain in throat and right side of lower abdomen

Dr. Saurav Arora

Homeopathy

Dear sir for the time being you can take Robinia 30, 04 drops in half cup water and Nixocid tab 2 tab thrice daily for a month, but as this case needs supervision, discussion and examination you need to visit a homeopath so that he can discuss your case in detail, get some investigations, do examination and guide you accordingly,

FAQs

What is the best time to take Pylozol 40mg Tablet?

Usually, Pylozol 40mg Tablet is taken once a day, first thing in the morning. If you take Pylozol 40mg Tablet twice a day, take 1 dose in the morning and 1 dose in the evening. The tablets should be swallowed whole (remember not be chewed or crushed) and taken at least 1 hour before a meal with some water.

Can I take Pylozol 40mg Tablet with domperidone?

Yes, Pylozol 40mg Tablet can be safely taken with domperidone as no harmful effects have been reported clinically. A fixed-dose combination of these two medicines is also available. Domperidone works by increasing the gut motility and Pylozol 40mg Tablet decreases the acid production in the stomach. So, this combination is very effective in the treatment of reflux esophagitis associated with acidity, heartburn, intestinal and stomach ulcers.

Can I take antacids along with Pylozol 40mg Tablet?

Yes, you can take antacids along with Pylozol 40mg Tablet. Take it 2 hours before or after you take Pylozol 40mg Tablet.

Can I take Pylozol 40mg Tablet for a long term?

Pylozol 40mg Tablet is usually prescribed for short term use only. However, if need arises, such as for treating peptic ulcer disease and Zollinger Ellison syndrome (ZES), Pylozol 40mg Tablet may be prescribed for a long term duration as well. Long term use may carry an increased risk for side effects and must be discussed with the doctor. Please use Pylozol 40mg Tablet as advised by your doctor and under their supervision.

What are the long term side effects of Pylozol 40mg Tablet?

If Pylozol 40mg Tablet is used for more than 3 months, certain long term side effects may be seen. The most important of these is low magnesium levels in your blood which may make you feel tired, confused, dizzy, shaky or dizzy. You may also have muscle twitches or irregular heartbeat. If the use is further prolonged for more than a year, you may have an increased risk of bone fractures, stomach infections and vitamin B12 deficiency. Vitamin B12 deficiency can make you anemic, as a result of which you may feel more tired, weak, or pale. Additionally you may have palpitations, shortness of breath, lightheadedness, indigestion, loss of appetite, flatulence (gas) or nerve problems such as numbness, tingling and problem in walking.

Can I stop taking Pylozol 40mg Tablet if I feel better?

If you have been taking Pylozol 40mg Tablet for a long time, stopping it abruptly may lead to increased acid production, thereby worsening your symptoms. Therefore, you must discuss any dose changes or if you wish to come off Pylozol 40mg Tablet.

Can Pylozol 40mg Tablet cause weight gain?

Weight gain is reported in less than 1% of the patients taking Pylozol 40mg Tablet but the exact cause is unknown. One possible explanation is higher food intake once the reflux symptoms are relieved. Lifestyle modifications such as proper diet and exercise can help to prevent weight gain.

Is Pylozol 40mg Tablet safe to use?

Yes, Pylozol 40mg Tablet is relatively safe to use. Most of the people who take Pylozol 40mg Tablet do not get a side effect. It is advised to be taken as directed by the doctor for maximum benefit.

Can I take Pylozol 40mg Tablet with ranitidine?

Yes, Pylozol 40mg Tablet can be taken with ranitidine. According to research reports, there are no significant interactions seen between Pylozol 40mg Tablet and ranitidine. However, you must take them together only if prescribed by the doctor.

Can I take alcohol with Pylozol 40mg Tablet?

No, alcohol intake is not advised with Pylozol 40mg Tablet. Alcohol itself does not affect the working of Pylozol 40mg Tablet, but it can increase the acid production. This may further cause worsening of your symptoms

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Wallace JL, Sharkey KA. Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman's: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: The McGraw-Hill Companies, Inc.; 2011. [Accessed 24 Jan. 2019] (online) Available from:
Esomeprazole. Wilmington, DE: AstraZeneca Pharmaceuticals; 1989 [revised Dec. 2014]. [Accessed 28 Mar. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Esomeprazole. [Updated 2019 Jun 3]. [Accessed 20 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 28 Mar. 2019] (online) Available from:
Esomeprazole [Prescribing Information]. Haridwar, Uttarakhand: Pure & Cure Healthcare Pvt. Ltd.; 2023. [Accessed 22 Jun. 2023] (online) Available from:
Esomeprazole [Prescribing Information]. Haridwar, Uttarakhand: Pure & Cure Healthcare Pvt. Ltd.; 2023. [Accessed 22 Jun. 2023] (online) Available from:

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