Simulect Injection
Prescription Required
Product introduction
Simulect Injection belongs to the immunosuppressant group of medicines. It regulates the immune system to prevent rejection of the kidney transplantation. It is usually prescribed in combination with some other medicines.
Simulect Injection is a prescription medicine that must be administered by a healthcare professional. You must receive the exact dose of it as per the prescription. An overdose of this medicine may have serious side effects on the body.
The common side effects of this medicine are nausea, vomiting, constipation, etc. It may also cause an injection site reaction (redness, pain, and swelling). The medicine can safely be used in children.
Before taking this medicine, it is important to consult your doctor if you have any ongoing medication for any underlying disease. Pregnant and breastfeeding women must inform the doctor prior to the initiation of this treatment. During the treatment, your doctor may advise you some laboratory tests to know the effects of the medicine in the body.
Simulect Injection is a prescription medicine that must be administered by a healthcare professional. You must receive the exact dose of it as per the prescription. An overdose of this medicine may have serious side effects on the body.
The common side effects of this medicine are nausea, vomiting, constipation, etc. It may also cause an injection site reaction (redness, pain, and swelling). The medicine can safely be used in children.
Before taking this medicine, it is important to consult your doctor if you have any ongoing medication for any underlying disease. Pregnant and breastfeeding women must inform the doctor prior to the initiation of this treatment. During the treatment, your doctor may advise you some laboratory tests to know the effects of the medicine in the body.
Uses of Simulect Injection
- Prevention of kidney transplant rejection
Benefits of Simulect Injection
In Prevention of kidney transplant rejection
Simulect Injection is used with other medications to prevent kidney transplant rejection. Rejection usually happens due to attack by the immune system of the person receiving the transplanted organ on the transplant itself, in people who are receiving kidney transplants. This medicine reduces the activity of a person's own immune system and prevents any such rejection.
Side effects of Simulect Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Simulect
- Nausea
- Constipation
- Abdominal pain
- Diarrhea
- Indigestion
- Vomiting
- Weight gain
- Headache
- Pain
- Swelling of hands
- High blood pressure
- Anemia (low number of red blood cells)
- Injection site reactions (pain, swelling, redness)
How to use Simulect Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Simulect Injection works
Simulect Injection suppresses the activity of body's immune system and prevents rejection of the kidney transplantation.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Simulect Injection. Please consult your doctor.
Pregnancy
SAFE IF PRESCRIBED
Simulect Injection is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Breast feeding
SAFE IF PRESCRIBED
Simulect Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
SAFE
Simulect Injection does not usually affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Simulect Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Simulect Injection may not be needed in these patients. Please consult your doctor.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Simulect Injection in patients with liver disease. Please consult your doctor.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
- Simulect Injection is given as an injection into the veins by a healthcare provider only.
- The first dose is given 2 hours before transplantation and a second dose after 4 days of surgery.
- Avoid taking any vaccination while on treatment with this medicine without doctor consultation.
- Simulect Injection may increase your susceptibility to infections. Inform your doctor if you get any signs of infection during treatment.
Fact Box
Chemical Class
Monoclonal antibody (mAb)
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
IL-2 Receptor anatgonist
Interaction with drugs
Taking Simulect with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Basiliximab may raise blood levels of Ciclosporin.
Caution is advised when taking Basiliximab with Ciclosporin. Your doctor may closely monitor the effects of Ciclosporin if used
Basiliximab may raise blood levels of Ciclosporin.
Caution is advised when taking Basiliximab with Ciclosporin. Your doctor may closely monitor the effects of Ciclosporin if used
Basiliximab may raise blood levels of Tacrolimus.
If concurrent use is essential, your doctor may monitor your tacrolimus levels, potassium levels and kidney function closely. The
Patient concerns
User feedback
What are you using Simulect Injection for?
Prevention of*
100%
*Prevention of kidney transplant rejection
How much was the improvement?
Poor
50%
Excellent
33%
Average
17%
What were the side-effects while using Simulect Injection?
No Side Effec*
50%
Constipation
25%
Abdominal pai*
25%
*No Side Effect, Abdominal pain
How do you take Simulect Injection?
With or witho*
67%
With food
33%
*With or without food
Please rate Simulect Injection on price
Expensive
67%
Average
33%
FAQs
What is Simulect Injection used for?
Simulect Injection is a class of medications called immunosuppressants. It is used to prevent immediate transplant rejection (attack of the transplanted organ by the immune system of the person receiving the organ) in people who are receiving kidney transplants.
When you must not have Simulect Injection?
Inform your doctor if you have ever had an allergic reaction to basiliximab, the active ingredient in Simulect Injection, or to any of the other ingredients of this medicine. Also, inform if you are pregnant or breastfeeding before the start of the treatment.
How should this medicine be used?
This medicine comes as a powder to be mixed with water and injected intravenously (into a vein) by a doctor or nurse in a hospital or medical facility. It is usually given in 2 doses. The first dose is usually given 2 hours before the transplant surgery, and the second dose is usually given 4 days after the transplant surgery.
When should I call my doctor right away?
Get medical help right away if you have signs of allergic reaction such as rash, hives, itching, and blisters. Also, let your doctor know if you experience wheezing, difficulty breathing, fast heartbeat, muscle aches, swelling all over the body, fever, chills, difficult or painful urination.
Can Simulect Injection be given to a breastfeeding woman?
There are no studies available concerning the excretion of basiliximab into breast milk. However, since Simulect Injection is an immunoglobulin G (IgG1K) antibody, it may cross the human placenta and may be excreted in human milk. Women receiving Simulect Injection should not breastfeed for 4 months following the last dose.
How to relieve constipation during the treatment?
To relieve constipation, include fiber in your diet (fruits and vegetables), drink 8-10 glasses of fluids a day, and keep active. A stool softener (with a doctor's prescription) once or twice a day may prevent constipation. If you do not have a bowel movement for 2-3 days, consult your doctor.
How to get relief from diarrhea while on treatment with Simulect Injection?
Food items with soluble fiber can help relieve diarrhea as they help absorb excess fluid from the body. These food items include bananas (ripe), orange, boiled potatoes, white rice, curd, and oatmeal. Diarrhea can cause dehydration in the body, so drink 8-10 glasses of water to avoid dehydration. You can also have soups and juice frequently to hydrate yourself.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Lake DF, Briggs AD, Akporiaye ET. Immunopharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 979.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 124-25.
- Drugs.com. Basiliximab. [Accessed 06 Apr. 2019] (online) Available from:
- Medscape. Basiliximab. [Accessed 06 Apr. 2019] (online) Available from:
- Basiliximab. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation; 2018. [Accessed 28 Jan. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 06 Apr. 2019] (online) Available from:
Marketer details
Name: Novartis India Ltd
Address: Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Country of origin: India
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