Terifrac Injection is a man-made version of parathyroid hormone used to treat men and postmenopausal women who have severe osteoporosis with a high risk of fractures. It works by stimulating new bone formation, which improves bone density and decreases the risk of spinal fractures.
Terifrac Injection should be injected under the skin or given by a healthcare professional. You should use it regularly and at the same time each day to get the maximum benefit from it. Usually, it is recommended to take it for a maximum period of 2 years. However, follow the doctor’s advice and complete the course even if you feel better. It should be stored in the refrigerator at a temperature of 2°C to 8°C.
Some common side effects of this medicine include joint pain, injection site reactions (such as pain, swelling, and redness) and leg cramps. consult with your doctor if any of these bother you or do not go away.
Before taking this medicine, let your doctor know if you have kidney stones or any other kidney problems, as it can cause an increase in the amount of calcium in blood or urine. Pregnant and breastfeeding mothers should also consult with their doctors before taking this medicine. Your doctor may advise a bone scan to monitor the progress of your treatment.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Terifrac
Joint pain
Injection site reactions (pain, swelling, redness)
Nausea
Leg cramps
How to use Terifrac Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Terifrac Injection works
Terifrac Injection is a synthetic form of a natural human hormone called parathyroid hormone (PTH). It works by increasing the number and activity of bone-forming cells (osteoblasts). This strengthens the bones and minimizes the risk of fractures.
Safety advice
Alcohol
CAUTION
Caution is advised when consuming alcohol with Terifrac Injection. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Terifrac Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Terifrac Injection during breastfeeding is not available. Please consult your doctor.
Driving
UNSAFE
Terifrac Injection may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CAUTION
Terifrac Injection should be used with caution in patients with kidney disease. Dose adjustment of Terifrac Injection may be needed. Please consult your doctor. Use of Terifrac Injection is not recommended in patients with severe kidney disease.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Terifrac Injection in patients with liver disease. Please consult your doctor.
What if you forget to take Terifrac Injection?
If you miss a dose of Terifrac Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Terifrac Injection should be injected every day under the skin (subcutaneous injection) of the thigh or abdomen.
Do not take it for more than 2 years.
You may have low blood pressure and dizziness during the initial few days.
If you feel dizzy (light-headed) after injection, sit or lie down until you feel better.
Tell your doctor immediately if you experience nausea, vomiting, constipation, low energy, or muscle weakness. These may be signs of high calcium levels in your blood.
Tell your doctor if you are breastfeeding, pregnant or plan to become pregnant.
Fact Box
Chemical Class
Parathyroid Hormone Analogs
Habit Forming
No
Therapeutic Class
HORMONES
Action Class
Parathyroid Hormone (PTH) Analogues
Interaction with drugs
Taking Terifrac with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Pamidronate may reduce the efficacy of Teriparatide.
If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.
Risedronate may reduce the efficacy of Teriparatide.
If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.
Etidronate may reduce the efficacy of Teriparatide.
If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.
Severe pain in heels and ankles, and pain in lower back. Tests conducted revealed some concerns with bone density (particularly high fracture risk for AP Spine L1-L4), and out of range results for Hydroxy Vit D ESR and HSCRP (3.84 mg/L). Patient has taken the medicines but would like to seek second opinion before proceeding with the prescribed injections (which are clearly very expensive). Pain has subsided since taking the medicines.
Vipul Aggarwal
She has age related osteoporosis. Treatment suggested is absolutely correct. And i agree with it. U can consider inj terifrac. Which is a cheaper Indian alternative but forteo is the best if u can afford it
While inject terifrac injection,body gets shivers and painfull.Leg cramps and can't pull up both the leg but I have fracture on only left leg.what should i do now.i can't sleep well because of this injection.please do needful.
Dr. Akshat Goel
Orthopaedics
Ask your treating doctor for an alternative therapy
I am Prashant Jodh,he is my father, my question is father having osteoporosis with fracture in spinalcord.doctor advice him terifrac inj for the dose of six months. But problem is my father is not taking solid food. Therefore his body is weak.he can't stand on his own feet.terifrac inj is continue and three mths completed.kindly advice something that he can stand his own feet at least.father having no sugar and BP problem. All the reports are normal. Urine infection was there sometimes.now they take liquid intake only in a very few quantity. Pl adv me for more improvement.
Dr. Akshat Goel
Orthopaedics
Ask the treating doctor to prescribe a spinal brace (eg; Taylor's brace) for him which will help to sit and stand daily massage will also help to improve the muscle tone
What were the side-effects while using Terifrac Injection?
Limb pain
25%
Dizziness
20%
Joint pain
15%
Injection sit*
15%
No Side Effec*
10%
*Injection site pain, No Side Effect
How do you take Terifrac Injection?
With food
56%
With or witho*
37%
Empty stomach
7%
*With or without food
Please rate Terifrac Injection on price
Expensive
63%
Average
20%
Not Expensive
17%
FAQs
Is Terifrac Injection a steroid?
No, Terifrac Injection is not a steroid. However, this medicine may be used to treat osteoporosis caused by long-term use of steroids. Generally, this medicine is used to treat osteoporosis in women of postmenopausal age group and in men who have increased risk of fracture.
Can I take this medication in long term for osteoporosis?
Terifrac Injection should not be taken for longer than 2-year course. It is important to inform the doctor if you have taken this medication in the past, as you should not receive more than one treatment of 24 months course more than once in your lifetime.
How is Terifrac Injection stored at home?
Always keep this medicine stored in a refrigerator at a temperature of about 2°C to 8°C. Be cautious, the temperature should not decrease further as freezing may cause the medicine to get damaged and can lead to loss of activity. Therefore, avoid placing the Terifrac Injection pens close to the ice compartment of the refrigerator. If properly stored this medication can be used up to 28 days after the first injection. If the pen is not empty within 28 days please discard it safely.
Who should not use Terifrac Injection?
The doctor will decide whether the medicine is required for a patient or not. There are few conditions in which the use of Terifrac Injection should be avoided such as in patients with kidney impairment, Paget’s disease, any type of bone cancers or unexplained high levels of serum calcium. It should also be avoided by children, young adult or growing age, pregnant or lactating females. Hence, before starting the medication inform the doctor about any medical condition and the medication you are taking. This will help the doctor to design a proper therapy for you.
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
Bikle DD. Agents That Affects Bone Mineral Homoestasis. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 766.
Friedman PA. Agents Affecting Mineral Ion Homeostasis and Bone Turnover. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1300