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MD Pharmacology, MBBS
Last updated
26 Jan 2026 | 10:46 PM (IST)

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Silirate-U 140mg/300mg Tablet

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Storage
Store below 30°C

Product introduction

Silirate-U 140mg/300mg Tablet is a combination medicine used in the treatment of liver disease. It is the prescription medicine works by improving the functioning of the liver.

Silirate-U 140mg/300mg Tablet is taken with or without food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your healthcare team know about all other medications you are taking as some may affect, or be affected by this medicine.

The most common side effects are diarrhea and sticky stools. Most of these are temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about any of these side effects.

Before taking this medicine, you should tell your doctor if you are pregnant, planning pregnancy or breastfeeding. You should tell your doctor if you have any kidney or liver diseases so that your doctor can prescribe a suitable dose for you.


Uses of Silirate-U Tablet

  • Liver disease

Benefits of Silirate-U Tablet

In Liver disease

Liver disease affects the liver’s ability to process toxins, produce bile, and support digestion, leading to fatigue, poor appetite, and abnormal liver tests. Silirate-U 140mg/300mg Tablet helps support liver function and bile flow, which can improve digestion and reduce liver-related discomfort. Its use supports liver cell protection and overall liver health, helping maintain better liver function over time.

Side effects of Silirate-U Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Silirate-U

  • Diarrhea
  • Sticky stools

How to use Silirate-U Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Silirate-U 140mg/300mg Tablet may be taken with or without food.

How Silirate-U Tablet works

Silirate-U 140mg/300mg Tablet is a combination of two medicines: Silymarin and Ursodeoxycholic Acid. They work by protecting the liver from harmful chemical substances (free radicals), thus preventing liver damage.

Safety advice

Alcohol
CAUTION
Alcohol should be used with caution while taking Silirate-U 140mg/300mg Tablet.
Pregnancy
CONSULT YOUR DOCTOR
The safety of Silirate-U 140mg/300mg Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Silirate-U 140mg/300mg Tablet during breastfeeding is not available. Please consult your doctor.
Driving
SAFE
Silirate-U 140mg/300mg Tablet does not usually affect your ability to drive.
Kidney
CONSULT YOUR DOCTOR
There is limited data available on the use of Silirate-U 140mg/300mg Tablet in patients with kidney disease. Please consult your doctor.
Liver
SAFE IF PRESCRIBED
Silirate-U 140mg/300mg Tablet is safe to use in patients with liver disease. No dose adjustment is recommended.

What if you forget to take Silirate-U Tablet?

If you miss a dose of Silirate-U 140mg/300mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine

Quick tips

  • Silirate-U 140mg/300mg Tablet is used for the treatment of various liver disease and helps in its proper functioning.
  • Your doctor may monitor your liver function and bilirubin levels regularly.
  • Avoid smoking and drinking as it further degrades liver functioning.
  • Avoid fatty food, take a healthy diet, and exercise regularly.
  • Keep sipping water or have sugar-free gum in order to relieve dryness in the mouth.

Fact Box

Habit Forming
No
Therapeutic Class
GASTRO INTESTINAL

Patient concerns

Sir can u suggest best tonic or tablet for liver health
Dr. Sunil Sekhri
Diabetology
Get LFT done and send the reports to see the functions of Liver
This is my blood test report what it shows Regular pain in stomachMale, 31I have regular pain in abdomen both side I got blood test and in my report showing: 1. SGOT value is- 60.9, u/i 2. SGPT value is -88.3, u/i 3. Alkaline phosphate value is -179.6, u/i 4. GGT value is 187.7, u/i Is there any worry about that or serious thing
Dr. Sfurti Mann
Internal Medicine
Get a fibroscan for liver fone May be fatty liver

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Ursodiol. Birmingham, Alabama: Axcan Pharma US, Inc.; 1997 [revised Nov. 2009]. [Accessed 15 Apr.. 2019] (online) Available from:External Link
  2. ScienceDirect. Silymarin. [Accessed 15 Apr. 2019] (online) Available from:External Link
  3. Ursodiol. Birmingham, Alabama: Axcan Pharma US, Inc; 1997. [Accessed 15 Apr. 2019] (online) Available from:External Link

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Address: Pabhat Road , Zirakpur - 160001, Punjab, India
Country of origin: India

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