Ryzodeg 100IU/ml Penfill is a combination of two medicines, a long-acting and a rapid-acting type of insulin, used to treat types 1 and 2 diabetes mellitus in both adults and children. It provides a steady level of insulin in the body for an entire day and helps control blood sugar levels.
Ryzodeg 100IU/ml Penfill can be prescribed by itself or along with other diabetes medicines. Your doctor or nurse will teach you how to inject it under the skin correctly. You should use this medicine regularly as per the dose advised to get the most benefit. It is usually taken once daily at the same time every day. However, when administration at the same time of the day is not possible, it may be taken at a different time. Always ensure that there is a minimum gap of 8 hours between doses.
If you stop taking it, your blood sugar levels may rise very high and put you at risk of serious complications. It is only part of a treatment program that should include a healthy diet, regular exercise, and weight reduction, as your doctor advises.
This medicine's most common side effect is low blood sugar levels (hypoglycemia). To prevent this, it is important always to inject the correct dose of medicine only, have regular meals, and monitor your blood sugar levels regularly. Drinking excessive alcohol can also lead to a fall in your blood sugar levels. Other common side effects include allergic reactions, injection site reactions, lipodystrophy, itching, rash, edema, and weight gain.
Do not use this medicine when you have low blood sugar levels (hypoglycemia). Tell your doctor if you have ever had kidney, liver, or heart problems before starting treatment. Pregnant or breastfeeding women should also consult their doctor before using it.
Ryzodeg 100IU/ml Penfill combines long-acting insulin degludec and rapid-acting insulin aspart to provide flexible and convenient blood sugar control in patients with diabetes. The long-acting component helps maintain steady insulin levels throughout the day and night, while the rapid-acting insulin manages blood sugar spikes after meals. This reduces the number of injections needed, improves glycemic control, and helps lower the risk of hypoglycemia (low blood sugar), especially at night, making it a highly effective option for people with diabetes.
Side effects of Ryzodeg Solution for Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Ryzodeg
Hypoglycemia (low blood glucose level)
Injection site reactions (pain, swelling, redness)
Lipodystrophy (skin thickening or pits at the injection site)
Itching
Rash
Edema (swelling)
Weight gain
How to use Ryzodeg Solution for Injection
Your doctor or nurse will guide you how to use this medicine.
How Ryzodeg Solution for Injection works
Insulin degludec and insulin aspart. Insulin degludec has a prolonged duration of action while insulin aspart has a fast onset of action. Together, they ensure rapid and consistent sugar control by facilitating reuptake of sugar in muscle and fat cells, and suppressing the production of sugar in the liver.
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Ryzodeg 100IU/ml Penfill.
Pregnancy
CONSULT YOUR DOCTOR
Ryzodeg 100IU/ml Penfill may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Ryzodeg 100IU/ml Penfill during breastfeeding is not available. Please consult your doctor.
Driving
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
Kidney
SAFE IF PRESCRIBED
Ryzodeg 100IU/ml Penfill is safe to use in patients with kidney disease. No dose adjustment of Ryzodeg 100IU/ml Penfill is recommended. However, frequent and regular monitoring of blood glucose levels is advised.
Liver
SAFE IF PRESCRIBED
Ryzodeg 100IU/ml Penfill is safe to use in patients with liver disease. No dose adjustment of Ryzodeg 100IU/ml Penfill is recommended. However, frequent and regular monitoring of blood glucose levels is advised.
What if you forget to take Ryzodeg Solution for Injection?
If you miss a dose of Ryzodeg 100IU/ml Penfill, take it with your next main meal. Do not take extra insulin to make up for the missed dose. Always consult your doctor if you are not sure what to do.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
Take it 15 minutes before or within 20 minutes after starting a meal.
Injection below the skin of the abdomen results in faster absorption than other injection sites, such as the skin of the upper arms, thighs, or buttocks. After injection, the site of injection should not be massaged.
Injection sites must be rotated to prevent hard lumps from developing at one site.
Change to another type or brand of insulin should be done under strict medical supervision as it may require a change in dosage.
Hypoglycemia (low blood sugar level) may occur when taken along with other antidiabetic medicines, alcohol, or by delaying/skipping a meal. Carry a sugar source with you for immediate relief.
Do not share your insulin device with others, even if the needle has been changed. You may give other people a serious infection or get it from them.
Opened vials/cartridges can be kept at room temperature for up to 4 weeks, while unopened vials must be stored in the refrigerator (2°C–8°C).
Fact Box
Habit Forming
No
Therapeutic Class
ANTI DIABETIC
Patient concerns
Pl tell me is there any affordable substitute for following insulin ryzodeg I was using Lantus Solostar as sugar level is not steady Fasting 190 and pp 260 I have been advised to use ryzodeg insulin I found tht this is slightly on higher side pl advice PATIENT
Dr. Sanjay Bhatt
Physician
For priscribing substitute medicine wants to see the patient as needs complete medical history. You can discuss your problem with your doctor otherwise visit our clinic.
Insulin changed from ryzodeg to eglucent 25 75 but sugar levels not normal How many days we need to wait
Dr. Sanjay Bhatt
Physician
And then need dose adjuatmentA person can control his or her sugar levels by regular exercise and walk or regular aerobic exercises at least 30 to 45 minutes per day.MEDICAL NUTRITIONAL THERAPY THAT IS TO MAINTAIN CALORIES INTAKE AS PER BMI .TAKE HELP OF DIABETIC EDUCATOR. VISIT YOU DOCTOR AND FOLLOW ALL WHAT DOCTOR SUGGESTED. ALWAYS IN TIME ALL ROUTINE INVESTIGATIONS SHOULD BE DONE.you SHOULD not treat it as disease but start of a healthy life.Uncontrolled sugar levels for long time leads to lower limb weakness which is neuropathy and which is followed by foot ulcers and other complications.online prescription is not allowed without seeing pt.so contact doctor nearby for any change or dose adjustment or visit my clinic at gurgaon sector 52 RdCity snergy multi speciality clinic near SRS MARKET
Eglucent mix 25 75 replaced by doctors for ryzodeg but not able to set glucose levels. How many days should we wait administration is 30 units in evening before meal and 27,in morning
Dr. Sanjay Bhatt
Physician
A person can control his or her sugar levels by regular exercise and walk or regular aerobic exercises at least 30 to 45 minutes per day.MEDICAL NUTRITIONAL THERAPY THAT IS TO MAINTAIN CALORIES INTAKE AS PER BMI .TAKE HELP OF DIABETIC EDUCATOR. VISIT YOU DOCTOR AND FOLLOW ALL WHAT DOCTOR SUGGESTED. ALWAYS IN TIME ALL ROUTINE INVESTIGATIONS SHOULD BE DONE.you SHOULD not treat it as disease but start of a healthy life.Uncontrolled sugar levels for long time leads to lower limb weakness which is neuropathy and which is followed by foot ulcers and other complications.online prescription is not allowed without seeing pt.so contact doctor nearby for any change or dose adjustment or visit my clinic at gurgaon sector 52 RdCity snergy multi speciality clinic near SRS MARKET
Ryzodeg injection is better or lantus is better Is price more important and is higher price drug of the two injections said above Justified if it's higher value is better or the effectivity of both injections is identical
Dr. Sanjay Bhatt
Physician
Action and reaction of every medicine changes from patient to patient. Discuss with your doctor as he knows your medical history and sugar level. So he can priscribe for you a better medicine
A person can control his or her sugar levels by doing regular exercise and walk or regular aerobic exercises at least 30 to 45 minutes per day.MEDICAL NUTRITIONAL THERAPY THAT IS TO MAINTAIN CALORIES INTAKE AS PER BMI .TAKE HELP OF DIABETIC EDUCATOR. VISIT YOUR DOCTOR AND FOLLOW ALL WHAT DOCTOR SUGGESTED.IN TIME ALL ROUTINE INVESTIGATIONS SHOULD BE DONE.you should not treat it as disease but a start of a healthy life.Uncontrolled sugar levels for long time leads to lower limb weakness which is neuropathy and which is followed by foot ulcers and other complications like kidney or heart problems .online prescription is not allowed without seeing pt.so contact doctor nearby for any change or dose adjustment or visit my clinic at gurgaon sector 52 RdCity snergy multi speciality clinic near SRS MARKET
Diabetes is a medical condition in which sugar, or glucose, levels build up in your bloodstream. There?s not enough insulin to move the sugar into your cells, which are where the sugar is used for energy. This causes your body to rely on alternative energy sources in your tissues, muscles, and organs. This is a chain reaction that can cause a variety of symptoms. Type 2 diabetes can develop slowly. The symptoms may be mild and easy to dismiss at first. The early symptoms may include: constant hunger a lack of energy fatigue weight loss excessive thirst frequent urination dry mouth itchy skin blurry visionDiet is an important tool to keep your heart healthy and blood sugar levels within a safe and healthy range. It doesn?t have to be complicated or unpleasant. The diet recommended for people with type 2 diabetes is the same diet just about everyone should follow. It boils down to a few key actions: Eat meals and snacks on schedule. Choose a variety of foods that are high in nutrition and low in empty calories. Be careful not to overeat. Read food labels closely.
A person can control his or her sugar levels by regular exercise and walk or regular aerobic exercises at least 30 to 45 minutes per day.MEDICAL NUTRITIONAL THERAPY THAT IS TO MAINTAIN CALORIES INTAKE AS PER BMI .TAKE HELP OF DIABETIC EDUCATOR. VISIT YOU DOCTOR AND LOW ALL WHAT DOCTOR SUGGESTED.IN TIME ALL ROUTINE INVESTIGATIONS SHOULD BE DONE.you souls not treat it as disease but start of a healthy life.Uncontrolled sugar levels for long time leads to lower limb weakness which is neuropathy and which is followed by foot ulcers and other complications.online prescription is not allowed without seeing pt.so contact doctor nearby for any change or dose adjustment or visit my clinic at gurgaon sector 52 RdCity snergy multi speciality clinic near SRS MARKET
What are you using Ryzodeg Solution for Injection for?
Type 2 diabet*
67%
Type 1 diabet*
23%
Others
10%
*Type 2 diabetes mellitus, Type 1 diabetes mellitus
How much was the improvement?
Excellent
51%
Average
33%
Poor
16%
What were the side-effects while using Ryzodeg 100IU/ml Penfill?
No Side Effec*
72%
Hypoglycemia *
7%
Lipodystrophy*
7%
Weight gain
4%
Rash
4%
*No Side Effect, Hypoglycemia (low blood glucose level), Lipodystrophy (skin thickening or pits at the injection site)
How do you take Ryzodeg Solution for Injection?
With food
50%
With or witho*
46%
Empty stomach
4%
*With or without food
Please rate Ryzodeg 100IU/ml Penfill on price
Expensive
81%
Average
14%
Not Expensive
5%
FAQs
What is Ryzodeg 100IU/ml Penfill?
Ryzodeg 100IU/ml Penfill is a combination of two types of insulin: insulin degludec (long-acting) and insulin aspart (rapid-acting). It is used to help control blood sugar levels in people with diabetes.
How does Ryzodeg 100IU/ml Penfill work?
Ryzodeg 100IU/ml Penfill works by mimicking the natural insulin produced by the pancreas. Insulin aspart helps manage blood sugar levels after meals, while insulin degludec provides a steady release of insulin to control blood sugar between meals and overnight.
Who should use Ryzodeg 100IU/ml Penfill?
Ryzodeg 100IU/ml Penfill is prescribed for adults, adolescents, and children over 2 years old with Type 1 or Type 2 diabetes who require insulin to manage their blood sugar levels.
How should I use Ryzodeg 100IU/ml Penfill?
Ryzodeg 100IU/ml Penfill should be injected under the skin (subcutaneously) using a compatible insulin delivery device (pen). It is typically administered once or twice daily, with at least one dose given with a main meal. Follow your doctor's instructions on dosage and timing.
Can Ryzodeg 100IU/ml Penfill be mixed with other insulins?
No, Ryzodeg 100IU/ml Penfill should not be mixed with other insulins. Follow the exact prescription instructions. Avoid combining it with other insulin products in the same injection.
How should I store Ryzodeg 100IU/ml Penfill?
Store Ryzodeg 100IU/ml Penfill in a refrigerator between 2°C and 8°C. Do not freeze it. After opening, the pen can be stored at room temperature for up to 28 days. Keep it away from direct heat and sunlight.
Can Ryzodeg 100IU/ml Penfill be used during pregnancy or breastfeeding?
If you are pregnant or planning to become pregnant, consult your doctor before using Ryzodeg 100IU/ml Penfill. It is important to maintain good blood sugar control during pregnancy. If you are breastfeeding, your doctor will determine if Ryzodeg 100IU/ml Penfill is suitable for you.
What should I do in case of an overdose?
An overdose of Ryzodeg 100IU/ml Penfill can cause hypoglycemia (low blood sugar). Symptoms may include dizziness, confusion, sweating, and shakiness. If you suspect an overdose, consume sugar or a sugary snack, and contact your healthcare provider immediately.
Can Ryzodeg 100IU/ml Penfill be used by children?
Yes, Ryzodeg 100IU/ml Penfill is approved for use in children over 2 years of age who have diabetes. The dosage for children will depend on individual needs, as determined by the doctor.
Do I need to monitor my blood sugar levels while using Ryzodeg 100IU/ml Penfill?
Yes, regular blood sugar monitoring is essential when using Ryzodeg 100IU/ml Penfill. Your doctor will guide you on how often you should check your levels and adjust your insulin dose if necessary.
What should I do if I experience an allergic reaction to Ryzodeg 100IU/ml Penfill?
Allergic reactions to insulin are rare, but if you experience symptoms such as rash, itching, difficulty breathing, or swelling of the face or throat, seek medical help immediately.
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
Insulin degludec and insulin aspart injection. Bagsvaerd, Denmark: Novo Nordisk A/S; 2015 [revised Sep. 2015]. [Accessed 08 Apr. 2019] (online) Available from:
Country of origin: Denmark Expires on or after: June, 2025
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