Rifnex 450mg/300mg Capsule
Prescription Required
Product introduction
Rifnex 450mg/300mg Capsule is a combination medicine used in the treatment of tuberculosis. It prevents the growth of the microorganisms that cause the infection.
Rifnex 450mg/300mg Capsule is a prescription medicine and it is to be taken as suggested by the doctor. It should be taken in an empty stomach and take it at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine. The medicine may take some to show its effects on the symptoms. However, it is advised to consult the doctor if you feel an aggravation of the condition or if your condition does not improve.
Some common side effects of this medicine are nausea, vomiting, fever, dark-colored urine, sweating, increased saliva, etc. To cope up with the side effects, you should drink plenty of water. If any of the side effects get aggravated, you must consult your doctor immediately. Generally, serious side effects are rare. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.
Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Patients with liver and kidney ailments must take this medicine with proper consultation and caution. Pregnant or breastfeeding women should also consult with the doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. During the treatment, you must take adequate rest and eat a healthy diet for a faster recovery. While on the medication, your doctor may ask for a few laboratory and diagnostic tests to know the effects of the medicine on your body.
Rifnex 450mg/300mg Capsule is a prescription medicine and it is to be taken as suggested by the doctor. It should be taken in an empty stomach and take it at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine. The medicine may take some to show its effects on the symptoms. However, it is advised to consult the doctor if you feel an aggravation of the condition or if your condition does not improve.
Some common side effects of this medicine are nausea, vomiting, fever, dark-colored urine, sweating, increased saliva, etc. To cope up with the side effects, you should drink plenty of water. If any of the side effects get aggravated, you must consult your doctor immediately. Generally, serious side effects are rare. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.
Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Patients with liver and kidney ailments must take this medicine with proper consultation and caution. Pregnant or breastfeeding women should also consult with the doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. During the treatment, you must take adequate rest and eat a healthy diet for a faster recovery. While on the medication, your doctor may ask for a few laboratory and diagnostic tests to know the effects of the medicine on your body.
Uses of Rifnex Capsule
Benefits of Rifnex Capsule
In Treatment of Tuberculosis (TB)
Rifnex 450mg/300mg Capsule is a combination of medicines that is used to treat tuberculosis, an infectious disease that mainly affects the lungs but can affect other parts of the body as well. It kills as well as stops the growth of infection causing bacteria and helps in treating the infection. Take it in the dose and duration advised by the doctor. Your symptoms may improve before the infection is completely cured. Do not stop taking it without consulting your doctor as doing so may cause the infection to return or worsen. Follow your doctor’s instructions carefully to get maximum benefit.
Side effects of Rifnex Capsule
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Rifnex
- Dark colored urine
- Rash
- Vomiting
- Jaundice
- Fever
- Increased liver enzymes
- Nausea
- Peripheral neuropathy (tingling and numbness of feet and hand)
How to use Rifnex Capsule
Take this medicine in the dose and duration as advised by your doctor. Rifnex 450mg/300mg Capsule is to be taken empty stomach.
Avoid Rifnex 450mg/300mg Capsule with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
Avoid Rifnex 450mg/300mg Capsule with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
How Rifnex Capsule works
Rifnex 450mg/300mg Capsule is a combination of two antibiotics: Rifampicin and Isoniazid, which treats tuberculosis (TB). Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by TB bacteria to make essential proteins and to reproduce. Isoniazid prevents these bacteria from forming their own protective covering. Together, they kill the bacteria and eradicate the infection.
Safety advice
Alcohol
UNSAFE
Consuming alcohol while taking Rifnex 450mg/300mg Capsule may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
Pregnancy
CONSULT YOUR DOCTOR
Rifnex 450mg/300mg Capsule may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
SAFE IF PRESCRIBED
Rifnex 450mg/300mg Capsule is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Driving
UNSAFE
Rifnex 450mg/300mg Capsule may cause side effects which could affect your ability to drive.
Rifnex 450mg/300mg Capsule can cause fits, mental health problems and optic neuritis (inflammation of the optic nerve that may cause loss of vision.) This may affect your driving ability.
Rifnex 450mg/300mg Capsule can cause fits, mental health problems and optic neuritis (inflammation of the optic nerve that may cause loss of vision.) This may affect your driving ability.
Kidney
CAUTION
Rifnex 450mg/300mg Capsule should be used with caution in patients with kidney disease. Dose adjustment of Rifnex 450mg/300mg Capsule may be needed. Please consult your doctor.
Liver
CAUTION
Rifnex 450mg/300mg Capsule should be used with caution in patients with liver disease. Dose adjustment of Rifnex 450mg/300mg Capsule may be needed. Please consult your doctor.
Use of Rifnex 450mg/300mg Capsule is not recommended in patients with severe liver disease.
Use of Rifnex 450mg/300mg Capsule is not recommended in patients with severe liver disease.
What if you forget to take Rifnex Capsule?
If you miss a dose of Rifnex 450mg/300mg Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
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Quick tips
- You have been prescribed Rifnex 450mg/300mg Capsule for the treatment of tuberculosis.
- Finish the full course of the medication, even if you feel better. Stopping it early may make the infection come back.
- Take it on an empty stomach, preferably at the same time everyday.
- It may discolour your urine, sweat, saliva and tears a reddish-orange colour. This is normal and not harmful.
- Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
- Avoid drinking alcohol while taking Rifnex 450mg/300mg Capsule as this may increase the risk of side effects on the liver.
- Use an alternative or additional contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Rifnex 450mg/300mg Capsule as it may make hormonal contraceptives such as the pill less effective.
- Do not take indigestion remedies (antacids) within at least two hours of taking Rifnex 450mg/300mg Capsule.
Fact Box
Habit Forming
No
Therapeutic Class
ANTI INFECTIVES
Patient concerns
FAQs
What is Rifnex 450mg/300mg Capsule?
Rifnex 450mg/300mg Capsule is a combination of two medicines: Rifampicin and Isoniazid. It is used in the treatment of tuberculosis. Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by tuberculosis bacteria to make essential proteins and reproduce. Isoniazid prevents the tuberculosis causing bacteria from forming their own protective covering. Together, they kill the bacteria and eradicate the infection.
What is the most important information I should know about the Rifnex 450mg/300mg Capsule?
Take the proper course of drug that has been prescribed to you. Do not stop in between even if you begin to feel better. Avoid alcohol while taking this medicine as it increases the risk of damage to your liver during treatment. Tell your doctor immediately if you experience vision changes, loss of appetite, tiredness, stomach pain, nausea or vomiting, yellow skin or eyes or dark-colored urine.
What is the best time to take Rifnex 450mg/300mg Capsule?
Take Rifnex 450mg/300mg Capsule exactly as directed by your doctor. It is best to take the medicine on an empty stomach one hour before or two hours after meals.
Does Rifnex 450mg/300mg Capsule cause change in urine color/turn urine orange?
Yes, Rifnex 450mg/300mg Capsule can change the color of your urine (skin, sweat, saliva, tears and feces) to brownish-red or orange. This effect is not harmful.
Does the use of Rifnex 450mg/300mg Capsule make birth control pills ineffective?
Yes, Rifnex 450mg/300mg Capsule can make birth control pills less effective. So, ask the doctor about using a birth control method which does not affect your hormone levels (such as a condom, diaphragm and spermicide).
What are the instructions for storage and disposal of Rifnex 450mg/300mg Capsule?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Isoniazid/rifampicin. Guildford Surrey: Aventis Pharma Limited; 1999 [revised 12 Mar. 2019]. [Accessed on 10 Apr. 2019] (online) Available from:
- Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy. In: Hilal-Dandan R, Brunton LL. Goodman and Gilman's Manual of Pharmacology and Therapeutics. 2nd ed. New York, New York: The McGraw-Hill Companies, Inc.; 2014. [Accessed 10 Apr. 2019] (online) Available from:
- Isoniazid. Nottingham, Nottinghamshire: Boots Contract Manufacturing; 2015. [Accessed 10 Apr. 2019] (online) Available from:
Marketer details
Name: Zenlabs Ethica Ltd
Address: Plot No. 194-195, 3rd Floor, Industrial Area, Phase-II, Chandigarh (India) - 160002
Country of origin: India
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