Rifabutin 150mg Tablet
Prescription Required
Product introduction
Rifabutin 150mg Tablet is an antibiotic, used in the treatment of tuberculosis with HIV (human immunodeficiency virus) infection. It helps to fight germs (bacteria) called mycobacteria, which cannot be destroyed by other antibiotics in people who have a weaker immunity.
Rifabutin 150mg Tablet may be used alone or in combination with other medicines to help prevent serious infections caused by microorganisms like mycobacterium avium complex (MAC). It should be taken in the dose and duration as advised by the doctor. This medicine should be taken on an empty stomach. It is better to take it at the same time each day to get the most benefit and you should keep on taking this medicine for as long as you are prescribed. Stopping it early may make the infection to come back and harder to treat.
Some people may develop side effects like decreased white blood cells, anemia, rash, nausea, and fever. These side effects are usually temporary and go away during treatment as your body adjusts to the medicine. Consult your doctor if these side effects bother you or do not go away.
Before starting treatment with this medicine, you should tell your doctor if you are pregnant, breastfeeding, or suffering from any liver, kidney, or heart problems or if you are allergic to any medicine. You may be regularly monitored with blood tests and chest x-rays to check that you do not have active tuberculosis or any other mycobacterial disease. Your doctor may advise for regular eye examination and liver function tests while using it.
Rifabutin 150mg Tablet may be used alone or in combination with other medicines to help prevent serious infections caused by microorganisms like mycobacterium avium complex (MAC). It should be taken in the dose and duration as advised by the doctor. This medicine should be taken on an empty stomach. It is better to take it at the same time each day to get the most benefit and you should keep on taking this medicine for as long as you are prescribed. Stopping it early may make the infection to come back and harder to treat.
Some people may develop side effects like decreased white blood cells, anemia, rash, nausea, and fever. These side effects are usually temporary and go away during treatment as your body adjusts to the medicine. Consult your doctor if these side effects bother you or do not go away.
Before starting treatment with this medicine, you should tell your doctor if you are pregnant, breastfeeding, or suffering from any liver, kidney, or heart problems or if you are allergic to any medicine. You may be regularly monitored with blood tests and chest x-rays to check that you do not have active tuberculosis or any other mycobacterial disease. Your doctor may advise for regular eye examination and liver function tests while using it.
Uses of Rifabutin Tablet
- Tuberculosis with HIV infection
Benefits of Rifabutin Tablet
In Tuberculosis with HIV infection
Rifabutin 150mg Tablet helps treat Mycobacterium avium complex disease (MAC; a bacterial infection that may cause serious symptoms) in patients with human immunodeficiency virus (HIV) infection. It kills as well as stops the growth of infection causing bacteria and helps in treating the infection. Take it in the dose and duration advised by the doctor. Your symptoms may improve before the infection is completely cured. Do not stop taking it without consulting your doctor as doing so may cause the infection to return or worsen. Follow your doctor’s instructions carefully to get maximum benefit.
Side effects of Rifabutin Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Rifabutin
- Nausea
- Rash
- Fever
- Anemia (low number of red blood cells)
- Decreased white blood cell count
How to use Rifabutin Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Rifabutin 150mg Tablet is to be taken empty stomach.
Avoid Rifabutin 150mg Tablet with acidic food and beverages such as sugar, certain dairy products, fish, processed foods, fresh meats and processed meats,sodas and other sweetened beverages.
Avoid Rifabutin 150mg Tablet with acidic food and beverages such as sugar, certain dairy products, fish, processed foods, fresh meats and processed meats,sodas and other sweetened beverages.
How Rifabutin Tablet works
Rifabutin 150mg Tablet works by inhibiting an enzyme DNA-dependent RNA polymerase in bacteria, leading to the suppression of RNA synthesis that is required for survival and this leads to cell death of infection-causing bacteria. This helps treat Mycobacterium avium complex disease (tuberculosis) in patients with human immunodeficiency virus (HIV) infection.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Rifabutin 150mg Tablet. Please consult your doctor.
Pregnancy
SAFE IF PRESCRIBED
Rifabutin 150mg Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Breast feeding
SAFE IF PRESCRIBED
Rifabutin 150mg Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
SAFE
Rifabutin 150mg Tablet does not usually affect your ability to drive.
Kidney
CAUTION
Rifabutin 150mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Rifabutin 150mg Tablet may be needed. Please consult your doctor.
Liver
CAUTION
Rifabutin 150mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Rifabutin 150mg Tablet may be needed. Please consult your doctor.
What if you forget to take Rifabutin Tablet?
If you miss a dose of Rifabutin 150mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Rifabutin 150mg Tablet
₹8.32/Tablet
Macbutin Tablet
Macleods Pharmaceuticals Pvt Ltd
₹42.83/tablet
415% costlier
Quick tips
- Rifabutin 150mg Tablet is used to treat tuberculosis in patients with HIV.
- Seek immediate medical attention if you develop sudden wheeziness, difficulty in breathing, pain in the chest, swelling of eyelids, face, or lips, rash or itching.
- Taking Rifabutin 150mg Tablet may change the color of your urine to red/orange. You may also experience coloring of the skin and other body fluids and also of soft contact lenses.
- You may be regularly monitored with blood tests and chest X-rays to check that you do not have active tuberculosis or any other mycobacterial disease.
- You may also undergo regular eye examinations while using Rifabutin 150mg Tablet.
- Use non-hormonal birth control techniques (condom, diaphragm with spermicide) to prevent pregnancy, as Rifabutin 150mg Tablet can make birth control pills less effective.
Fact Box
Chemical Class
Macrolactams
Habit Forming
No
Therapeutic Class
ANTI INFECTIVES
Action Class
RNA polymerase inhibitors- Rifamycins
Interaction with drugs
Taking Rifabutin with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Use other methods of contraception (IUDs, depot or barrier methods) both during and for 28 days following the discontinuation of Rifabutin. Rifabutin may reduce the efficacy of All
Do not consume Tenofovir Alafenamide with Rifabutin. Rifabutin may reduce blood levels of Tenofovir Alafenamide.
Do not consume Ulipristal acetate with Rifabutin. If Ulipristal acetate is essential, ensure a gap of At least 4 weeks after discontinuing Rifabutin. Please consult your doctor.
R
If concurrent use is essential, consult your doctor. Rifabutin may reduce blood levels of Sorafenib.
Do not consume Ranolazine with Rifabutin. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Rifabutin may reduce
Patient concerns
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Gumbo T. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1550-554.
- Chambers HF, Deck DH. Antimycobacterial Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 829.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1212-13.
- Rifabutin. Sandwich, Kent: Pfizer Limited; 2003 [revised Dec. 2015]. [Accessed 25 Jan. 2019] (online) Available from:
- Medscape. Rifabutin. [Accessed 01 Apr. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 01 Apr. 2019] (online) Available from:
Marketer details
Name: Lupin Ltd
Address: 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India
Country of origin: India
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